• The transcription factor cyclic AMP-responsive element binding protein (CREB) is involved in important neuronal functions, such as synaptic plasticity and neuronal survival. (biomedcentral.com)
  • A synthase for cyclic AMP-GMP (cAG, also referenced as 3′-5′, 3′-5′ cGAMP) called DncV is associated with hyperinfectivity of Vibrio cholerae but has not been found in many bacteria, raising questions about the prevalence and function of cAG signaling. (pnas.org)
  • Here, we define IFI16 dynamics in space and time and its distinct functions from the DNA sensor cyclic dinucleotide GMP-AMP synthase (cGAS). (asm.org)
  • To date, several DNA sensors that activate the canonical STING/TBK-1/IRF3 signaling axis have been proposed, including IFI16 ( 4 - 6 ) and, most recently, the DNA sensor cyclic GMP-AMP synthase (cGAS) ( 15 - 18 ). (asm.org)
  • The suggestion a decade ago that metformin reduces glucose synthesis through activation of the enzyme AMP-activated protein kinase (AMPK) has recently been challenged by genetic loss-of-function experiments. (nih.gov)
  • One of the important candidates is cyclic AMP (cAMP), which is long known as a potent suppressor at least of T cell activation and function. (frontiersin.org)
  • Cyclic AMP-responsive element-dependent activation of Epstein-Barr virus zebra promoter by human herpesvirus 6. (asm.org)
  • Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (cGAMP) from ATP and GTP (PubMed:23258413, PubMed:23707061, PubMed:23722159, PubMed:24077100, PubMed:25131990). (rcsb.org)
  • 000143240 001__ 143240 000143240 005__ 20180913055601.0 000143240 022__ $$a0014-2999 000143240 02470 $$2PMID$$a6263646 000143240 0247_ $$2doi$$a10.1016/0014-2999(81)90395-2 000143240 037__ $$aARTICLE 000143240 245__ $$aVIP-and glucagon-induced formation of cyclic AMP in intact retinae in vitro 000143240 269__ $$a1981 000143240 260__ $$c1981 000143240 336__ $$aJournal Articles 000143240 520__ $$aVIP, glucagon or several other neuropeptides were applied to intact retinae in vitro. (epfl.ch)
  • In tissue samples from canine eyes, fenoldopam at a concentration of 10(-4) M increased the endogenous cyclic AMP level from a basal value of 26.0 +/- 4.6 to 64.2 +/- 5.7 pmol/mg protein. (arvojournals.org)
  • 1. Platelet behaviour in vitro in relation to cyclic AMP was studied longitudinally during pregnancy and in the same women when they were not pregnant. (clinsci.org)
  • Our understanding of cyclic AMP signaling in the nucleus has expanded considerably over the past decade, owing in large part to the characterization of cyclic AMP-responsive promoter elements, transcription factors that bind them, and signal-dependent coactivators that mediate target gene induction. (nih.gov)
  • The existence of eukaryotic CNB domains not associated with binding of cyclic nucleotides suggests that orphan CNB domains in other eukaryotes may bind undiscovered signalling molecules. (nature.com)
  • It was of interest to determine whether the dibutyryl analog of cyclic AMP and other adenine nucleotides regulate conduction anesthesia as well. (springer.com)
  • As measured by radioimmunoassay, fenoldopam at a concentration of 10(-5) M caused a 4-fold increase in the cyclic AMP content, from a basal level of 24.4 +/- 1.9 to 101.8 +/- 6.3 pmol/mg protein, of the trabecular meshwork samples from porcine eyes. (arvojournals.org)
  • 2017. https://www.tabers.com/tabersonline/view/Tabers-Dictionary/750877/all/cyclic_AMP. (tabers.com)
  • Phototaxis and thermotaxis by Dictyostelium discoideum slugs on water agar were impaired by the presence in the agar of adenosine, which is a cyclic AMP receptor antagonist in aggregating amoebae. (biologists.org)
  • Cyclic AMP is thus seen to mediate the actions of several catabolic hormones as well as promote the release of an anabolic hormone which acts in part by opposing cyclic AMP. (diabetesjournals.org)
  • For instance, all the steroid hormones (testosterone, estrogen, progesterone) require cyclic AMP for their production. (nethealthbook.com)
  • It is only possible to determine the changes in the metabolic pathways in time consuming research settings by measuring the various "substrates" , "enzymes" and hormones that are involved in the complex biochemical pathways involving cyclic AMP. (nethealthbook.com)
  • These results support the proposal that LomTKs are involved in controlling the release of the adipokinetic hormones and suggest that all LomTK isoforms may participate in this cyclic AMP-mediated event. (kuleuven.be)
  • Serezani CH, Ballinger MN, Aronoff DM, Peters-Golden M. Cyclic AMP: master regulator of innate immune cell function. (biovendor.com)
  • Moreover, MP407 is able to increase the cyclic AMP formation both in resting and activated platelets. (ovid.com)
  • 2. There was a progressive decline during pregnancy in sensitivity of platelets to inhibition of the arachidonic acid-induced release reaction by agents which act via cyclic AMP. (clinsci.org)
  • The secretion of cyclic di-AMP was dependent on MdrT, a multidrug resistance transporter, and LO28 exhibited a very high level of mdrT expression. (asm.org)