• Epirubicin is favoured over doxorubicin, the most popular anthracycline, in some chemotherapy regimens as it appears to cause fewer side-effects. (wikipedia.org)
  • Epirubicin monotherapy was shown to be therapeutically equivalent to doxorubicin monotherapy in patients who had to receive previous chemotherapy for advanced breast cancer. (wikipedia.org)
  • Equimolar doses of epirubicin and doxorubicin have been shown to be therapeutically equivalent in patients with metastatic breast cancer. (wikipedia.org)
  • The mechanism of action of epirubicin is similar to that of doxorubicin and other anthracycline drugs. (wikipedia.org)
  • The observed clinical differences between epirubicin and doxorubicin can be explained by the pharmacokinetic differences based on the different affinity to DNA and lipophilicity, as there is no indication that different mechanisms are involved in their activity. (wikipedia.org)
  • tell your doctor and pharmacist if you are allergic to epirubicin, daunorubicin (Cerubidine, DaunoXome), doxorubicin (Doxil), idarubicin (Idamycin), any other medications, or any of the ingredients in epirubicin injection. (medlineplus.gov)
  • Chemotherapy comprised one of the following combinations for 3-6 cycles: cisplatin 50 mg/m 2 (d1) + cyclophosphamide 500 mg/m 2 (d1) + epirubicin 60 mg/m 2 (d1), or gemcitabine 900 mg/m 2 (d1, 8) + docetaxel 100 mg/m 2 (d8), or doxorubicin 60 mg/m 2 (d1) + ifosfamide 1.5 g/m 2 (d1-4). (heraldopenaccess.us)
  • Researchers found that 4 of the 37 evaluable patients achieved a response, all of which were after progression on prior topoisomerase 2 inhibitors, such as doxorubicin and epirubicin. (cancertherapyadvisor.com)
  • the two groups then received an additional four cycles of pembrolizumab or placebo, and both groups received doxorubicin-cyclophosphamide or epirubicin-cyclophosphamide. (themednet.org)
  • Aprepitant is used to prevent acute and delayed sickness that can be caused by chemotherapy, in particular by a medicine called cisplatin, cyclophosphamide, doxorubicin or epirubicin. (telehealthpharmacy.ie)
  • The Bharatanatyam dancer was treated with the chemotherapy drugs Docetaxel and Epirubicin, before having 20 cycles of Her2-directed immunotherapy. (cambridgecancer.org.uk)
  • In patients with breast cancer receiving adjuvant 5-fluorouracil/epirubicin/cyclophosphamide followed by docetaxel (FEC-D), we evaluated the impact of chemotherapy total cumulative dose (TCD), and early (FEC) versus late (D only) dose reductions, on survival outcomes. (jnccn.org)
  • This study sought to retrospectively characterize outcomes for patients with node-negative and node-positive breast cancer receiving adjuvant trastuzumab in combination with docetaxel/cyclophosphamide (DCH), docetaxel/carboplatin/trastuzumab (TCH), or fluorouracil/epirubicin/cyclophosphamide followed by docetaxel/trastuzumab (FEC-DH) chemotherapy in Alberta, Canada, from 2007 through 2014. (jnccn.org)
  • Her treatment included Mohs paste application, together with chemotherapy (four cycles of 5-fluorouracil, epirubicin, and cyclophosphamide, and four cycles of docetaxel). (biomedcentral.com)
  • It is marketed by Pfizer under the trade name Ellence in the US and Pharmorubicin or Epirubicin Ebewe elsewhere. (wikipedia.org)
  • To assess the feasibility of QOL assessment in a cohort of Tunisian cancer patients, the EORTC QLQ-C30 questionnaire was administered to 23 women treated with adjuvant chemotherapy for early breast cancer on an outpatient basis at baseline and during the 3rd cycle of chemotherapy. (who.int)
  • After definitive surgery, the patients received adjuvant pembrolizumab or placebo every 3 weeks for up to nine cycles. (themednet.org)
  • Additionally the administration of more dose intensive epirubicin-containing regimens to patients with metastatic breast cancer has been associated with improved response rates, but not increased overall survival. (wikipedia.org)
  • Average cumulative dose was also calculated for early (cycles 1-3) and late (cycles 4-6) chemotherapy. (jnccn.org)
  • In thisopen-label phase I study, irinotecan was administered IV at a fixeddose of 250 mg/m2 on day 1 in combination with capecitabine at a fixeddose of 1,500 mg/m2 for days 2 to 7 and epirubicin starting at a dose of40 mg/m2 and escalating by 10 mg/m2 in cohorts of three patients forthose with metastatic adenocarcinomas. (cancernetwork.com)
  • With the addition of granulocytecolony-stimulating factor (G-CSF [Neupogen]) to the regimen,patients received epirubicin at clinically relevant doses after dose-escalation.Results of the topoisomerase activity will be reported with thefinal results of this phase I study. (cancernetwork.com)
  • With the addition of granulocyte colony-stimulating factor (G-CSF [Neupogen]) to the regimen, patients received epirubicin at clinically relevant doses after dose-escalation. (cancernetwork.com)
  • A dose-dependent, reversible leukopenia and/or neutropenia is the predominant manifestation of hematologic toxicity associated with epirubicin and represents the most common acute dose-limiting toxicity of this drug. (recallguide.org)
  • This toxicity appears to be dependent on the cumulative dose of Epirubicin Hydrochloride Injection and represents the cumulative dose-limiting toxicity of the drug. (recallguide.org)
  • A phase I trial of panobinostat and epirubicin in solid tumors with a dose expansion in patients with sarcoma [published online ahead of print February 21, 2016]. (cancertherapyadvisor.com)
  • Treatment delays or dose reductions for toxicity occurred in 10% and 5% of cycles, respectively. (aboutdrugspdf.com)
  • Purpose: To determine the tolerability and feasibility of double-cycle, high-dose chemotherapy followed by peripheral blood stem-cell transplantation (PBSCT) after conventional chemotherapy or chemoradiotherapy for small cell lung cancer (SCLC). (the-medical-dictionary.com)
  • Conclusion: Double-cycle, high-dose ICE therapy followed by PBSCT is tolerable and feasible even after conventional chemotherapy or chemoradiotherapy in patients with SCLC. (the-medical-dictionary.com)
  • The combination of irinotecan (Camptosar), epirubicin, andcapecitabine (Xeloda) has shown an acceptable toxicity profile. (cancernetwork.com)
  • Epirubicin may increase your risk for developing leukemia (cancer of the white blood cells), especially when it is given in high doses or together with certain other chemotherapy medications. (medlineplus.gov)
  • In a retrospective survey, including 9144 patients, mostly with solid tumors in advanced stages, the probability of developing CHF increased with increasing cumulative doses of Epirubicin Hydrochloride Injection (Figure 5). (recallguide.org)
  • May also received two doses of Navelbine for each 5-FU cycle. (laziy.com)
  • The results showed that overexpression of CALCRL in HL-60 and Molm-13 could confer resistance properties to AML cells and reduce the DNA damage and cell cycle G0/G1 phase blocking effects caused by daunorubicin (DNR) and others. (bvsalud.org)
  • Epirubicin comes as a solution (liquid) to be injected intravenously (into a vein) by a doctor or nurse in a medical facility along with other chemotherapy medications. (medlineplus.gov)
  • Epirubicin is an intravenously administered drug. (mrmed.in)
  • Participants received panobinostat 20 to 60 mg orally on days 1, 3, and 5, followed by epirubicin 75 mg/m 2 intravenously on day 5 in 3-week cycles. (cancertherapyadvisor.com)
  • While undergoing the Cytotron treatment, May continued to receive the 5-FU-Navelbine regimen (the 14th cycle). (laziy.com)
  • It is given in combination with a steroid, eg dexamethasone, and a 5HT3 antagonist, eg ondansetron, as part of a three day regimen around each cycle of chemotherapy. (telehealthpharmacy.ie)
  • Epirubicin is an anthracycline drug used for chemotherapy. (wikipedia.org)
  • Treatment with panobinostat and epirubicin is well tolerated and may be active in patients with sarcoma who are refractory to anthracycline-based therapy, a study published in the journal Annals of Oncology has shown. (cancertherapyadvisor.com)
  • Panobinostat and epirubicin treatment…may reverse anthracycline resistance," the authors wrote. (cancertherapyadvisor.com)
  • Epirubicin was reported to block DNA replication either through direct DNA damage or indirectly through inhibition of replication proteins such as topoisomerase. (nature.com)
  • Epirubicin then stabilizes the topoisomerase II-DNA complex, resulting in irreversible DNA strand breakage, leading to cell death. (wikipedia.org)
  • It acts throughout the entire cell cycle and by direct intercalating into DNA triggers DNA breakage by topoisomerase II, causing subsequent cytocydal activity. (medscape.com)
  • Because inhibition of histone deacetylase appears to improve the efficacy of topoisomerase 2 inhibitors, researchers sought to evaluate panobinostat combined with epirubicin in patients with refractory sarcoma. (cancertherapyadvisor.com)
  • Epirubicin is primarily used against breast and ovarian cancer, gastric cancer, lung cancer and lymphomas. (wikipedia.org)
  • Significantly higher pathologic complete remission rate after neoadjuvant therapy with trastuzumab, paclitaxel, and epirubicin chemotherapy: results of a randomized trial in human epidermal growth factor receptor 2-positive operable breast cancer. (hemonc.org)
  • Epirubicin Hydrochloride Injection should be administered only under the supervision of qualified physicians experienced in the use of cytotoxic therapy. (recallguide.org)
  • Such adverse effects are serious and can be life-threatening and commonly occur during the initial cycles of cytotoxic therapy [ 8 - 10 ]. (hindawi.com)
  • Breast tumour volume and blood flow measured by MRI after one cycle of epirubicin and cyclophosphamide-based neoadjuvant chemotherapy as predictors of pathological response. (ox.ac.uk)
  • Over the course of the chemotherapies, [fasting] had additive effects" and by cycle four of chemotherapy, the difference became statistically and clinically significant, indicating "much better" quality of life in short-term-fasting group. (medscape.com)
  • The chemotherapy regimens in the trial included four cycles of adriamycin or epirubicin , followed by taxane therapy. (medscape.com)
  • Total and differential WBC, red blood cell (RBC), and platelet counts should be assessed before and during each cycle of therapy with Epirubicin Hydrochloride Injection. (recallguide.org)
  • If it occurs, delayed cardiotoxicity usually develops late in the course of therapy with Epirubicin Hydrochloride Injection or within 2 to 3 months after completion of treatment, but later events (several months to years after treatment termination) have been reported. (recallguide.org)
  • Do not take this injection if you are allergic to Epirubicin or any other ingredients of this medicine, pregnant or breastfeeding, or have severe liver and bladder problems.Store Epirubicin in the refrigerator (2°C to 8°C). Do not freeze. (mrmed.in)
  • Cell cycle-specific with activity in the S-phase as single agent and has for many years been combined with biochemical modulator leucovorin.Has activity as single agent that inhibits DNA replication and transcription. (medscape.com)
  • Epirubicin inhibits DNA, RNA, and protein synthesis by exerting cytotoxic activity. (mrmed.in)
  • Results showed that TIGAR was increased and relocated to the nucleus after epirubicin or hypoxia treatment in cancer cells. (nature.com)
  • Thus, one mechanism of epirubicin combined TACE treatment for HCC was through induction of synergistic DNA damage. (nature.com)
  • DNA damage in HepG2 cells after TIGAR knockdown with or without treatment of epirubicin or CoCl 2 was detected by Comet assay. (nature.com)
  • After a couple cycles of treatment I learned to get ahead of the side effects by taking my prescribed medications in advance of the onset of the side effects. (cancer.org)
  • Epirubicin may cause serious or life-threatening heart problems at any time during your treatment or months to years after your treatment has ended. (medlineplus.gov)
  • Your doctor will order tests before and during your treatment to see if your heart is working well enough for you to safely receive epirubicin. (medlineplus.gov)
  • My Oncologist programmed for my treatment 6 cycles of chemotherapy which I am currently fulfilling thanks to the funds raised in this campaign, and 25 sessions of Radiotherapies that have already been carried out satisfactorily. (gofundme.com)
  • Before beginning treatment with epirubicin, patients should recover from acute toxicities (such as stomatitis, neutropenia, thrombocytopenia, and generalized infections) of prior cytotoxic treatment. (recallguide.org)
  • These effects do not usually predict subsequent development of delayed cardiotoxicity, are rarely of clinical importance, and are generally not considered an indication for the suspension of epirubicin treatment. (recallguide.org)
  • Cell cycle analysis revealed that cells exhibiting synergistic drug responses displayed a shift from G1 to S-phase compared to cells showing additive features upon dual treatment. (sciencenet.cn)
  • Treatment with panobinostat and epirubicin is well tolerated and may be active in patients with sarcoma. (cancertherapyadvisor.com)
  • Your treatment may be given for a set number of cycles, or it will keep going until the drug stops working or you have side effects which stop you from continuing treatment. (ivcanceredsheets.com)
  • 14 Cycle 2 Day 1 Nivolumab X X NIVOLUMAB Page 2 INTRAVENOUS CANCER TREATMENT EDUCATION Common Side Effects Common side effects that have been known to happen in patients receiving nivolumab are listed in the left side of this table. (ivcanceredsheets.com)
  • The study adds to other evidence suggesting that fasting around chemotherapy cycles may reduce toxicity and adverse effects associated with chemotherapy. (medscape.com)
  • I was in other surgery May 25th 2017 for extracting four positive lymph nodes, so after that gave me a prescription for 6 chemotherapy cycles and 25 sessions of Radiotherapy. (gofundme.com)
  • It is planned to complete the chemotherapy cycles for the month of February of the year 2018. (gofundme.com)
  • Cytotoxicity can occur at any stage of the cell cycle, but cell is most vulnerable to action of these drugs in G1 and S phase. (medscape.com)
  • A medical oncologist will determine how many cycles of chemotherapy are needed and what combination of drugs will work best. (epnet.com)
  • Monitoring for potential cardiotoxicity is also important, especially with greater cumulative exposure to epirubicin. (recallguide.org)
  • The aim of Epirubicin as adjuvanted therapy is to eradicate micro metastasis and prolong disease free survival. (wikipedia.org)
  • It may be injected once every 21 days for 6 cycles of therapy or it may be injected twice (on days 1 and 8) every 28 days for six cycles of therapy. (medlineplus.gov)
  • Epirubicin is given as a cycle therapy. (mrmed.in)
  • The combination of Epirubicin and tamoxifen lead to an increase survival in node-positive postmenopausal women with hormone receptor-positive breast tumours. (wikipedia.org)
  • Hang in there for at least two cycles and give your oncologist time to mitigate the side effects before you decide to forgo something that can make your quality of life much better in the long term. (cancer.org)
  • Patients received pemetrexed (500 mg/m2) with vitamin supplementation and oxaliplatin (120 mg/m2) every 21 days for six cycles or until disease progression occurred. (aboutdrugspdf.com)
  • Epirubicin is used in combination with other medications to treat breast cancer in patients who have had surgery to remove the tumor. (medlineplus.gov)
  • epirubicin decreases effects of adenovirus types 4 and 7 live, oral by pharmacodynamic antagonism. (medscape.com)
  • epirubicin decreases effects of influenza virus vaccine quadrivalent, adjuvanted by pharmacodynamic antagonism. (medscape.com)
  • Most common grade 3/4 toxic effects were neutropenia in 41% of patients (19% of cycles) and thrombocytopenia in 11% of patients (4% of cycles). (aboutdrugspdf.com)
  • Conversely, tumour volume was found to be a good predictor of pathological response (smaller tumours did better) at both baseline (area under the receiver operating characteristic curve 0.80) and after one cycle of NACT (area under the receiver operating characteristic curve 0.81). (ox.ac.uk)
  • Health-related quality of life assessments occurred at baseline and after each chemotherapy session (cycle four at day 7) as well as after 4 and 6 months. (medscape.com)
  • Epirubicin can cause a severe decrease in the number of blood cells in your bone marrow. (medlineplus.gov)
  • METHODS: In this prospective cohort study, dynamic contrast-enhanced MRI was performed in 35 females with breast cancer before and after one cycle of epirubicin and cyclophosphamide-based NACT (EC90). (ox.ac.uk)
  • CONCLUSION & ADVANCES IN KNOWLEDGE: The change in breast tumour blood flow following one cycle of EC90 did not predict pathological response. (ox.ac.uk)
  • Doctors prescribe epirubicin alongside other medications to treat breast cancer in people who have already had surgery to remove the tumor. (medicalnewstoday.com)
  • The other important message is that many esophageal cancer patients experience an improvement in their ability to swallow after the first or second cycle of chemotherapy. (cancer.org)
  • Afin d'estimer la faisabilité d'une évaluation de la qualité de vie dans une cohorte de patients cancéreux tunisiens, nous avons présenté le questionnaire QLQ-C30 de l'EORTC à 23 femmes traitées par chimiothérapie adjuvante en ambulatoire pour un cancer du sein à un stade précoce, au début du traitement et pendant le troisième cycle de chimiothérapie. (who.int)
  • Il est nécessaire d'améliorer encore l'infrastructure de soins et la sensibilisation du public en matière de cancer si l'on veut réaliser des études fiables sur la qualité de vie des cancéreux. (who.int)