• In the mouse, topical vitamin A has been shown to prevent the UV-induced epidermal hypovitaminosis A, while topical vitamin E prevents oxidative stress and cutaneous and systemic immunosuppression elicited by UV. (nih.gov)
  • Thus constitutive epidermal vitamins A and E appear complementary in preventing UV-induced deleterious cutaneous and systemic effects, and these properties can be reinforced by topical application of retinol or retinaldehyde and topical alpha-tocopherol. (nih.gov)
  • However, fundamental assumptions, considerations, and principles of study design that are relevant to systemic (serum or plasma) PK may not necessarily translate directly to analyzing the results of cutaneous PK studies. (nih.gov)
  • Proteinuria is not a feature of localized cutaneous disease but can be seen in systemic amyloidosis. (medscape.com)
  • They can be sparse or numerous (similar plasma cell infiltrate occurs in nodular pulmonary amyloidosis but usually is absent in cutaneous lesions of primary systemic amyloidosis). (medscape.com)
  • LBs encapsulate antimicrobial peptides (AMPs), and PS or systemic or topical GC administration downregulated epidermal expression of murine AMPs cathelin-related AMP and β-defensin 3. (jci.org)
  • Cutaneous vasculitis is associated with systemic vasculitis in a minority of patients. (dermnetnz.org)
  • The kinetic modelling of drug transfer from a transdermal system to the systemic circulation was based on equations describing drug transport between the delivery system and the stratum corneum, the partitioning and diffusion of the drug within the stratum corneum, the delivery of the drug from the stratum corneum to viable epidermal and dermal tissue, and diffusion through that tissue to the cutaneous microcirculation. (cdc.gov)
  • Penicillin-allergic women who do not have a history suggestive of IgE-mediated reaction, (pruritic rash, urticaria (hives), immediate flushing, hypotension, angioedema, or respiratory distress) recurrent reactions to administration of a beta-lactam antibiotic, reactions to multiple beta-lactam antibiotics, positive penicillin allergy test, or a history of rare delayed onset cutaneous or systemic reactions following administration of a penicillin or a cephalosporin should receive cefazolin for GBS intrapartum prophylaxis. (cdc.gov)
  • The ulcer became larger despite administration of oral erythromycin and dicloxacillin. (cdc.gov)
  • Single modality oral chemotherapy was chosen based on successful outcomes of cutaneous lymphoma treatment in domestic animals and for ease of administration. (vin.com)
  • Oral, intramuscular or intravenous administration in 3 to 4 daily doses. (e-lactancia.org)
  • The administration of the drug was discontinued and oral prednisolone treatment was introduced at 1 mg/kg body weight dose for two weeks, decreasing the dose with 5 mg, at every 3 days. (spandidos-publications.com)
  • Transdermal drug administration has a number of advantages compared with the oral route: it avoids gastrointestinal absorption and hepatic first-pass metabolism, minimizes adverse effects arising from peak plasma drug concentrations and improves patient compliance. (unige.ch)
  • In outpatient surgery, administration of oral Passiflora incarnata as a premedication reduces anxiety without inducing sedation. (lww.com)
  • In 10 young males (25 ± 5 years), cutaneous vascular conductance (CVC) and sweat rate were evaluated at four intradermal forearm skin sites infused with (1) lactated Ringer solution (control), (2) 10 mm N ω -nitro-l-arginine (l-NNA), a non-specific NOS inhibitor, (3) 10 mm ketorolac, a non-specific COX inhibitor, or (4) a combination of l-NNA and ketorolac. (nih.gov)
  • Sixty-six patients with cutaneous leishmaniasis lesions completed the study. (who.int)
  • Cutaneous leishmaniasis causes skin lesions with various clinical features from slow-healing lesions to permanent scars (3), resulting in social stigma and psychological disorders that negatively affect the quality of life (4). (who.int)
  • To evaluate safety and efficacy of Lip-AmB 0.4% in cutaneous leishmaniasis patients. (who.int)
  • Cutaneous leishmaniasis is the most common form of leishmaniasis and it is endemic in about 90 countries, with 600 000 to 1 million new cases annually. (who.int)
  • Cutaneous leishmaniasis is a vector-borne parasitic disease caused by different Leishmania species and transmitted through sand fly bites, specifically in uncovered parts of the body. (who.int)
  • Editorial Note: An estimated 12 million cases of leishmaniasis, visceral and cutaneous, occur worldwide each year (1). (cdc.gov)
  • Old World cutaneous leishmaniasis is similarly widespread from the Union of Soviet Socialist Republics through the Middle East and Africa. (cdc.gov)
  • Autochthonous human cutaneous leishmaniasis has been rarely seen in the United States and appears limited to south central Texas (3). (cdc.gov)
  • A low or absent titer for cutaneous leishmaniasis does not rule out infection, as antibody may not be produced. (cdc.gov)
  • The present case reminds U.S. clinicians that leishmaniasis should be included in the differential diagnosis of cutaneous ulcers in travelers, foreign visitors, and immigrants from endemic areas. (cdc.gov)
  • Cutaneous leishmaniasis (CL) generally presents with a single or several localised cutaneous ulcers without involvement of mucous membranes. (scielo.br)
  • Cutaneous leishmaniasis (CL) is endemic in the State of Rio de Janeiro (RJ), Brazil, with 548 confirmed cases between 2007 and 2015 ( MS 2016 MS - Ministério da Saúde. (scielo.br)
  • Retrospective study of 151 patients with cutaneous leishmaniasis treated with meglumine antimoniate. (scielo.br)
  • Decreased effect of glucantime in cutaneous leishmaniasis complicated with secondary bacterial infection. (scielo.br)
  • Eisai Corporation of North America announced that the US Food and Drug Administration (FDA) has approved an efficacy supplemental biologics license application (sBLA) for denileukin diftitox (Ontak) solution for intravenous injection for the treatment of patients with persistent or recurrent cutaneous T-cell lymphoma (CTCL) whose malignant cells express the CD25 component of the interleukin (IL)-2 receptor (CD25+). (cancernetwork.com)
  • Cutaneous T-cell lymphoma (CTCLs) characterized by cutaneous infiltration of malignant monoclonal T-lymphocytes is a rare lymphoma affecting around 6.4 cases per million individuals every year. (delveinsight.com)
  • The total incident population of Cutaneous T-cell lymphoma in the 7MM was around 7.5K in 2021 , with the US accounting for the highest patient share/incidence. (delveinsight.com)
  • CTCL is further characterized by mycosis fungoides (MF), Sézary syndrome, and primary cutaneous peripheral T cell lymphoma, while the most common CTCL type is mycosis fungoides. (delveinsight.com)
  • Soligenix is preparing to commercialize SGX301 in the US and entered into a strategic partnership with Daavlin for the supply and distribution of SGX301 companion light devices to treat cutaneous T-cell lymphoma . (delveinsight.com)
  • Currently, this drug is in Phase II (NCT03385226) to assess the effect of pembrolizumab combined with radiotherapy in patients with relapsed, refractory, specified stages of Cutaneous T-cell Lymphoma (CTCL) Mycosis Fungoides (MF)/Sezary Syndrome (SS). (delveinsight.com)
  • Cutaneous reactions, liver dysfunction and other side effects were examined every 2 weeks after starting ATD administration. (nih.gov)
  • The frequencies of cutaneous reactions in patients taking 30 mg/day MMI and hepatotoxicity in those taking 300 mg/day PTU were high. (nih.gov)
  • Hepatotoxicity developed later than cutaneous reactions with PTU. (nih.gov)
  • Severe Cutaneous Adverse Reactions: Severe cutaneous adverse reactions, including events of fatal or life-threatening Stevens-Johnson Syndrome (SJS), can occur in patients treated with TIVDAK. (nih.gov)
  • Immediately withhold TIVDAK for suspected severe cutaneous adverse reactions, including SJS. (nih.gov)
  • Permanently discontinue TIVDAK for confirmed Grade 3 or 4 severe cutaneous adverse reactions, including SJS. (nih.gov)
  • An extended model of skin absorption and transdermal delivery including biotransformation reactions associated with cutaneous metabolism was presented. (cdc.gov)
  • Transdermal drug delivery and cutaneous metabolism. (cdc.gov)
  • The advantages of the skin as a route for drug administration included elimination of gastrointestinal and hepatic metabolism, minimization of interpatient and intrapatient variability, maintenance of a constant drug concentration within the biophase, expansion of the duration of drug effect, reduction of the possibility of over and under dosing, simplification of the medication regiment, and easy termination of drug input at any time. (cdc.gov)
  • A definitive diagnosis of cutaneous zygomycosis is based on a tissue biopsy of the involved skin, which classically demonstrates broad based, irregular, sparsely septate hyphae that branch at 90° angles. (medscape.com)
  • Repeat biopsy taken 4 mo after initial diagnosis was interpreted as cutaneous lymphoma with a strong reaction of almost all tumor cells to anti-CD3 antibody, consistent with a T-cell tumor. (vin.com)
  • Postmortem examination confirmed a diagnosis of cutaneous mastocytoma and revealed eosinophilic infiltration of the small intestine. (uu.nl)
  • The histopathology revealed a dense perivascular neutrophilic infiltration, fibrinoid necrosis of the vessel walls, leukocytoclastic and red blood cell extravasation, confirming the diagnosis of cutaneous leukocytoclastic vasculitis ( Figs. 3 and 4 ). (spandidos-publications.com)
  • Primary cutaneous zygomycosis may occur as a result of direct inoculation of mold spores into a damaged skin (e.g., from burns or trauma). (medscape.com)
  • Primary cutaneous amyloidosis is a form of amyloidosis, a group of conditions in which an abnormal protein (called amyloid) builds up in various organs and tissues throughout the body. (nih.gov)
  • In Primary cutaneous amyloidosis, specifically, this protein accumulates in the skin. (nih.gov)
  • There are three main forms of Primary cutaneous amyloidosis: Lichen amyloidosis - multiple itchy, raised spots which are scaly and red/brown in color. (nih.gov)
  • The exact underlying cause of Primary cutaneous amyloidosis is poorly understood. (nih.gov)
  • When Do Symptoms of Primary cutaneous amyloidosis Begin? (nih.gov)
  • Cutaneous small-vessel vasculitis can be idiopathic / primary , or secondary to infection , drug or disease. (dermnetnz.org)
  • Laboratory studies, such as a complete blood cell count, serum chemistry profile, and liver function tests, often were part of a general workup in several case reports of patients with nodular localized cutaneous amyloidosis. (medscape.com)
  • Nodular localized cutaneous amyloidosis does not cause any abnormal findings in these studies. (medscape.com)
  • The amyloid in nodular localized cutaneous amyloidosis is located in the reticular dermis and subcutaneous fat, and this finding clearly differentiates nodular localized cutaneous amyloidosis from other forms of amyloidosis. (medscape.com)
  • The cutaneous PK of topical products can be monitored by continuous in vivo measurement of drug concentrations in the dermis by either dermal Open Flow Microperfusion (dOFM) or dermal microdialysis (dMD) and may be monitored in the epidermis by other techniques (e.g., spectroscopic tomography). (nih.gov)
  • The purpose of this funding opportunity is to support the research and development necessary to optimize the clinical study design to compare cutaneous pharmacokinetics (PK) based approaches and develop bioequivalence (BE) standards based on appropriate PK endpoints for topical dermatological drug products. (nih.gov)
  • The pharmacokinetics of acyclovir after intravenous administration have been evaluated in adult patients with normal renal function during Phase 1/2 studies after single doses ranging from 0.5 to 15 mg/kg and after multiple doses ranging from 2.5 to 15 mg/kg every 8 hours. (drugs.com)
  • Pruritus will tend to occur within minutes to hours of administration of an offending agent. (dermcast.tv)
  • The skin is the first line of defense against microbial infection, and psychological stress (PS) has been shown to have adverse effects on cutaneous barrier function. (jci.org)
  • Pharmacological blockade of the stress hormone corticotrophin-releasing factor or of peripheral GC action, as well as topical administration of physiologic lipids, normalized epidermal AMP levels and delivery to LBs and decreased the severity of GAS infection during PS. (jci.org)
  • The term hypersensitivity vasculitis is used for cutaneous small vessel vasculitis due to known drug or infection. (dermnetnz.org)
  • Drugs are frequently responsible for cutaneous small vessel vasculitis, particularly in association with infection, malignancy or autoimmune disorders . (dermnetnz.org)
  • It has been shown that once the source of infection is eliminated, the administration of penicillin provides no statistically significant added benefit. (dentalcare.com)
  • 90 Another study confirmed that once the source of infection is eliminated, the administration of penicillin provides no statistically significant added benefit. (dentalcare.com)
  • Compared with the parenteral route, transdermal administration entails no risk of infection. (unige.ch)
  • Secondary cutaneous zygomycosis is rare and results from hematogenous dissemination from a preexisting (usually noncutaneous) source. (medscape.com)
  • Secondary cutaneous small vessel vasculitis often affects older people, because they are more likely to have diseases and medications (alone or in combination) that are potential causes of vasculitis. (dermnetnz.org)
  • however the number of reports regarding cutaneous leukocytoclastic vasculitis (CLCV) are limited. (spandidos-publications.com)
  • We report a case, a 58-year-old, 60 kg weight, non-smoking woman suffering of lung adenocarcinoma and brain metastases treated with erlotinib monotherapy with 150 mg/day dose, who presents cutaneous leukocytoclastic vasculitis after 8 months of initiating the treatment. (spandidos-publications.com)
  • The late onset of 240 days of the vasculitis and the presumed inefficiency of the drug lead to the speculation that the appearance of cutaneous vasculitis could be a worsening clinical marker of the tumor response. (spandidos-publications.com)
  • This limited number of cases precludes any meaningful interpretation of data about the erlotinib induced cutaneous vasculitis. (spandidos-publications.com)
  • Further investigations are needed to assess cutaneous vasculitis. (spandidos-publications.com)
  • We have found eight published cases of cutaneous vasculitis induced by erlotinib treatment. (spandidos-publications.com)
  • Author: Based on Dr Amy Stanway's article on Cutaneous Vasculitis, 2003. (dermnetnz.org)
  • There are several types of cutaneous vasculitis. (dermnetnz.org)
  • Who gets cutaneous small vessel vasculitis? (dermnetnz.org)
  • Cutaneous small vessel vasculitis mainly affects adults of all races over the age of 16. (dermnetnz.org)
  • Cancer is found in fewer than 5% of patients with cutaneous small vessel vasculitis. (dermnetnz.org)
  • In conclusion, the restoration of anti-inflammatory and pro-resolutive phenotype of wound macrophages by the topical administration of low-dose Aspirin represents a promising therapeutic approach in chronic wounds. (figshare.com)
  • Administration of high-dose loop diuretics and/or ultrafiltration in patients with pulmonary edema can be helpful, although this should be balanced with the possibility of worsening renal dysfunction because the kidneys are often damaged by cholesterol embolism. (medscape.com)
  • Libtayo is an anti-PD-1 therapy developed by Regeneron and Sanofi, which was approved by the U.S. Food and Drug Administration (FDA) last year for the treatment of patients with metastatic CSCC or locally-advanced CSCC who are not candidates for curative surgery or curative radiation. (biospace.com)
  • When Do Symptoms of Cutaneous-skeletal hypophosphatemia syndrome Begin? (nih.gov)
  • The use of kinetic modelling was illustrated using drugs approved by the Food and Drug Administration for use with transdermal delivery systems such as scopolamine for the treatment of motion sickness, nitroglycerin for the treatment of heart disease, clonidine for the treatment of hypertension, and estradiol for the treatment of female menopausal symptoms. (cdc.gov)
  • [ 3 ] and others detailed the potential use of steroid therapy for advanced disease, including those with acute renal failure or in those with pronounced cutaneous manifestations. (medscape.com)
  • Acyclovir Injection is a formulation for intravenous administration. (drugs.com)
  • Learn more about clinical trials from this U.S. Food & Drug Administration webpage. (nih.gov)
  • Onset usually occurs 4-28 days after administration of the causal medication and is most frequently associated with anticonvulsants, antibacterial sulfonamides, allopurinol, nevirapine, and oxicams (non-steroidal anti-inflammatory drugs), but many other medications have also been implicated. (orpha.net)
  • In the past, it was frequently seen with administration of antisera ( serum sickness) but is now more often due to drugs, infections and disease. (dermnetnz.org)
  • Multiple case reports have found that low-density lipoprotein (LDL) apheresis with the concomitant administration of other medications has produced favorable clinical outcomes. (medscape.com)
  • Functional constitutive nitric oxide synthase (NOS) is required for full expression of reflex cutaneous vasodilation that is attenuated in aged skin. (uncg.edu)
  • Using intradermal microdialysis, we evaluated the roles of nitric oxide synthase (NOS) and cyclooxygenase (COX) in β-adrenergic cutaneous vasodilatation and sweating elicited by administration of isoproterenol. (nih.gov)
  • We evaluated the hypotheses that (1) nitric oxide synthase (NOS) contributes to β-adrenergic cutaneous vasodilatation, whereas cyclooxygenase (COX) limits the vasodilatation, and (2) COX contributes to β-adrenergic sweating. (nih.gov)
  • Administration, Cutaneous" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (jefferson.edu)
  • The expectation is that the funded work will establish appropriate study designs, and acceptance criteria for a demonstration of BE based on cutaneous PK endpoints for drug products with a cutaneous site of action. (nih.gov)
  • These cutaneous PK-based approaches can directly monitor the rate and extent to which a topically administered drug becomes available at or near a site of action in the skin. (nih.gov)
  • This homeopathic product has not been evaluated by the Food and Drug Administration for safety or efficacy. (nih.gov)
  • Introduction to Administration and Kinetics of Drugs See Nanomedicine for an overview of all the ways in which nanotechnology has improved drug delivery. (msdmanuals.com)
  • Drug administration is the giving of a drug by one of several means (routes). (msdmanuals.com)
  • Padcev was approved by the Food and Drug Administration (FDA) in 2019. (medicalnewstoday.com)
  • The Food and Drug Administration (FDA) tracks side effects of drugs they have approved. (medicalnewstoday.com)
  • The Food and Drug Administration (FDA) approves prescription drugs such as Tecentriq to treat certain conditions. (medicalnewstoday.com)
  • The Food and Drug Administration (FDA) believes that the recommendations in this guidance document will improve the quality of postmarketing safety reports and clarify the industry's current safety reporting responsibility to assure public health. (cdc.gov)
  • 1This guidance has been prepared by the Epidemiology Branch in the Center for Biologics Evaluation and Research (CBER) at the Food and Drug Administration. (cdc.gov)
  • According to the Food and Drug Administration (FDA), which regulates alcohol-based hand sanitizers as an over-the-counter drug, methanol (methyl alcohol) is not an acceptable ingredient. (cdc.gov)
  • Because of these breakthroughs, the U.S. Food and Drug Administration (FDA) has approved 3 combinations of these newer medications to treat advanced melanoma. (aad.org)
  • They ensure a constant rate of drug administration and a prolonged action. (unige.ch)
  • For elderly people, who are often polymedicated, transdermal drug delivery can be a good alternative route of administration. (unige.ch)
  • Dr. Micheletti returned Friday morning for an illuminating hour to discuss cutaneous drug eruptions. (dermcast.tv)
  • Cutaneous drug eruptions are common, costly, and responsible for a fair amount of morbidity and mortality in medicine. (dermcast.tv)
  • Further discussion highlighted urticarial responses to medications, which account for up to 25% of cutaneous drug eruptions. (dermcast.tv)
  • CBD remains unregulated by the Food and Drug Administration (FDA) and has not been subjected to the same conclusive trials as most medications pertaining to its many specific uses. (jmir.org)
  • The latter research is being conducted as part of the Yale Tobacco Center of Regulatory Science, which is funded by the United States Food and Drug Administration for the purpose of providing science-based knowledge to guide regulation of tobacco. (jbpierce.org)
  • We hypothesized that acute local BH4 administration or arginase inhibition would similarly augment reflex vasodilation in aged skin during passive whole body heat stress. (uncg.edu)
  • We also show that combined inhibition of NOS and COX augments β-adrenergic sweating These new findings advance our basic knowledge regarding the physiological control of cutaneous blood flow and sweating, and provide important and new information to better understand the physiological significance of β-adrenergic receptors in the skin. (nih.gov)
  • Here, we demonstrated in an excisional skin injury in diet-induced diabesity murine model that topic low-dose Aspirin (36µg/wound/day) administration improved cutaneous wound healing by increasing wound closure through the promotion of the inflammation resolution program of macrophages. (figshare.com)
  • SAJAZIR (icatibant) injection 30 mg/3ml (10 mg/mL) is provided as a sterile, isotonic, and buffered solution of icatibant acetate in a single-use, prefilled syringe for subcutaneous administration. (rxlist.com)
  • Advantages of this treatment included minimal side effects and ease of administration. (vin.com)
  • TREATMENT PREPARATION AND ADMINISTRATION: A volume of 25 μL was applied to the dorsum of both ears of all animals daily for three consecutive days. (europa.eu)
  • Less than 8% of cutaneous clindamycin passes into plasma (van Hoogdalem 1998, Eller 1998, Barza 1982). (e-lactancia.org)