• The results indicate that [3H]LSD can be used to label the 5-HT receptors coupled to adenylate cyclase activity. (erowid.org)
  • D-1 receptors are associated with an adenylate cyclase system whereas D-2 receptors are not. (nature.com)
  • The butyrophenone domperidone also binds to central dopamine receptors 12 , but it is a very weak antagonist of dopamine-sensitive adenylate cyclase 13 (Table 1), suggesting that it may bind only to D-2 receptors. (nature.com)
  • In the retina of many species, a dopamine-sensitive adenylate cyclase has been demonstrated 14,15 , indicating the presence of D-1 receptors. (nature.com)
  • Measurements of adenylyl cyclase activity in membranes from cells expressing m5-HT1B receptors showed that serotonergic agonists mediated the inhibition of adenylyl cyclase activity with a rank order of potency comparable to their affinity constants. (nih.gov)
  • Transmembrane guanylyl cyclases are homodimeric receptors activated by a diverse range of endogenous ligands. (guidetopharmacology.org)
  • In all three, chlorpyrifos evoked deficits in multiple components of the adenylyl cyclase cascade: expression and activity of adenylyl cyclase itself, functioning of G-proteins that link neurotransmitter and hormone receptors to cyclase activity, and expression of neurotransmitter receptors that act through this cascade. (duke.edu)
  • Naturally occurring, glutamine-deficient light-oxygen-voltage receptors likely serve as bona fide photoreceptors, as we showcase for a diguanylate cyclase. (nature.com)
  • Membrane-associated guanylyl cyclases on the other hand are homodimeric enzymes that act as receptors for divers polypeptide ligands. (iisc.ac.in)
  • In mammals, there are seven isoforms of receptors guanylyl cyclase, GC-A through GC-G. These recptors have a highly conseved modular domin organization with an N-terminal extracellular domain, a single transmembrane domain and a C- terminal intra cellular regions. (iisc.ac.in)
  • A class of cellular membrane receptors that either have an intrinsic guanylate cyclase activity or are closely coupled to specific guanylate cyclases within the cell. (bvsalud.org)
  • Adenylate cyclase activity was higher in the glial cells than in the neuronal fraction, while guanylate cyclase activity was equally detected in both cell fractions. (fluoridealert.org)
  • Adenylate cyclase was mainly derived from the particulate fraction of both brain cell homogenates, whereas the major portion of guanylate cyclase activity was found in their soluble rather than in the particulate fractions. (fluoridealert.org)
  • sGC has several structural and functional properties in common with adenylyl cyclases (ACs). (nih.gov)
  • Adenylyl cyclases V and VI are the particular adenylyl cyclases present in beta cells of the human pancreas. (reactome.org)
  • The G-protein beta-gamma complex interacts with adenylyl cyclases via protein-protein interactions with the C1 and C2 cytoplasmic loops of adenylyl cyclase. (reactome.org)
  • In the case of adenylyl cyclases V and VI the interaction inhibits cyclase activity. (reactome.org)
  • The possible role of intracellular Ca 2+ level in the regulation of guanylyl cyclase activity as well as L. donovani infectivity was explored by measuring the intracellular survival of the parasites in mammalian macrophages after treatments, which decrease or elevate the intracellular Ca 2+ . (ias.ac.in)
  • Over the years multiple mechanisms of regulation of GC-C activity has been identified including allosteric controlled by various domains in the receptor and phosphorylation-mediated regulation of guanylyl cyclase activity. (iisc.ac.in)
  • Moreover, treatment with selective inhibitors of soluble guanylyl cyclase also reduced infectivity, even in cases of calcium ionophore-treated parasites. (ias.ac.in)
  • To delineate these effects, we used PKA pathway inhibitors (adenylyl cyclase [AC], cAMP, and PKA) to modulate the effects of alcohol on dust-stimulated TNF-a release in the bronchial epithelial cell line, BEAS-2B. (cdc.gov)
  • The interaction may produce either stimulation or inhibition of the adenylyl cyclase depending on the particular adenylyl cyclase. (reactome.org)
  • The series of molecular signals generated as a consequence of a dopamine receptor binding to its physiological ligand, followed by inhibition of adenylyl cyclase and a subsequent decrease in the concentration of cyclic AMP. (yeastrc.org)
  • Family members have conserved ligand-binding, catalytic (guanylyl cyclase) and regulatory domains with the exception of NPR-C which has an extracellular binding domain homologous to that of other NPRs, but with a truncated intracellular domain which appears to couple, via the G i/o family of G proteins, to activation of phospholipase C, inwardly-rectifying potassium channels and inhibition of adenylyl cyclase activity [ 19 ]. (guidetopharmacology.org)
  • The pituitary adenylate cyclase-activating polypeptide/adenylate cyclase-activating polypeptide 1 (pituitary) ( PACAP/ADCYAP1 ) gene maps to this region. (lww.com)
  • Our lab has demonstrated an important role of the neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP) in stress and emotional behavior. (uvm.edu)
  • Pituitary adenylate cyclase-activating polypeptide ( PACAP ) is a neuropeptide with widespread occurrence and diverse functions. (bvsalud.org)
  • Association analysis of the pituitary adenylate cyclase-acti. (lww.com)
  • Pituitary Adenylate Cyclase-Activating Polypeptide" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (childrensmercy.org)
  • This graph shows the total number of publications written about "Pituitary Adenylate Cyclase-Activating Polypeptide" by people in this website by year, and whether "Pituitary Adenylate Cyclase-Activating Polypeptide" was a major or minor topic of these publications. (childrensmercy.org)
  • Below are the most recent publications written about "Pituitary Adenylate Cyclase-Activating Polypeptide" by people in Profiles. (childrensmercy.org)
  • They bind PITUITARY ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE with high affinity and trigger intracellular changes that influence the behavior of CELLS. (ouhsc.edu)
  • Age-related decline of autocrine pituitary adenylate cyclase-activating polypeptide impairs angiogenic capacity of rat cerebromicrovascular endothelial cells. (ouhsc.edu)
  • Effect of pituitary adenylate cyclase-activating polypeptide supplementation, applied during or after vitrification on mouse embryo. (bvsalud.org)
  • Erowid.org: Erowid Reference 2857 : Serotonin-sensitive Adenylate Cyclase in Neural Tissue and Its Similarity to the Serotonin Receptor: A Possible Site of Action of Lysergic Acid Diethylamide. (erowid.org)
  • In the current study, rats were exposed to dexamethasone or terbutaline during late gestation and the development of beta-receptor binding capabilities and adenylate cyclase activity evaluated in membrane preparations from kidney and lung. (rti.org)
  • Although dexamethasone and terbutaline also caused significant changes in development of beta-receptor binding capabilities, in neither tissue could these effects account for the direction or magnitude of the changes in adenylate cyclase reactivity. (rti.org)
  • These results suggest that adenylate cyclase and guanylate cyclase without intimate coupling to the transmitter-receptor system, but with activation by NaF or NaN3, may be distributed ubiquitously in the cells separated from rat cerebral cortex. (fluoridealert.org)
  • Our findings indicate that the Yersinia peptide possesses receptor binding affinity and cyclase stimulating activity intermediate between known E. coli ST analogs and human uroguanylin. (umsystem.edu)
  • We also demonstrate that MsGC-β3 is capable of forming heterodimers with the nitric oxide (NO)-sensitive guanylyl cyclase subunits MsGC-α1 and MsGC-β1. (biologists.com)
  • Nelociguat (BAY60-4552) is a nitric oxide sensitive soluble guanylate cyclase stimulator. (biochempartner.com)
  • As part of nitric oxide-cyclic GMP transduction signaling operative in higher eukaryotes and involved in the long-term potentiation, a soluble guanylyl cyclase has also been detected in this lower eukaryote. (ias.ac.in)
  • Molecular analysis, mutation screening, and association study of adenylate cyclase type 9 gene (ADCY9) in mood disorders. (wikigenes.org)
  • Plecanatide is an agonist of guanylate cyclase-C. Plecanatide increases intestinal transit and fluid through a buildup of cGMP. (biochempartner.com)
  • The intracellular region contains a juxtamembrane domain followed by a protein-kinase domain, a linker region and a catalytic guanylyl cyclase domain. (iisc.ac.in)
  • TWiP solves two cases this week, the Man with Issues after COVID-19, and the Man with Left Arm Weakness, then describe how the malaria parasite evades mosquito immunity by glutaminyl cyclase-mediated posttranslational protein modification. (microbe.tv)
  • NKY 80 is an inhibitor of adenylyl cyclase (AC). (adooq.com)
  • ODQ potent and selective inhibitor of soluble guanylyl cyclase (sGC). (biochempartner.com)
  • The soluble adenylyl cyclase inhibitor, KH7, however, significantly increased the inflammatory response to hog barn dust. (cdc.gov)
  • Two recent reports, however, show that there is likely to be an additional class of soluble guanylyl cyclases that do not need a second subunit for activity. (biologists.com)
  • Cinaciguat (BAY 58-2667) is the first of a new class of soluble guanylate cyclase (sGC) activators in clinical development for acute decompensated heart failure. (biochempartner.com)
  • Using a highly sensitive high-performance liquid chromatography-tandem mass spectrometry method, we report that highly purified recombinant sGC of rat possesses nucleotidyl cyclase activity. (nih.gov)
  • Any process that modulates the frequency, rate or extent of cyclase activity. (mcw.edu)
  • Phentolamine competitively inhibited 5-HT octopamine dopamine and norepinephrine stimulated adenylate cyclase activity. (erowid.org)
  • Bacteria such as E. coli, V. Cholerae, and Y. enterocolitica have evolved ST's which mimic native guanylin/uroguanylin peptides by activating guanylate cyclase C (GC-C), yet possess increased resistance to heat/enzymatic degradation as well as superagonist activity by virtue of a third disulfide bond. (umsystem.edu)
  • In this work, we have compared the ability of these peptides to target GC-C and engender production of cGMP with that of an ST analog derived from Yersinia enterocolitica.Previous results had suggested that the Y. enterocolitica sequence may elicit higher cyclase activity than other peptides in this class. (umsystem.edu)
  • MsGC-β3, identified in the tobacco hornworm Manduca sexta , was the first example of a soluble guanylyl cyclase that exhibited enzyme activity without the need for coexpression with additional subunits. (biologists.com)
  • These results suggest that chlorpyrifos can affect cell development by altering the activity and reactivity of the adenylyl cyclase signaling cascade, a major control point for trophic regulation of cell differentiation. (duke.edu)
  • These mutations are thought to enhance adenylate cyclase 5 enzyme activity and lead to higher levels of cAMP within cells, so they are described as "gain-of-function" mutations. (medlineplus.gov)
  • Soluble guanylyl cyclases are heterodimeric enzymes which are activated by nitic oxide. (iisc.ac.in)
  • Soluble guanylyl cyclase (sGC) regulates several important physiological processes by converting GTP into the second-messenger cGMP. (nih.gov)
  • soluble guanylate cyclase (sGC), and cGMP signalling pathways. (lu.se)
  • Not considering MB itself, blocking soluble guanylate cyclase (sGC), the final NO/cGMP messenger, in smooth muscle is underestimated and deserves a place in the present and future. (biomedcentral.com)
  • A cyclase is an enzyme, almost always a lyase, that catalyzes a chemical reaction to form a cyclic compound. (wikipedia.org)
  • Although bulk-separated neurons and glial cells almost failed to change intracellular cyclic nucleotide levels in response to some putative neurotransmitters, activation of adenylate cyclase by NaF was found to be greater in neuronal than in glial cell fractions, and was observed more clearly in the soluble than in the particulate fractions. (fluoridealert.org)
  • Forskolin (FsK) is a naturally occurring diterpene in the roots of the Indian Coleus plant that activates adenylyl cyclase resulting in an elevation in intracellular cAMP levels. (chapman.edu)
  • Das, Pijush K. (2006) Regulation of guanylyl cyclase by intracellular Ca 2+ in relation to the infectivity of the protozoan parasite, Leishmania donovani International Journal of Biochemistry & Cell Biology, 38 (8). (ias.ac.in)
  • Together these results suggest a possible link between guanylyl cyclase, intracellular Ca 2+ content and parasite infectivity. (ias.ac.in)
  • The ability of a series of compounds to compete for [3H]LSD binding sites correlated closely with their ability to inhibit 5-HT stimulation of adenylate cyclase. (erowid.org)
  • the effect resulted from increases in the enzyme itself, as both basal adenylate cyclase and forskolin-stimulation of the enzyme were also increased by dexamethasone. (rti.org)
  • Sympathetic control through β-adrenergic stimulation is propagated by adenylyl cyclase (AC). (tmc.edu)
  • Our study demonstrates a circadian rhythm of contrast sensitivity that peaks during the daytime, and that its regulation involves interactions of D4Rs, the clock gene Npas2 , and the clock-controlled gene adenylyl cyclase 1 ( Adcy1 ) in a subset of retinal ganglion cells (RGCs). (jneurosci.org)
  • The gene encoding the soluble guanylyl cyclase was cloned, sequenced and over expressed in bacterial system. (ias.ac.in)
  • The ADCY5 gene provides instructions for making an enzyme called adenylate cyclase 5. (medlineplus.gov)
  • Other ADCY5 gene mutations prevent production of adenylate cyclase 5. (medlineplus.gov)
  • Sodium azide greatly increased guanylate cyclase in the particulate fraction, but did not affect it considerably in the soluble one. (fluoridealert.org)
  • Addition of catalase to the reaction mixture together with NaN3 further stimulated guanylate cyclase both int he soluble and the particulate fractions. (fluoridealert.org)
  • Guanylyl cyclase C (GC-C) is a member of particulate guanylyl cyclases, discovered primarily as the target of a family of heat stable enterotoxins (ST), produced by enterotoxigenic Escherichia coli (ETEC). (iisc.ac.in)
  • In conclusion, soluble "guanylyl" cyclase possesses much broader substrate specificity than previously assumed. (nih.gov)
  • Forskolin is a cell-permeable diterpenoid that possesses anti-hypertensive, positive inotropic, and adenylyl cyclase activating properties. (adooq.com)
  • MGV354 is a novel potent, selective soluble Guanylate Cyclase (sGC) activator, lowers intraocular pressure (IOP) in preclinical models of glaucoma. (biochempartner.com)
  • Praliciguat is a guanylate cyclase activator, vasodilator. (biochempartner.com)
  • Cinaciguat hydrochloride is a potent soluble guanylate cyclase (GC) activator with EC50 of 15 nM in platelets. (biochempartner.com)
  • The aim of our study was to identify whether RBCs could produce NO and activate soluble guanylate cyclase (sGC) in platelets. (uni-wuerzburg.de)
  • The pharmacological properties of a serotonin-sensitive adenylate cyclase (AC) found in the nervous tissue of insects were investigated. (erowid.org)
  • Calcium at concentrations above 300 EM signincantly reduced both [3H]LSD binding and 5-HT activation of adenylate cyclase. (erowid.org)
  • Distribution and different activation of adenylate cyclase by NaF and of guanylate cyclase by NaN3 in neuronal and glial cells separated from rat cerebral cortex. (fluoridealert.org)
  • Distribution of adenylate cyclase and guanylate cyclase activities in neuronal perikarya and glial cells separated from rat brain, and cellular differences in activation between of adenylate cyclase by NaF and of guanylate cyclase by NaN3 have been studied. (fluoridealert.org)
  • Activation of Adenylyl Cyclase Reduces TGF-b Profibrotic Response in O" by M. Qadri, Rennolds S. Ostrom et al. (chapman.edu)
  • Researchers suggest that the polymorphisms associated with increased type 2 diabetes risk may decrease the ability of the adenylate cyclase 5 enzyme to produce cAMP, resulting in the abnormal response to glucose that occurs in type 2 diabetes. (medlineplus.gov)
  • In these photoreceptors, the C-terminus of the rhodopsin is directly linked to either a histidine kinase (histidine kinase rhodopsin), a phosphodiesterase (rhodopsin phosphodiesterase, RPDE), or a guanylyl cyclase (rhodopsin guanylyl cyclase, RGC). (elifesciences.org)