AnatomyChemicals and DrugsTechnology, Industry, Agriculture
CyclamatesCyclohexylaminesSaccharinAspartameSweetening AgentsIntestine, Large
SodiumAspartameSweetenerSweetenersArtificialSaccharin and cyclamateCyclohexylamine19371969BitternessRatsChemicalsProductsSugarCountriesDaysStudiesStudySafePeopleSweetenersSaccharin and cyclamatesCyclamic acidSucaryl19702022Ingredient1996CitationDrugsBeverageTypeAdditionApplicationMainLateLinkAuthorsStatusReport
Sodium27
  • Cyclamate is the sodium or calcium salt of cyclamic acid (cyclohexanesulfamic acid), which itself is prepared by reacting freebase cyclohexylamine with either sulfamic acid or sulfur trioxide. (wikipedia.org)
  • Prior to 1973, Abbott Laboratories produced sodium cyclamate (Sucaryl) by a mixture of ingredients including the addition of pure sodium (flakes or rods suspended in solvent) with cyclohexylamine, chilled and filtered through a high speed centrifugal separator, dried, granulated and micro-pulverised for powder or tablet usage. (wikipedia.org)
  • Sodium cyclamate, E 952 is a synthetic food sweetener with high sweetening power. (infocons.org)
  • This by sulphonation with chlorosulphonic acid in chloroform and treatment with barium hydroxide and sulphuric acid forms sodium cyclamate. (infocons.org)
  • It is 10 times more toxic than sodium cyclamate. (infocons.org)
  • Cyclamate, chemically known as sodium cyclohexyl sulfamate, is a commonly used additive in food production. (joinedfortunechemical.com)
  • In the world of sweeteners, sodium cyclamate stands out as a versatile and cost-effective option . (echem-bv.com)
  • We're here to introduce you to the benefits of sodium cyclamate and why it's the perfect choice for your business. (echem-bv.com)
  • What Is Sodium Cyclamate? (echem-bv.com)
  • Why Choose Sodium Cyclamate? (echem-bv.com)
  • fourthly, Sugar Reduction: With the growing consumer demand for reduced sugar products, sodium cyclamate can help you create healthier alternatives without sacrificing sweetness. (echem-bv.com)
  • When purchasing sodium cyclamate for your business, it's crucial to source it from reputable suppliers who adhere to strict quality standards. (echem-bv.com)
  • Incorporating sodium cyclamate into your product formulations can provide a competitive edge in today's health-conscious market. (echem-bv.com)
  • Explore the possibilities of sodium cyclamate for sale and transform your products into healthier, more flavorful options. (echem-bv.com)
  • It is the world's largest manufacturer of sodium cyclamate and China's biggest producer of cyclohexylamine. (byyoursidestudios.com)
  • With many years' industry experiences in Mainland China, we have finished the first-phase construction of the production units for industrial cyclohexylamine, dicyclohexylamine and sodium cyclamate. (byyoursidestudios.com)
  • This method makes it possible to determine five artificial sweeteners (acesulfame-K, aspartame, saccharine, sodium cyclamate and sucralose) in white wine (and white-wine-based beverages), within concentration ranges of up to 50 mg/L for saccharine, 125 mg/L for acesulfame-K and 250 mg/L for sucralose, sodium cyclamate and aspartame. (oiv.int)
  • It appears in the composition of the products as sodium and calcium cyclamates and cyclamic acid. (uchile.cl)
  • The purpose of this research was to assess the effect of sodium cyclamate in kidneys of rats fetuses considering morphometric changes of glomerulus, proximal and distal convoluted tubules, and collecting duct. (uchile.cl)
  • Ten pregnant rat (Rattus norvegicus) weighting an average of 238 g were divided into two groups: 5 in the control group and 5 in treated group with sodium cyclamate. (uchile.cl)
  • Between the 10th and the 14th pregnancy day, 5 rats received an intraperitoneal daily injection of 60 mg/kg of body weight of sodium cyclamate during 5 days. (uchile.cl)
  • There were a significant decrease in fetal and placentae weight in treated group with sodium cyclamate (p = 0.004) when compared with control group. (uchile.cl)
  • In the glomerular volume and cell nuclei size of proximal and distal convoluted tubules and collecting duct of kidneys of rats fetuses treated with sodium cyclamate, the increase was statistically significant. (uchile.cl)
  • The results showed that the use of sodium cyclamate was effective in the reduction of fetal and placentae weight, and lenght of umbilical cords. (uchile.cl)
  • Sodium cyclamate, which is popular in Europe, is around 30 to 40 times sweeter than traditional sugar. (jpost.com)
  • Butylated-hydroxyanisol (25013165), butylated-hydroxytoluene (128370), D(+)tryptophan (153946), sodium-cyclamate (139059) and sodium-saccharin (128449) produced weak responses. (cdc.gov)
  • 1996). For example, chlorophenol red selectively reacts with chlorine dioxide at pH 7 with a detection limit of 0.12 mg/L. The interferences from chlorine may be reduced by the addition of oxalic acid, sodium cyclamate, or thioacetamide (Sweetin et al. (cdc.gov)
Aspartame2
Sweetener5
  • Cyclamate is an artificial sweetener. (wikipedia.org)
  • Cyclamate was marketed in tablet form for use by diabetics as an alternative tabletop sweetener, as well as in a liquid form. (wikipedia.org)
  • Cyclamate is approved as a sweetener in at least 130 countries. (wikipedia.org)
  • Cyclohexylamine (CAS # 108-91-8, EC # 203-629-0) is a human metabolite of the artificial sweetener cyclamate, which is produced by intestinal microflora. (infocons.org)
  • In 1969, the Food and Drug Administration banned the sweetener cyclamate after lab studies indicated that large doses of the sweetener led to bladder cancer in animals. (snopes.com)
Sweeteners3
  • the mixture of 10 parts cyclamate to 1 part saccharin is common and masks the off-tastes of both sweeteners. (wikipedia.org)
  • While Tab contained two artificial sweeteners - saccharin and cyclamate - cyclamate was the more important of the two. (snopes.com)
  • In 1969 Federal govt bans use of artificial sweeteners known as cyclamates. (faqs.org)
Artificial1
  • The cyclamate is used as artificial non-caloric sweetner in a wide variety of foods and beverages, being 30 times as sweet as sugar without the bitter after-taste of saccharin. (uchile.cl)
Saccharin and cyclamate1
  • Knowing that mixtures of saccharin and cyclamate exert reduced bitterness compared to the single compounds raised the question [of] whether this might be due to mutual inhibition of bitter taste receptor responses," Behrens said to Science Daily. (jpost.com)
Cyclohexylamine4
  • citation needed] In 1966, a study reported that some intestinal bacteria could desulfonate cyclamate to produce cyclohexylamine, a compound suspected to have some chronic toxicity in animals. (wikipedia.org)
  • In animals and humans, the ability of bacterial microflora to convert cyclamate to cyclohexylamine varies over time for the same individual. (infocons.org)
  • Cyclohexylamine, which is the main metabolite of cyclamates, is formed mainly in the intestines under the influence of enterococci. (infocons.org)
  • Cyclamates are largely not metabolised by the human body and therefore there is a risk to aquatic organisms and the environment if wastewater treatment plants do not effectively remove them and their main metabolite: cyclohexylamine. (infocons.org)
19374
  • citation needed] Cyclamate was discovered in 1937 at the University of Illinois by graduate student Michael Sveda. (wikipedia.org)
  • Cyclamates are the salts of cyclohexylaminosulphonic acid discovered by Sveda as early as 1937. (infocons.org)
  • Discovered in 1937, cyclamate was first marketed in 1949, and banned by the FDA as potentially harmful in 1970. (britannica.com)
  • Kirsch wanted to create a soda for diabetics and people with cardiovascular problems, so he used cyclamate , which was discovered in 1937 by a graduate student working at a University of Illinois chemistry lab after he licked some of the substance and found that it tasted sweet. (snopes.com)
19693
  • Further research resulted in a 1969 study that found the common 10:1 cyclamate-saccharin mixture increased the incidence of bladder cancer in rats. (wikipedia.org)
  • Sales continued to expand, and in 1969, annual sales of cyclamate had reached $1 billion, which increased pressure from public safety watchdogs to restrict the usage of cyclamate. (wikipedia.org)
  • Abbott Laboratories claimed that its own studies were unable to reproduce the 1969 study's results, and, in 1973, Abbott petitioned the FDA to lift the ban on cyclamate. (wikipedia.org)
Bitterness1
  • Abbott intended to use cyclamate to mask the bitterness of certain drugs such as antibiotics and pentobarbital. (wikipedia.org)
Rats2
  • The released study was showing that eight out of 240 rats fed a mixture of saccharin and cyclamates, at levels equivalent to humans ingesting 550 cans of diet soda per day, developed bladder tumors. (wikipedia.org)
  • Although the FDA has stated that a review of all available evidence does not implicate cyclamate as a carcinogen in mice or rats, cyclamate remains banned from food products in the United States. (wikipedia.org)
Chemicals1
  • In 1970 a ruling of the United States Food and Drug Administration was sufficient to limit severely the use of a group of chemicals known as the cyclamates, many tons of which had been marketed annually in the country's favorite soft drinks and in many other food products. (druglibrary.org)
Products1
  • in October 1970, the FDA, under a new commissioner, banned cyclamate completely from all food and drug products in the United States. (wikipedia.org)
Sugar1
  • About 30 times sweeter than sugar, cyclamate isn't metabolized, making it ideal for people who need to avoid sugar. (snopes.com)
Countries1
  • Due to both carcinogenic, mutagenic, teratogenic effects, in some countries such as the USA, cyclamates are not allowed in the diet. (infocons.org)
Days1
  • Generally, ingested cyclamate is excreted from the body within 1-2 days. (infocons.org)
Studies1
  • The patent for cyclamate was purchased by DuPont and later sold to Abbott Laboratories, which undertook the necessary studies and submitted a New Drug Application in 1950. (wikipedia.org)
Study2
  • The authors concluded that the study failed to demonstrate that cyclamate was carcinogenic because the cancers were all different and there was no way to link cyclamate to each of them. (wikipedia.org)
  • A study in the journal Cell Chemical Biology uncovered that saccharin is able to inhibit the activity of bitter taste receptors, which are stimulated by cyclamate. (jpost.com)
Safe1
  • In the Philippines, cyclamate was banned until the Philippine Food and Drug Administration lifted the ban in 2013, declaring it safe for consumption. (wikipedia.org)
People1
  • But there are also people in whom a large proportion of ingested cyclamate (60%) is metabolised. (infocons.org)
Sweeteners3
  • the mixture of 10 parts cyclamate to 1 part saccharin is common and masks the off-tastes of both sweeteners. (wikipedia.org)
  • Structures of artificial sweeteners--cyclamic acid and sodium cyclamate with other cyclamates. (nih.gov)
  • After just three weeks of testing, the Health, Education and Welfare Secretary abruptly declared a ban on cyclamate sweeteners. (encyclopedia.com)
Saccharin and cyclamates2
  • The released study was showing that eight out of 240 rats fed a mixture of saccharin and cyclamates, at levels equivalent to humans ingesting 550 cans of diet soda per day, developed bladder tumors. (wikipedia.org)
  • The Eisenstadts developed a granular powder using saccharin and cyclamates, and named it Sweet ' n Low, after Benjamin Eisenstadt ' s favorite Tennyson poem. (encyclopedia.com)
Cyclamic acid1
  • Cyclamate is the sodium or calcium salt of cyclamic acid (cyclohexanesulfamic acid), which itself is prepared by reacting freebase cyclohexylamine with either sulfamic acid or sulfur trioxide. (wikipedia.org)
Sucaryl1
  • Prior to 1973, Abbott Laboratories produced sodium cyclamate (Sucaryl) by a mixture of ingredients including the addition of pure sodium (flakes or rods suspended in solvent) with cyclohexylamine, chilled and filtered through a high speed centrifugal separator, dried, granulated and micro-pulverised for powder or tablet usage. (wikipedia.org)
19702
  • in October 1970, the FDA, under a new commissioner, banned cyclamate completely from all food and drug products in the United States. (wikipedia.org)
  • In 1970 a ruling of the United States Food and Drug Administration was sufficient to limit severely the use of a group of chemicals known as the cyclamates, many tons of which had been marketed annually in the country's favorite soft drinks and in many other food products. (druglibrary.org)
20221
  • The report forecast global Cyclamate market to grow to reach xxx Million USD in 2022 with a CAGR of xx% during the period 2022E-2028F due to coronavirus situation. (statsandresearch.com)
Ingredient1
  • It was also a case of supremely bad luck, bad judgment, and a fateful ingredient known as cyclamate. (mentalfloss.com)
19961
  • 1996). For example, chlorophenol red selectively reacts with chlorine dioxide at pH 7 with a detection limit of 0.12 mg/L. The interferences from chlorine may be reduced by the addition of oxalic acid, sodium cyclamate, or thioacetamide (Sweetin et al. (cdc.gov)
Citation1
  • citation needed] In 1966, a study reported that some intestinal bacteria could desulfonate cyclamate to produce cyclohexylamine, a compound suspected to have some chronic toxicity in animals. (wikipedia.org)
Drugs1
  • Abbott intended to use cyclamate to mask the bitterness of certain drugs such as antibiotics and pentobarbital. (wikipedia.org)
Beverage1
  • Forty-nine women consumed a beverage containing 60 mg of cyclamate. (nih.gov)
Type1
  • At the same time, we classify Cyclamate according to the type, application by geography. (statsandresearch.com)
Addition1
  • But Marvin Eisenstadt was able to use his chemical expertise and devise a new formula for Sweet ' n Low, made with saccharin but without the addition of cyclamates. (encyclopedia.com)
Application2
  • The patent for cyclamate was purchased by DuPont and later sold to Abbott Laboratories, which undertook the necessary studies and submitted a New Drug Application in 1950. (wikipedia.org)
  • The market research includes historical and forecast market data, demand, application details, price trends, and company shares of the leading Cyclamate by geography. (statsandresearch.com)
Main1
  • The report offers detailed coverage of Cyclamate industry and main market trends with impact of coronavirus. (statsandresearch.com)
Late1
Link1
  • The authors concluded that the study failed to demonstrate that cyclamate was carcinogenic because the cancers were all different and there was no way to link cyclamate to each of them. (wikipedia.org)
Authors1
  • In both models conducted by the authors the intake of all LNCS, except cyclamate, were below the ADI for all population groups. (sweeteners.org)
Status1
  • First, this report covers the present status and the future prospects of the global Cyclamate market for 2018-2027. (statsandresearch.com)
Report1
  • Finally, the report provides detailed profile and data information analysis of leading Cyclamate company. (statsandresearch.com)