Versus hostGVHDAcuteDiseaseLesionsSevereManifestationsChronicEruptionSystemicHypersensitivityKidney graftDonorImmuneAutoimmunePolymerase chain reMycosis fungoidesInvolvementLymphomaPatientsLichen planusInfectionSquamousDrug reactions2018CGVHDClinicalDiscontinueTransplantationSkinInfusionTissueLichenoidLesion
Versus host30
- They can also occur in association with graft versus host disease. (wikipedia.org)
- Dr. Cowen's primary research interest involves chronic graft-versus-host disease (cGVHD) and autoinflammatory diseases. (nih.gov)
- This is chronic graft versus host disease. (nih.gov)
- Rehabilitation Interventions in the Multidisciplinary Management of Patients With Sclerotic Graft-Versus-Host Disease of the Skin and Fascia. (nih.gov)
- Calcinosis Cutis in the Setting of Chronic Skin Graft-Versus-Host Disease. (nih.gov)
- Graft-versus-host disease (GvHD) prophylaxis included post-transplant cyclophosphamide (PT-Cy). (bvsalud.org)
- Skin is commonly affected by graft versus host disease (GVHD), a complication of bone marrow transplantation (BMT). (bvsalud.org)
- Mouse colon impacted by acute graft-versus-host disease. (wikipedia.org)
- Graft-versus-host disease ( GvHD ) is a syndrome , characterized by inflammation in different organs. (wikipedia.org)
- GvHD can also occur after a blood transfusion , known as Transfusion-associated graft-versus-host disease or TA-GvHD if the blood products used have not been gamma irradiated or treated with an approved leukocyte reduction system. (wikipedia.org)
- Micrographs of grades of skin graft-versus-host disease: Ranging from grade I GvHR (with minimal vacuolization in the epidermis) to grade II GvHR (with vacuolization and dyskeratotic bodies) to grade III GvHR (with sub epidermal cleft formation) and finally to grade IV GvHR (with separation of the dermis from the epidermis). (wikipedia.org)
- In the clinical setting, graft-versus-host disease is divided into acute and chronic forms, and scored or graded on the basis of the tissue affected and the severity of the reaction. (wikipedia.org)
- In the classical sense, acute graft-versus-host disease is characterized by selective damage to the liver , skin (rash), mucosa , and the gastrointestinal tract . (wikipedia.org)
- Newer research indicates that other graft-versus-host disease target organs include the immune system (the hematopoietic system , e.g., the bone marrow and the thymus ) itself, and the lungs in the form of immune-mediated pneumonitis . (wikipedia.org)
- [6] Chronic graft-versus-host disease also attacks the above organs, but over its long-term course can also cause damage to the connective tissue and exocrine glands . (wikipedia.org)
- This is transfusion-associated graft-versus-host disease (GvHD) occurring in an immunosuppressed patient. (passmed.uk)
- 1. Acute graft-versus-host disease (aGvHD): usually presents with skin and/or liver and/or gut involvement. (passmed.uk)
- 2. Chronic graft-versus-host disease (cGvHD). (passmed.uk)
- To guide its deliberations, ACIP used the Evidence to Recommendations Framework and the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) approach ( 8 ) to evaluate possible benefits (prevention of herpes zoster, postherpetic neuralgia, and herpes zoster-related hospitalizations) and harms (serious adverse events [SAEs],** immune-mediated disease, graft-versus-host-disease, graft rejection, and reactogenicity) associated with RZV. (cdc.gov)
- The most common adverse event following allogeneic hematopoietic stem cell transplantation (HSCT) is graft-versus-host disease (GVHD), which can increase morbidity and mortality in HSCT patients. (oncologynurseadvisor.com)
- Prophylaxis against aspergillosis is recommended during prolonged neutropenia for patients who are at high risk for aspergillosis, allogeneic stem cell transplant patients with graft versus host disease, lung transplant recipients, and certain other solid organ transplant recipients under certain conditions. (cdc.gov)
- For patients with acute cutaneous graft-versus-host disease (GVHD) and Stevens-Johnson syndrome/toxic epidermal necrolysis- (SJS/TEN)-like features, the prognosis is not well described. (uptodatefree.ir)
- See "Cutaneous manifestations of graft-versus-host disease (GVHD)", section on 'Diagnosis' . (uptodatefree.ir)
- Not recommended in patients w/ skin barrier defects eg, Netherton's syndrome, lamellar ichthyosis, generalized erythroderma or cutaneous graft versus host disease. (azurewebsites.net)
- Aerosolized formulations of amphotericin B may be considered as prophylaxis in patients with prolonged neutropenia (patients receiving induction/reinduction therapy for acute leukemia and allogeneic hematopoietic stem cell transplant recipients following conditioning or during treatment of graft versus host disease) and in lung transplant recipients. (medscape.com)
- Monitor for severe acute graft-versus-host disease (GVHD) and steroid-refractory GVHD. (nih.gov)
- Graft versus host disease (GVHD), a severe immunogenic complication of allogeneic hematopoietic stem cell transplantation (HSCT), represents the most frequent cause of transplant-related mortality (TRM). (hindawi.com)
- Graft versus host disease (GVHD) represents the most frequent cause of TRM. (hindawi.com)
- After transplantation, he suffered acute graft-versus-host disease with a systemic rash and severe diarrhea. (biomedcentral.com)
- The graft-versus-myeloma effect: Chronic graft-versus-host disease but not acute graft-versus-host disease prolongs survival in patients with multiple myeloma receiving allogeneic transplantation. (myeloma.org.uk)
GVHD3
- Diagnosis of GVHD is difficult because of its broad presentation that may manifest similar to other conditions such as drug reactions and viral infections. (oncologynurseadvisor.com)
- In a retrospective cohort study of 31 patients with acute cutaneous GVHD, the 16 patients with SJS/TEN-like features were more likely to have systemic complications (eg, hematologic abnormalities, hepatitis, diarrhea, renal dysfunction, and bacteremia), lower survival rates at two months, and higher risk for mortality at five years [ 4 ]. (uptodatefree.ir)
- Shortly before graft infusion, GVHD prophylaxis (immunosuppression) is started. (hindawi.com)
Acute1
- Acute transfusion reactions present during or within 24 hours of a blood transfusion. (passmed.uk)
Disease15
- In immunocompetent hosts, nontuberculous mycobacteria can colonize body surfaces and be secreted for prolonged periods without causing disease. (cdc.gov)
- In the immunocompromised host, an uncontrolled proliferation of primarily colonizing or contaminating pathogens or commensals can progress to severe disease. (cdc.gov)
- This is a training, natural history of disease, and screening protocol for the evaluation, treatment and follow-up of patients with dermatologic diseases and systemic diseases with cutaneous manifestations. (nih.gov)
- Quality of Life in Patients With Skin of Color and Chronic Graft-vs-Host Disease. (nih.gov)
- Not to be confused with Host-versus-graft disease . (wikipedia.org)
- Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) represent opposite ends of a spectrum of disease that results from an adverse reaction, most often to certain medications. (rarediseases.org)
- In immunocompetent hosts: Localized pulmonary infection in people with underlying lung disease, allergic bronchopulmonary disease, and allergic sinusitis. (cdc.gov)
- Stevens-Johnson syndrome/TEN is a rare disease typically associated with a drug reaction. (clinicaladvisor.com)
- The differential diagnosis for SJS/TEN includes erythema multiforme (EM), autoimmune bullous diseases (including linear IgA dermatosis), autoimmune disease (including bullous lupus erythematosus), staphylococcal scalded skin syndrome (SSSS), graft-vs-host disease (GVHD), generalized fixed bullous drug eruption, and acute generalized exanthematous pustulosis (AGEP). (clinicaladvisor.com)
- In the first study to assess efficacy of apremilast , a phosphodiesterase-4 inhibitor, for cutaneous DM, the addition of apremilast to other therapies for cutaneous DM was associated with improvement in the Cutaneous Dermatomyositis Disease Area and Severity Index (CDASI) in seven of eight patients with refractory cutaneous dermatomyositis [ 5 ]. (uptodatefree.ir)
- However, MAI has been found to cause cutaneous disease in individuals mostly with immunosuppression, although it has also been reported in immunocompetent patients as well. (medscape.com)
- A review of 8 cases of cutaneous MAI infection occurring secondary to disseminated disease found a median patient age of 22.2 years, with a range of 2-28 years. (medscape.com)
- Surgery for aspergillosis should be considered for localized disease that is easily accessible to debridement (eg, invasive fungal sinusitis, localized cutaneous disease). (medscape.com)
- Thus, LP appears to be related to the pattern of immune dysregulation induced by HCV, probably in a host with an underlying susceptibility for autoimmune disease. (thedoctorsdoctor.com)
- Cervical vertebrae 1,2, …?Ca: Calcium?Ca: Cancer?Ca: Carcinoma?Ca: Cardiac arrest?Ca: Coronary artery?CA-125: A tumor marker for ovarian cancer?CAB: Cellulose acetate butyrate?CABG: Coronary artery bypass graft?CACI: Computer-Assisted Continuous Infusion?CAD: Coronary artery disease?CAG: ?CAH: Chronic active hepatitis?CAH: Congenital adrenal hyperplasia?calid. (kuwaitpharmacy.com)
Lesions6
- Variants of cutaneous lichen planus are distinguished based upon the appearance of the lesions and/or their distribution. (wikipedia.org)
- The lesions typically resolve within 2 weeks, and no cutaneous or systemic sequelae are generally observed. (medscape.com)
- Therefore, suspicious cutaneous lesions should be biopsied for histopathologic examination, and special stains and tissue cultures should be performed for detecting fungi, viruses, and bacteria, including mycobacteria ( 3 , 4 ). (cdc.gov)
- In 30% of patients, cutaneous lesions are associated with joints inflammation, in diseases such as psoriatic arthritis (PsA) or Systemic Lupus Erythematous (SLE). (ukri.org)
- 1 A typical cutaneous reaction manifests as macular lesions first appearing on the upper back and lateral neck, jaw, ears, palms, and soles. (oncologynurseadvisor.com)
- OBJECTIVE: We sought to determine whether viral transcripts were present within the skin of patients with HCV and LP, and if systemic virologic response to interferon alfa and ribavirin correlated with response of the LP.Materials and methods A total of 4 men and 1 woman all presented with cutaneous eruptions of LP, and 1 had oral LP lesions. (thedoctorsdoctor.com)
Severe6
- Other signs occurring in temporal relationship with a blood transfusion such as severe dyspnoea, pyrexia, or loss of consciousness may be the first indication of a more severe, potentially fatal reaction. (passmed.uk)
- SJS and TEN are classified as severe cutaneous adverse reactions (SCAR), a subcategory of adverse drug reactions (ADR). (rarediseases.org)
- A severe cutaneous reaction may include blisters with full-thickness necrosis. (oncologynurseadvisor.com)
- 2,4 In 1993, consensus-based definitions of severe cutaneous adverse reactions (SCAR) were introduced, noting subgroups of severe bullous skin reactions including SJS, TEN, and SJS/TEN overlap. (clinicaladvisor.com)
- Temporarily interrupt the infusion of POTELIGEO for mild to severe (Grades 1 to 3) infusion reactions and treat symptoms. (nih.gov)
- Stevens-Johnson syndrome and toxic epidermal necrolysis are severe cutaneous hypersensitivity reactions. (msdmanuals.com)
Manifestations2
- Through the Dermatology Consultation Service at the NIH Clinical Center, patients with a variety of rare diseases with cutaneous manifestations are evaluated. (nih.gov)
- Initial symptoms are nonspecific, flu-like, and may precede cutaneous manifestations by a few days. (clinicaladvisor.com)
Chronic1
- Because of chronic rejection, the patient lost the kidney graft 5 years later, in 1995, and went back on dialysis with a well-functioning pancreas graft. (cdc.gov)
Eruption4
- The term lichenoid reaction (lichenoid eruption or lichenoid lesion) refers to a lesion of similar or identical histopathologic and clinical appearance to lichen planus (i.e., an area which resembles lichen planus, both to the naked eye and under a microscope). (wikipedia.org)
- Host-Pathogen Interactions in Human Polyomavirus 7‒Associated Pruritic Skin Eruption. (nih.gov)
- Herpes zoster is a painful, cutaneous eruption, usually involving one to three adjacent dermatomes, § resulting from reactivation of latent varicella-zoster virus. (cdc.gov)
- Kaposi varicelliform eruption (KVE) is the name given to a distinct cutaneous eruption caused by herpes simplex virus (HSV) type 1, HSV-2, coxsackievirus A16, or vaccinia virus that infects a preexisting dermatosis. (medscape.com)
Systemic2
- Aggressive resuscitation, nutritional support, thorough surgical excision of infected wounds, early wound closure, grafting and the development of effective topical and systemic chemotherapy have largely improved morbidity and mortality rates of burn patients. (who.int)
- Proposed mechanisms to account for the increased susceptibility of individuals with AD to develop KVE or EH include systemic immune defects involving both cell-mediated and humoral immunity, as well as impairment in cutaneous immune responses that are interrelated with the defective mechanical barrier properties of affected skin in person with AD. (medscape.com)
Hypersensitivity3
- 3 Stevens-Johnson syndrome/TEN is a delayed-type drug hypersensitivity reaction with a typical latency time of 4 weeks, although symptoms may be seen after 8 weeks in vulnerable individuals and even 30 weeks in some cases. (clinicaladvisor.com)
- 5.4 Hypersensitivity Syndrome Reaction. (libreriastudium.it)
- Lenalidomide desensitization for delayed hypersensitivity reactions in 5 patients with multiple myeloma. (myeloma.org.uk)
Kidney graft1
- The choice of antiviral medication and duration of treatment are important considerations to ensure optimal patient outcomes and kidney graft function and survival. (lidsen.com)
Donor2
- Allogeneic transplants involve grafts from a genetically nonidentical donor of the same species and are the transplant type most often used in children. (oncologynurseadvisor.com)
- Lastly, a fourth type of wound healing can also be considered when the overlying tissue is partially lost (abrasion) or intentionally removed (epithelialized free gingival graft donor site), so a de-epithelialized connective tissue layer is exposed and heals by re-epithelialization from the normal contiguous epithelium 2 . (medsci.org)
Immune4
- White blood cells of the donor's immune system which remain within the donated tissue (the graft) recognize the recipient (the host) as foreign (non-self). (wikipedia.org)
- Transfusion reactions may be immune-mediated and non-immune-mediated. (passmed.uk)
- The incubation period for aspergillosis is unclear and likely varies depending on the dose of Aspergillus and the host immune response. (cdc.gov)
- In a study reported in the Journal of Clinical Oncology, Phillips et al found that immune-related cutaneous adverse events in patients receiving immune checkpoint inhibitors generally responded to symptom- and phenotype-directed dermatologic therapies, and that biologic therapies were effective in. (ascopost.com)
Autoimmune2
- Her research interests include autoimmune dermatology, cutaneous vasculitis, and cutaneous drug reactions. (weillcornell.org)
- According to published observations, an autoimmune reaction may be triggered by the viral S epitope. (thedoctorsdoctor.com)
Polymerase chain re6
- M. chelonae was identified by polymerase chain reaction. (cdc.gov)
- Other diagnostic tools include radiology, galactomannan antigen detection, Beta-D-glucan detection, and polymerase chain reaction (PCR). (cdc.gov)
- immunohistochemical staining and polymerase chain reaction analysis using autopsy samples also indicated the growth of Acanthamoeba in the brain. (biomedcentral.com)
- In addition to pathologic examination, immunohistochemical stains for lymphoid markers and reverse-transcriptase polymerase chain reaction for HCV was performed on the biopsy specimens. (thedoctorsdoctor.com)
- Although all patients were seropositive for HCV RNA at the time of biopsy, we were unable to detect HCV RNA by reverse-transcription polymerase chain reaction in any of the patients. (thedoctorsdoctor.com)
- CONCLUSION: The virus was not found in the LP lesion using reverse-transcription polymerase chain reaction for HCV. (thedoctorsdoctor.com)
Mycosis fungoides1
- Cutaneous T-cell lymphoma is a general term from mycosis fungoides or occur spontane- to identify non-Hodgkin's T-cell lymphomas ously, although some authors now consider that primarily affect the skin. (bvsalud.org)
Involvement3
- Early cutaneous involvement typically includes the presternal region of the trunk, face, and proximal parts of the limbs. (clinicaladvisor.com)
- One case series revealed cutaneous involvement in 6 of 30 cases of DMAI infection. (medscape.com)
- Cutaneous involvement by multiple myeloma. (myeloma.org.uk)
Lymphoma2
- Cutaneous B-cell lymphoma includes follicle centre, marginal zone, and diffuse large B-cell lymphoma, which have all been reported to respond to intravenous rituximab. (dermnetnz.org)
- subtypes of cutaneous T-cell lymphoma, SS is a malignant neoplasm originating the most common of which are mycosis from T lymphocytes, which involves the fungoides and Sézary syndrome (SS). (bvsalud.org)
Patients10
- These images are a random sampling from a Bing search on the term "Cutaneous Conditions in Febrile Patients. (fpnotebook.com)
- In addition, patients who experience adverse reactions to experimental therapeutic agents or manifest unrelated skin conditions while at the NIH are assessed and treated. (nih.gov)
- It is important to consider cutaneous infection with Mycobacterium avium-intracellulare (MAI, or MAC) in patients with antibiotic-resistant cellulitis, nonhealing nodules, and ulcers, as well as in patients who are immunosuppressed with evidence of disseminated MAI (DMAI) infection. (medscape.com)
- Clinicopathologic models predicting non-sentinel lymph node metastasis in cutaneous melanoma patients: Are they useful for patients with a single positive sentinel node? (elsevierpure.com)
- La réanimation agressive, la prise en charge nutritionnelle, l'excision chirur- gicale complète des plaies infectées, la fermeture rapide des plaies, les greffes et la mise au point d'une chimiothérapie locale et systémique efficace ont permis d'améliorer grandement le taux de morbidité et de mortalité chez les patients brûlés. (who.int)
- The most common adverse reactions (reported in ≥20% of patients) are rash, infusion related reactions, fatigue, diarrhea, musculoskeletal pain, and upper respiratory tract infection ( 6.1 ). (nih.gov)
- however, one theory holds that altered drug metabolism (eg, failure to clear reactive metabolites) in some patients triggers a T-cell-mediated cytotoxic reaction to drug antigens in keratinocytes. (msdmanuals.com)
- In addition, these patients had greater allergen sensitization, greater frequency of food allergy and/or asthma, and had a much higher frequency of cutaneous infections with pathogens such as Staphylococcus aureus or molluscum contagiosum. (medscape.com)
- A number of associated cutaneous findings have been reported in up to 15% of these patients including lichen planus-like eruptions (LP). (thedoctorsdoctor.com)
- Cutaneous biopsies were performed on all patients. (thedoctorsdoctor.com)
Lichen planus2
- Lichen planus may be categorized as affecting mucosal or cutaneous surfaces. (wikipedia.org)
- Lichenoid keratoses (also known as "benign lichenoid keratosis", and "Solitary lichen planus") is a cutaneous condition characterized by brown to red scaling maculopapules, found on sun-exposed skin of extremities. (wikipedia.org)
Infection5
- We describe a case of localized cutaneous M. chelonae infection after a dog bite in a kidney-pancreas transplant recipient. (cdc.gov)
- Occasional outbreaks of cutaneous infection have been traced to contaminated biomedical devices. (cdc.gov)
- Primary cutaneous MAI infection generally occurs in hosts who are immunocompetent after traumatic introduction into the soft tissue. (medscape.com)
- Primary cutaneous MAI infection is rare, with 12 cases reported in the literature prior to 1997. (medscape.com)
- although most case reports of primary cutaneous MAI infection have been in individuals aged 2-10 years, adult cases have also been described. (medscape.com)
Squamous2
- External haemorrhoids lie below the dentate line, are covered by squamous epithelium and innervated by cutaneous nerves. (passmed.uk)
- Notably, we are presenting the first survival data for neoadjuvant Libtayo therapy in cutaneous squamous cell carcinoma and the first results for Libtayo in combination with ubamatamab, our investigational MUC16xCD3 bispecific antibody, in recurrent ovarian cancer. (biospace.com)
Drug reactions2
- Adverse drug reactions caused the largest proportion of the rashes (48%), and vancomycin was the most common culprit (involved in 30% of the cases). (actasdermo.org)
- 5.3 Drug Reactions. (libreriastudium.it)
20181
- Another review from 2018 of 30 cases of cutaneous MAI reported an average age of 44.2 years, with a range of 4-82 years. (medscape.com)
CGVHD1
- He is Co-Study Chair of a multi-disciplinary NIH initiative aimed at the study and treatment of cGVHD (04-C-0281) and Principal Investigator of a therapeutic study of topical ruxolitinib for cutaneous cGVHD (18-AR-0035). (nih.gov)
Clinical1
- Initial management consisted of en una paciente con topical corticosteroids and oral antihistamines with little clinical response. (bvsalud.org)
Discontinue1
- Permanently discontinue POTELIGEO for any life-threatening infusion reaction ( 5.2 ). (nih.gov)
Transplantation1
- DMEK uses a thinner graft than DSEK and has superior results (eg, faster healing, fewer rejections, and better visual acuity) compared to both DSEK and full-thickness corneal transplantation. (merckmanuals.com)
Skin5
- Cutaneous forms are those affecting the skin, scalp, and nails. (wikipedia.org)
- The reaction may start with a persistent fever and nonspecific, flu-like symptoms followed by appearance of erythematous macules (red spots) that may cover a large part of the body, and painful blistering of the skin and mucous membranes. (rarediseases.org)
- [ 5 ] Furthermore, the addition of interleukin (IL)-4 and IL-13 (both overexpressed in Th-2 inflammatory reactions) amplified vaccinia virus replication in human skin. (medscape.com)
- The importance of cathelicidins in antiviral skin host defense was confirmed by the observation of higher levels of HSV-2 replication in cathelicidin-deficient mouse skin compared with that seen in skin from their wild-type counterparts. (medscape.com)
- KVE has also been reported after epidermal disruption caused by vigorous scrubbing, dermabrasion, burns, and skin grafts. (medscape.com)
Infusion1
- Temporarily interrupt POTELIGEO for any infusion reaction. (nih.gov)
Tissue2
- An analysis of nearly 38,000 adverse reactions to dupilumab reported to VigiBase, the World Health Organization's global pharmacovigilance database, found a 9 percent rate of musculoskeletal and connective tissue adverse effects [ 3 ]. (uptodatefree.ir)
- This is the prototypical lichenoid tissue reaction . (thedoctorsdoctor.com)
Lichenoid1
- Sometimes dental materials or certain medications can cause a lichenoid reaction. (wikipedia.org)
Lesion1
- Within a few weeks, the lesion disappeared completely, and the patient retained good pancreatic graft function. (cdc.gov)