Cutaneous nerve fibers nerve fibers unmyelinated. Medical search. Frequent questions

Working at the Department of Clinical Neurophysiology, Academic Hospital, Uppsala, they collected data resulting in the first papers representing three areas to become major fields of microneurography, i.e. afference from intra-muscular sense organs during voluntary contractions, response of cutaneous sense organs related to touch stimuli, and efferent sympathetic activity controlling the constriction of human blood vessels. (wikipedia.org)
Testing in patients with selective deafferentation revealed impaired pain judgments to graded mechanical stimuli only when thickly myelinated fibers were absent. (ljmu.ac.uk)
The electrical stimuli on the skin preferentially activate low-threshold, myelinated nerve fibers. (medscape.com)
We used focused, non-damaging, short near-infrared laser heat stimuli (wavelength 1470/1475 nm) to study the involvement of TRPV1-expressing nerve fibers in the encoding of heat pain intensity. (biomedcentral.com)
Heating of dermal and epidermal nerve fibers in humans with laser stimuli of ≥ 2.5 mJ (≥ 25 ms, 100 mW) induced pain that increased linearly as a function of stimulus intensity in double logarithmic space across two orders of magnitude and was completely abolished by desensitization using topical capsaicin. (biomedcentral.com)
Small myelinated Aδ fibers and unmyelinated C fibers are responsible for the transmission of painful stimuli to the spinal cord where these afferent primary fibers terminate in the dorsal horn. (healthbeautytips.in)
Similarly in cutaneous LCH, overreaction to stimuli such as a dermotropic MCPyV infection may occur [12]. (mayabouchenaki.com)

The canonical view is that touch is signaled by fast-conducting, thickly myelinated afferents, whereas pain is signalled by slow-conducting, thinly myelinated ("fast" pain) or unmyelinated ("slow" pain) afferents. (ljmu.ac.uk)
Here, we performed single-unit axonal recordings (microneurography) from cutaneous mechanoreceptive afferents in healthy participants. (ljmu.ac.uk)
In the hairy skin of humans there is a specific type of nerve fibers called C-tactile (CT) afferents which are optimally activated by a light stroking of the skin, like a caress. (gu.se)
The terminals of unmyelinated sensory afferents serve two general functions. (jneurosci.org)
Most pain related information is forwarded from the periphery to the central nervous system by unmyelinated primary afferents (C fibres) called nociceptors. (biomedcentral.com)
When Aβ large fiber afferents or C-fibers inhibit Aδ pain fibers, this is known as "Gate Control" pain inhibition, first posited in 1965 when Melzack and Wall(4) observed that mechanical Aβ stimulation could reduce pain. (justia.com)

Any peripheral nerve that can be reached may be a target for microneurography recordings, typically in the arm or leg, although recording from facial nerves and the vagus nerve have also been achieved. (wikipedia.org)
Some nerves contain only autonomic fibers, e.g., the vagus nerve. (evokedpotential.com)
The auricular branch of the vagus nerve is a sensory nerve emerging from the superior ganglion of the vagus nerve, joined by branches from the glossopharyngeal (CN IX) and facial nerves, and innervating the lower part of the tympanic membrane and the floor of the external auditory canal. (unboundmedicine.com)

Cutaneous tissue nociceptors terminate just below the skin, producing a well-defined, localized pain of short duration due to the high concentration of nerve endings. (newworldencyclopedia.org)
Nociceptors for pain also appear to be "free nerve" endings in skin and muscle. (cdc.gov)
Small diameter DRG cells, in contrast, have unmyelinated axons and are principally nociceptors and thermoceptors. (jneurosci.org)
Lamina II, also called the substantia gelatinosa, contains many interneurons and is believed to play a major role in processing and modulating nociceptive input from cutaneous nociceptors. (brainkart.com)
The majority of tissues and organs are innervated by special sensory receptors (nociceptors) connected to primary afferent nerve fibers of differing diameters. (healthbeautytips.in)

We found, in mice, that the sciatic nerve invasion by blood vessels begins around embryonic day 16 and continues until birth. (elifesciences.org)
Using mouse genetic models, the authors show that Schwann cells regulate vascularization of the sciatic nerve and are required for a decrease in vascular density postnatally. (elifesciences.org)
Due to this effect, researchers wondered if salidroside might be able to help recovery from sciatic nerve injuries, so they tested it out. (dpsnutrition.net)
To address this, we conducted a quantitative analysis of the spatial and temporal changes in the number of inhibitory terminals, as detected by glutamic acid decarboxylase 65 (GAD65) immunoreactivity, in the superficial dorsal horn of the spinal cord following a chronic constriction injury (CCI) to the sciatic nerve in rats. (biomedcentral.com)

Nerve fibers (axons) of various kinds are more or less randomly mixed in most nerves. (wikipedia.org)
7 These fibers, which originate in the skin at the junction of the dermis and epidermis, have thin axons but extensive terminal branching. (asahq.org)
Peripheral nerves, connecting the central nervous system (CNS) to the rest of the body, are composed of axons covered by myelinating and non-myelinating Schwann cells (SC). (elifesciences.org)
Nerves are the gross structures carrying motor, sensory, and autonomic axons to the end organs. (evokedpotential.com)
Nerves, whether peripheral or spinal, are made up of the axons traveling between the central nervous system and the peripheral end organ. (evokedpotential.com)
A nerve is composed of thousands of axons ranging in size from less than 1 to 20 mm in diameter.Nerves are made up of afferent and efferent fibers. (evokedpotential.com)
Communication between different parts of the nervous system depends on the propagation of nerve impulse (action potentials) along the axons of neurons. (evokedpotential.com)
The compound action potential recorded from a nerve trunk after supramaximal stimulation is the summation of action potentials from many axons. (evokedpotential.com)
The neuronal cell bodies of a nerve's axons are in the brain, the spinal cord, or ganglia, but the nerves run only in the peripheral nervous system. (unboundmedicine.com)
Nerves with axons that conduct electrochemical impulses toward the central nervous system (CNS) are afferent, nerves with axons that conduct impulses away from the CNS are efferent, and nerves with both afferent and efferent axons are mixed. (unboundmedicine.com)
The components of the eighth cranial nerve (CN VIII) carrying axons that convey information regarding sound and balance between the spiral ganglion in the inner ear and the cochlear nuclei in the brainstem. (unboundmedicine.com)
Myelin- A type of organic insulation surrounding nerve axons to protect them and increase MNCV, as well as prevent electrical current from escaping the axon. (dpsnutrition.net)

The afferent input from these fibers inhibits propagation of nociception carried in the small, unmyelinated C fibers by blocking transmission along these fibers to the target or T cells located in the substantia gelatinosa (laminae 2 and 3) of the dorsal horn. (medscape.com)
Functional and topographical properties of field potentials evoked in rat dorsal horn by cutaneous C‐fibre stimulation. (lu.se)
These unmyelinated C-fibers transmit itch impulses to the ipsilateral dorsal horn of the spinal cord, 3 where they synapse with itch-specific secondary neurons. (asahq.org)
GDNF also prevents the slowing of conduction velocity that normally occurs after axotomy in a population of small diameter DRG cells and the A-fiber sprouting into lamina II of the dorsal horn. (jneurosci.org)
Some unmyelinated afferent (C) fibers have been shown to enter the spinal cord via the ventral nerve (motor) root, accounting for obser-vations that some patients continue to feel pain even after transection of the dorsal nerve root (rhizotomy) and report pain following ventral root stimulation. (brainkart.com)
Pain fibers may ascend or descend one to three spinal cord segments in Lissauer's tract before synapsing with second-order neurons in the gray matter of the ipsilateral dorsal horn. (brainkart.com)
Isolectin B4 (IB4) labelling was used to define the location within the dorsal horn directly affected by the injury to the peripheral nerve. (biomedcentral.com)
Nerve injury is accompanied by many alterations in the dorsal horn of the spinal cord which play a role in driving and maintaining the accompanying pain. (biomedcentral.com)
3) Summary information is passed via interneurons to spinal fibers to the brain, with an interplay such that stronger signals in arriving to the dorsal horn inhibit weaker ones. (justia.com)

Proprioceptive and somatic motor fibers are large. (evokedpotential.com)
A somatic motor nerve originating in the abducens nucleus in the pons. (unboundmedicine.com)
and those of the vagal nerve are located in the jugular ganglion (somatic) and the ganglion nodosum (visceral). (brainkart.com)

Microneurography is a neurophysiological method employed to visualize and record the traffic of nerve impulses that are conducted in peripheral nerves of waking human subjects. (wikipedia.org)
To study nerve impulses of an identified nerve, a fine tungsten needle microelectrode is inserted into the nerve and connected to a high input impedance differential amplifier. (wikipedia.org)
The exact position of the electrode tip within the nerve is then adjusted in minute steps until the electrode discriminates nerve impulses of interest. (wikipedia.org)
A unique feature and a significant strength of the microneurography method is that subjects are fully awake and able to cooperate in tests requiring mental attention, while impulses in a representative nerve fibre or set of nerve fibres are recorded, e.g. when cutaneous sense organs are stimulated or subjects perform voluntary precision movements. (wikipedia.org)
Before the microneurography technique was developed in the late 1960s, impulses in peripheral nerves had been recorded in animal experiments alone using a technique that involved dissection and splitting the nerve. (wikipedia.org)
With regard to fiber diameter there are two main categories: myelinated A-fibers are large and conduct impulses at high or moderate speed (5-75 m/s) while unmyelinated C-fibers are small and conduct impulses at low speed (around 1 m/s). (wikipedia.org)
In microneurography recordings, A- and C-fiber impulses differ in shape and polarity of the main upstroke of the action potential. (wikipedia.org)
The proposed mechanism for closing the gate is inhibition of the C-fiber nociception by impulses in activated myelinated fibers. (medscape.com)
A sympathetic nerve to the heart that carries impulses that speed the heart rate. (unboundmedicine.com)
A nerve that conducts impulses toward the brain or spinal cord. (unboundmedicine.com)

Anzini P, Neuberg DH, Schachner M, Nelles E, Willecke K, Zielasek J, Toyka KV, Suter U, Martini R. Structural abnormalities and deficient maintenance of peripheral nerve myelin in mice lacking the gap junction protein connexin 32. (2medicalcare.com)
Since then the more "popular" research has caught up and they are actively looking for ways to thicken myelin (the insulation around nerves. (dpsnutrition.net)

Basically fiber diameter is closely related to function, e.g. the cutaneous pain system is dependent on small nerve fibers whereas discriminative touch is dependent on large fibers. (wikipedia.org)
A threshold stimulus evokes only a small potential resulting from activity in a few large fibers. (evokedpotential.com)

The inflammatory prostaglandins sensitize nerve endings to the action of bradykinin, histamine, and other inflammatory factors, making them more likely to transmit pain. (aneskey.com)
Capsaicin is thought to lead to the depletion of substance P in C fibers (C fibers are unmyelinated nerves that transmit pain), resulting in their reduced peripheral excitability. (aneskey.com)

Unmyelinated epidermal nerve fiber and myelinated dermal nerve fiber densities were quantified in skin biopsies from six subjects. (harvard.edu)
Skin biopsies revealed that cryolipolysis decreased epidermal nerve fiber density as well as dermal myelinated nerve fiber density, which persisted throughout the study. (harvard.edu)

Transcutaneous electrical nerve stimulation (TENS) currently is one of the most commonly used forms of electroanalgesia. (medscape.com)
When painful peripheral stimulation occurs, however, the information carried by C fibers reaches the T cells and opens the gate, allowing pain transmission centrally to the thalamus and cortex, where it is interpreted as pain. (medscape.com)
A transcutaneous electrical nerve stimulation (TENS) unit consists of 1 or more electrical-signal generators, a battery, and a set of electrodes. (medscape.com)
the fibers are subdivided into subgroups labeled with Greek letter having successively higher stimulation thresholds and slower conduction velocities. (evokedpotential.com)

[ 7 ] The gate usually is closed, inhibiting constant nociceptive transmission via C fibers from the periphery to the T cell. (medscape.com)

Because fibers are mixed in most nerves, it is usually essential to record from an individual nerve fiber at a time to explore the properties of a functional system, although multi-unit recording has been very rewarding in studies of sympathetic efferent activity. (wikipedia.org)

An individual nerve consists of a number of fascicles, i.e. bundles of nerve fibers enclosed within a connective tissue sheath containing the different nerve fibers. (wikipedia.org)

As afferent fibers enter the spinal cord, they segre-gate according to size, with large, myelinated fibers becoming medial, and small, unmyelinated fibers becoming lateral. (brainkart.com)
In addition to Aδ pain fibers, Aβ ("A-Beta") nerves transmitting motion sensations and C-fibers transmitting cold information join in the substantia gelatinosa of the spinal cord. (justia.com)

As injury progresses, fine, terminal cutaneous nerves can also be injured, but this type of injury is rare and has not been found in all reported studies [1]. (austinpublishinggroup.com)
Aside from the generation of action potentials, the C-fiber terminal is a secretory system from which peptides such as calcitonin gene-related peptide (CGRP) and tachykinins are released ( Holzer, 1988 ). (jneurosci.org)

Despite the crucial role of vascularization to ensure nerve homeostasis and regeneration, the mechanisms governing nerve invasion by blood vessels remain poorly understood. (elifesciences.org)
Also noteworthy, 4-MC has been shown to promote regeneration of even unmyelinated nerves as well as relieve chronic pain and depression-like behavior in nerve injuries by boosting BDNF (8,9). (dpsnutrition.net)

The scarcity of pain receptors in these areas produces a dull, poorly-localized pain of longer duration than cutaneous pain. (newworldencyclopedia.org)
The neural elements of somatosensory receptors in the hands and feet represent the distal extreme of long afferent fibers, and thus, are par- ticularly vulnerable in the distal axonopathies. (cdc.gov)
Heat and warmth receptors travel primarily through unmyelinated C fibers, whereas cold receptors travel along A-δ nerve fibers, although some overlap does occur. (aneskey.com)

Our data suggest that controlled skin cooling to specifically target cutaneous nerve fibers has the potential to be useful for prolonged relief of cutaneous pain and might have a use as a research tool to isolate and study cutaneous itch-sensing nerves in human skin. (harvard.edu)
Pain models have demonstrated an upregulation of abnormal sodium channels in damaged peripheral sensory nerves. (aneskey.com)
Its method of action is to deplete-or "burn out"-small peptides in cutaneous nerves that are involved in sending pain transmissions to the brain. (aneskey.com)
Cutaneous pain is caused by injury to the skin or superficial tissues. (newworldencyclopedia.org)
Examples of injuries that produce cutaneous pain include paper cuts, minor (first degree) burns, and lacerations (cuts). (newworldencyclopedia.org)
Usually, the electrodes are initially placed on the skin over the painful area, but other locations (eg, over cutaneous nerves, trigger points, acupuncture sites) may give comparable or even better pain relief. (medscape.com)
The unmyelinated fibers are small and include autonomic fibers and fibers carrying pain and temperature. (evokedpotential.com)
Animals with pain after chronic constriction injury of the infraorbital nerve (CCI-Pain) displayed higher spontaneous and evoked activity in PB neurons, and a dramatic increase in after-discharges-responses that far outlast the stimulus-compared to controls. (iasp-pain.org)
Pain fibers originating from the head are carried by the trigeminal (V), facial (VII), glossopharyngeal (IX), and vagal (X) nerves. (brainkart.com)
The capsaicin receptor TRPV1 is activated by noxious temperatures, however, acute heat pain is only marginally affected in mice after TRPV1 knockout but completely eliminated in mice lacking TRPV1 positive fibers. (biomedcentral.com)
The essential finding was that the pain sensation is conducted slowly along thin unmyelinated C nerve fibers, traveling at about two meters per second. (dentalvibe.com)
Our detailed analysis of GAD65+ inhibitory terminals clearly revealed that nerve injury induced a transient loss of GAD65 immunoreactive terminals and suggests a potential involvement for these alterations in the development and amelioration of pain behaviour. (biomedcentral.com)
Muscle, skin and injury pain travel from the body to the substantia gelatinosa in the posterior half of the spine on Aδ ("A-Delta") fibers. (justia.com)

The anterior superior alveolar nerves, branches of the infraorbital nerve (from CN V2), run in canals in the anterior wall of the maxillary sinus and innervate the upper incisors, canines, premolars, and often part of the first molar. (unboundmedicine.com)

CONCLUSION: With advanced nerve conduction studies available, nerve biopsy is losing its relevance. (bvsalud.org)
However, in our experience, nerve biopsy did complement the clinical findings and nerve conduction studies, with which a close correlation is required to make the histopathology of nerve biopsy more relevant in terms of guiding further specific workup and management. (bvsalud.org)
Reports of nerve conduction study (NCS), nerve and synovial biopsy and other diagnostic tests were retrieved from laboratory records. (bvsalud.org)
We identified A-fiber high-threshold mechanoreceptors (A-HTMRs) that were insensitive to gentle touch, encoded noxious skin indentations, and displayed conduction velocities similar to A-fiber low-threshold mechanoreceptors. (ljmu.ac.uk)
Thus, due to amplitude differences and different conduction velocities, different fiber groups can be distinguished in our recordings. (evokedpotential.com)
The assessment of nerve injury includes a careful neurological examination, sometimes accompanied by tests, e.g., electromyography or nerve conduction studies. (unboundmedicine.com)
Mean Nerve Conduction Velocity (MNCV)- How fast electrical signals move through a nerve. (dpsnutrition.net)

Peripheral nerves are vascularized by a dense network of blood vessels to guarantee their complex function. (elifesciences.org)
We show that, while the axon guidance molecule Netrin-1 promotes nerve invasion by blood vessels via the endothelial receptor UNC5B during embryogenesis, myelinated Schwann cells negatively control intra-nervous vascularization during post-natal period. (elifesciences.org)

Ulnar nerve repair by the silicone chamber technique. (lu.se)

Neuropathy (peripheral neuropathy)- A term used to describe a condition of damage, dysfunction or disease to nerves anywhere in the peripheral nervous system. (dpsnutrition.net)

In contrast, an impulse such as a vibration is conducted rapidly along thick myelinated A-beta nerve fibers at a rate of 75 meters per second. (dentalvibe.com)
The DV3 device could also be considered for use in medical practices when local anesthesia is used without sedation, as the use of vibration to prevent discomfort from cutaneous injection has been reported in two clinical trials, one that involved taking blood in a pediatric population and the other involving eyelid surgery. (dentalvibe.com)

The gasserian ganglion contains the cell bodies of sensory fibers in the oph-thalmic, maxillary, and mandibular divisions of the trigeminal nerve. (brainkart.com)

That portion of the nasal mucosa containing the sensory nerve endings for SMELL , located at the dome of each NASAL CAVITY . (lookformedical.com)

Actually, the concern of nerve damage was a major obstacle for the development of microneurography because the approach of inserting a needle electrode in a human nerve was generally regarded as potentially dangerous and involving substantial risk of permanent nerve damage. (wikipedia.org)
Microneurography is based on tungsten needle microelectrodes which are inserted through the skin and into a nerve. (wikipedia.org)

However, there have been very few documented cases in the medical literature of peripheral Small Fiber Polyneuropathy (SFN) as a result of accidental hypothermic exposure. (austinpublishinggroup.com)
CI can often cause peripheral neuropathy, and recent studies have reported that injury to large, myelinated fibers is obvious but lacking in small, myelinated, or unmyelinated fibers [1]. (austinpublishinggroup.com)
However, we have observed a patient with Small Fiber Neuropathy (SFN) complaining of sensory symptoms limited to both feet after frostbite and report the case with a literature review here. (austinpublishinggroup.com)
As the stimulus strength is increased, more fibers are excited, and their activity is added to the compound action potential as each additionally activated fiber produces a small increment in the recorded voltage. (evokedpotential.com)
Our Diabetic Neuropathy Device™ (DND) is the first non-invasive tool cleared by the FDA to identify and measure both large and small nerve fibers in peripheral extremities. (diabetes-testing-centers.com)
It is 1 device that performs 2 tests (small and large fiber neuropathy), and has 3 reimbursements. (diabetes-testing-centers.com)

Symptoms of nerve injury include paresthesias, loss of sensation and position sense, impaired motor function, cranial nerve malfunction, changes in reflexes, and impairments in glandular secretion. (unboundmedicine.com)
cranial nerve for illus. (unboundmedicine.com)
The proximal axonal processes of the first-order neurons in these ganglia reach the brainstem nuclei via their respective cranial nerves, where they synapse with second-order neurons in brainstem nuclei. (brainkart.com)

In conclusion, cryolipolysis causes significant and prolonged decreases in cutaneous sensitivity. (harvard.edu)

In this study, the histopathological spectrum of the nerve biopsies received is being revisited to analyze the various clinical and pathologic features and also to assess their relevance. (bvsalud.org)
MATERIALS AND METHODS: Retrospective analysis of the data retrieved was done for 74 cases of nerve biopsies. (bvsalud.org)
Nine nerve biopsies did not show any abnormal histopathological features, while 13 nerve biopsies were found to be inadequate for diagnosis, both these groups were categorized as noncontributory. (bvsalud.org)
An immune-mediated epineurial microvasculitis has been demonstrated in nerve biopsies. (medlink.com)

A measure of the ability of a nerve to perform this function would be of major clinical value in the identification of disease involving a nerve. (evokedpotential.com)

The posterior auricular nerve is a motor branch of the facial nerve (CN VII) that innervates the posterior and intrinsic auricular muscles. (unboundmedicine.com)

Nerve repair and axonal transport. (lu.se)

The excitability of a nerve can be defined in terms of the two variables of a stimulus voltage and duration. (evokedpotential.com)
If the strength of the current (or voltage) is plotted against the duration of a stimulus needed to produce excitation of a nerve, a curve is obtained, which is called a strength duration curve. (evokedpotential.com)
The rheobase is the minimal voltage needed to produce excitation with a long stimulus duration (usually 300 ms) and the chronaxie is the time required to excite a nerve by a stimulus with a voltage twice as large as the rheobase (Fig. 26). (evokedpotential.com)

In this study we completed an in-depth review of literature relating to cutaneous thermography, analyzed the basic theory of commonly used instrumentation and postulated new concepts relating to paraspinal thermoceptive neuronal sympathetic function. (wholisticthermography.com)
Peripheral administration of nerve growth factor in the adult rat produces a thermal hyperalgesia that requires the presence of sympathetic post-ganglionic neurones. (2medicalcare.com)
Well, they are coming up behind me on a path I already blazed, so let's revisit and focus on the role of nerve signals in muscle growth, mind/muscle connection, sympathetic/parasympathetic functions, and reaction speed. (dpsnutrition.net)

Paraspinal cutaneous thermal asymmetries and anomalies are shown to be suggestive of various pathophysiological alterations, and in particular, the vertebral subluxation complex (VSC). (wholisticthermography.com)

Paraspinal cutaneous thermal anomalies have long been held to be suggestive of vertebral subluxation. (wholisticthermography.com)

The inferior alveolar nerve (from CN V3) runs in the mandibular canal, giving off branches to the lower teeth and gingivae as it passes. (unboundmedicine.com)
A sensory branch of the mandibular nerve (CN V3) It passes through the parotid gland en route to the ear, where it innervates skin of the pinna, external auditory canal, and tympanic membrane. (unboundmedicine.com)

In people with impingement or nerve injuries it will help alleiviate discomfort, weakness, and muscular atrophy. (dpsnutrition.net)

A shift in the strength duration curve indicates a change in excitability and is seen in nerve diseases. (evokedpotential.com)

Since most CI-induced cases of neuropathy affect large, myelinated fibers, motor symptoms are more common than sensory symptoms. (austinpublishinggroup.com)
BACKGROUND: Nerve biopsy has been widely used to investigate patients with peripheral neuropathy and in many centers, it is still a part of the diagnostic armamentarium. (bvsalud.org)
Diabetes often leads to neuropathy, which causes a significant reduction in MNCV, as well as the NGF content of nerves. (dpsnutrition.net)

Quantitative sensory testing (QST) that investigates and discriminates the function of C, Aδ and Aβ fibers is included as an instrumental test to monitor nerve fiber function. (mdpi.com)
However, during normal function, the electrical activities of the fibers in a nerve are asynchronous and cancel each other out. (evokedpotential.com)
Spinal nerve-cell-body function is suggested as the primary mechanism responsible for the asymmetries and anomalies commonly observed in paraspinal and other thermograms. (wholisticthermography.com)
Nerve Restore deals with the function, dysfunction, and optimization of Nerve Signals. (dpsnutrition.net)

Herein, we present our experience of five cases of leprosy that presented with predominant articular involvement in the absence of cutaneous manifestations. (bvsalud.org)
CONCLUSION: A combination of tenosynovitis and thickened nerves in association with symmetric polyarthritis should raise a suspicion of leprosy even in the absence of cutaneous features. (bvsalud.org)

All of these patients had thickened peripheral nerves and abnormal NCS. (bvsalud.org)

Exposure of the peripheral C-fiber terminals to inflammatory mediators such as bradykinin, serotonin, prostaglandins, leukotriences, and protons induces depolarization of the terminals as evidenced by the generation of action potentials and/or sensitization of the terminals ( Basbaum, 1991 ). (jneurosci.org)

Anatomy75

Organisms3

Diseases16

Chemicals and Drugs13

Analytical, Diagnostic and Therapeutic Techniques and Equipment18

Psychiatry and Psychology4

Phenomena and Processes14

Disciplines and Occupations2

Technology, Industry, Agriculture2

Stimuli7

AFFERENTS6

Vagus nerve3

Nociceptors5

Sciatic Nerve4

Axons12

Dorsal9

Somatic3

Impulses10

Myelin2

Large fibers2

Transmit2

Epidermal nerve2

STIMULATION4

Nociceptive1

Efferent1

Connective tissue sheath1

Spinal cord2

Terminal2

Regeneration2

Receptors3

Pain13

Infraorbital nerve1

Conduction7

Blood vessels2

Ulnar Nerve1

Peripheral nervou1

Vibration2

Trigeminal nerve1

Endings1

Microneurography2

Small6

CRANIAL3

Sensitivity1

Biopsies4

Clinical1

Facial1

Axonal1

Stimulus3

Sympathetic3

Alterations1

Thermal1

Mandibular2

Injuries1

Duration1

Neuropathy3

Function4

Absence2

Abnormal1

19911