• There are a number of other kinds of lupus erythematosus including discoid lupus erythematosus, neonatal lupus, and subacute cutaneous lupus erythematosus. (wikipedia.org)
  • The three main categories of lesions are chronic cutaneous (discoid) lupus, subacute cutaneous lupus, and acute cutaneous lupus. (wikipedia.org)
  • Similarly, subacute cutaneous lupus manifests as red, scaly patches of skin but with distinct edges. (wikipedia.org)
  • Subacute cutaneous lupus erythematosus (SCLE) is a nonscarring, non-atrophy-producing, photosensitive dermatosis. (medscape.com)
  • Early lesions of subacute cutaneous lupus erythematosus may simulate polymorphous light eruption. (medscape.com)
  • Subacute cutaneous lupus erythematosus (SCLE) occurs in genetically predisposed individuals, most often in patients with human leukocyte antigen B8 (HLA-B8), human leukocyte antigen DR3 (HLA-DR3), human leukocyte antigen DRw52 (HLA-DRw52), and human leukocyte antigen DQ1 (HLA-DQ1). (medscape.com)
  • Subacute cutaneous lupus erythematosus (SCLE) Systemic lupus erythematosus is a chronic, multisystem, inflammatory disorder of autoimmune etiology, occurring predominantly in young women. (msdmanuals.com)
  • CLE can be classified based on clinical and histopathologic findings: typical morphological subsets are acute cutaneous (ACLE), subacute cutaneous (SCLE), intermittent cutaneous [ICLE, also termed lupus erythematosus tumidus (LET)], and chronic cutaneous (CCLE) lupus erythematosus ( 2 , 3 ). (frontiersin.org)
  • The molecular and cellular mechanisms involved in the expression of cutaneous LE remain unclear (3 6 7 There are three clinical subtypes of cutaneous LE: acute cutaneous LE (ACLE) subacute cutaneous LE and chronic cutaneous LE (also known as discoid LE). (researchdataservice.com)
  • Acute cutaneous lupus manifests as a rash. (wikipedia.org)
  • other subtypes include acute cutaneous lupus erythematosus (ACLE) and chronic cutaneous lupus erythematosus. (medscape.com)
  • Chronic cutaneous lupus erythematosus includes discoid lupus erythematosus (DLE), lupus erythematous panniculitis/profundus, lupus tumidus, and chilblain lupus. (medscape.com)
  • Furthermore, the levels were correlated with the patients' cutaneous disease activity severity levels as measured by the Cutaneous Lupus Area and Severity Index (CLASI). (medscape.com)
  • We have also developed a model of cutaneous lupus induced by the adoptive transfer of T cells specific for a pseudo-autoantigen. (umassmed.edu)
  • Cutaneous lupus erythematosus (CLE) is an interferon (IFN)-driven autoimmune disease that may be limited to the skin or can be associated with systemic lupus erythematosus (SLE). (frontiersin.org)
  • Cutaneous lupus erythematosus (CLE) is a heterogeneous autoimmune skin disease that can occur isolated to the skin or with additional systemic manifestation in several organs [systemic lupus erythematosus (SLE)] ( 1 ). (frontiersin.org)
  • Accordingly disruption of the TNFR1-mediated signaling pathway and blockade of DC generation may prove to be of therapeutic value in patients with cutaneous lupus erythematosus. (researchdataservice.com)
  • Cutaneous lupus erythematosus (LE) has been reported as the third most common cause of industrial disability among dermatological diseases (5). (researchdataservice.com)
  • See Cutaneous Clues to Accurately Diagnosing Rheumatologic Disease , a Critical Images slideshow, to help recognize cutaneous manifestations of rheumatologic diseases. (medscape.com)
  • Fry described the association with gluten hypersensitivity in 1967, whereas clinical improvement of cutaneous manifestations with gluten deprivation was noted in 1973. (scielo.br)
  • Oral LP (OLP) can be the sole clinical presentation of the disease or accompanied by cutaneous or other mucosal manifestations including the genital area, gastrointestinal tract, and eyes. (hindawi.com)
  • Cutaneous manifestations may occur before systemic disease and can enable early risk stratification into subtypes, which affect prognosis. (dermatoljournal.com)
  • Likewise, with primary cutaneous lymphomas associated with a poorer prognosis, treatment is different for isolated or grouped lesions than for multiple lesions (see Treatment and Management). (medscape.com)
  • IFN-α was reported to be important in the pathogenesis of cutaneous LE (11) and increased numbers of IFN-producing plasmacytoid dendritic cells (pDCs) have been found in skin lesions (12 13 Tissue damage in SLE is usually associated with autoantibody production and immune complex formation and deposition (2). (researchdataservice.com)
  • In 1937, Guogerot and Burnier described the coexistence of oral, cervical, and stomach LP lesions with no cutaneous involvement as "plurimucosal LP" [ 9 ]. (hindawi.com)
  • In autoimmune disorders, the immune system produces antibodies to an endogenous antigen (autoantigen). (msdmanuals.com)
  • Antibodies to a foreign antigen may cross-react with an unaltered autoantigen (eg, antibodies to streptococcal M protein may cross-react with human heart muscle). (msdmanuals.com)
  • The Diagnostic Automation SSA (Ro) ELISA test kit is designed to detect IgG class antibodies to different autoantigens in human sera. (rapidtest.com)
  • Follow-up tests for anti-Th/To antibodies are recommended if limited cutaneous SSc is clinically suspected, and testing for anti-PM/Scl antibody reactivity is recommended if SSc-AIM overlap syndrome is suspected. (rheumatologyadvisor.com)
  • Despite their immune diversity, the majority of IMCAs is commonly associated with auto-antibodies against cerebellar autoantigens. (springer.com)
  • The prevalence of AMAs was higher in patients with lcSSc than in those with diffuse cutaneous SSc (dcSSc) and is strongly associated with the presence of ACAs. (scientificarchives.com)
  • Recent studies have demonstrated that the autoantigens targeted in diffuse scleroderma are unified by their enrichment in nucleolini and by their susceptibility to fragmentation in a novel metal-dependent reaction that requires the generation of reactive oxygen species. (drlauda.at)
  • [ 2 ] The reaction is believed to be related to ultraviolet (UV) light modulation of autoantigens, epidermal cytokines, and adhesion molecules, with resultant keratinocyte apoptosis. (medscape.com)
  • 3. Eskandarian A., Jahani S., Hejazi H., Yousefi H., Raissi V. Investigation of Toxoplasma gondii infection in Cutaneous Leishmaniasis patients of the Isfahan province. (uod.ac)
  • Simultaneously, serum levels of IgE were measured, and cutaneous tests for hypersensitivity reactions were performed. (thedoctorsdoctor.com)
  • Autoantigens normally sequestered from the immune system can become exposed and cause an autoimmune reaction (eg, systemic release of melanin-containing uveal cells after eye trauma triggers sympathetic ophthalmia). (msdmanuals.com)
  • Found in patients with limited cutaneous systemic sclerosis (SSc), and, in combination with Raynaud phenomenon, is prognostic for onset of limited cutaneous SSc. (rheumatologyadvisor.com)
  • Cutaneous Vasculitis Cutaneous vasculitis refers to vasculitis affecting small- or medium-sized vessels in the skin and subcutaneous tissue but not the internal organs. (merckmanuals.com)
  • Cutaneous vasculitis may be limited to the. (merckmanuals.com)
  • Patients with DH and CD may have the same association with histocompatibility antigens (HLA), the presence of circulating IgA against transglutaminase autoantigens and clinical remission on gluten-free diet. (scielo.br)
  • The observation that revelation of immunocryptic epitopes in self-antigens may initiate the autoimmune response has prompted the search for processes that induce novel autoantigen structure as potential initiators of autoimmunity. (drlauda.at)
  • Although exposure to UV light and other environmental triggers may contribute to the initiation of cutaneous LE by triggering apoptosis of keratinocytes it is unclear how the inflammatory process begins and is sustained (10). (researchdataservice.com)
  • [ 7 ] described paraneoplastic pemphigus with cutaneous and serologic features of pemphigus foliaceus in a patient with an underlying lymphoma. (medscape.com)
  • Current studies, in collaboration with Dr. Kate Fitzgerald , are focused on delineation of the critical cell types and mechanisms responsible for lung inflammation and cutaneous disorders in these SAVI mice. (umassmed.edu)
  • The mast cell-activating signals in urticaria are ill defined and likely to be heterogeneous and diverse (IgE-mediated Type I-reaction, non specific histamine liberators, activation of complement, autoimmune mediated urticaria - IgG against IgE or against high affinity IgE-receptor and IgE against autoantigens, as well as other poorly understood mechanisms). (cyberderm.net)
  • Researches on DH have shown that it is not just a bullous skin disease, but a cutaneous-intestinal disorder caused by hypersensitivity to gluten. (scielo.br)
  • It is incompletely understood whether DH is a cutaneous manifestation of CD or is a separate entity, accompanied by a gluten-related enteropathy. (ndnr.com)
  • The tumor type and the extent of cutaneous involvement are the 2 most relevant prognostic factors in primary CBCL. (medscape.com)
  • however, some patients require additional agents to control their cutaneous disease. (medscape.com)
  • Thus, primary biliary cirrhosis (PBC) is the most frequent autoimmune liver disease described in SSc patients and more often complicated specifically with limited cutaneous SSc (lcSSc) [ 4 ]. (scientificarchives.com)
  • The development of cutaneous lymphoma is only partially understood. (medscape.com)
  • Diseases formerly designated as reticulosis or reticulosarcomatosis are currently classified according to the World Health Organization (WHO)/European Organization for Research and Treatment of Cancer (EORTC) classification (WHO-EORTC classification) for primary cutaneous lymphomas and the WHO classification. (medscape.com)
  • Cutaneous lichen planus (CLP) most commonly involves the flexor surfaces of the extremities and presents as small itchy violaceous Papules in middle-aged adults. (hindawi.com)
  • The diagnosis of CBCL is established by analysis of skin biopsy specimen, using histomorphology and cytomorphology, immunohistochemistry and phenotypic features, and genotyping and cytogenetic studies (see Workup of Cutaneous B-Cell Lymphoma). (medscape.com)
  • have renormalized various levels or understand your Cutaneous certain traditional items What has a Top up-to-date or much shop Circannual Rhythms: Endogenous Annual Clocks in the? (4-buescher.de)
  • Confirmation by an antigen-specific immunoassay is recommended to support the association with limited cutaneous SSc. (rheumatologyadvisor.com)
  • The autoantigens include glutamic acid decarboxylase 65 (GAD65), voltage-gated Ca 2+ channel (VGCC), metabotropic glutamate receptor type 1 (mGluR1), and glutamate receptor delta (GluRdelta). (springer.com)
  • Cutaneous lymphomas represent a unique group of lymphomas and are the second most frequent extranodal lymphomas. (medscape.com)
  • Italian Group for Cutaneous Immunopathology. (scielo.br)
  • The frequency of cutaneous lymphomas is 0.3 case per 100,000 population per year, with 10% (in the United States) to 20% (in Europe) being cutaneous B-cell lymphomas (CBCLs), marginal zone lymphomas, or follicle center lymphomas (FCLs). (medscape.com)
  • One study reported a slightly lower rate of cutaneous B-cell lymphoma in Argentina compared with the United States and Europe. (medscape.com)
  • Hives can appear in any part of the cutaneous surface, showing variable size and extension. (cyberderm.net)