• Some of the terms applied to this lesion included pigmented ameloblastoma, retinal anlage tumor, melanotic progonoma, melanotic adamantinoma, and pigmented epulis of infancy. (medscape.com)
  • The same age differential is noted with respect to the more common odontogenic tumors (eg, ameloblastoma, odontoma, adenomatoid odontogenic tumor, calcifying epithelial odontogenic tumor, ameloblastic fibroma, odontogenic myxoma, odontogenic fibroma). (medscape.com)
  • The most common odontogenic tumors were adenomatoid odontogenic tumor and ameloblastoma (10.5% each). (bvsalud.org)
  • The histologic appearance of MNTI is usually that of a small, dark, cell neoplasm suggestive of neuroblastoma, rhabdomyosarcoma, Ewing sarcoma, lymphoma, desmoplastic small round cell tumor, and peripheral primitive neuroectodermal tumor. (medscape.com)
  • Infratentorial primitive neuroectodermal tumor that is, by definition, malignant and invasive and thus classified as Grave IV by the WHO. (uchicago.edu)
  • Consider clinical, radiographic, laboratory, and histologic findings when establishing a proper differential diagnosis for melanotic neuroectodermal tumor of infancy (MNTI). (medscape.com)
  • Neville B, Damm D, Allen C. Melanotic Neuroectodermal Tumor of Infancy. (medscape.com)
  • Melanotic neuroectodermal tumor of infancy--a neoplasm of neural crese origin. (medscape.com)
  • Cutler LS, Chaudhry AP, Topazian R. Melanotic neuroectodermal tumor of infancy: an ultrastructural study, literature review, and reevaluation. (medscape.com)
  • Melanotic neuroectodermal tumor of infancy (MNTI) is a relatively uncommon osteolytic-pigmented neoplasm that primarily affects the jaws of newborn infants. (medscape.com)
  • In 1966, Borello and Gorlin reported a case with high urinary excretion of vanillylmandelic acid (VMA), suggesting a neural crest origin, and they proposed the term melanotic neuroectodermal tumor of infancy. (medscape.com)
  • [ 6 ] Since then, numerous histochemical, immunohistochemical, electron microscopic, and tissue culture studies have supported the neural crest origin and confirmed the preferred term of melanotic neuroectodermal tumor of infancy. (medscape.com)
  • Several patients with melanotic neuroectodermal tumor of infancy (MNTI) have demonstrated a high urinary excretion of VMA. (medscape.com)
  • Melanotic neuroectodermal tumor of infancy (MNTI) is a rare neoplasm and approximately 485 cases have been reported in the literature to date worldwide. (medscape.com)
  • Melanotic neuroectodermal tumor of infancy (MNTI) has a slight male predilection, with a male-to-female ratio of 1.3:1. (medscape.com)
  • [ 14 ] A few cases of melanotic neuroectodermal tumor of infancy (MNTI) have been reported in adults, notably, a 23-year-old man, a 39-year-old woman, and a 67-year-old woman. (medscape.com)
  • Most melanotic neuroectodermal tumors of infancy (MNTIs) are benign and effectively managed by aggressive surgical excision. (medscape.com)
  • OBJECTIVE: The aim of this systematic review was to determine the computed tomographic (CT) imaging characteristics of maxillary and mandibular melanotic neuroectodermal tumor of infancy (MNTI). (bvsalud.org)
  • In addition to a diagnosis of MNTI, the young age of the patient and the maxillary alveolar ridge location are also compatible with a clinical diagnosis of congenital epulis of the newborn. (medscape.com)
  • The identification of this second cell population helps differentiate MNTI from other small, round, blue cell tumors. (medscape.com)
  • A comprehensive systematic review of 472 cases of MNTI found that age at diagnosis is an important prognostic indicator in these tumors. (medscape.com)
  • BACKGROUND: The zygomatic implant perforated (ZIP) flap technique provides immediate reconstruction and rapid dental rehabilitation for low-level malignant tumors. (bvsalud.org)
  • Only very few tumors produce metastases and death. (medscape.com)
  • [ 3 ] Gastric metastases are frequently seen in cutaneous melanoma. (medscape.com)
  • INTRODUCTION: Benign intraosseous maxillary tumors, although uncommon among the adolescents, represent a major challenge to the maxillofacial surgeons. (bvsalud.org)
  • AIM OF THE WORK: To investigate the clinical and pathological patterns, treatment, and outcome of benign intraosseous maxillary tumors in adolescents. (bvsalud.org)
  • PATIENTS AND METHODS: A 10-years prospective study included patients between 12-18 years who presented with benign intraosseous maxillary tumors and surgically treated (conservative surgery or radical resection) with immediate reconstruction. (bvsalud.org)
  • Comparative RNA-seq analysis aids in diagnosis of a rare pediatric tumor. (beds.ac.uk)
  • Medulloblatoma is the most common posterior fossa (i.e. infratentorial) tumor in children (although some sources will state that it is the second most common behind cerebellar astrocytoma), making up approximately 18% of all primary pediatric brain tumors. (uchicago.edu)
  • Covering all aspects of skin disease from basic science through pathology and epidemiology to clinical practice, the text is recognized for its unparalleled coverage of diagnosis. (rooksdermatology.com)
  • Outcome for infants is poorer, but for those infants with localized disease at the time of diagnosis, survival rates in the 30-50% range are reported. (uchicago.edu)
  • Once a differential diagnosis is established from the clinical and radiographic findings, histologic evaluation is necessary to determine the final diagnosis. (medscape.com)
  • Although the histologic appearance is characteristic, special immunohistochemical stains may be used to make a definitive diagnosis. (medscape.com)
  • Note: In children, brain tumors are the most common solid tumor and the second most common malignancy (after leukemia). (uchicago.edu)
  • Most patients, by some estimates more than 90%, present with the tumor in the first year of life, usually from age 1-6 months, with a peak between the second and sixth month of life. (medscape.com)
  • This number is even higher for patients who have tumors with favorable molecular phenotypes. (uchicago.edu)
  • A tumor (abnormal growth of tissue) of the nervous system. (beds.ac.uk)
  • These melanocytic cells are of neuroectodermal origin, and melanocytic tumors may arise from these cells. (medscape.com)
  • CONCLUSIONS: Non-odontogenic tumors were more common than odontogenic tumors. (bvsalud.org)
  • Central giant cell granulomas and ossifying fibromas were the most common non-odontogenic tumors. (bvsalud.org)
  • EANO guidelines on the diagnosis and treatment of diffuse gliomas of adulthood. (beds.ac.uk)
  • Diagnosis and treatment of hyperprolactinemia: an Endocrine Society clinical practice guideline. (beds.ac.uk)
  • Approximately 60% of brain tumors are infratentorial, 25% are supratentorial, and 15% arise in the midline. (uchicago.edu)
  • There is also significant neurological morbidity associated with brain tumors. (uchicago.edu)
  • Long-term sequelae of childhood brain tumors are often from the effects of chemotherapy and/or radiation therapy. (uchicago.edu)
  • 1. Crawford, J. Childhood Brain Tumors. (uchicago.edu)
  • Depends on the size, subtype, and dissemination of the tumor at the time of diagnosis. (uchicago.edu)
  • 1.5 cm diameter) residual tumor by postoperatively imaging, and no evidence of metastatic spread within the neuraxis. (uchicago.edu)
  • With current therapies, 60-70% of children with average-risk medulloblastoma can be expected to be alive and free of disease five years after diagnosis. (uchicago.edu)
  • Cutler LS, Chaudhry AP, Topazian R. Melanotic neuroectodermal tumor of infancy: an ultrastructural study, literature review, and reevaluation. (medscape.com)
  • 5. Clinicopathological, immunohistochemical, and ultrastructural study of 13 cases of melanotic schwannoma. (nih.gov)
  • 19. Ex vivo quality-switched ruby laser irradiation of cutaneous melanocytic lesions: persistence of S-100-, HMB-45- and Masson-positive cells. (nih.gov)
  • These melanocytic cells are of neuroectodermal origin, and melanocytic tumors may arise from these cells. (medscape.com)
  • The histologic appearance of MNTI is usually that of a small, round blue cell neoplasm suggestive of neuroblastoma, rhabdomyosarcoma, Ewing sarcoma, lymphoma, desmoplastic small round cell tumor, and peripheral primitive neuroectodermal tumor. (medscape.com)
  • Melanotic neuroectodermal tumor of infancy--a neoplasm of neural crese origin. (medscape.com)
  • Multiple dysplastic nevi and lentigines were reduced in number in a patient with familial gastrointestinal stromal tumors syndrome after treatment with imatinib mesylate. (medscape.com)
  • diagnosis of bilateral benign tumors of salivary origin was made. (9lib.co)
  • Consider clinical, radiographic, laboratory, and histologic findings when establishing a proper differential diagnosis for melanotic neuroectodermal tumor of infancy (MNTI). (medscape.com)
  • Once a differential diagnosis is established from the clinical and radiographic findings, histologic evaluation is necessary to determine the final diagnosis. (medscape.com)
  • Although the histologic appearance is characteristic, special immunohistochemical stains may be used to make a definitive diagnosis. (medscape.com)
  • 8. Primary cutaneous PEComa: distinctive clear cell lesions of skin. (nih.gov)
  • DKC can be characterized by cutaneous pigmentation, premature graying, dystrophy of the nails , leukoplakia of the oral mucosa, continuous lacrimation due to atresia of the lacrimal ducts , often thrombocytopenia , anemia , testicular atrophy in the male carriers, and predisposition to cancer . (mdwiki.org)
  • Radiation lentigo resembles UV-induced lentigo, but it often includes other histopathologic signs of long-term cutaneous radiation damage such as epidermal atrophy, subcutaneous fibrosis, keratosis, and telangiectasias. (medscape.com)
  • ABSTRACT: Peptide receptor radionuclide therapy (PRRT) is a treatment option for somatostatin receptor-positive, unresectable or metastatic neuroendocrine tumors (NETs). (bvsalud.org)
  • [ 3 ] Gastric metastases are frequently seen in cutaneous melanoma. (medscape.com)
  • In addition to a diagnosis of MNTI, the young age of the patient and the maxillary alveolar ridge location are also compatible with a clinical diagnosis of congenital epulis of the newborn. (medscape.com)
  • The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Neuroendocrine and Adrenal Gland Tumors focus on the diagnosis, treatment, and management of patients with neuroendocrine tumors (NETs), adrenal tumors, pheochromocytomas, paragangliomas, and multiple endocrine neoplasia. (bvsalud.org)
  • These guidelines discuss the diagnosis and management of both sporadic and hereditary neuroendocrine and adrenal tumors and are intended to assist with clinical decision-making. (bvsalud.org)
  • The classic histomorphology of this tumor is made up of uniform, spindle-shaped cells, arranged in a storiform pattern. (mdpi.com)
  • Tumor cells characteristically infiltrate the underlying subcutis in a honeycomb pattern. (mdpi.com)
  • The stages of this type of pigmentation start from an early patch stage, to become plaque-like which then develop into larger nodules- known as the tumour stage. (wikipedia.org)
  • BACKGROUND: Peptide receptor radionuclide therapy (PRRT) with radiolabeled somatostatin receptor (SSR) analogs is now an established systemic treatment for neuroendocrine tumors (NET). (bvsalud.org)