Cxcr4 chemokine receptors. Medical search. Frequent questions

We demonstrate here that interferon-γ (IFN-γ) increases the expression of chemokine receptors CCR1, CCR3, and CCR5 in monocytoid U937 cells as detected by cell surface molecule labeling and mRNA expression, as well as by intracellular calcium mobilization and cell migration in response to specific ligands. (johnshopkins.edu)
Weitzenfeld P, Ben-Baruch A. The chemokine program, and its own CCR5 and CXCR4 receptors, as potential goals for individualized therapy in tumor. (bioshockinfinitereleasedate.com)
Interestingly, receptors which expression declines during NK cell differentiation (CCR5, CCR7, and CXCR3) are commonly associated with adaptive T cell responses to viruses, whereas receptors that are upregulated along the differentiation axis (CXCR1, CXCR2, CX3CR1, CMKLR1) are typical for neutrophils and macrophages as a part of the innate immune response. (confex.com)
We describe the role of allelic polymorphism in the gene coding for the CCR5 chemokine receptor with regard to susceptibility to and disease course of HIV infection. (cdc.gov)
The receptors are widely distributed on homozygous for the CCR5 32 bp deletion. (cdc.gov)
Several human chemokine receptors have been sons than for those homozygous for the wild classified as such on the basis of similarity of type CCR5 (12,17-19,23). (cdc.gov)
The discovery of the gene sequences and predicted protein structures, role of CCR5 alleles has prompted studies of but their ligands have not been identified the possible role of many other host genes in (orphan receptors). (cdc.gov)
Therefore, the aims of this study were to evaluate the effectiveness of Maraviroc, a CCR5 antagonist, and AMD3100, a CXCR4 antagonist, to alter 1) the self-administration of fentanyl, an opioid, and cocaine, a stimulant, using a food versus drug choice procedure and 2) the analgesic effects of fentanyl in a radiant heat assay. (iasp-pain.org)
These data suggest that antagonism of CXCR4 and CCR5 may be of use in the ongoing effort to develop medications for the treatment of SUDs. (iasp-pain.org)
What do we know about the function of the CCR5 co-receptor? (sciforums.com)
First, CCR5 is a chemokine receptor (its ligand is RANTES) involved in chemotaxis, among other things. (sciforums.com)
Do we know for sure that HIV-1 binds to the receptor site of either CCR5 or CXCR4, or is it a random length along the peptide (although it obviously has to be outside the cell)? (sciforums.com)
Some G protein- coupled receptors in the chemokine receptor family, including CCR5, CXCR4, CCR3, CCR2b, and CCR8 in the chemokine receptor family, have been identified as HIV coreceptors. (qedbio.com)
Developed in 2007, the chemokine receptor antagonist blocks entry of certain specific strains of HIV, which attach to a particular protein on the immune cell's surface known as chemokine receptor 5 (CCR5). (hdkino.org)

Until recently, SDF-1 and CXCR4 were believed to be a relatively monogamous ligand-receptor pair (other chemokines are promiscuous, tending to use several different chemokine receptors). (wikipedia.org)
Recent evidence demonstrates ubiquitin is also a natural ligand of CXCR4. (wikipedia.org)
MIF is an additional ligand of CXCR4 CXCR4 is present in newly generated neurons during embryogenesis and adult life where it plays a role in neuronal guidance. (wikipedia.org)
CXCL12 (over-)expressing cancers might not sense the CXCL12 gradient released from the metastasis target tissues since the receptor, CXCR4, is saturated with the ligand produced in an autocrine manner. (wikipedia.org)
V160I) in the fourth transmembrane region of CXCR4 was detected in one colon cancer cell line (PD) and one melanoma cell line (LB). CXCR4 was expressed and functional in both PD and LB cells, PD and LB cells migrated specifically toward the receptor ligand, CXCL12 and P-Erk was specifically induced by CXCL12. (cnr.it)
eCl Upon ligand-induced activation, receptors were internalized and found in intracellular vesicles. (cell-signaling-pathways.com)
This co-internalization was observed either with CXCL11 as the CXCR7-selective ligand (e-h) or with CXCL12 as YIL 781 the ligand for both receptors (i-l). (cell-signaling-pathways.com)
CXCR4 protein could be detected on the surface of 16% of the RPE cells using flow cytometry, Calcium mobilization in response to the CXCR4 ligand stromal cell-derived factor 1 alpha (SDF-1 alpha) indicated that the CXCR4 receptors were functional, Incubation with SDF-1 alpha resulted in secretion of monocyte chemoattractant protein-1, IL-8, and growth-related oncogene iv, RPE cells also migrated in response to SDF-1 alpha. (elsevierpure.com)
The receptor N-terminus is external and contributes to ligand binding while the carboxy terminus (COOH) allows for interaction with signaling molecules and downstream signaling. (biolegend.com)
This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. (cancerindex.org)
Hematopoietic stem cell mobilizer binds to the CXCR4 chemokine receptor and inhibits the binding of its ligand, stromal cell-derived factor-1-alpha (SDF-1-alpha). (drugs.com)
The alpha- chemokine SDF-1 is the ligand for EXCR4 and prevents infection by T-cell tropic HIV-1. (qedbio.com)
The ligand CXCL12 (SDF-1) is a homeostatic chemokine with a central role in hematopoietic cells homing to and release from bone marrow. (lu.se)

d This anti-apoptotic effect could be reversed by co-incubation with the CXCR7-selective antagonist CCX733 (0.1?M) but not significantly by CXCR4-selective antagonist AMD3100 (5?M). Both antagonists experienced no inhibitory effects on their own (not shown). (cell-signaling-pathways.com)
AMD3100, a CXCR4 antagonist, enhanced the docetaxel cytotoxicity in vitro. (iiarjournals.org)
Chemokine receptor 4 (CXCR4) has been explored with radiolabelled CXCR4 antagonist (AMD3100) for imaging and future targeted radiation therapy for malignant lymphoma. (aacrjournals.org)

CXCR-4 is an alpha-chemokine receptor specific for stromal-derived-factor-1 (SDF-1 also called CXCL12), a molecule endowed with potent chemotactic activity for lymphocytes. (wikipedia.org)
Expression of this receptor in cancer cells has been linked to metastasis to tissues containing a high concentration of CXCL12, such as lungs, liver and bone marrow. (wikipedia.org)
However, in breast cancer where SDF1/CXCL12 is also expressed by the cancer cells themselves along with CXCR4, CXCL12 expression is positively correlated with disease free (metastasis free) survival. (wikipedia.org)
In vitro, A431 cells harboring CXCR4(G574A) migrated specifically toward CXCL12 and CXCL12 induced ERK phosphorylation. (cnr.it)
Clements D, Markwick LJ, Puri N, Johnson SR. Part from the CXCR4/CXCL12 axis in lymphangioleiomyomatosis and angiomyolipoma. (bioshockinfinitereleasedate.com)
The chemokine CXCL12 (stromal cell-derived factor-1, SDF-1) and its receptor CXCR4 play a major role in tumor initiation, promotion, progression and metastasis, especially for breast cancer cells. (cell-signaling-pathways.com)
After exposure to CXCL12 or CXCL11, the receptors were rapidly internalized alone or in close proximity. (cell-signaling-pathways.com)
As seen best in immunofluorescence, CXCL12 activation initially resulted in a mostly individual internalization of both receptors (5?min, Fig.?2c, place) as detected by individual red and green dots and a lower frequency of yellow (merged fluorescence) dots. (cell-signaling-pathways.com)
c Both chemokine ligands, namely 5 nM CXCL11 and 1 nM CXCL12, significantly reduced staurosporine-induced apoptosis. (cell-signaling-pathways.com)
The chemokines are found in the synovial fluid of people with rheumatoid arthritis and include CXCL12, CXCL11, and CCL5. (jax.org)
Biological Function Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation (PubMed:10452968, PubMed:28978524, PubMed:18799424, PubMed:24912431). (qedbio.com)

The human NK cell repertoire is functionally diversified through a tightly regulated differentiation process characterized by an early transition from CD56bright to CD56dim NK cells, followed by coordinated changes in expression of inhibitory receptors, including NKG2A and killer cell immunoglobulin-like receptors (KIR). (confex.com)

Click on the receptor to sort the ligands to the top. (biolegend.com)
A dysregulated immune system (including changes in the number and/or function of immune cells, cytokine levels, and the expression of inhibitory receptors or their ligands) plays a key role in the development of HCC. (wjgnet.com)
Developing computational methods to relate receptors by the similarity of their ligands, rather than by protein sequence or structure. (ucsf.edu)
Since the new relationships are articulated by ligands, they may be directly tested both on isolated receptors and, increasingly, against model whole organisms, such as zebra fish, C. elegans and mice. (ucsf.edu)
Moreover, these receptors are functional, as treatment of FRT tissue cells with ligands for TLR and NOD induces production of proinflammatory CXCL8 [ 13 ], and those receptors actively participate in immune response to pathogens, as Neisseria gonorrhea and HIV-1 [ 14 ]. (hindawi.com)
Cultured lung fibroblasts expressed the chemokine receptors CXCR4 and CCR7 and responded chemotactically to their cognate ligands, stromal cell-derived factor-1α and secondary lymphoid chemokine, respectively. (jci.org)

Plerixafor (AMD3100) is a drug, approved for routine clinical use, which directly blocks the CXCR4 receptor. (wikipedia.org)
As expected, treatment with AMD3100, a specific CXCR4 inhibitor, reduced the in vivo growth of CXCR4(G574A) tumor b(G574A) but surprisingly, increased the growth of CXCR4(G574A) A431 cells. (cnr.it)
While the mutation impairs cell growth in vivo, the CXCR4 inhibitor, AMD3100, stimulated the growth of cells harboring CXCR4(G574A). (cnr.it)
Stimulation with the CXCR4- or CXCR7-selective non-peptide antagonists AMD3100 and CCX733 resulted not only in single internalization but partly also in co-internalization of the two receptors. (cell-signaling-pathways.com)

Chemokines are a class of cytokines that induce chemotaxis (migration) of target cells. (biolegend.com)
While some chemotaxis is induced by inflammation or damaged cells, other chemokines function in homeostasis. (biolegend.com)

Two chemokine receptors, CXCR4 and CX3CR1, were broadly expressed, implying a potentially central role in cell trafficking. (broadinstitute.org)

Moreover, the sensitivities of the subclones to an inhibitor of epidermal growth factor receptor were dissimilar. (nature.com)
The Phase 2 clinical trial is designed to evaluate the company's CXCR4 inhibitor motixafortide in combination with PD-1 inhibitor cemiplimab and standard of care chemotherapies gemcitabine and nab-paclitaxel, versus gemcitabine and nab-paclitaxel alone, in first-line pancreatic cancer (PDAC). (kron4.com)

Once at the site of injury, immune cells can react by releasing additional cytokines and chemokines, bringing more cells into the fold. (biolegend.com)
A membrane-based antibody array for the parallel determination of the relative levels of selected mouse cytokines and chemokines. (rndsystems.com)

Motixafortide inhibits CXCR4, a chemokine receptor and a well validated therapeutic target that is over-expressed in many human cancers including pancreatic ductal adenocarcinoma (PDAC). (kron4.com)
Ibalizumab does not block the binding of gp120 to CD4 but rather inhibits the conformation changes in the CD4/gp120 complex that allows binding to a second cellular receptor, chemokine-receptor-4 (CXCR4), thus inhibiting HIV replication. (nih.gov)
In addition, BD inhibits expression of pro-metastastic genes PLAU and CXCR4 , in breast cancer xenografts. (spandidos-publications.com)

Semi-quantification of receptor internalization was achieved by labeling the glycocalyx of the cell surface with WGA (a lectin that binds to sialic acid and phosphorylated Erk, control with antagonists alone). (cell-signaling-pathways.com)

The O'Boyle/Kirby team thwarted the synovium-attacking T cells with PS372424, a small-molecule agonist for CXCR3 and several other chemokine receptors. (jax.org)

CXCR4 antagonists disrupt the specific interaction of chemokines with CXCR4 and may elicit therapeutic potential. (aacrjournals.org)

Chemokines receptors are seven transmembrane spanning G protein-coupled receptors that allow cells to migrate towards increasing chemokine gradients. (biolegend.com)

WHIM like mutations in CXCR4 were recently identified in patients with Waldenström's macroglobulinemia, a B-cell malignancy. (wikipedia.org)
The presence of CXCR4 WHIM mutations has been associated with clinical resistance to ibrutinib in patients with Waldenström's macroglobulinemia. (wikipedia.org)
Because mutations in the CXCR4 gene could regulate its function we sequenced the coding region of the CXCR4 gene in 18 human melanoma and 3 human colon carcinoma cell lines. (cnr.it)
The syndrome is cause by mutations in CXCR4, a chemokine receptor expressed by hematopoietic and non-hematopoietic cells. (lu.se)
Mutations on Btk components of the pre-B-cell and B-cell receptor (lambdα5, Ig-α, and Ig-β), or the scaffolding protein BLNK account for approximately 90% of defects in early B-cell development. (medscape.com)

The level of CXCR4 mRNA expression, but not cell surface expression, increased on stimulation,vith It-lp or TNF-alpha. (elsevierpure.com)
Results: Only CXCR4 mRNA levels in gastric cancer tissues were correlated with docetaxel sensitivity (R 2 =0.23, p=0.019) and significantly higher in resistant specimens (p=0.038). (iiarjournals.org)
Conclusion: CXCR4 mRNA expression levels may be a potential predictive biomarker in gastric cancer. (iiarjournals.org)

We are primarily using cytomegaloviruses to examine how the pathogens alter signaling pathways directed by G-protein coupled receptors (GPCRs) to facilitate robust replication in tissues important for host-host dissemination. (uc.edu)
Applying these to G-Protein Coupled Receptors (GPCRs), which are the single largest family of signaling receptors in human cells. (ucsf.edu)

Consequently, the purpose of the present research was the immunohistochemical evaluation of CXCR4 manifestation in BP-NEN using the monoclonal rabbit anti human being CXCR4 antibody UMB-2, which, as opposed to additional anti-CXCR4 antibodies, prospects mainly to membranous staining from the receptor. (bioshockinfinitereleasedate.com)
contamination by 4,6-diamidino-2-phenylindole (DAPI) staining and (CXCR4) and (CXCR7) fluorescent (secondary) antibodies in resting cells. (cell-signaling-pathways.com)
The Mouse Cytokine Array, Panel A utilizes capture antibodies spotted onto a nitrocellulose membrane to allow high-throughput multi-analyte profiling of 40 cytokines, chemokines, and more in a single sample. (rndsystems.com)
Antibodies to CXCR4 may block HIV-1 and HIV-2 infection of human target cells. (qedbio.com)

Chemokine receptors (CR), which can mediate migration of immune cells to the site of inflammation, also function as coreceptors for human immunodeficiency virus (HIV) entry into CD4 + T lymphocytes and antigen- presenting cells. (johnshopkins.edu)
Retinal pigment epithelial (RPE) cells form part of the blood-retina barrier and have recently been shown to produce various chemokines in response to proinflammatory cytokines, As the scope of chemokine action has been shown to extend beyond the regulation of leukocyte migration, we have investigated the expression of chemokine receptors on RPE cells to determine whether they could be a target for chemokine signaling. (elsevierpure.com)
The T cells in rheumatoid arthritis and other autoimmune diseases express CXCR3, a chemokine receptor associated with cell migration. (jax.org)
In summary, the O'Boyle/Kirby team demonstrated that systemically administered PS372424 engages the chemokine T cell migration system and re-directs chemo-attraction (receptor desensitization) away from inflammatory chemokines expressed in synovial fluid. (jax.org)
This process is mediated by chemokines, which guide cell migration by binding to their specific receptors. (confex.com)
We found that the chemokine-induced migration capability of NK cells correlated closely with the expression level of corresponding chemokine receptor, leading to subset specific responses to various chemokine gradients (D). (confex.com)
This receptor mediates neutrophil migration to sites of inflammation. (cancerindex.org)
Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. (cancerindex.org)

CXCR4 is one of several chemokine co-receptors that HIV can use to infect CD4+ T cells. (wikipedia.org)
It has been also shown that CXCR4 signalling regulates the expression of CD20 on B cells. (wikipedia.org)
Drugs that block the CXCR4 receptor appear to be capable of "mobilizing" hematopoietic stem cells into the bloodstream as peripheral blood stem cells. (wikipedia.org)
In a small human clinical trial to evaluate the safety and efficacy of fucoidan ingestion (brown seaweed extract), 3g daily of 75% w/w oral fucoidan for 12 days increased the proportion of CD34+CXCR4+ from 45 to 90% and the serum SDF-1 levels, which could be useful in CD34+ cells homing/mobilization via SDF-1/CXCR4 axis. (wikipedia.org)
To give insight into the function of the mutant CXCR4 receptor, human A431, epidermoid carcinoma cells, were stably transfected with both mutant and wild type CXCR4. (cnr.it)
This is the first report of a spontaneously occurring, functionally active CXCR4 mutation in human cancer cells. (cnr.it)
The increased expression of these chemokine receptors also results in an enhanced HIV-1 entry into cells. (johnshopkins.edu)
Hartmann TN, Burger JA, Glodek A, Fujii N, Burger M. CXCR4 chemokine receptor and integrin signaling co-operate in mediating adhesion and chemoresistance in little cell lung tumor (SCLC) cells. (bioshockinfinitereleasedate.com)
Immunofluorescence and goldClabeling by light and electron microscopy, respectively, revealed that both receptors were localized at the cell surface in non-stimulated cells. (cell-signaling-pathways.com)
Our findings suggest that CXCR4 and CXCR7 closely YIL 781 interact in breast malignancy cells. (cell-signaling-pathways.com)
RT-PCR analysis indicated that the predominant receptor expressed on RPE cells was CXCR4. (elsevierpure.com)
As SDF-1 alpha expression by RPE cells was detected constitutively, we postulate that SDP-1-CXCR4 interactions may modulate the affects of chronic inflammation and subretinal neovascularization at the RPE site of the blood-retina barrier. (elsevierpure.com)
Attracted cells move toward areas of higher concentrations of the chemokine. (biolegend.com)
Due to their function of targeting cells to specific organs, homeostatic chemokines can also be involved in cancer and metastasis. (biolegend.com)
Many inflammatory chemokines attract a wide variety of cells in both the innate and adaptive arms of immunity. (biolegend.com)
Upon sensing the inflammatory chemokine, cells will extravasate from the blood vessel and follow the gradient to its source. (biolegend.com)
Normally, they bind to their respective T cell receptors, activating the T cells and recruiting them to attack the joint synovia. (jax.org)
Interestingly, CCR1 and CXCR6 were expressed mainly on less differentiated NKG2A+ CD56dim NK cells (B). Next, we stratified the chemokine receptor expression on mature KIR+ NK cells based on the expression of self (educated) or non-self KIR (uneducated). (confex.com)
The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. (cancerindex.org)
In this review, we have discussed the status and roles of various immune effector cells ( e.g ., dendritic cells, natural killer cells, macrophages, and T cells), their cytokine profile, and the chemokine-receptor axis in promoting or impeding HCC. (wjgnet.com)
One major discovery was that members of the chemokine receptor family serve as cofactors for HIV entry into cells. (cdc.gov)
However, some CD4+ T cells express another chemokine receptor, CXCR4 (which can also serve as a coreceptor for HIV-1). (sciforums.com)
Motixafortide leverages the expression of the CXCR4 receptor on different immune cells and potentiates the immune system against the tumor. (kron4.com)
CXCR4 associates with the surface CD4-gp120 complex before HIV enters target cells. (qedbio.com)
Lymphoma cells are reported to over-express chemokine receptors that favors leukocyte infiltration, promotes tumorigenesis, angiogenesis, immune evasion, and metastasis. (aacrjournals.org)
The mature B cells circulate between secondary lymphoid organs and migrate into lymphoid follicles of the spleen and lymph nodes in response to further stimuli and various chemokines. (medscape.com)

Specificity This antibody recognizes human and mouse CXCR4 (40 kD). (qedbio.com)
Ibalizumab is a humanized monoclonal antibody to CD4, the cell surface receptor for the HIV-1 envelope glycoprotein (gp120), which is used to treat patients with multidrug resistant HIV-1 infection. (nih.gov)
Ibalizumab (eye' ba liz' ue mab) is a recombinant humanized monoclonal antibody to CD4, the cell surface receptor for the HIV-1 envelope glycoprotein 120 (gp120). (nih.gov)

Homeostatic chemokines are constitutively expressed in particular organs or tissues. (biolegend.com)
Specific chemokine receptors are often required to gain entry (or exit) from certain organs and tissues like the thymus and bone marrow. (biolegend.com)

The B-cell receptor consists of an Ig molecule anchored to the cell's surface. (msdmanuals.com)

Chemoattractant cytokines ('chemokines') are immune system messengers that can alter the therapeutic and abuse-related effects of opioids and stimulants. (iasp-pain.org)

In order to delineate the homing patterns of distinct NK cell subsets, we used high-dimensional flow cytometry combined with functional assays to map the NK cell chemokine receptor expression and migratory behavior. (confex.com)

Our findings demonstrated that CXCR4 targeting with CB significantly inhibited the spontaneous and induced-production of key inflammatory cytokines by monocytes isolated from JIA patients. (frontiersin.org)
These chemokines also have a more diverse range of functions compared to inflammatory chemokines. (biolegend.com)
In the event of infection, injury, or tissue damage, inflammatory chemokines are often released to address the problem. (biolegend.com)
The team's research suggests that agonist-induced chemokine receptor desensitization may mitigate not only rheumatoid arthritis but other inflammatory diseases, including psoriasis, multiple sclerosis and inflammatory bowel disease. (jax.org)
During infection, macrophages have diverse roles including phagocytosis of foreign bodies, release of cytotoxic factors, and coordination of the inflammatory response via the secretion of chemokines and cytokines ( 3 , 4 ). (frontiersin.org)

Earlier HIV infec- receptor gene polymorphism in HIV infection, tion diagnosis, inhibition of ongoing HIV replica- only genes of the HLA system were thought to tion with antiretroviral therapy (in industrialized protect against HIV infection. (cdc.gov)
A panel of 11 genes selected according to microarray analysis were validated and tested further in 11 cancer cell lines, resulting in 4 genes, CXCR4, CDK6, USP15 and CDH1. (iiarjournals.org)

It is speculated this interaction may be through CXCR4 mediated signalling pathways. (wikipedia.org)

Dr. Marchese has had a long-standing interest in understanding the molecular mechanisms governing G protein-coupled receptor signaling. (mcw.edu)
Research in the Marchese lab is directed towards understanding the molecular mechanisms governing G protein-coupled receptor (GPCR) signaling. (mcw.edu)
Human cytomegalovirus G protein-coupled receptor US28 promotes latency by attenuating c-fos. (uc.edu)
The protein encoded by this gene is a member of the G-protein-coupled receptor family. (cancerindex.org)

To explore such an alternative strategy, we investigated the effects of targeting the CXCR4 receptor using the histamine analog clobenpropit (CB). (frontiersin.org)

Our data provide evidence for a relationship of cellular pathways that are induced by IFN-γ with those that regulate chemokine receptor expression. (johnshopkins.edu)

Interestingly, in vivo studies showed that the growth of A431 tumors harboring CXCR4(G574A) was delayed compared to those harboring WT CXCR4. (cnr.it)
Introduction For most tumors, the overexpression from the chemokine receptor CXCR4 is connected with increased malignancy and poor individual outcomes. (bioshockinfinitereleasedate.com)

The results show that the polycation/siRNA/PFOB nanoemulsions are capable of efficiently silencing the expression of STAT3 and inhibiting chemokine receptor CXCR4 - two validated targets in pulmonary fibrosis. (cdc.gov)

186544-26-3 manufacture As in additional tumor entities, CXCR4 overexpression considerably correlates with unfavorable individual outcome. (bioshockinfinitereleasedate.com)
As opposed to a great many other tumor entities, the part of CXCR4 manifestation is not evaluated in common and atypical lung carcinoids up to now, and there are just limited data on CXCR4 manifestation in SCLC [26, 27]. (bioshockinfinitereleasedate.com)
Furthermore, previous studies looking into the manifestation of CXCR4 in various tumor entities by immunohistochemistry (IHC) frequently yielded just cytoplasmic or nuclear staining of the membrane-bound receptor [28, 29]. (bioshockinfinitereleasedate.com)
The function of adhesion substances and chemokine receptor CXCR4 (Compact disc184) in little cell lung tumor. (bioshockinfinitereleasedate.com)
Chemokine receptor CXCR4 and early-stage non-small cell lung tumor: design of appearance and relationship with result. (bioshockinfinitereleasedate.com)

To determine whether the observed differences in chemokine receptor expression translate into altered chemokine responsiveness between the subsets, we combined the transwell system with multicolor flow cytometry. (confex.com)

Chronic exposure to THC has been shown to increase T lymphocyte CXCR4 expression on both CD4+ and CD8+ T lymphocytes in rhesus macaques. (wikipedia.org)
CXCR4, CCR4, and CCR2 expression was relatively uniform across all subsets. (confex.com)
The present results show that peripheral blood NK cell chemokine receptor profile changes in a coordinated fashion during NK cell differentiation and is further influenced by the expression of self-specific KIR. (confex.com)

Conclusions With raising malignancy, BP-NEN obviously differ in the extent of CXCR4 manifestation. (bioshockinfinitereleasedate.com)

C-X-C chemokine receptor type 4 (CXCR-4) also known as fusin or CD184 (cluster of differentiation 184) is a protein that in humans is encoded by the CXCR4 gene. (wikipedia.org)
This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. (cancerindex.org)

Phagocytosis can involve the recognition of pathogen- and damage-associated molecular patterns (PAMPs and DAMPs, respectively) through pattern recognition receptors (PRRs) on the macrophage surface ( 5 , 6 ). (frontiersin.org)

CXCR4 (also called Fusin, LESTR, HUMSTR) is a principal coreceptor for T-cell tropic strains of HIV-1. (qedbio.com)

HIV isolates that use CXCR4 are traditionally known as T-cell tropic isolates. (wikipedia.org)
The chemokine receptor CXCR4 is widely expressed in human cancers and regulates cell invasion, proliferation and survival. (cnr.it)
Without activation, receptors were scattered alone or lay in close proximity at the cell surface. (cell-signaling-pathways.com)
CXCR4 messenger RNA levels correlate with HIV-1 permissiveness in diverse human cell types. (qedbio.com)
CXCR4 binding efficacy and toxicity studies were performed on CXCR4 expressing cancer cell-lines. (aacrjournals.org)

citation needed] CXCR4 is upregulated during the implantation window in natural and hormone replacement therapy cycles in the endometrium, producing, in presence of a human blastocyst, a surface polarization of the CXCR4 receptors suggesting that this receptor is implicated in the adhesion phase of human implantation. (wikipedia.org)

Anatomy48

Organisms14

Diseases11

Chemicals and Drugs112

Analytical, Diagnostic and Therapeutic Techniques and Equipment26

Phenomena and Processes45

Disciplines and Occupations1

Information Science3

CCR514

Ligand13

Antagonist3

CXCL1211

Followed by coordinated changes in expressi1

Ligands6

AMD31004

Chemotaxis2

CX3CR11

Inhibitor2

Cytokines and chemokines2

Inhibits3

Binds1

Small molecule1

Antagonists1

Seven transmembrane1

Mutations5

MRNA3

GPCRs2

Antibodies4

Migration8

Cells26

Antibody3

Tissues2

Cell's surface1

Therapeutic1

Functional1

Inflammatory5

Genes2

Interaction1

Protein-coupled receptor4

Histamine1

Pathways1

Tumors2

Pulmonary fibrosis1

Tumor5

Flow cytometry1

Expression3

Malignancy1

Gene2

Molecular1

Fusin1

Cell5

Adhesion1