Current signal transduction therapy. Medical search. Frequent questions

Intervention in growth factor activated signaling pathways by renally targeted kinase inhibitors. (rug.nl)
In evaluating the response of platelet signaling pathways to antiplatelet agents, we have found that the platelet protein Drp1 is under the control of a dual phosphorylation system. (sbir.gov)
In this review, we summarize currently available therapies and clinical trials, directed towards a plethora of pathways and components dysregulated during PDAC carcinogenesis. (lu.se)
We have developed a rule-based model of crosstalk between the HMGB1 signaling pathway and other key cancer signaling pathways. (biomedcentral.com)
Moreover, the models also predict that mutations of RAS, ARF and P21 in the context of HMGB1 signaling can influence the cancer cell's fate - apoptosis or survival - through the crosstalk of different pathways. (biomedcentral.com)
The cell cycle is strictly regulated and controlled by a complex network of signaling pathways [ 1 ], comprised of hundreds of proteins. (biomedcentral.com)
Moreover, a number of extracellular proteins can bind to their receptors and activate signaling pathways that promote the proliferation of cancer cells. (biomedcentral.com)
The HMGB1 signal transduction can influence the cell's fate by two important processes - apoptosis and cell proliferation - which are regulated respectively by the proteins p53 and CyclinE, acting in two different signaling pathways. (biomedcentral.com)
Many studies have found evidence of crosstalk between the two signaling pathways involving p53 and CyclinE [ 15 ]. (biomedcentral.com)
Which signaling pathways are fundamental for describing HMGB1 signal transduction, and what mechanisms are responsible to explain recent results linking overexpression of HMGB1 with decrease of apoptosis (and increased cancer cell survival)? (biomedcentral.com)
Current research in lymphoma is focused on two areas of lymphoma biology-the signal transduction pathways used to maintain the growth of malignant lymphocytes and the role of the tumor microenvironment in lymphoma growth and survival. (elsevierpure.com)
This review focuses on three signaling pathways: the phosphatidylinositol 3-kinase/mammalian target of rapamycin (PI3K/mTOR) pathway, the B-cell receptor/spleen tyrosine kinase (BCR/Syk) pathway, and the protein kinase C-beta (PKC-β) pathway, known to be important to lymphoma cells. (elsevierpure.com)
Gene enrichment analysis revealed that these lncRNA-related mRNAs are associated with cell adhesion, collagen adhesion, cell differentiation, and mainly enriched in ECM-receptor interaction and PI3K-Akt signaling pathways. (biomedcentral.com)
Although, little is known about the molecular mechanisms that underlie glioblastoma formation, a number of signal transduction routes, such as the Notch, EGFR and p53 pathways, seem to play an important role in the formation/maintenance of GBM. (cns.org)
In cancer, genetic and epigenetic alterations ultimately culminate in discordant activation of signal transduction pathways driving the malignant process. (eur.nl)
Pharmacological or biological inhibition of such pathways holds significant promise with respect to devising rational therapy for cancer. (eur.nl)
Molecular alterations in lung cancer include genetic changes, epigenetic changes, and changes in the expression or activity of kinases that comprise signaling pathways within cells. (johnshopkins.edu)
Signaling pathways are attractive targets for lung cancer therapy because activation of signaling pathways contributes to tumor growth and therapeutic resistance, and constitutively active signaling commonly occurs in lung cancer. (johnshopkins.edu)
This review will discuss signaling pathways that are relevant to lung cancer. (johnshopkins.edu)
Mucin 1 lies on the tubular cell apical surface and has a role in signal transduction pathways. (medscape.com)

Tirupal, B.Chandra Mohan and S.Srinivas Kumar, "Multimodal Medical Image Fusion Techniques - A Review", Current Signal Transduction Therapy, a SCOPUS Free Journal, vol.15, no.1, pp.1-22, March 2020, ISSN 1574-3624. (gpcet.ac.in)

ChemDiv's Inhibitors of beta-Catenin Signaling Library contains 8,000 compounds. (chemdiv.com)
The mTOR inhibitors temsirolimus and everolimus have demonstrated antitumor activity in all types of lymphoma, the Syk inhibitor fostamatinib has activity in diffuse large B-cell lymphoma and chronic lymphocytic leukemia, and the PKC-β inhibitor enzastaurin is being used as consolidation therapy after remission in diffuse large B-cell lymphoma. (elsevierpure.com)
Immune Checkpoint Inhibitors in cancer Therapy. (mu-varna.bg)
We will discuss specific signaling aberrations found in lung cancers, review the status of signaling inhibitors being developed for lung cancer, identify emerging targets, and provide recommendations for the development of agents designed to inhibit signal transduction. (johnshopkins.edu)

In this review, potential mechanisms of resistance to therapy will be addressed, starting from the outside of the cells looking at the potential role the ECM may play, then continuing with EGF receptor alterations, which may contribute to resistance to therapy with antibodies. (eurekaselect.com)
The role of FcγRIIIa receptor polymorphism in antibody-dependent cell-mediated cytotoxicity (ADCC), which may be a mechanism of anticancer activity of cetuximab will be discussed, as well as the resistance to radiotherapy and receptor blocking therapy mediated by the insulin-like growth factor receptor I (IGF-1R). (eurekaselect.com)
This protein regulates signal transducing molecules, which include members of the Srckinase family of non-receptor tyrosine kinases, serine/threonine kinases and transcription factors. (eurekaselect.com)
Key interests: Receptor function and signal transduction in inflammation in cardiovascular disease. (wustl.edu)
PD-L1 is involved in the signaling of programmed cell death through the receptor PD-1, a cell surface receptor that plays a crucial role in immune system suppression and promotes tolerance to host cells. (mu-varna.bg)
Yvonne Jones is Director of the Cancer Research UK Receptor Structure Research Group which is focused on the structural biology of extracellular recognition and signalling complexes. (ox.ac.uk)
The lectin-like oxidised low-density lipoprotein (LOX-1) scavenger receptor binds to oxidized low density lipoprotein (oxLDL) and mediates both signaling and trafficking outcomes. (bvsalud.org)

If some important proteins are mutated or there are defects in the signaling mechanisms, normal cell growth regulation will break down, possibly leading to the occurrence of cancer in the future. (biomedcentral.com)
The current focus is on the neutrophils in the context of chronic ischemic injury and heart failure with specific interest in the mechanisms underlying neutrophil activation, in particular, damage associated molecular patterns generated myocardial dysfunction (DAMPs) that interact to generate distinct neutrophil responses. (wustl.edu)
In this manuscript, we review the current literature regarding how HPV-infected cells avoid apoptosis and the molecular mechanisms involved in these events. (mdpi.com)
What mechanisms trigger dysfunctional signalling? (ox.ac.uk)
These include systems involved in cell guidance (e.g. semaphorin/plexin and ephrin/Eph signalling), as well as mechanisms controlling signalling by the Wnt family of morphogens. (ox.ac.uk)
Radiotherapy was delivered to ipsilateral axil- cancer patients in the future, it is essential to increase our lary and supraclavicular lymph nodes and the remaining knowledge in mechanisms responsible for drug resistance, breast parenchyma after breast conservation surgery or tho- and to define reliable indicators for response to therapy. (lu.se)
Understanding the mechanisms underlying embryonic beta cell development will be a prerequisite for the development of a universally available cell replacement therapy in diabetes. (lu.se)

The roles of b-catenin are 'classically' defined: as an adhesion protein and as a signaling protein, transducing extracellular signals to the nucleus to modify gene expression. (chemdiv.com)

In the intrinsic pathway the cell kills itself because it senses cell stress, while in the extrinsic pathway the cell kills itself because of signals from other cells. (wikipedia.org)
Weak external signals may also activate the intrinsic pathway of apoptosis. (wikipedia.org)
He adds, "Combination of several agents targeting more than one antigenic determinant, gene mutation, or signal transduction pathway might be the most effective strategy, and could hold the promise of substantial benefit, and could represent a targeted solution similar to the total therapy approach pioneered by Don Pinkel in the 1960s with chemotherapeutic agents. (medscape.com)
In this work, we construct a simple model of HMGB1 signal transduction to investigate tumorigenesis on the basis of known signaling pathway studies [ 16 - 21 ]. (biomedcentral.com)
The Wnt pathway mediates the biological processes of the canonical or non-canonical pathway, depending on the involvement of β-catenin in signal transduction. (chemdiv.com)
The recently described role of the Wnt/β-catenin pathway in the regulation of immune cell infiltration of microenvironment tumor resumes interest because of its potential impact to rection of immune therapy. (chemdiv.com)
This article presents the roles of the Wnt/β-catenin pathway in cancer and current therapeutic strategies involving this pathway. (chemdiv.com)
The γc-dependent cytokine receptors use the Janus Kinase (JAK)/Signal transducer and activator of transcription (STAT) signaling pathway to mediate gene activation or repression. (unina.it)

In this paper, we ask the following questions: How do these proteins and their mutations change the cell's fate - apoptosis or survival - when HMGB1 signal transduction is activated? (biomedcentral.com)
Notum deacylates Wnt proteins to suppress signalling activity. (ox.ac.uk)

Breast cancer is the most common malignancy affecting women and there remains a need for effective adjuvant therapies for this disease, for which plant sterols may play a distinctive role. (mdpi.com)
Because the definitive treatment of cutaneous melanoma is surgery, medical management is reserved for adjuvant therapy of patients with advanced melanoma. (medscape.com)
consequently, these patients are classified as high risk and should be considered for adjuvant therapy. (medscape.com)

Recent advances in the development and application of array-based peptide-substrate kinase activity screens show great promise in overcoming the discrepancy between the evaluation of aberrant cell signaling in specific malignancies or even individual patients and the currently available ensemble of highly specific targeted treatment strategies. (eur.nl)

Extracellular modulators of Wnt signalling. (ox.ac.uk)

In patients with no BRAF mutation (ie, wild-type BRAF ), current guidelines from the National Comprehensive Cancer Network (NCCN) recommend single-agent immunotherapy with the programmed cell death-1 (PD-1) inhibitor pembrolizumab or nivolumab or combination therapy with nivolumab plus ipilimumab. (medscape.com)

The multiple aberrations in the path that occur with many WNT- directed therapies represent an area having importance for developmental therapy. (chemdiv.com)

HMGB1 can activate a series of signaling components, including mitogen-activated protein kinases (MAPKs) and AKT, which play an important role in tumor growth and inflammation, through binding to different surface receptors, such as RAGE and TLR2/4. (biomedcentral.com)
Current targeted therapies can slow tumor growth (eg, BRAF inhibition) or release the brakes on the immune response, resulting in tumor lysis (eg, PD-1 inhibition). (medscape.com)

Thus, understanding the complete role of Hsp90 signaling in cardiovascular systems will help to develop therapeutic approaches to cure many cardiovascular diseases such as ischemia/reperfusion injuries, atherosclerosis, congestive heart failure etc. (eurekaselect.com)
Implication of larger array of potential targets are to be studied for therapeutic purpose to improve our current understanding of the mechanistic insight required to translate these therapies into clinical treatment paradigms. (cns.org)
Current treatment strategies are largely ineffective due to advanced stage at diagnosis and the inherent therapeutic resistance of lung cancer cells. (johnshopkins.edu)

Notch signaling is aberrantly activated in GBM and orchestrates the malignant traits of GBM, but current knowledge regarding the downstream players of Notch in GBM remains limited. (cns.org)

Signal transduction and targeted therapy 2023 0 0. (cdc.gov)
Current research in immunology 2023 0 0. (cdc.gov)
Current Bioinformatics (2023) 18 (3): 266. (aacrjournals.org)

These results have important implications for proposed RP therapies, such as vitamin A supplementation, which may be ineffective or even detrimental for certain RP genotypes. (jneurosci.org)
However, the ability of HPV-infected cells to resist apoptotic signals renders such therapies ineffective. (mdpi.com)
Although the current generation of dCas9-based transcription activators is able to achieve up-regulation of some endogenous loci, the magnitude of transcriptional up-regulation achieved by individual single-guide RNAs (sgRNAs) 12 typically ranges from low to ineffective 8 - 11 . (cdc.gov)

Signal transduction inhibitor therapy for lymphoma. (elsevierpure.com)
Dive into the research topics of 'Signal transduction inhibitor therapy for lymphoma. (elsevierpure.com)

For example, they modulate signal-transduction cascades, and show both cytostatic (inhibiting cell growth) and cytotoxic (cell-killing) activities towards cancer cells. (i-sis.org.uk)

It is crucial that we continue to develop new therapies for use in uveitis that aim to suppress disease activity, prevent accumulation of damage, and preserve visual function for patients with the minimum possible side effects. (dovepress.com)

Many of the current efforts regarding anti-cancer drug development are focused on directing tumor cells to undergo apoptosis. (mdpi.com)

These studies are critical in translating this novel understanding of neutrophil pathology in heart failure into effect clinical therapies. (wustl.edu)

I am an experienced early-phase clinical trialist and current serve as a steering member of the COG ALL committee, the COG Myeloid Diseases Vice-Chair of Relapse, the LLS PedAL Clinical Trials Leader, and the COG Developmental Therapeutics committee Vice-Chair of Biology for Hematologic Malignancies. (upenn.edu)

Therefore, in the current era they are termed autosomal dominant (AD) tubulointerstitial nephritis. (medscape.com)

Prior to 2006, Trials was published as Current Controlled Trials in Cardiovascular Medicine (CCTCVM). (360qikan.com)

Wnt/β-catenin signaling is a branch of a functional network that is involved in a broad range of biological systems including stem cells, embryonic development and adult organs. (chemdiv.com)

The study reported by Dr Topp and colleagues enrolled 189 patients with Philadelphia chromosome-negative, primary refractory or relapsed disease (first relapse within 12 months of first remission, relapse within 12 months after allogeneic hemopoietic stem cell transplantation, or no response to or relapse after first salvage therapy or beyond). (medscape.com)
Given the results from current research on the tumor kinome, generating network views on aberrant tumor cell signaling is critical to meet this challenge. (eur.nl)
This course is a survey of contemporary problems in microbal, plant, protozoan, and animal cell and biosystems signaling. (unh.edu)
The group's research addresses fundamental questions about cell-cell signalling systems of importance to human health. (ox.ac.uk)
Which features are necessary for normal signal transduction into the cell? (ox.ac.uk)
Beta cell replacement therapy is the only available cure for type 1 diabetes. (lu.se)

My overarching career goal as an academic pediatric oncologist and translational physician-scientist is to develop successful precision medicine therapies for children with high-risk leukemias aimed at decreasing relapse risk, minimizing toxicity, and improving long-term survival. (upenn.edu)
1%. However, outcomes have improved because of the identification of certain mutations that can be targeted for therapy, and current 5-year survival rates are 19% (23% for women and 16% for men). (msdmanuals.com)

In this educational review, we outline the ideal characteristics of drugs for uveitis and review the data to support the use of current and emerging therapies in this context. (dovepress.com)

Lung transplantation is a potentially curative therapy for patients with end-stage pulmonary disease. (nature.com)
Secondary chemoprevention is targeted at patients with cancer who, in order to prevent recurrent disease or to prevent metachronous primary diseases, have undergone potentially curative therapy. (medscape.com)

However, they do not fully explain the resistance to multimodal therapy. (eurekaselect.com)
Glioblastoma multiforme (GBM) is a highly aggressive brain tumor characterized by increased necrosis and intense resistance to therapy. (cns.org)
Overexpression of ErbB1 and ErbB2 that occurs in several types of cancers is associated with poor prognosis leading to resistance to ErbB1-directed therapies. (bvsalud.org)

In this review, we summarize the current status of traditional vaccines, and also address the potential applications and advantages of synthetic biology technologies in the development of viral vaccines. (cip.com.cn)

Neoadjuvant therapy for high-risk resectable melanoma has demonstrated significant efficacy in early clinical trials. (medscape.com)

Graduate student and faculty presentations on current topics in the molecular life sciences and biomedical sciences. (unh.edu)

cystic fibrosis gene therapy. (stanford.edu)

β-catenin is a component of the complex cadherin complex whose stabilization is required to activate Wnt/β-catenin signaling. (chemdiv.com)

Current projects within the group focus on signalling systems of importance in developmental biology. (ox.ac.uk)

Here we will review the research progress of active components of Polygonum cuspidatum in tumor diseases therapy, mainly including resveratrol, polydatin, emodin, and chrysophanic acid (Figure 1 ). (hindawi.com)
Thus, a narrative review was performed to describe the current knowledge. (nih.gov)

McCarty [4] reviewed current prospects for controlling cancer growth with nutrients and plant chemicals and suggested that combinations of plant chemicals would enhance cure rates with standard therapies. (i-sis.org.uk)
McCarty M. Current prospects for controlling cancer growth with non-cytotoxic agents-nutrients, phytochemicals, herbal extracts, and available drugs. (i-sis.org.uk)
An imbalance in the structural and signaling properties of β-catenin often leads to disease and unregulated growth associated with cancer and metastasis. (chemdiv.com)
Cancer Biology and Therapy , 3 (2), 147-155. (johnshopkins.edu)
A better understanding the biology of the above-mentioned features will indeed lead to more effective cancer therapy options in prostate cancer. (uni-hamburg.de)
Students are able to independently evaluate current, English-language technical literature in the field of cancer research. (tum.de)

Current Oncology, 2022;29(5):3044- 3060. (mu-varna.bg)
To that end, molecular techniques mixed with scientific experience of the medical scientist Dr. Mansour complemented by clinical medical oncology expertise of Dr. Oing are gathered to promote the current bidirectional translational research project entitled DRAGOON. (uni-hamburg.de)

Current Research and Scholarly Interests Dr. Gardner's investigative program during his academic career has involved a two-pronged approach, including both clinical and basic research. (stanford.edu)
Research areas: Current research focuses on the role of damage associated molecular patterns produced by dysfunctional and failing hearts in recruitment of immune cells and their activation contributing to progressive decline in heart function and left ventricle adverse remodeling in heart failure. (wustl.edu)

This module handbook serves to describe contents, learning outcome, methods and examination type as well as linking to current dates for courses and module examination in the respective sections. (tum.de)

At the ASH meeting, one expert commented that she believes that new therapies such as this one will revolutionize treatment of hematologic cancers. (medscape.com)

My particular clinical interests include integration of comprehensive leukemia genetic data with therapy selection for children with high risk newly-diagnosed and relapsed ALL and AML with a focus on precision medicine treatment approaches. (upenn.edu)
and studies of genetic, chemical, radiologic and other treatment therapies. (ed.gov)

The goal is to provide the hematologist/oncologist background information on these new agents and understand their current and potential role in the management of patients. (elsevierpure.com)

The MBL2 genotype relates to COVID-19 severity and may help to select the optimal therapy. (cdc.gov)

The crosswalk shows the CIP code number and title in the previous version and the current version of the CIP. (ed.gov)

Anatomy20

Organisms14

Chemicals and Drugs100

Analytical, Diagnostic and Therapeutic Techniques and Equipment24

Phenomena and Processes57

Disciplines and Occupations2

Information Science4

Pathways20

1574-36241

Inhibitors4

Receptor7

Mechanisms7

Extracellular signals1

Pathway8

Proteins2

Adjuvant3

Kinase1

Modulators1

Immunotherapy1

Aberrations1

Tumor growth2

Therapeutic3

Malignant1

20233

Ineffective3

Inhibitor2

Modulate1

Suppress1

Apoptosis1

Pathology1

Malignancies1

Tubulointerstitial1

Cardiovascular Medicine1

Biological1

Cell6

Survival2

Context1

Potentially curative therapy2

Resistance3

Summarize1

Melanoma1

Life Sciences1

Gene Therapy1

Activate1

Developmental1

Review2

Cancer6

Oncology2

Research2

Methods1

Hematologic1

Treatment2

Role1

Severity1

Title1