• The FLT3 inhibitors sorafenib, midostaurin, quizartinib and gilteritinib have been tested in monotherapy in several settings including refractory or relapsed AML (R/R AML), post-transplant maintenance as well as in combination with intensive chemotherapy (ICT) or non-intensity regimens. (dovepress.com)
  • Similarly, the outcomes of myeloablative conditioning and reduced-intensity conditioning regimens for allo-HCT and their relationship with pretransplant consolidation cycles for patients in first complete remission are also unknown. (ascopost.com)
  • Check specific guidelines for restaging and dosage adjustments for chemotherapy and/or radiation therapy depending on positron-emission tomography (PET) scanning throughout the various regimens. (medscape.com)
  • Regimens that combine chemotherapy and radiation therapy (RT) have replaced RT alone for treatment of early-stage, favorable disease. (medscape.com)
  • The different chemotherapy regimens [include] the classic SWOG [Cancer Research Network] regimens, so it's etoposide, carboplatin/pemetrexed, cisplatin/pemetrexed-the newer regimens for adenocarcinoma or nonsquamous disease-and then weekly carboplatin/paclitaxel, or even carboplatin/paclitaxel every 3 weeks. (targetedonc.com)
  • Therapy of lymphoblastic lymphoma (LL) has evolved with use of chemotherapy regimens modeled after those for acute lymphocytic leukemia (ALL). (ashpublications.org)
  • We treated 33 patients with LL with the intensive chemotherapy regimens hyper-CVAD (fractionated cyclophosphamide, vincristine, Adriamycin, and dexamethasone) or modified hyper-CVAD used for ALL at our institution. (ashpublications.org)
  • This trial also assigns patients into different chemotherapy treatment regimens based on risk (the chance of cancer returning after treatment). (policylab.us)
  • Treating patients with chemotherapy based on risk may help doctors decide which patients can best benefit from which chemotherapy treatment regimens. (policylab.us)
  • Blinatumomab and INO are being incorporated into induction chemotherapy regimens and combined with TKIs for ALL therapy. (biomedcentral.com)
  • A novel low-intensity regimen, miniHCVD-INO-blinatumomab, appears to be less toxic and more effective than conventional intensive chemotherapy regimens. (biomedcentral.com)
  • Blinatumomab and INO are being investigated in clinical trials for their incorporation into chemotherapy regimens and combined with TKIs for ALL therapy. (biomedcentral.com)
  • The goal of consolidation is to keep you in remission. (oncolink.org)
  • Retrospective analysis by the Center for International Blood and Marrow Transplant Research (CIBMTR): Prompt complete remission plus consolidation therapy yields improved survival after allogeneic hematopoietic cell transplantation (allo-HCT) for patients with acute myeloid leukemia (AML) receiving a myeloablative conditioning regimen and not a reduced-intensity conditioning regimen. (ascopost.com)
  • An important and unanswered question concerns the impact of the number of conventional AML chemotherapy induction cycles to achieve first complete remission on transplant outcomes. (ascopost.com)
  • Compared with the poor outcomes of patients who received allo-HCT during refractory (active) disease, the outcomes of patients who received more than one induction cycle to achieve complete remission is somewhat better but remains unsatisfactory. (ascopost.com)
  • After individualized treatment 239 patients (87.9 %) achieved complete remission, including 140 patients received initial treatment of 5-fluorouracil-based multidrug chemotherapy. (biomedcentral.com)
  • We describe the patient's successful treatment using standard-of-care chemotherapy and tyrosine kinase inhibitors, resulting in complete remission with no measurable residual disease. (bvsalud.org)
  • Therefore, in the first complete remission (1CR) of ALL, allo-HSCT is indicated for patients in whom the results of chemotherapy are predicted to be poor. (bvsalud.org)
  • After completing consolidation chemotherapy cycles, children usually don't need to continue with chemotherapy if the disease is in remission. (yashfiin.com)
  • Patients and Methods: We identified adults with favorable or intermediate cytogenetic risk AML in first complete remission after induction at Montefiore Medical Center from 1999 to 2015, and analyzed 81 patients who received consolidation with ≥2 cycles of chemotherapy, of whom 28 received autoHCT. (elsevierpure.com)
  • Remission and MRD status will be assessed after the first two cycles of chemotherapy and patients may receive up to a total of five cycles. (kronosbio.com)
  • Complete remission was seen in 43% of patients after two cycles of therapy. (medscape.com)
  • There are 2 forms of treatment for AML: induction therapy for complete remission (CR) and consolidation therapy to maintain CR. (pharmacytimes.com)
  • If patients remain in remission after these treatment cycles, they will no longer receive treatment. (pharmacytimes.com)
  • ONUREG is a nucleoside metabolic inhibitor indicated for continued treatment of adult patients with acute myeloid leukemia who achieved first complete remission (CR) or complete remission with incomplete blood count recovery (CRi) following intensive induction chemotherapy and are not able to complete intensive curative therapy ( 1 ). (nih.gov)
  • Induction therapy is the initial treatment of the chemotherapy that aimed to destroy as many leukemia cells as possible, achieve normal level of blood counts and treat acute lymphocytic leukemia into remission. (submityourassignment.com)
  • Overall, COP chemotherapy causes complete remission in about 70% of dogs with lymphoma for a median of 130 days. (vin.com)
  • Eligible patients were ages 55 years or older, had AML, and were within 4 months of achieving first complete remission (CR) or complete remission with incomplete blood count recovery (CRi) with intensive induction chemotherapy. (onuregpro.com)
  • Most patients up to the age of approximately 75 years should be considered for intensive combination chemotherapy with the aim to induce complete remission. (cancercentrum.se)
  • Chemotherapy drugs often used to treat AML are cytarabine and an anthracycline drug. (wikipedia.org)
  • Doctors may use a combination of chemotherapy drugs, such as cytarabine, and an anthracycline drug, such as daunorubicin. (medicalnewstoday.com)
  • 75 years old) followed by cytarabine consolidations and/or allogeneic stem-cell transplantation (ASCT). (dovepress.com)
  • The reduced-intensity chemotherapy backbone consists of three 28-day cycles of vincristine and dexamethasone for the induction phase, six 28-day cycles of alternating cytarabine (even-numbered cycles) and methotrexate (odd-numbered cycles), and eleven 28-day cycles of vincristine and prednisone for the maintenance phase. (confex.com)
  • On December 6, 2021 , Kronos Bio, Inc. (the "Company") announced that the first patient has been dosed in the registrational Phase 3 AGILITY clinical trial of entospletinib, a selective inhibitor targeting spleen tyrosine kinase ("SYK"), in combination with standard of care anthracycline and cytarabine (7+3) chemotherapy. (kronosbio.com)
  • After induction therapy, a patient is given consolidation therapy done with high-dose cytarabine. (pharmacytimes.com)
  • In the high-dose regimen, cytarabine is given at 3 g/ m2 every 12 hours for 3 days of each cycle. (pharmacytimes.com)
  • Patients and those who have favorable-risk AML will get 3 to 4 cycles of high-dose cytarabine. (pharmacytimes.com)
  • Although the incidence of acute nonlymphocytic leukemia is increased in PV, the incidence of acute leukemia in patients not exposed to chemotherapy or radiation therapy is low. (basicmedicalkey.com)
  • This phase III trial studies how well blinatumomab works in combination with chemotherapy in treating patients with newly diagnosed, standard risk B-lymphoblastic leukemia or B-lymphoblastic lymphoma with or without Down syndrome. (policylab.us)
  • This will look at how well carfilzomib works in combination with chemotherapy. (prinsesmaximacentrum.nl)
  • Treatment consists of a multi-drug chemotherapy regimen. (wikipedia.org)
  • If AML with chromosomal abnormalities such as inv(16) are often cured by the standard chemotherapy regimen. (wikipedia.org)
  • Generally older patients over 60 have a poor outlook due to prior health status before the diagnosis and the aggressive chemotherapy regimen used. (wikipedia.org)
  • The aggressive chemotherapy regimen can lead to long-term side effects such as prolonged anemia, leukocytopenia, neutropenia, and thrombocytopenia. (wikipedia.org)
  • The GOG 252 authors concluded that the toxicity and patient-reported outcomes support selection of the regimen consisting of IV carboplatin AUC 6 day 1, dose-dense paclitaxel 80 mg/m 2 IV once weekly, and bevacizumab 15 mg/kg IV day 1 given in 3-week cycles. (medscape.com)
  • A FAB/LMB96 group C chemotherapy regimen for aggressive and high-risk cancer was administered with a marked improvement in clinical symptoms. (hindawi.com)
  • Stage IA-IIA disease can be treated with the ABVD regimen for up to six cycles, or with the Stanford regimen for two cycles (ie, 8 weeks). (medscape.com)
  • The traditional regimen for induction chemotherapy, irrespective of favorable intermediate or unfavorable-risk AML, is the 7+3 regimen. (pharmacytimes.com)
  • Patients receive 3 to 4 cycles of a given consolidation regimen. (pharmacytimes.com)
  • MM treatment involves triplet therapy of lenalidomide (Revlimid), bortezomib (Velcade), and a 4-6 cycle regimen of dexamethasone. (pharmacytimes.com)
  • These protocols, which used different multiagent chemotherapies, were associated with improved results as therapy was intensified. (medscape.com)
  • this consisted of 2 cycles of induction therapy with infusions of daunomycin, cytosine arabinoside, etoposide (ADE therapy). (medscape.com)
  • some patients will need ongoing maintenance therapy depending on how much consolidation treatment they have received, as well as if they had a stem cell transplant. (oncolink.org)
  • Chemotherapy is broken down into 2 phases: Induction therapy: first short and invasive phase of treatment with the goal to clear the blood of blasts and reduce the number of blasts in the bone marrow back to normal. (wikipedia.org)
  • Consolidation therapy: second phase given in cycles that occur after the patient has recovered from induction therapy. (wikipedia.org)
  • Targeted drug therapy may also be suitable if AML does not respond to chemotherapy. (medicalnewstoday.com)
  • In the past two decades, therapy for newly diagnosed APL has evolved from an all- trans retinoic acid (ATRA)+chemotherapy backbone for all patients to the addition of arsenic trioxide (ATO) to ATRA with omission of chemotherapy in low-risk patients as a new standard of care. (nature.com)
  • Typically, patients with acute blood cancer undergo several rounds of induction therapy, followed by up to four rounds of consolidation therapy. (europa.eu)
  • He was treated with chemotherapy per protocol Children's Oncology Group Protocol ARST0332 and proton beam therapy to the involved mediastinum, pericardium, and heart. (allenpress.com)
  • This large retrospective analysis on behalf of the CIBMTR shows again that among patients eligible for allo-HCT, only one induction cycle to achieve first complete remis sion, particularly when combined with one consolidation therapy, is associated with better outcomes after myeloablative conditioning and not reduced-intensity conditioning. (ascopost.com)
  • Received weekly cisplatin 40 mg m2 for 5 to 6 cycles as concurrent chemotherapy with radiation therapy. (who.int)
  • To make room in the bones for the transplanted cells, you will need chemotherapy or radiation therapy first. (yashfiin.com)
  • Induction consolidation was administered with 8 or 9 alternating cycles of chemotherapy over 5 to 6 months with intrathecal chemotherapy prophylaxis, followed by maintenance therapy. (ashpublications.org)
  • Giving monoclonal antibody therapy with chemotherapy may kill more cancer cells. (policylab.us)
  • We report a survival case of invasive splenic mucormycosis involving the liver caused by Rhizopus microsporus in a patient during consolidation therapy for acute monocytic leukemia (AML-M 5 ). (frontiersin.org)
  • Should it be used as "a single agent or in combination therapy, for induction, consolidation, or maintenance, or as part of a large combination or succession of treatments? (medscape.com)
  • It is a type of drug therapy and the ultimate goal of chemotherapy is to kill leukemia cells using anticancer drugs until there is no trace of any leukemia cells in the body. (submityourassignment.com)
  • Typically, chemotherapy treatment is given to the patient in cycles and in phases: induction, consolidation and maintenance therapy. (submityourassignment.com)
  • The second phase of chemotherapy, consolidation therapy, is usually intense too and lasts about four to eight months. (submityourassignment.com)
  • If the child tolerates the induction therapy and there is no progression (worsening) of the disease, a second cycle of carfilzomib in combination with the consolidation chemotherapy is possible. (prinsesmaximacentrum.nl)
  • A total of 472 patients who completed induction with or without consolidation therapy were randomized 1:1 to receive ONUREG ® 300 mg (n=238) or placebo (n=234) orally on Days 1 to 14 of each 28-day treatment cycle. (onuregpro.com)
  • NCCN Guidelines ® Category 1, Preferred recommendation applies to AML patients age ≥60 in the post-induction setting who received previous intensive therapy and were unable to receive any of all recommended consolidation, regardless of risk status. (onuregpro.com)
  • To date he has had four cycles of cytotoxic chemotherapy and is due to have consolidation radiotherapy in the near future. (the-medical-dictionary.com)
  • Risk factors include prolonged exposures to petrochemicals, prior receipt of cytotoxic chemotherapy, or precursory conditions that may evolve into AML. (pharmacytimes.com)
  • Intrathecal chemotherapy can be used to treat cancer found in the cerebral spinal fluid or to prevent leukemia from spreading there. (yashfiin.com)
  • Treatment for patients with acute myeloid leukemia involves intensive chemotherapy to destroy the leukemic cell population as rapidly as possible and to prevent the emergence of a resistant clone. (medscape.com)
  • Hospitalization is necessary in patients with acute myeloid leukemia for managing chemotherapy and for treating complications related to the disease and its treatment, usually infections or febrile neutropenic episodes. (medscape.com)
  • The first-line treatment typically includes chemotherapy combined with immunotherapy, which is a combination of medications that destroy the cancer cells. (rarediseases.org)
  • However, the trial also showed increased toxicity with IP chemotherapy versus IV chemotherapy. (medscape.com)
  • If participants cannot tolerate toxicity, must have received at least 4 cycles of cisplatin. (who.int)
  • This case illustrates retinal toxicity secondary to intravitreal chemotherapy for vitreous seeds with melphalan. (aboonline.org.br)
  • Mylotarg is a monoclonal antibody linked to a chemotherapy drug. (keehealthcare.com)
  • The incorporation of blinatumomab into conventional chemotherapy backbones, potentially including other monoclonal antibodies, should produce opportunities to assess the feasibility of such combinations and to increase treatment efficacy," he writes. (medscape.com)
  • Giving blinatumomab and combination chemotherapy may work better than combination chemotherapy alone in treating patients with B-ALL. (policylab.us)
  • Blinatumomab also has a fairly short half-life, making its optimal mode of delivery a continuous infusion over the course of 4-week cycles. (medscape.com)
  • It seems more likely that we should use blinatumomab sequentially with chemotherapy instead of concurrently. (medscape.com)
  • Vosaroxin dose was reduced to 70 mg/m2 in consolidation cycles, which were repeated in approximately four to five week intervals for a total of up to seven cycles. (baycitycapital.com)
  • Given the use of cisplatin and paclitaxel as first-line treatment for persistent or recurrent cervical cancer, we aimed to estimate the maximum tolerated dose (MTD) of the PARP inhibitor veliparib when added to chemotherapy. (wustl.edu)
  • Dose-limiting toxicities (DLTs) were assessed at first cycle. (wustl.edu)
  • Administer an antiemetic before each dose for at least the first 2 cycles ( 2.2 ). (nih.gov)
  • Increase monitoring to every other week for the 2 cycles after any dose reduction. (nih.gov)
  • Administer an antiemetic 30 minutes prior to each dose of ONUREG for the first 2 cycles. (nih.gov)
  • The recommended dose is 250 mcg/m2/day administered IV over a 2-hour period beginning two to four hours after bone marrow infusion, and not less than 24 hours after the last dose of chemotherapy or radiotherapy. (wikidoc.org)
  • A Phase 2 study of ponatinib with chemotherapy in newly diagnosed Ph+ ALL reported improved long-term outcomes versus a second-generation tyrosine kinase inhibitor (TKI) (Sasaki 2016). (confex.com)
  • The randomized, double-blind, placebo-controlled trial is designed to assess the efficacy and safety of entospletinib in combination with intensive induction and consolidation chemotherapy in approximately 180 adults who have been newly diagnosed with NPM1-mutated AML. (kronosbio.com)
  • Lanraplenib is being developed for the treatment of patients with relapsed/refractory FLT3-mutated AML and patients newly diagnosed with NPM1-mutated and/or FLT3-mutated AML who are older than 75 years old or are not eligible for intensive induction chemotherapy. (kronosbio.com)
  • Central nervous system prophylaxis will be administered 2×/month in Cycles 1-6. (confex.com)
  • Antiemetic prophylaxis may be omitted after 2 cycles if there has been no nausea and vomiting. (nih.gov)
  • Patients with optimally debulked (≤1 cm) stage III ovarian cancer after front-line surgery should be offered intraperitoneal (IP) chemotherapy. (medscape.com)
  • Transplant-eligible patients had the option of autologous stem cell transplantation (ASCT) consolidation instead of MR. The primary end point was the complete response (CR) rate to VcR-CVAD. (elsevierpure.com)
  • Introduction: In the United States, autologous hematopoietic cell transplantation (autoHCT) has fallen out of favor over chemotherapy consolidation for non-high-risk acute myeloid leukemia (AML) when allogeneic hematopoietic cell transplantation (alloHCT) is unfeasible, which is common in racial minorities because of donor registry under-representation and socioeconomic challenges. (elsevierpure.com)
  • Autologous transplantation consolidation for non-high-risk acute myeloid leukemia is less frequently used, yet not fully abandoned. (elsevierpure.com)
  • We compared outcomes of consolidation strategies in a minority-rich cohort in the Bronx with limited access to allogeneic transplantation. (elsevierpure.com)
  • Autologous transplantation conferred relapse-free and overall survival benefit over chemotherapy consolidation alone, the current standard in the United States, and it might constitute a valuable option for ethnic/racial minorities. (elsevierpure.com)
  • Sargramostim is a colony stimulating factor that is FDA approved for the treatment of granulocytopenia following induction chemotherapy in acute myelogenous leukemia , mobilization and following transplantation of autologous peripheral blood progentior cells, myeloid reconstitution after autologous bone marrow transplantation, myeloid reconstitution after allogeneic bone marrow transplantation and bone marrow transplantation failure or engraftment delay. (wikidoc.org)
  • Transfer to a pediatric cancer center is usually necessary for initial diagnostic studies and is mandatory for management of chemotherapy and treatment-related complications. (medscape.com)
  • In March 1999, a 62-year-old white, Caucasian woman who had worked as a chemotherapy nurse from 1973 to 1979 sought treatment at Eisenhower Medical Center after having pain in her left knew for 2 weeks. (cdc.gov)
  • Doctors may also recommend this treatment to those with relapsed or resistant AML after they undergo re-induction chemotherapy. (medicalnewstoday.com)
  • Postterm choriocarcinoma patients were usually accompanied by several high-risk factors that should received combined chemotherapy to prevent delay in adequate treatment. (biomedcentral.com)
  • 5-fluorouracil-based multidrug chemotherapy, which has been applied at PUMCH for several decades, can be an effective initial treatment for postterm choriocarcinoma patients. (biomedcentral.com)
  • Some individuals will require hospitalization for treatment, while others will get chemotherapy at home via infusion and oral drugs. (yashfiin.com)
  • Chemotherapy and radiation is a tough treatment. (targetedonc.com)
  • Two weeks of treatment-free interval are recommended prior to the subsequent cycle. (biomedcentral.com)
  • For example, can it improve long-term outcomes compared with standard chemotherapy, and can it be used earlier in the course of the disease and in combination with other treatment approaches? (medscape.com)
  • Treatment is largely based on the choice of chemotherapy protocol chosen by the oncologist. (drbharatpatodiya.com)
  • We give induction chemotherapy which is just 7 days following which admission needs to be continued for supportive care like blood transfusion and infection treatment. (drbharatpatodiya.com)
  • Chemotherapy treatment usually involves combinations of various anti-leukemic drugs rather than a single drug as the cancer cells can be attacked in several different ways and different drugs behave differently in controlling leukemia cells growth process. (submityourassignment.com)
  • There are more than 50 chemotherapy drugs used in the chemotherapy treatment and they can be divided into several groups based on their chemical structure, the mechanism and interrelationship to another drug. (submityourassignment.com)
  • The treatment with carfilzomib will then continue during the consolidation chemotherapy treatment. (prinsesmaximacentrum.nl)
  • For other intermediate or adverse risk AML patients, oral azacitidine (ONUREG ® ) is a 2A recommended treatment in the post-induction setting, regardless of consolidation status. (onuregpro.com)
  • The results of the multivariate analysis showed that history of resistance to multidrug chemotherapy, liver metastasis and FIGO score greater than 12 were independent risk factors of prognosis. (biomedcentral.com)
  • More emphasis should be placed on those who have history of resistance to multidrug chemotherapy, liver metastasis or a FIGO score greater than 12. (biomedcentral.com)
  • Efforts to overcome chemotherapy resistance by including multidrug resistance modifiers (e.g., cyclosporin or its analogue PSC 833) in the induction schedule have as yet not met with reproducible success in prospective comparative studies. (ashpublications.org)
  • In the induction part of the study, we investigate how safe the drug carfilzomib is in combination with other chemotherapy in infants, children, and young adults with recurrent or refractory acute lymphoblastic leukemia. (prinsesmaximacentrum.nl)
  • Because of the patient's need for intense chemotherapy and supportive care, guaranteed venous access is critical. (medscape.com)
  • With chemotherapy, however, considerable improvement in the duration and quality of the patient's life can be expected. (vin.com)
  • Scheduling the timing and dosage of chemotherapy treatments often relies on the doctor's intuition. (europa.eu)
  • This is an important study, and ultimately, I think our goal is to overcome the use of chemotherapy and radiation, which can destroy healthy cells along with malignant ones," commented Catherine Bollard, MD, MBChB, a bone and marrow transplant specialist at George Washington University/Children's National Medical Health System, Washington, DC. (medscape.com)
  • Lymphoma is the most common haematopoietic malignancy in dogs, and is the most responsive to chemotherapy. (vin.com)
  • all patients with this histologic subtype should be considered for chemotherapy. (medscape.com)
  • Interestingly, chemotherapy, including hydroxyurea, has been associated with acute leukemia in JAK2 V617F-negative stem cells in some PV patients. (basicmedicalkey.com)
  • Chemotherapy may be given to your child for several months, and this may include intrathecal chemo (usually for acute lymphocytic leukemia/ALL). (yashfiin.com)
  • The relapse rate remains high after chemotherapy for adult patients with acute lymphoblastic leukemia (ALL). (biomedcentral.com)
  • Chemotherapy is the main type and the most common way to treat the leukemia. (submityourassignment.com)
  • Doctors can use stem cell transplants or bone marrow transplants to give people with AML higher doses of chemotherapy. (medicalnewstoday.com)
  • Chemotherapy for AML is broken down into three phases: induction phase, consolidation (or intensification), and maintenance phase. (oncolink.org)
  • This involves giving chemotherapy in cycles followed by a period of rest in between to allow the body to recover. (medicalnewstoday.com)
  • This phase involves providing a person with low doses of chemotherapy or other drugs for months to years. (medicalnewstoday.com)
  • However the recipient may develop certain complications because of chemotherapy or because of the foreign stem cells in the patient. (drbharatpatodiya.com)
  • The recommended dosage of ONUREG is 300 mg orally once daily with or without food on Days 1 through 14 of each 28-day cycle. (nih.gov)
  • Induction chemotherapy consisting of 3 days of idarubicin at 12 mg/m 2 daily and 7 days of cytosine arabinoside by continuous infusion at 100 mg/m 2 was given to the patient. (cdc.gov)
  • Cycles occurred every 21 days until progression. (wustl.edu)
  • Patients with previously untreated mantle cell lymphoma received VcR-CVAD chemotherapy every 21 days for 6 cycles, followed by MR for 2 years. (elsevierpure.com)
  • Administer ONUREG 300 mg orally once daily on Days 1 through 14 of each 28-day cycle ( 2.2 ). (nih.gov)
  • We first treat the child with combination chemotherapy with carfilzomib for 22 days. (prinsesmaximacentrum.nl)
  • The child will then receive 22 days of consolidation chemotherapy with carfilzomib. (prinsesmaximacentrum.nl)
  • For many years, most children in the United States were treated with chemotherapy protocols developed by the Children's Cancer Group and the Pediatric Oncology Group. (medscape.com)
  • We compared autoHCT consolidation outcomes with chemotherapy alone in a minority-rich cohort in the Bronx. (elsevierpure.com)