• Cyclic AMP receptors from slime molds are a distinct family of G-protein coupled receptors. (wikipedia.org)
  • In D. discoideum, the cyclic AMP receptors coordinate aggregation of individual cells into a multicellular organism, and regulate the expression of a large number of developmentally-regulated genes. (wikipedia.org)
  • Cell surface cyclic AMP receptors are not included (CYCLIC AMP RECEPTORS), nor are the eukaryotic cytoplasmic cyclic AMP receptor proteins, which are the regulatory subunits of CYCLIC AMP-DEPENDENT PROTEIN KINASES. (bvsalud.org)
  • The Au disk electrode, which was modified with the designed 17-mer oligopeptide, responded to cyclic AMP but virtually did not respond to any other cyclic nucleotides using the ion channel sensor mechanism. (elsevierpure.com)
  • Endothelin receptor type A signals both the accumulation of inositol phosphates and the inhibition of cyclic AMP generation in rat myometrium: stimulation and desensitization. (aspetjournals.org)
  • In E. coli (and other Gram-negative bacteria) the cyclic AMP receptor protein (CRP/CAP) regulates more than 500 genes. (ku.dk)
  • Chen, R & Lee, JC 2003, ' Functional roles of loops 3 and 4 in the cyclic nucleotide binding domain of cyclic AMP receptor protein from Escherichia coli ', Journal of Biological Chemistry , vol. 278, no. 15, pp. 13235-13243. (utmb.edu)
  • Cyclic AMP receptor protein was originally identified as a catabolite gene activator protein. (bvsalud.org)
  • 4. By contrast, platelet cyclic AMP accumulation in response to a variety of adenylate cyclase stimulators was reduced from early pregnancy, throughout the gestational period, compared with post-natally. (portlandpress.com)
  • 5. Compared with healthy women, platelets from women with a previous history of pre-eclampsia tended to accumulate less cyclic AMP in response to adenylate cyclase stimulators. (portlandpress.com)
  • Cyclic AMP is synthesized from ATP by adenylate cyclase located on the inner side of the plasma membrane and anchored at various locations in the interior of the cell. (wikipedia.org)
  • Fasciola hepatica were collected from fresh beef livers and particulate fractions of whole flukes, 'tails' or 'heads' (anterior ends) assayed for adenylate cyclase (AC) activity and cyclic AMP concentration using a protein binding assay. (erowid.org)
  • In the presence of O.i mM 5HT, AC activity in the fluke particles was inhibited by 0.5 mcM LSD, and LSD also antagonized the 5HT stimulated increase in cyclic AMP levels, Adenine, adenosine, histamine (Calbiochem), adrenaline (Mann), tryptophan, dopamine, GTP (Sigma - Chem. (erowid.org)
  • Fetal hemoglobin inducers such as hemin, butyrate, and hydroxyurea stimulate γ-globin gene expression by activating the cyclic GMP (cGMP)-dependent pathway. (elsevierpure.com)
  • Although cGMP activates the cyclic AMP (cAMP)-dependent pathway by suppressing cGMP-inhibited phosphodiesterase 3 (PDE3), the effects of the cAMP-dependent pathway on γ-globin gene expression are unknown. (elsevierpure.com)
  • The models of most immune evasion during innate immune responses are conserved, including altering the post-transcriptional modifications (PTMs) of vital proteins to inactivate or degrade these components, eluding DNA sensing from PRRs, decreasing cyclic GMP-AMP (cGAMP) cellular abundance, and modifying metabolism approach in host cells ( Eaglesham and Kranzusch, 2020 ). (frontiersin.org)
  • In addition, cAMP binds to and regulates the function of ion channels such as the HCN channels and a few other cyclic nucleotide-binding proteins such as Epac1 and RAPGEF2 . (wikipedia.org)
  • Cyclic AMP binds to specific locations on the regulatory units of the protein kinase, and causes dissociation between the regulatory and catalytic subunits, thus enabling those catalytic units to phosphorylate substrate proteins. (wikipedia.org)
  • A group of enzymes that are dependent on CYCLIC AMP and catalyze the phosphorylation of SERINE or THREONINE residues on proteins. (rush.edu)
  • Alterations in cyclic amp metabolism associated with photoreceptor cel" by R N. Lolley, S Y. Schmidt et al. (jax.org)
  • Alterations in cyclic amp metabolism associated with photoreceptor cell degeneration in the c3h mouse. (jax.org)
  • Using a mouse model of genetic copper misregulation, in combination with pharmacological alterations in copper status and imaging studies in a 3T3-L1 white adipocyte model, we found that copper regulates lipolysis at the level of the second messenger, cyclic AMP (cAMP), by altering the activity of the cAMP-degrading phosphodiesterase PDE3B. (nih.gov)
  • Cyclic AMP is a ubiquitous secondary message that regulates a large variety of functions. (utmb.edu)
  • Intracellular signaling by the second messenger cyclic AMP (cAMP) activates the Ras-related small GTPase Rap1 through the guanine exchange factor Epac. (johnshopkins.edu)
  • The results demonstrated that two cyclic AMP responsive elements (CREs) in the proximal promoter region of C/EBPβ were involved in the positive regulation of C/EBPβ transcription during granulocyte-macrophage colony-stimulating factor (GM-CSF)-induced differentiation of bone marrow cells. (harvard.edu)
  • Scholars@Duke publication: Regulation of tyrosine hydroxylase mRNA by glucocorticoid and cyclic AMP in a rat pheochromocytoma cell line. (duke.edu)
  • The cyclic GMP-AMP synthase (cGAS)-Stimulator of Interferon Genes (STING) pathway is a critical defender to sense various pathogens and trigger innate immunity of mammalian cells. (frontiersin.org)
  • Dysfunctional telomeres trigger cellular senescence mediated by cyclic GMP-AMP synthase. (bvsalud.org)
  • We found that this phenomenon is caused not by telomere shortening , but by cyclic GMP -AMP synthase (cGAS) recognizing cytosolic chromatin fragments and then activating the stimulator of interferon genes ( STING ) cytosolic DNA -sensing pathway and downstream interferon signaling. (bvsalud.org)
  • Cyclic AMP-Dependent Protein Kinase Type II" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uchicago.edu)
  • A cyclic AMP-dependent protein kinase subtype primarily found in particulate subcellular fractions. (uchicago.edu)
  • This graph shows the total number of publications written about "Cyclic AMP-Dependent Protein Kinase Type II" by people in this website by year, and whether "Cyclic AMP-Dependent Protein Kinase Type II" was a major or minor topic of these publications. (uchicago.edu)
  • Below are the most recent publications written about "Cyclic AMP-Dependent Protein Kinase Type II" by people in Profiles. (uchicago.edu)
  • In eukaryotes, cyclic AMP works by activating protein kinase A (PKA, or cAMP-dependent protein kinase ). (wikipedia.org)
  • 5HT (Calbiochem) caused a marked concentration-dependent accumulation of cyclic AMP especially in 'heads', maximal activation of AC occurring at i mM, and an accompanying increase in motility of the isolated fluke head. (erowid.org)
  • Included under this category are two cyclic-AMP-dependent protein kinase subtypes, each of which is defined by its subunit composition. (rush.edu)
  • A novel 17-mer peptide ligand for cyclic AMP was designed using the amino acid sequences of essential subsites in various cyclic AMP-dependent protein kinase (protein kinase A) families. (elsevierpure.com)
  • The function consequences of mutation in loop 3 of CRP are similar to that of site A and site B in the regulatory subunits of cyclic AMP-dependent protein kinases. (utmb.edu)
  • 3. Basal platelet cyclic AMP levels, and those in the presence of a phosphodiesterase inhibitor, did not change throughout the period of the study. (portlandpress.com)
  • cAMP decomposition into AMP is catalyzed by the enzyme phosphodiesterase . (wikipedia.org)
  • Maxi-mum accumulation of cyclic AMP occurred in 5-10 min. (erowid.org)
  • 2',3'-cGAMP sodium (2'-3'-cyclic GMP-AMP sodium) is a endogenous cGAMP in mammalian cells. (medchemexpress.com)
  • Cyclic GMP-AMP containing mixed phosphodiester linkages is an endogenous high-affinity ligand for STING. (medchemexpress.com)
  • The degree of activation by cyclic AMP was inversely correlated with endogenous cyclic AMP and 5HT concentration. (erowid.org)
  • The objective of this work is to examine the capacity of a mechanical stress to cause changes in cell/substratum and cell/cell interactions via the second messenger cAMP pathway (cyclic Adenosine Monophosphate). (utc.fr)
  • cGAS recognizes the pathogenic DNA in the cytosol and then synthesizes 2′3′-cyclic GMP-AMP (2′3′cGAMP). (frontiersin.org)
  • Treatment of a subclone of the PC12 pheochromocytoma cell line, PC8b, with either dexamethasone or 8-bromo cyclic AMP resulted in increased translational activity of tyrosine hydroxylase mRNA (mRNATH). (duke.edu)
  • PC8b cells treated with either dexamethasone or 8-bromo cyclic AMP yielded greater mRNATH hybridization on Northern blot analysis and accumulated higher molecular weight tyrosine hydroxylase RNA species. (duke.edu)
  • This indicates that the designed 17-mer peptide actually acted as a selective ligand for cyclic AMP. (elsevierpure.com)
  • Thus, the roles played by loop 3 in CRP may represent a more common mechanism employed by cyclic nucleotide binding domain in modulating ligand binding affinity and intramolecular communication. (utmb.edu)
  • Based on the sequence differences between CRP and cyclic nucleotide gated channel, three mutants of CRP were constructed: deletion (residues 54-56 in loop 3 were deleted), insertion (loop 4 was lengthened by 5 residues between Glu-78 and Gly-79) and double mutants. (utmb.edu)
  • Erowid.org: Erowid Reference 3068 : Adenosine Cyclic 3',5'-Monophosphate in the Liver Fluke, fasciola hepatica. (erowid.org)
  • Earl Sutherland of Vanderbilt University won a Nobel Prize in Physiology or Medicine in 1971 "for his discoveries concerning the mechanisms of the action of hormones", especially epinephrine, via second messengers (such as cyclic adenosine monophosphate, cyclic AMP). (wikipedia.org)
  • Cyclic AMP response element modulator is a basic leucine zipper transcription factor that is regulated by CYCLIC AMP . (online-medical-dictionary.org)
  • Protein kinase activity was 2-5 times greater in the 'head' than in the posterior end of the fluke and in both particulate and supernatant fractions half-maximal activation was obtained at 0.1-0.4 mcM cyclic AMP. (erowid.org)
  • Incubation of fluke heads for 5 min with 1 mM 5HT increased protein kinase activity of both fractions in the absence of added cyclic AMP, but with 5 mcM cyclic AMP protein kinase activity was increased inthe particulate and decreased in the super-natant fraction. (erowid.org)
  • A transcriptional regulator in prokaryotes which, when activated by binding cyclic AMP, acts at several promoters. (bvsalud.org)
  • Kreisberg, JI , Venkatachalam, MA & Patel, PY 1984, ' Cyclic AMP-associated shape change in mesangial cells and its reversal by prostaglandin E 2 ', Kidney international , vol. 25, no. 6, pp. 874-879. (uthscsa.edu)
  • The enhanced levels of cyclic AMP were preserved by both caffeine and papaverine, and NaF up to 5 mM caused a specific stimulation of AC. (erowid.org)
  • To test whether either cyclic nucleotide influenced the direction, their pre-stimulus levels were pharmacologically manipulated. (syr.edu)
  • both strongly stimulated motility but had no effect on cyclic AMP levels. (erowid.org)
  • glucagon (Lilly) and noradrenaline (Winthrop) had no effect on motility or cyclic AMP levels. (erowid.org)
  • 5-Methoxytryptamine (1 mM, Calbiochem) caused a 4-fold increase in motility similar to 5HT but had a much diminished effect on cyclic AMP and AC acitivity, while tryptamine (Calbiochem), 5 - hydroxydimethyltryptamine (Sigma-Chem. (erowid.org)