Cxcr2 receptor. Medical search. Frequent questions

In addition to excreted products, the receptors ICAM-1, CXCR1, and CXCR2, which all were elevated with SBE exposure, were also decreased with G31P treatment. (cdc.gov)
ELR-positive C-X-C chemokines specifically induce the migration of neutrophils, and interact with chemokine receptors CXCR1 and CXCR2. (immunochemistry.com)
Interleukin-8 (IL-8), a member of a family of structurally related cytokines, is a neutrophil chemotactic cytokine that can signal through the CXCR1 and CXCR2 receptor. (genscript.com)
IL-8, first isolated from osteosarcoma cells, contains the ELR-motif (N-terminal Glu-Leu-Arg amino acid sequence) and signals through the CXCR1 and CXCR2 receptors. (thermofisher.com)

RR genotype) was associated with higher CXCR2 expression and more tissue neutrophils. (frontiersin.org)
and d) IL-1β neutralization reduced CXCR2 expression on bone marrow and blood neutrophils and their subsequent accrual to colonic tissue. (frontiersin.org)
Ester forms of the nicotinamide glycolate antagonized CXCL1-stimulated chemotaxis (IC 50 = 42 nM) and calcium flux (IC 50 = 48 nM) in human neutrophils, but they were inactive in cell-free assays of 125 I-CXCL8/CXCR2 binding and CXCL1-stimulated guanosine 5′- O -(3-[ 35 S]thio)triphosphate ([ 35 S]GTPγS) exchange. (aspetjournals.org)
Binding of IL-8 to the receptor causes activation of neutrophils. (joplink.net)
Chemokine (CXC motif) ligand 1 (CXCL1) acts as a key chemoattractant for neutrophils by binding specifically to its corresponding G protein-coupled receptor chemokine (CXC motif) receptor 2 (CXCR2) (11, 12). (researchsquare.com)
Interestingly, receptors which expression declines during NK cell differentiation (CCR5, CCR7, and CXCR3) are commonly associated with adaptive T cell responses to viruses, whereas receptors that are upregulated along the differentiation axis (CXCR1, CXCR2, CX3CR1, CMKLR1) are typical for neutrophils and macrophages as a part of the innate immune response. (confex.com)

Chemokines that regulate neutrophil migration by signaling through the CXCR2 receptor are markedly elevated by brain injury and are associated with the propagation of secondary damage. (edu.au)
We demonstrate a significant attenuation of neutrophil infiltration in Cxcr2−/− mice at 12 hours and 7 days after CHI, despite increased levels of CXC neutrophil-attracting chemokines in the lesioned cortex. (edu.au)
The data presented here describe the cellular pharmacology of the acid and ester forms of the nicotinamide glycolate pharmacophore, a potent antagonist of CXCR2 signaling by the chemokines CXCL1 and CXCL8. (aspetjournals.org)
Chemokines receptors are seven transmembrane spanning G protein-coupled receptors that allow cells to migrate towards increasing chemokine gradients. (biolegend.com)
Use this table to quickly identify the chemokines that bind to each receptor. (biolegend.com)
Chemokines and their corresponding receptors have been well-characterized in RA progression, but less so in OA pathogenesis. (researchsquare.com)
Chemokines and chemokine receptors are critical players in the disease processes of two inflammatory joint diseases: rheumatoid arthritis (RA) and osteoarthritis (OA) (1). (researchsquare.com)
Both diseases are characterized by the extravasation of leukocytes from the vascular endothelium into the synovial tissue, a process that involves numerous chemokines and their receptors acting as synovial chemotactic mediators (5). (researchsquare.com)
All three isoforms of GRO are CXC chemokines that can signal through the CXCR1 or CXCR2 receptors. (peprotech.com)
This process is mediated by chemokines, which guide cell migration by binding to their specific receptors. (confex.com)
Interleukin 8 (IL-8, CXCL8) is a 72 amino acid pro-inflammatory factor which belongs to the CXC subfamily of chemokines, and are bound by the cell surface receptors IL-8RA and IL-8RB. (thermofisher.com)

Knock-down studies involving the chemokine receptor CXCR2 alleviates both replicative and oncogene-induced senescence (OIS) and diminishes the DNA-damage response. (wikipedia.org)

IL8RB is also known as CXCR2, and CXCR2 is now the IUPHAR Committee on Receptor Nomenclature and Drug classification-recommended name. (wikipedia.org)
IL8RB, IL8RA, which encodes another high affinity IL8 receptor, and IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. (wikipedia.org)
Intra-assay Precision (Precision within an assay): 3 samples with low, middle and high level Interleukin 8 Receptor Beta (IL8Rb) were tested 20 times on one plate, respectively. (biomatik.com)
Inter-assay Precision (Precision between assays): 3 samples with low, middle and high level Interleukin 8 Receptor Beta (IL8Rb) were tested on 3 different plates, 8 replicates in each plate. (biomatik.com)
This assay has high sensitivity and excellent specificity for detection of Interleukin 8 Receptor Beta (IL8Rb). (biomatik.com)
No significant cross-reactivity or interference between Interleukin 8 Receptor Beta (IL8Rb) and analogues was observed. (biomatik.com)

This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. (wikipedia.org)
The N-Ac-PGP- and CXCL1-induced neutrophil influx and the increased pulmonary tissue MPO levels were inhibited by the CXCR2 antagonists SB225002 and SB332235. (nih.gov)
Moreover, N-Ac-PGP administration enhanced the CXCL1 levels in bronchoalveolar lavage fluid, which could not be attenuated by both CXCR2 antagonists. (nih.gov)
The N-Ac-PGP-induced release of CXCL1 is independent of CXCR2. (nih.gov)
Acid forms of the nicotinamide glycolate were inactive in whole-cell assays of chemotaxis and calcium flux, but they inhibited 125 I-CXCL8/CXCR2 binding and CXCL1-stimulated [ 35 S]GTPγS exchange. (aspetjournals.org)
CXCR2, c-Raf and MAPKs was found to regulate CXCL1-induced IL-6 expression in OASFs and RASFs. (researchsquare.com)
Our present work suggests that the CXCL1/CXCR2 axis helps to orchestrate inflammatory responses in OA and RA SFs. (researchsquare.com)
We have elucidated the molecular mechanisms involved in the increase in IL-6 expression caused by CXCL1 incubation in SFs, which was regulated by its receptor CXCR2, c-Raf and MAPK signaling components, and activator protein-1 (AP-1) transcriptional activation. (researchsquare.com)

To elucidate whether CXCR2 is involved in N-Ac-PGP-induced neutrophil migration and activation, studies using specific antagonists were performed in vivo. (nih.gov)
In conclusion, neutrophil migration induced by N-Ac-PGP is mediated via direct CXCR2 interaction. (nih.gov)
This receptor mediates neutrophil migration to sites of inflammation. (cancerindex.org)

C-X-C chemokine receptor 2 (CXCR2) is a chemotactic receptor that is critical in neutrophil mobilization from bone marrow to blood and tissue sites. (frontiersin.org)
Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. (joplink.net)

Intraperitoneal applications of CXCR2 antagonist SB225002 or SB332235 were administered 1h prior and 1h after oropharyngeal aspiration. (nih.gov)
CXCR1/CXCR2 antagonist CXCL8(3-74)K11R/G31P blocks lung inflammation in swine barn dust-instilled mice. (cdc.gov)
In this study we test the ability of a CXCR1/CXCR2 antagonist, CXCL8(3-74)K11R/G31P (G31P) to block many of the features of lung-inflammation in response to challenge with SBE in an established mouse exposure system. (cdc.gov)

Recombinant Human GRO-α/MGSA is a 7.8 kDa protein consisting of 73 amino acids, including the 'ELR' motif common to the CXC chemokine family that binds to CXCR1 or CXCR2. (peprotech.com)

Despite initial and often dramatic responses of epidermal growth factor receptor (EGFR)-addicted lung tumors to the EGFR-specific tyrosine kinase inhibitors (TKIs) gefitinib and erlotinib nearly all develop resistance and relapse. (technologybooksindustrialprojectreports.com)

The real implications of our findings need to be tested in clinical settings to determine whether patients with advanced prostate cancer benefit from CXCR2 inhibition, alone or in combination with a hormone inhibitor," he says. (futurity.org)

Interleukin 8 receptor, beta is a chemokine receptor. (wikipedia.org)
This protein is a receptor for interleukin 8 (IL8). (wikipedia.org)

CXCR2 is the receptor that CXCL3 binds. (goldbio.com)

Here, we demonstrate that NK cells (haNKs) engineered to express a PD-L1 chimeric antigen receptor (CAR) haNKs killed a panel of human and murine head and neck cancer cells at low effector-to-target ratios in a PD-L1-dependent fashion. (elifesciences.org)
The biological activity determined by a chemotaxis bioassay using human CXCR2 transfected murine BaF3 cells is in a concentration range of 5-50 ng/ml. (goldbio.com)

Upon binding to their receptors, cytokines activate JAKs which then phosphorylate the cytokine receptor, thereby creating docking sites for signaling molecules, notably, members of the signal transducer and activator of transcription (STAT) family that ultimately lead to gene expression. (justia.com)

Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. (wikipedia.org)
The selectin adhesion molecules and chemoattractant receptors synergistically regulate leukocyte migration into lymphoid tissues and sites of inflammation, but little is known about how these families of receptors modulate each other's function. (upenn.edu)
We found that the chemokine-induced migration capability of NK cells correlated closely with the expression level of corresponding chemokine receptor, leading to subset specific responses to various chemokine gradients (D). (confex.com)

Here, we describe the pre-clinical in vitro and in vivo study of irradiated haNK cells engineered to express a second-generation chimeric antigen receptor (CAR) targeting programmed death-ligand 1 (PD-L1). (elifesciences.org)

Targeting a cell surface receptor essential for the function and survival of resistant prostate cancer cells can halt tumor growth, researchers report. (futurity.org)
This occurs because a receptor on the surface of neuroendocrine cells called CXCR2, which creates the optimal environment for prostate tumor cells to proliferate and spread, drives tumor growth. (futurity.org)

Thus induction of FGF2 and FGFR1 following chronic adaptation to EGFR-specific TKIs provides a novel autocrine receptor tyrosine kinase-driven bypass pathway in a subset of lung cancer cell lines that are initially sensitive to EGFR-specific TKIs. (technologybooksindustrialprojectreports.com)

The role of the IL-33-ST2-CXCL3-CXCR2 axis in PDAC metastasis was evaluated in three clinically relevant mouse PDAC models. (bmj.com)
The highest level of CXCL3 was found in PDAC relative to other cancer types and its receptor CXCR2 was almost exclusively expressed in CAFs. (bmj.com)
Activation of CXCR2 by CXCL3 induced a CAF-to-myoCAF transition and α-smooth muscle actin (α-SMA) was uniquely upregulated by the CXCL3-CXCR2 signalling. (bmj.com)
Type III collagen was identified as the CXCL3-CXCR2-targeted adhesive molecule responsible for myoCAF-driven PDAC metastasis. (bmj.com)

The receptor N-terminus is external and contributes to ligand binding while the carboxy terminus (COOH) allows for interaction with signaling molecules and downstream signaling. (biolegend.com)
However, agonist-dependent activation of cell surface receptors is sometimes required to promote interaction with a PDZ protein. (embl.de)
STARD12 co-expressed genes participated in cell cycle and DNA replication, and STARD14 were enriched in ECM-receptor interaction. (medsci.org)

This study thus investigated the function of CXCR2 in posttraumatic inflammation and secondary degeneration by examining Cxcr2-deficient (Cxcr2−/−) mice over 14 days following closed head injury (CHI). (edu.au)
CXCR2 is also expressed by immune cells and involved in inflammation, and scientists are developing a drug that inhibits its function for patients with chronic obstructive pulmonary disease (COPD). (futurity.org)

This coincides with reduced tissue damage, neuronal loss, and cell death in Cxcr2−/− mice compared to wild-type controls, with heterozygotes showing intermediate responses. (edu.au)

Because CXCR2 is ubiquitously expressed by neuroendocrine cells in prostate cancer of all stages, targeting CXCR2 may particularly benefit patients whose tumors are advanced, recurrent, and resistant to currently available therapies," Huang says. (futurity.org)

NK cells express germ-line receptors that are either stimulatory or inhibitory, and the summation of these signals determines activation status ( Caligiuri, 2008 ). (elifesciences.org)
The human NK cell repertoire is functionally diversified through a tightly regulated differentiation process characterized by an early transition from CD56bright to CD56dim NK cells, followed by coordinated changes in expression of inhibitory receptors, including NKG2A and killer cell immunoglobulin-like receptors (KIR). (confex.com)

The protein encoded by this gene is a member of the G-protein-coupled receptor family. (wikipedia.org)
The chemokine signal is transduced by chemokine receptors (G-protein coupled receptors) expressed on the immune cells. (genome.jp)
After receptor activation, the alpha- and beta-gamma-subunits of G protein dissociate to activate diverse downstream pathways resulting in cellular polarization and actin reorganization. (genome.jp)

Here, we investigated the biological mechanisms that regulate neutrophil CXCR2 expression after CDI, and the influence of host genetics on this process. (frontiersin.org)

Also, ectopic expression of CXCR2 results in premature senescence via a p53-dependent mechanism. (wikipedia.org)

Conversely, CXCR3 was expressed at lower levels on educated NK cells (C). No difference was observed for CXCR2 expression. (confex.com)
Induced by IFN-gamma (IFN-γ), the ELR-negative chemokine CXCL9 (MIG) elicits its effects by binding to the cell surface chemokine receptor CXCR3. (immunochemistry.com)

Mutations in CXCR2 cause hematological traits. (wikipedia.org)

Interactions between L-selectin and chemoattractant receptors were therefore examined using transfected rat basophilic leukemia cell lines (RBL-2H3) that expressed human L-selectin along with human leukocyte chemoattractant receptors. (upenn.edu)
In order to delineate the homing patterns of distinct NK cell subsets, we used high-dimensional flow cytometry combined with functional assays to map the NK cell chemokine receptor expression and migratory behavior. (confex.com)
The present results show that peripheral blood NK cell chemokine receptor profile changes in a coordinated fashion during NK cell differentiation and is further influenced by the expression of self-specific KIR. (confex.com)

We have previously reported that a single nucleotide polymorphism (SNP) in leptin receptor (LEPR), present in up to 50% of people, influenced CDI-induced neutrophil CXCR2 expression and tissue neutrophilia. (frontiersin.org)
In sum, our data indicate that IL-1β is a key molecular mediator that communicates between gastro-intestinal tract (i.e. site of CDI) and bone marrow (i.e. primary neutrophil reservoir) and regulates the intensity of CDI-induced tissue neutrophilia by modulating CXCR2 expression. (frontiersin.org)

Genomics and transcriptomic alterations of the glutamate receptors in acute myeloid leukemia. (cdc.gov)

Specific chemokine receptors are often required to gain entry (or exit) from certain organs and tissues like the thymus and bone marrow. (biolegend.com)
Upon culture in endothelial growth media, these cells expressed endothelial lineage markers, such as CD31, Tie2, and VEGF receptor 2 (VEGFR2), and incorporated into blood vessels in ischemic tissues. (hindawi.com)

The chemokine receptors CXCR1/2 are involved in a variety of inflammatory diseases, including chronic obstructive pulmonary disease. (aspetjournals.org)

Interestingly, CCR1 and CXCR6 were expressed mainly on less differentiated NKG2A+ CD56dim NK cells (B). Next, we stratified the chemokine receptor expression on mature KIR+ NK cells based on the expression of self (educated) or non-self KIR (uneducated). (confex.com)

To determine whether the observed differences in chemokine receptor expression translate into altered chemokine responsiveness between the subsets, we combined the transwell system with multicolor flow cytometry. (confex.com)

Anatomy2

Organisms1

Chemicals and Drugs24

Analytical, Diagnostic and Therapeutic Techniques and Equipment1

Phenomena and Processes4

CXCR1 and CXCR24

Neutrophils6

Chemokines11

Involving the chemokine receptor1

IL8RB6

CXCL18

Neutrophil migration3

Chemotactic2

Antagonist3

Motif1

Epidermal growth f1

Inhibitor1

Interleukin2

Binds1

Murine2

Cytokine1

Migration3

Antigen1

Tumor2

Pathway1

CXCL34

Interaction3

Inflammation2

Mice1

Cancer1

Inhibitory2

Protein3

Regulate1

Mechanism1

CXCR32

Mutations1

Cell3

Tissue2

Genomics1

Tissues2

Inflammatory1

CCR11

Expression1