• It captures decamethylcyclopentasiloxane (cyclic monomer) market trends, pays close attention to decamethylcyclopentasiloxane (cyclic monomer) manufacturers and names suppliers. (marketpublishers.com)
  • At the present time, from five to ten publications relevant to cyclic nucleotides and the nervous system appear each week. (springer.com)
  • Many articles concerned with some aspect of central function contain, buried within their text, experiments with or related to cyclic nucleotides. (springer.com)
  • The powerful combination of electrophysiology, biochemistry, patch‐clamp fluorometry and X‐ray crystallography has begun to unravel the mystery of how CNG channels are regulated and how the binding of cyclic nucleotides lead to channel opening. (els.net)
  • CNG channels are ion channels regulated by the direct binding of cyclic nucleotides. (els.net)
  • Photoreceptors are retinal cells that contain a high density of ion channels regulated by the binding of cyclic nucleotides. (els.net)
  • Olfaction is the process of odour sensation, also regulated by the binding of cyclic nucleotides. (els.net)
  • Cyclic nucleotides are small ligands used to control the gating of CNG channels. (els.net)
  • Cyclic nucleotides, including cyclic AMP (cAMP), cyclic GMP (cGMP) and cyclic ADP-ribose, have been extensively studied as second messengers of intracellular events initiated by activation of GPCRs. (sigmaaldrich.com)
  • Signaling through cyclic nucleotide second messengers regulates a wide array of metabolic, physiological, functional processes, making cyclic nucleotides and related enzymes vital targets in research of diseases such as cancer, diabetes and cardiovascular disease. (sigmaaldrich.com)
  • They belong to the voltage-gated ion channel superfamily but their activities are controlled by intracellular cyclic nucleotides instead of transmembrane voltage. (sigmaaldrich.com)
  • The purpose of the present volume, the first of two on the pharmacology, biochemistry, and physiology of cyclic nucleotides, is to provide a comprehensive and up-to-date anthology on the nature and role of these important chemical regulators. (springer.com)
  • By so doing, the contributors present the role of cyclic nucleotides in relationship to other intracellular regulators. (springer.com)
  • The first section focuses on the detailed pharmacology and chemistry of cyclic nucleotides, including their formation, degradation, measurement, and interaction with various modulatory agents, such as receptors and calcium. (springer.com)
  • Within the brain, cyclic nucleotides transduce neuromodulatory signals into functional outputs for individual neurons leading to changes in neural networks themselves or their function. (frontiersin.org)
  • To accomplish this, cyclic nucleotides are coupled to many downstream effectors ( Antoni, 2000 ). (frontiersin.org)
  • The levels of cyclic nucleotides and the activities of downstream effectors are not uniform throughout the cell, but instead form specific nanodomains or microdomains inside the cell. (frontiersin.org)
  • Release from intracellular Ca 2+ stores is accomplished by the small molecular compounds D-myo-inositol 1,4,5-trisphosphate (InsP 3 ), cyclic ADP-ribose (cADPR) and nicotinic acid adenine dinucleotide phosphate (NAADP). (ingentaconnect.com)
  • The second section is concerned with the biochemistry of protein phosphorylation, a process which appears to be one of the most important mechanisms for the intracellular expression of cyclic nucleotide action in eukaryotic cells. (springer.com)
  • cyclic n's those in which the phosphate group bonds to two atoms of the sugar forming a ring, as in cyclic AMP and cyclic GMP, which act as intracellular second messengers. (thefreedictionary.com)
  • In the liver, glucagon and the catecholamines cause an increase in the intracellular level of cyclic AMPby stimulating adenyl cyclase. (diabetesjournals.org)
  • Cyclic Polymers (Second Edition) reviews the many recent advances in this rapidly expanding subject since the publication of the first edition in 1986. (waterstones.com)
  • The preparation, characterisation, properties and applications of a wide range of organic and inorganic cyclic oligomers and polymers are described in detail, together with many examples of catenanes and rotaxanes. (waterstones.com)
  • Experimental techniques and theoretical aspects of cyclic polymers are included, as well as examples of their uses such as ring opening polymerisation reactions to give commercially important materials. (waterstones.com)
  • For the further synthesis of functional monomers and polymers, azide-functional cyclic carbonates were synthesized from the bromo-functional monomers. (diva-portal.org)
  • The cyclic olefin polymers preferably contain i) cyclic olefin units having polar functional moieties, ii) cyclic olefin units having acid labile moieties that inhibit solubility in aqueous alkaline solutions. (google.com.au)
  • Symptoms associated with cyclic neutropenia may include fever, a general feeling of ill health (malaise), and/or sores (ulcers) of the mucous membranes of the mouth. (rarediseases.org)
  • Symptoms of the following disorders may be similar to those of cyclic neutropenia. (rarediseases.org)
  • Symptoms of cyclic neutropenia include fever , malaise , oral ulcers , gingival inflammation , edema, and sore throat . (wikidoc.org)
  • Interference with thyroid function from low cyclic AMP levels causes slow mentation, weight gain and low energy (hypothyroidism symptoms). (nethealthbook.com)
  • Because of their close proximity to the left ventricular ejection, elastic arteries are constantly exposed to high levels of cyclic stretch and dilate by approximately 10% with each heartbeat. (frontiersin.org)
  • It is only possible to determine the changes in the metabolic pathways in time consuming research settings by measuring the various "substrates" , "enzymes" and hormones that are involved in the complex biochemical pathways involving cyclic AMP. (nethealthbook.com)
  • The primary finding associated with cyclic neutropenia is a severe chronic decrease in certain white blood cells (neutrophils). (rarediseases.org)
  • Cyclic neutropenia is a subdivision of severe chronic neutropenia. (rarediseases.org)
  • Cyclic treatment strategies in Chronic Myeloid Leukemia (CML) are characterized by alternating applications of two (or more) different drugs, given one at a time. (aimsciences.org)
  • It is this interest in cannabis in the World, coupled with recognition of a cyclic vomiting illness associated with its chronic use that beckons a review of the most current articles, as well as a contribution from our own experiences in this area. (mdpi.com)
  • Cyclic structure of glucose" last modified May 13, 2017. (ehow.co.uk)
  • These were used as starting materials for the click synthesis of triazole-functional cyclic carbonate monomers through Cu(I)-catalyzed azide-alkyne cycloaddition. (diva-portal.org)
  • This paves the way for facile synthesis of a wide range of novel functional cyclic carbonate monomers and polycarbonates, limited only by the availability of suitable functional alkynes. (diva-portal.org)
  • Whether or not cyclic AMP plays a regulatory role in basement membrane synthesis is presently unknown. (diabetesjournals.org)
  • Cyclic Defrost was chosen as a case study for the Australia Council for the Arts' Fuel 4 Arts' Protein project in 2005 based on it receiving a 'New Audiences' grant in 2002. (wikipedia.org)
  • In humans, cyclic AMP works by activating protein kinase A (PKA, also known as cAMP-dependent protein kinase ). (wikidoc.org)
  • Cyclic AMP binds to specific locations on the regulatory units of the protein kinase, and causes dissociation between the regulatory and catalytic subunits, thus activating the catalytic units and enabling them to phosphorylate substrate proteins. (wikidoc.org)
  • Dibutyryl-cAMP is a cell-permeable cyclic AMP (cAMP) analog that activates cAMP-dependent protein kinases (Schwede et al. (stemcell.com)
  • Current and future fluorescent protein reporters will be essential to elucidate the role of cyclic nucleotide signaling dynamics in the functions of individual neurons and their networks. (frontiersin.org)
  • cAMP, the prototypical cyclic nucleotide, transduces G-protein signals to activate protein kinase A (PKA) and exchange protein activated by cAMP (Epac). (frontiersin.org)
  • Mechanism Cyclic Lipopeptide Depolarizes l cell membranes IV. (tripdatabase.com)
  • We present a mechanism by which Alzheimer's cases may be reduced or perhaps even prevented through the use of non-synthetic, steroid hormones prescribed in a cyclic dosing schedule that mimics the rhythmic, escalating and descending production normally observed in a reproductive female body. (scirp.org)
  • This could be secondary to basement membrane thickening, but there is also evidence that the cyclic AMP mechanism may be defective. (diabetesjournals.org)
  • Cyclic mechanical loading did not change the expression of the fibronectin ED-A splice variant, but did decrease the paracrine expression of TGFβ1, thereby suggesting a possible regulation mechanism for the observed effects. (uva.nl)
  • Cyclic neutropenia is a rare blood disorder characterized by recurrent episodes of abnormally low levels of certain white blood cells (neutrophils) in the body. (rarediseases.org)
  • In most cases, episodes of neutropenia recur every 21 days (cyclic) and may last for three to six days. (rarediseases.org)
  • Individuals with cyclic neutropenia may be abnormally susceptible to various bacterial infections that often affect the skin, digestive (gastrointestinal) tract, and respiratory system. (rarediseases.org)
  • Cyclic neutropenia may be inherited or acquired. (rarediseases.org)
  • Investigators have determined that cases of sporadic and autosomal dominant cyclic neutropenia may be caused by disruption or changes (mutations) of the ELANE gene located on the short arm (p) of chromosome 19 (19p13.3). (rarediseases.org)
  • Cyclic neutropenia appears to affect males and females in equal numbers. (rarediseases.org)
  • Cyclic neutropenia is a condition in which the neutrophil count periodically and regularly rises and falls. (wikidoc.org)
  • Cyclic neutropenia first described in the year 1910 in an infant with recurrent fever . (wikidoc.org)
  • There is no established system for the classification of cyclic neutropenia. (wikidoc.org)
  • Cyclic neutropenia is caused by heterozygous mutation in the ELA2 (ELANE) gene . (wikidoc.org)
  • Cyclic neutropenia should be differentiated from other disorders manifesting with recurrent fever , aphthous stomatitis , and pharyngitis . (wikidoc.org)
  • For more information on cyclic neutropenia differential diagnosis please click here . (wikidoc.org)
  • There is no racial predilection to cyclic neutropenia. (wikidoc.org)
  • Cyclic neutropenia affects men and women equally. (wikidoc.org)
  • There are no established risk factors for cyclic neutropenia. (wikidoc.org)
  • There is insufficient evidence to recommend routine screening for cyclic neutropenia. (wikidoc.org)
  • Diagnosis of cyclic neutropenia is based on the clinical picture and the exclusion of other possible causes of neutropenia . (wikidoc.org)
  • There is no diagnostic criteria for the diagnosis of cyclic neutropenia. (wikidoc.org)
  • to the regulation of cyclic lipopeptide production. (tripdatabase.com)
  • In vitro and in vivo characterization of the Pseudomonas aeruginosa cyclic AMP (cAMP) phosphodiesterase CpdA, required for cAMP homeostasis and virulence factor regulation. (ebi.ac.uk)
  • Recent research may indicate that cAMP affects the function of higher order thinking in the prefrontal cortex through its regulation of ion channels called hyperpolarization-activated cyclic nucleotide-gated channels (HCN). (wikidoc.org)
  • Then we discuss a few examples of using cyclic nucleotide fluorescent biosensors to study regulation of neuronal function and finish with a discussion of advances in the field. (frontiersin.org)
  • Cyclic AMP plays an important role in the regulation of metabolism generally. (diabetesjournals.org)
  • cyclic compound, any one of a class of compounds whose molecules contain a number of atoms bonded together to form a closed chain or ring. (encyclopedia.com)
  • In organic chemistry , a cyclic compound is a compound in which a series of carbon atoms are connected to form a loop or ring. (thefullwiki.org)
  • Although there has been significant progress made in understanding how the specific signaling of cyclic nucleotide second messengers is achieved, the mechanistic details in complex cell types like neurons are only just beginning to surface. (frontiersin.org)
  • In the past decade we have witnessed the birth and maturing of a field of research centering on the Ca2+ signaling functions of cyclic ADP-ribose (cADPR) and nicotinic acid adenine dinucleotide phosphate (NAADP), which structures and mechanisms of action are truly unique among all Ca2+ messengers. (waterstones.com)
  • The idea of compartmentalized signaling is an essential component to the cyclic nucleotide signaling model. (frontiersin.org)
  • A group of enzymes that are dependent on cyclic GMP and catalyzes the phosphorylation of serine or threonine residues of proteins. (labome.org)
  • Gels with phosphodiesterase-stable ligand structures are available for affinity chromatography of cyclic nucleotide-binding proteins. (photonics.com)
  • Six-membered cyclic structures like glucose are called "pyranose," after the hexagonal pyran molecule, which has 5 carbons and an oxygen in its ring just like glucose. (ehow.co.uk)
  • Acid-catalyzed positive photoresist compositions which are imageable with 193 nm radiation and are developable to form photoresist structures of high resolution and high etch resistance are enabled by the use of a combination of cyclic olefin polymer, photosensitive acid generator and a hydrophobic non-steroidal. (google.com.au)
  • The objective of this study is to report the clinical control of lymphedema associated with idiopathic cyclic edema using calcium dobesilate. (hindawi.com)
  • It is concluded that calcium dobesilate helps to control lymphedema secondary to idiopathic cyclic edema. (hindawi.com)
  • Ryanodine receptors, which function as calcium channels activated by binding of cyclic ADP ribose (cADPr), are present in nuclear membranes with their ligand binding sites facing the nucleoplasm. (sciencemag.org)
  • The key component is the complexing agent, which comprises a C3 -C5 aliphatic alcohol a cyclic, bidentate compound. (google.es)
  • The key component is the complexing agent, which comprises a C 3 -C 5 aliphatic alcohol a cyclic, bidentate compound selected from lactams and lactones. (google.es)
  • of the cyclic, bidentate compound. (google.es)
  • Benzene, a simple cyclic compound. (thefullwiki.org)
  • Related concepts in organic chemistry are so-called ring-closing reactions in which a cyclic compound is formed and ring-opening reactions in which rings are opened. (thefullwiki.org)
  • Cyclic ADP-ribose (cADPR) and Nicotinic Acid Adenine Dinucleotide. (ingentaconnect.com)
  • In clinical studies of premenopausal women with cyclic heavy menstrual bleeding (40 percent of whom had uterine fibroids), tranexamic acid reduced the quantity of menstrual bleeding by 40 to 65 percent. (aafp.org)
  • Studies of women with idiopathic or intrauterine device-related menorrhagia showed that tranexamic acid reduced average menstrual blood loss by 34 to 59 percent within three cycles, 6 - 10 and was more effective than nonsteroidal anti-inflammatory drugs, 6 , 9 , 10 oral luteal phase norethindrone, 8 and cyclic medroxyprogesterone acetate (Provera). (aafp.org)
  • The chief role of cyclic AMP in several tissues seems to be to facilitate or promote the mobilization of glucose and fatty acid reserves. (diabetesjournals.org)
  • Through polymerization of a series of alkyl halide-functional six-membered cyclic carbonates, semicrystalline chloro- and bromo-functional homopolycarbonates were obtained. (diva-portal.org)
  • Many people know what triggers their cyclic vomiting episodes. (mayoclinic.org)
  • The optical properties of a cyclic olefin copolymer, Topas™, made by Celanese AG, are presented. (spiedigitallibrary.org)
  • Homogeneous and immobilized one-component catalysts for the conversion of epoxides and carbon dioxide into cyclic carbonates at atmospheric pressure and room temperature have been developed. (rsc.org)
  • Cyclic voltammetry (CV) is an important electroanalytical method used to analyze the electronically activated molecules and its corresponding chemical reactions. (hindawi.com)
  • Furthermore, it will explore recent progress made in identification and development of both new and established therapeutic targets modulating cyclic nucleotide signalling. (grc.org)
  • Myle, B. and Kauffman, R., "The Use of Cyclic Voltammetric Antioxidant Analysis for Proactive Engine Oil Condition Monitoring Program," SAE Technical Paper 2000-01-1810, 2000, https://doi.org/10.4271/2000-01-1810 . (sae.org)
  • Such as inhibitors can be used, for example, as a means of increasing cyclic AMP in neurons and thus treating neurological problems, such as long term memory loss, if not preventing such maladies entirely. (freepatentsonline.com)
  • Cyclic [G(2′,5′)pA(3′,5′)p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase. (nature.com)
  • I had read a post a while back about SOD and how it mimics Cyclic Vomiting. (medhelp.org)
  • They found that gentle cyclic deformation, a process that repetitively stretches the crystal, helps to unpin or shakedown rows of atomic defects known as dislocations in the metal and move these dislocations closer to free surfaces in the sample. (eurekalert.org)
  • This finding was surprising to researchers because cyclic deformation has an opposite effect in micro- and macro-scale metal crystals. (eurekalert.org)
  • This work demonstrates how cyclic deformation, under certain controlled conditions, can lead to the removal of defects from crystals of small volume," says Suresh, who holds the Henry L. Hillman President's Chair at CMU. (eurekalert.org)