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ReperfusionIschemiaRIPCLocal ischemicPhenomenonRevealed that hypoxiaCardioprotectionHypoxiaMyocardialEndogenousOxidative stress1986Post-ischemicCardiacInjuryCerebralInfarct sizeHypoxicCoronary occlusionPeriodsRemoteStimulusTransientNITRIC-OXIDEMechanismsClinicalIncreases2022ExperimentalStrokeLiverEffectsProtectionReceptorReductionToleranceFunctionalDurationResistance
Reperfusion13
  • Ischaemic reperfusion injury (IRI) after tourniquet release during total knee arthroplasty (TKR) is related to postoperative cerebral complications. (medsci.org)
  • Tourniquet release during the late period of TKR can induce ischaemic-reperfusion injury, eliciting the activation of neutrophils, circulating pro-inflammatory cytokines, and reactive oxygen species [ 2 , 3 ]. (medsci.org)
  • brief cycles of coronary occlusion/ reperfusion) reduces myocardial infarct size. (bvsalud.org)
  • The increase in the incidence of ischaemic heart disease and acute myocardial infarction (AMI) in both high- and lowincome countries necessitates the development of myocardial salvaging/protection interventions, to be applied alongside standard reperfusion therapies. (sun.ac.za)
  • Three cycles of 5-min ischemia/5-min reperfusion induced by a blood pressure cuff served as RIPC stimulus. (silverchair.com)
  • To provide in vivo evidence that DJ‑1 is involved in the delayed cardioprotection induced by ischemic preconditioning (IPC) against oxidative stress caused by ischemia/reperfusion (I/R), the present study subjected male Sprague‑Dawley rats to IPC (3 cycles of 5‑min coronary occlusion/5‑min reperfusion) 24 h prior to I/R (30‑min coronary occlusion/120‑min reperfusion). (spandidos-publications.com)
  • 1986 ) described ischemic preconditioning as endogenous cardioprotective mechanisms to limit ischemia/reperfusion injury (IRI) via repeated cycles of brief ischemia/reperfusion. (conditionmed.org)
  • Background: Ischemic preconditioning (IPC) is described as brief ischemia-reperfusion (I/R) cycles to induce tolerance to subsequent in response to longer I/R insults. (ogu.edu.tr)
  • This technique is most commonly applied by inflating a blood pressure tourniquet on the upper arm to induce three five-minute cycles of ischaemia, with intervening periods of reperfusion. (researchforlife.org.nz)
  • Ischemic preconditioning, short periods of ischemia with intermittent reperfusion, has been shown to protect the myocardium from a subsequent longer ischemic insult (21-23). (lomr.org)
  • Short series of repetitive cycles of brief reperfusion and re-occlusion of the coronary artery applied at the onset of reperfusion, reduce the infarct size and coronary artery endothelial dysfunction. (eurekaselect.com)
  • The re-establishing of blood flow to an ischemic zone is called reperfusion [ 1 ]. (biomedcentral.com)
  • The rats in the IR group underwent 45 min partial kidney ischemia, and the animals in the IPC + IR group underwent two 5 min cycles of partial kidney ischemia followed by 10 min reperfusion and partial kidney ischemia for 45 min. (hindawi.com)
Ischemia10
  • Ischemic tolerance defines transient resistance to lethal ischemia gained by a prior sublethal noxious stimulus (i.e., preconditioning). (biomedcentral.com)
  • The fate of the brain tissue after focal cerebral ischemia is determined by the degree and duration of ischemia, and even without preconditioning, resident brain cells naturally respond to brain ischemia by mobilizing a host of defences and counter responses to mitigate cell injury and death [ 5 ]. (biomedcentral.com)
  • When the lethal ischemic insult is applied onto this latent protective phenotype, a separate set of responses are triggered that constitute ischemia-tolerant phenotype, which strikingly differs from the unprimed or unpreconditioned brain's phenotype (Figure 1 ). (biomedcentral.com)
  • In the absence of ischemic preconditioning (IPC), MCAO induces a large infarction (ischemia-sensitive phenotype). (biomedcentral.com)
  • Either normothermic or hypothermic ischemic preconditioning was elicited by either one or four periods of 5 minutes of regional ischemia. (neuraxismed.com)
  • Protection of the ischemic myocardium is known to occur as a result of ischemic preconditioning (PC), in which repetitive brief periods of ischemia protect the heart from a subsequent prolong ischemic insult. (eurekaselect.com)
  • and is an intrinsic process through which repeated short episodes of ischemia are instituted to protect the myocardium against subsequent ischemic insults [ 7 ]. (biomedcentral.com)
  • In two models of partial renal IR with and without ischemia preconditioning (IPC) and using Mas receptor (MasR) blockade, A779 or its vehicle, the renal vascular responses to angiotensin II (Ang II) administration in two-kidney-one-clip (2K1C) hypertensive rats were determined. (hindawi.com)
  • Ischemia preconditioning (IPC) against IR also was recognized as a process to minimize the kidney damage caused by IR [ 5 ]. (hindawi.com)
  • Brief periods of ischemia can protect a tissue from subsequent, prolonged ischemia, a phenomenon known as ischemic preconditioning, or IPC. (warf.org)
RIPC10
  • Remote ischaemic preconditioning (RIPC) is known to minimise IRI in previous studies. (medsci.org)
  • Meanwhile, the organ protective effect of ischaemic preconditioning could be induced when the episodic ischaemia is at distant tissues or organs, the concept being termed remote ischaemic preconditioning (RIPC) [ 9 ]. (medsci.org)
  • The application of RIPC into clinical fields is more useful than ischaemic preconditioning because it is easy to apply briefly preceding ischaemia to distant organs such as the limbs. (medsci.org)
  • Remote ischemic preconditioning (RIPC) may confer the protection in critical organs. (silverchair.com)
  • The role of remote ischemic preconditioning (rIPC) in hypoxia is not yet fully understood. (conditionmed.org)
  • 1993 ) introduced remote ischemic preconditioning (rIPC) as a strategy to limit IRI in an area far from that subject to the preconditioning protocol. (conditionmed.org)
  • Remote ischaemic preconditioning (RIPC) is the phenomenon whereby brief periods of ischaemia (reduced oxygen delivery) in one organ can have a protective effect against subsequent prolonged ischaemic insults in other organs. (researchforlife.org.nz)
  • One possibility is an effect from remote ischemic preconditioning (RIPC). (kidneynews.org)
  • Recent studies demonstrated that RIPC, induced by repeated cycle[s] of inflating and deflating blood pressure cuffs, could enhance renal protection against ischemic injuries through various humoral, anti-inflammatory, anti-oxidant, and anti-apoptotic effects," Nadeau-Fredette, et al. (kidneynews.org)
  • RIPC: Remote ischemic preconditioning. (wjgnet.com)
Local ischemic2
  • This was thought to be a local effect and was termed local ischemic preconditioning. (wikipedia.org)
  • Effects of local ischemic preconditioning on anaerobic upper body exercise performance. (utoronto.ca)
Phenomenon4
  • Ischaemic preconditioning describes the phenomenon where transient and brief ischaemia confers protection against a subsequent prolonged and injurious period of ischaemia. (medsci.org)
  • Although the phenomenon of ischaemic preconditioning (IPC) is associated with the desired protective capacity, the necessity of its application before sustained ischaemia limits its clinical potential. (sun.ac.za)
  • Ischemic preconditioning (IPC) is an important endogenous adaptive phenomenon first described by Murry et al ( 1 ) in 1986. (spandidos-publications.com)
  • This phenomenon named as preconditioning (PC) and tolerance has been shown to exist in many organs, most extensively in the heart. (biomedcentral.com)
Revealed that hypoxia1
  • Our previous study revealed that hypoxia preconditioning of H9c2 cardiomyocytes significantly increased the de novo synthesis of DJ-1 and induced cardioprotection against prolonged hypoxic injury 24 h later ( 17 ). (spandidos-publications.com)
Cardioprotection1
  • Chronic FGF-2 overexpression was associated with increased "local" FGF-2 release resulting in augmentation of kinases linked with ischemic preconditioning, angiogenesis and cardioprotection. (umanitoba.ca)
Hypoxia1
  • We demonstrated that hypoxia preconditioning enhanced the expression of Pim-1 kinase in MSCs in a time-dependent manner, as detected by quantitative PCR (qPCR) and western blot. (biomedcentral.com)
Myocardial6
  • remote ischemic conditioning reduced infarct size in ST-elevation myocardial infarction (STEMI) patients when used in the ambulance or emergency department as an adjunct therapy to primary percutaneous coronary intervention (PCI), or when used with thrombolytic drugs. (wikipedia.org)
  • Remote ischaemic conditioning before hospital admission, as a complement to angioplasty, and effect on myocardial salvage in patients with acute myocardial infarction: a randomised trial. (ox.ac.uk)
  • We tested the hypothesis that remote ischaemic conditioning during evolving ST-elevation myocardial infarction, and done before primary percutaneous coronary intervention, increases myocardial salvage. (ox.ac.uk)
  • METHODS: 333 consecutive adult patients with a suspected first acute myocardial infarction were randomly assigned in a 1:1 ratio by computerised block randomisation to receive primary percutaneous coronary intervention with (n=166 patients) versus without (n=167) remote conditioning (intermittent arm ischaemia through four cycles of 5-min inflation and 5-min deflation of a blood-pressure cuff). (ox.ac.uk)
  • INTERPRETATION: Remote ischaemic conditioning before hospital admission increases myocardial salvage, and has a favourable safety profile. (ox.ac.uk)
  • Buja LM and Entman ML: Modes of myocardial cell injury and cell death in ischemic heart disease. (spandidos-publications.com)
Endogenous1
  • Danger signal evoked in the brain by the stressing preconditioning stimulus induces complex endogenous protective mechanisms resulting to a latent protective phenotype. (biomedcentral.com)
Oxidative stress4
  • In accordance with these changes, Popdc1-null cardiomyocytes displayed impaired [Ca+2]i transients, increased vulnerability to oxidative stress and no pharmacologic preconditioning. (sdfca.org)
  • Accordingly, cardiomyocytes of the mutant hearts display impaired [Ca+2]i transients, higher sensitivity to oxidative stress and no pharmacologic preconditioning while the mutant hearts are more vulnerable to I/R injury and show no ischemic preconditioning. (sdfca.org)
  • Specifically, I aim to elucidate the roles of oxidative stress and neuroinflammation in maintaining or disrupting blood brain barrier (BBB) integrity in ischemic stroke using in vitro cell cultures and in vivo models of transient or permanent middle cerebral artery occlusion (MCAO) in rats and mice. (ufl.edu)
  • Targeted BRD4 protein degradation by dBET1 ameliorates acute ischemic brain injury and improves functional outcomes associated with reduced neuroinflammation and oxidative stress and preservation of blood-brain barrier integrity. (ufl.edu)
19861
  • Ischemic preconditioning (IPC) was first reported in 1986 by Murry et al. (biomedcentral.com)
Post-ischemic1
  • The major source of free radicals in post-ischemic tissue appears to be initiated by the formation of superoxide anion, formed by the action of xanthine oxidase. (lomr.org)
Cardiac5
  • BACKGROUND: Remote ischaemic preconditioning attenuates cardiac injury at elective surgery and angioplasty. (ox.ac.uk)
  • Overexpression of Pim-1 in stem/progenitor cells stimulated cell cycling and enhanced cardiac regeneration in vivo. (biomedcentral.com)
  • 9 ] reported that hypoxic preconditioning increases survival of cardiac progenitor cells via upregulation of Pim-1, discovering a method for nongenetic modification of Pim-1 in stem cells. (biomedcentral.com)
  • My results also provide direct evidence that transforming growth factor (TGF)-B plays an important role in antagonizing FGF-2 mediated cardiac myocyte entry into the cell cycle. (umanitoba.ca)
  • Overexpression of the kinase-deficient TGF-B receptors (TGF-BRII) resulted in serum-induced cardiac myocyte cell cycle entry as well as an amplification of FGF-2 induced S phase entry (13 fold versus 3 fold with FGF-2 alone). (umanitoba.ca)
Injury6
  • Remote ischemic conditioning (RIC) is an experimental medical procedure that aims to reduce the severity of ischaemic injury to an organ such as the heart or the brain, most commonly in the situation of a heart attack or a stroke, or during procedures such as heart surgery when the heart may temporary suffer ischaemia during the operation, by triggering the body's natural protection against tissue injury. (wikipedia.org)
  • Considering that tourniquet application during TKR is related to ischaemic injury, the organ protective effect of ischaemic preconditioning can have a beneficial role after tourniquet release during TKR. (medsci.org)
  • In the scenario of IT, PC stimulus primes the brain for subsequent injurious ischemic injury. (biomedcentral.com)
  • Taking into account both protective effects, ischemic and ozone oxidative preconditioning, against liver injury by I/R, the aim of this study is to stablish a comparison between them, in a liver I/R model. (lomr.org)
  • The effects of global mitochondrial calcium (Ca 2+ ) uniporter (MCU) deficiency on hypoxic-ischemic (HI) brain injury, neuronal Ca 2+ handling, bioenergetics and hypoxic preconditioning (HPC) were examined. (nyu.edu)
  • My work is trying to investigate molecular mechanisms involved in focal ischemic injury and develop novel therapeutic strategies for treatment of ischemic stroke. (ufl.edu)
Cerebral2
  • regulatory factor 9 in cerebral ischemic stroke. (rndsystems.com)
  • Since the first landmark experimental demonstration of ischemic tolerance in the gerbil brain in early 1990's, basic scientific knowledge on the mechanisms of cerebral ischemic tolerance increased substantially. (biomedcentral.com)
Infarct size2
  • To determine whether or not Ossabaw minipigs nevertheless had attenuated ST-segment elevation over repetitive IPC cycles, we compared Göttingen vs. Ossabaw minipigs in which IPC reduces infarct size. (bvsalud.org)
  • Hypothermic ischemic preconditioning with four cycles of 5-minute coronary occlusions resulted in a 94% reduction of infarct size but hypothermic ischemic preconditioning with one cycle resulted in no reduction of infarct size. (neuraxismed.com)
Hypoxic2
  • We proposed that hypoxic preconditioning could increase survival of bone marrow mesenchymal stem cells (MSCs) via upregulation of Pim-1 and aimed to determine the microRNAs that modulate the expression of Pim-1. (biomedcentral.com)
  • Hypoxic preconditioning could increase short-term survival of bone marrow MSCs via upregulation of Pim-1, and miR-206 was one of the critical regulators in this process. (biomedcentral.com)
Coronary occlusion1
  • The ST-segment elevation during coronary occlusion is progressively attenuated with increasing number of IPC cycles. (bvsalud.org)
Periods1
  • We find this to be a convenient alternative for passive BFR modalities such as Ischemic Precondition (IPC), post-exercise restitution or to apply during periods of immobilization to attenuate muscle loss. (fitcuffs.com)
Remote2
  • Other researchers confirmed this remote effect and found that performing the preconditioning protocol on kidney or gastrointestinal tissue also provided protection to the heart. (wikipedia.org)
  • Stankiewicz R, Grąt M. Direct, remote and combined ischemic conditioning in liver surgery. (wjgnet.com)
Stimulus1
  • an early phase occurring instantly and continuing for 3-4 h and a late (or delayed) phase occurring ~12 h after the preconditioning stimulus that may persist to 72 h ( 2 , 3 ). (spandidos-publications.com)
Transient2
  • In humans, transient ischemic attacks may be the clinical correlate of preconditioning leading to ischemic tolerance. (biomedcentral.com)
  • Therapeutic Benefits of Adropin in Aged Mice After Transient Ischemic Stroke via Reduction of Blood-Brain Barrier Damage. (ufl.edu)
NITRIC-OXIDE2
  • Although the mechanism of preconditioning is not yet known, it has been suggested that liver ischemic preconditioning is mediated by the inhibitory action of nitric oxide on endothelin and through the balance of adenosine and xanthine levels (24,27). (lomr.org)
  • Neurovascular protection by adropin in experimental ischemic stroke through an endothelial nitric oxide synthase-dependent mechanism. (ufl.edu)
Mechanisms2
  • The protection associated with preconditioning is one of the most powerful mechanisms of protection known. (lomr.org)
  • Neuroinflammatory mechanisms of blood-brain barrier damage in ischemic stroke. (ufl.edu)
Clinical2
  • However, it is not easy to apply ischaemic preconditioning in a clinical setting because brief organ ischaemia should be preceded after real ischaemic time [ 8 ]. (medsci.org)
  • With a proven track record in publications, Cyclus2 has established a gold standard in performance and clinical research for universities, hospitals and professional cycling teams. (cyclus2.com)
Increases1
  • Hypothermia during the preconditioning period increases the threshold for eliciting the infarct limitation of ischemic preconditioning. (neuraxismed.com)
20221
  • Mai 2022: Elie a reçu un prix pour la meilleure thèse de spécialisation en français à l'école de psychologie. (collabzium.com)
Experimental2
  • Neuroprotection by the cannabidiol aminoquinone VCE-004.8 in experimental ischemic stroke in mice. (ufl.edu)
  • Genetic Deletion or Pharmacological Inhibition of Cyclooxygenase-2 Reduces Blood-Brain Barrier Damage in Experimental Ischemic Stroke. (ufl.edu)
Stroke3
  • Editorial: Inflammation in ischemic stroke and novel therapeutic strategies for stroke treatment. (ufl.edu)
  • Ischemic Stroke Impacts the Gut Microbiome, Ileal Epithelial and Immune Homeostasis. (ufl.edu)
  • Neuroprotective effects of targeting BET proteins for degradation with dBET1 in aged mice subjected to ischemic stroke. (ufl.edu)
Liver3
  • It has been demonstrated that ozone, probably by means of an oxidative preconditioning (OP) mechanism, protected the liver against the damage mediated by reactive oxygen species. (lomr.org)
  • It has been demonstrated (17-18) that ozone, probably by means of an oxidative preconditioning mechanism, protected the liver against the damage produced by a chemical challenge mediated by ROS. (lomr.org)
  • Also, preconditioning has been demonstrated in intestine (24), brain (25) and liver (26). (lomr.org)
Effects3
  • Genetic and pharmacological studies have identified aldose reductase, heme oxygenase-1 (HO-1), and Mn-superoxide dismutase (MnSOD) as critical mediators of the antioxidative stress effects of late preconditioning ( 8 - 10 ). (spandidos-publications.com)
  • Effects of ischemic preconditioning prot. (ogu.edu.tr)
  • Taking into account that ischemic preconditioning (IschP) is also a protective mechanism, a comparative study between both preconditioning effects, with the aim to study the effectiveness of both protective procedures, was performed. (lomr.org)
Protection1
  • In 2002, Raj Kharbanda and Andrew Redington, working at the Hospital for Sick Children in Toronto, showed that non-invasively stopping and starting blood flow in the arm provided the same protection as invasive preconditioning of the heart. (wikipedia.org)
Receptor1
  • Involvement of Popdc1 in the regulation and signaling of tight junction formation and function, vesicular transport and receptor cycling has been exhibited [11]C[14]. (sdfca.org)
Reduction1
  • Normothermic ischemic preconditioning with one cycle had a 58% reduction and four cycles had a 95% reduction. (neuraxismed.com)
Tolerance1
Functional1
  • No improvement in functional recovery was observed in Popdc1-null hearts following ischemic preconditioning. (sdfca.org)
Duration1
  • The most severe cerebrospinal fluid and histologic changes occurred in the patient with the highest viral load, shortest duration of disease, and most medical preconditions. (cdc.gov)
Resistance1
  • The Wireless Edition is heavy-duty and comes with the same type of connectors, so this model can be used in conjunction with all of Fit Cuffs products and for all sorts of passive modalities, resistance exercises, and BFR-Cycling. (fitcuffs.com)