Curcumin intracellular membranes. Medical search. Frequent questions

Apoptosis results from the formation of ROS and mechanical forces of SDT through membrane disruption in a process called lipid peroxidation. (wikipedia.org)
RESULTS: The levels of cell death (propidium iodide positive cell numbers), apoptosis markers (caspases -3, -8, and -9), oxidative stress (cROS and mROS), mitochondria membrane depolarization, TRPM2 current density, and intracellular free Ca2+ and Zn2+ fluorescence intensity were upregulated in the HCQ group after stimulation with hydrogen peroxide and ADPR, but their levels were downregulated by treatments with CRC and TRPM2 blockers (ACA and carvacrol). (opticnervenetwork.com)
This study aimed to investigate the molecular mechanisms of protective effects of curcumin against cisplatin-induced kidney inflammation and apoptosis in rats. (thieme-connect.com)
Pre-treatment with curcumin significantly ameliorated inflammation and apoptosis induced by cisplatin. (thieme-connect.com)
Conclusions These data indicate that curcumin has nephroprotective properties against cisplatin-induced kidney damage in rats and this effect is associated with its anti-inflammatory and anti-apoptosis profiles, in addition to its antioxidant. (thieme-connect.com)
9 ] reported curcumin administration provided protection against cisplatin-induced renal tubular cell apoptosis. (thieme-connect.com)
Intracellular insults can initiate neuronal apoptosis via mitochondrial dysfunction or intrinsic pathway (Fig. 1 ). (biomedcentral.com)
the mitochondrial anticancer targets are called mitokan, which by selective accumulation in the mitochondria and damage to the mitochondrial membrane, leads to increased ros and apoptosis. (icbcongress.com)
current methods for treating cancer based on mitochondrial targeting are targeting mitochondrial atp mitochondrial membrane permeability, mitochondrial ros, and mitochondrial dna mtdnathe structure and function of mitochondria promote apoptosis through cytochrome c mechanisms. (icbcongress.com)

Study shows curcumin enhances antiretroviral delivery and reduces inflammation and oxidative stress in HIV, offering potential improvements in treating HIV-associated neurocognitive disorders. (news-medical.net)
An active nature product of Asian herb medicine, curcumin, shows many protective effects, including against inflammatory and oxidative stress conditions. (thieme-connect.com)
Previous studies have demonstrated that curcumin at a dose of 100 mg/kg orally in mice and 60 mg/kg in rats reduced concentration of tumor necrosis factor (TNF)-α and inhibited oxidative stress in cisplatin-induced nephrotoxicity [ 7 ] [ 8 ]. (thieme-connect.com)
Perilipin 5 (PLIN5) is a lipid-droplet-associated protein that coordinates intracellular lipolysis in highly oxidative tissues and is thought to regulate lipid metabolism in response to phosphorylation by protein kinase A (PKA). (uci.edu)

The CUR+CA-induced Ca 2+ cyt rise did not involve excessive influx of extracellular Ca 2+ but, rather, occurred due to massive Ca 2+ release from intracellular stores concomitant with inhibition of Ca 2+ cyt extrusion through the plasma membrane. (oncotarget.com)
Specifically, membrane transporters are responsible for ionic homeostasis between intracellular and extracellular environments. (geresdengle.com)
Triggering of autophagy is induced through multiple intracellular and extracellular stimuli including infection, proton concentration, starvation, metabolic perturbations and other chemical and physical stressors. (encyclopedia.pub)

Moreover, cell wall damage, cell membrane depolarization, intracellular adenosine triphosphate (ATP) decline, Ca 2+ and Mg 2+ leakage, cell morphological destruction and alterations in intracellular biomolecules were observed, which indicated the negative influence of MDA on cell membrane and cellular homeostasis. (frontiersin.org)

Mechanistic investigations revealed that through increasing the levels of intracellular reactive oxygen species (ROS), Gyp-L triggered protein ubiquitination and endoplasm reticulum (ER) stress response, leading to Ca 2+ release from ER inositol trisphosphate receptor (IP 3 R)-operated stores and finally cell death. (oncotarget.com)

Upon transfer to PVDF membranes, separated proteins were probed for p-Akt, p-p38, p-JNK, p-ERK1/2 and Grb-2. (morainetownshipdems.org)
the main pathway for cellular death is called the mitochondrial pathway, which is activated by a wide range of signals including radiation, cytotoxic drugs, cellular stress, and growth factor receptors and involves the release of proteins such as cytochrome c from mitochondrial membrane space. (icbcongress.com)
Their unique hourglass-shaped architecture is highly conserved among different bacterial membrane proteins and other biological channels. (ibecbarcelona.eu)

Here, we show that apoptotic response of AML cells to the synergistically acting polyphenols curcumin (CUR) and carnosic acid (CA), combined at low, non-cytotoxic doses of each compound was mediated solely by disruption of cellular Ca 2+ homeostasis. (oncotarget.com)
As mentioned above, accurate protein homeostasis (proteostasis) and elimination of damaged or exacerbated intracellular compounds are crucial for the cell survival and its proper function. (encyclopedia.pub)

High-performance liquid chromatography (HPLC) is efficiently used for the detection and quantification of curcumin [ 9 ]. (hindawi.com)

The Influence of Intracellular Glutathione Levels on the Induction of Nrf2-Mediated Gene Expression by α-Dicarbonyl Precursors of Advanced Glycation End Products. (ebsco.com)
This study aimed to investigate the role of intracellular glutathione (GSH) levels in the induction of Nrf2-mediated gene expression by α-dicarbonyl compounds. (ebsco.com)

Protects cell membranes against lipid peroxidation. (activeskincare.ca)

In brown fat inefficiency occurs through the "uncoupling protein" - a protein in the mitochondrial inner membrane - that converts the cell's fuel into heat rather than energy. (ayalasmagicspice.com)
some drugs are designed to disturb the respiratory tract and permeability of the mitochondrial membrane, which increases the levels of ros and regulates the expression of the gene in mitochondria. (icbcongress.com)

Almost a century after its isolation from turmeric, Lampe in 1913 [ 4 ] published the synthesis of curcumin in a series of steps starting with carbomethoxyferuloyl chloride and ethyl acetoacetate. (hindawi.com)
Curcumin, a natural polyphenolic compound derived from turmeric (Curcuma longa L), has proven to be a modulator of multiple intercellular signalling pathways linked to inflammation, to proliferation, growth, invasion, drug sensitivity, angiogenesis and metastasis of cancer cells. (researchgate.net)
Curcumin , a component of turmeric, induced fat browning in mice. (ayalasmagicspice.com)

These compounds work by altering membrane permeability in infected cells, leading to the release of immature viral particles, a mechanism distinct from current HBV treatments. (news-medical.net)

General porins are nature's sieving machinery in the outer membrane of Gram-negative bacteria. (ibecbarcelona.eu)

Curcumin has extensive therapeutic potential because of its antioxidant, anti-inflammatory, and antiproliferative properties. (hindawi.com)

Furthermore, miltefosine has shown a synergistic effect with several medicines, among others, with nanotized curcumin against (9), with amiodarone against (10), with allopurinol against canine VL produced by (11), and with pentamidine against and led to its use as the 1st oral treatment for VL (13, 14). (icsv20.org)
Based on literature and our own experience we propose new interventions, including the use of amiodarone, simvastatin, pioglitazone and curcumin. (spandidos-publications.com)

These optical properties are used for the isolation and purification of curcumin by various techniques and fluorescence which enable the monitoring of very low amounts of curcumin and related metabolites in plasma and urine in the range of 2.5 ng/mL [ 9 - 11 ]. (hindawi.com)

Plasma membranes are affected by increased levels of oxidation and reduced antioxidants in cellular membranes. (geresdengle.com)
the mitochondria are also calcium and intracellular ros regulators which are useful for cellular physiological activity. (icbcongress.com)
Modulation of intracellular GSH levels showed that the cytotoxicity and induction of the Nrf2-mediated pathway by MGO, GO and 3-DG was significantly enhanced by depletion of GSH, while a decrease in Nrf2-activation by MGO and GO but not 3-DG was observed upon an increase of the cellular GSH levels. (ebsco.com)

Curcumin, or (1E,6E)-1,7-bis (4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione, is a symmetric molecule also called diferuloyl methane (MW 368.38 g·mol -1 ) extracted from the dietary spice curcuma, historically used in Asian food and traditional medicine [ 1 ]. (hindawi.com)
As previously described curcumin [ 2 , 3 ] three chemical entities structure the molecule:2 o-methoxyphenol connected by a seven-carbon linker with an α , β -unsaturated diketone moiety (Figure 1(a) ).The resonance structure inside the molecule is responsible for its participation in many electron transfer reactions. (hindawi.com)
General consideration about the curcumin molecule. (hindawi.com)
In order to exploit the pharmacological potential of natural bioactive molecules with low water solubility, such as curcumin, it is necessary to develop formulations, such as amorphous polymer dispersions, which allow a constant release rate and at the same time avoid possible toxicity effects of the crystalline form of the molecule under scrutiny. (ibecbarcelona.eu)

Cavitation occurs as a specific interaction between ultrasound and aqueous surroundings and causes gas bubbles to break upon exposure to particular ultrasonic parameters, thus promoting penetration of the therapeutic into the biological tissues by generating cavities near the edge of the membrane.Cavitation can be broken down into stable and inertial cavitation. (wikipedia.org)

MARV assembles and buds from the host cell plasma where MARV matrix protein (mVP40) dimers associate with anionic lipids at the plasma membrane inner leaflet and undergo a dynamic and extensive self-oligomerization into the structural matrix layer. (uci.edu)

In addition, curcumin downregulated Ctr1 and OCT2 drug transporters as compared to cisplatin group. (thieme-connect.com)
Aging affects the plasma membrane of cells, and the membrane transporters. (geresdengle.com)

Therefore, in this study, we aimed to investigate the possible molecular mechanisms of anti-inflammatory and anti-apoptotic effects of curcumin in cisplatin-induced kidney damage. (thieme-connect.com)

Later, Pabon described a simple method for the synthesis of curcumin with high yields that is still in use today [ 5 ]. (hindawi.com)
a) Synthesis of curcumin by the general method proposed by Pabon [ 5 ]. (hindawi.com)

Although curcumin has shown significant efficacy in cell culture studies, it has shown limited efficacy in clinical studies when administered in conventional oral formulations. (researchgate.net)
A two-level study - a path test and a clinical trial compares the efficacy of 0.25% curcumin extract against 4 % hydroquinone. (activeskincare.ca)

However, the molecular mechanisms behind the anti-inflammatory and anti-apoptotic effects of curcumin in the cisplatin-induced kidney damage have not been explored. (thieme-connect.com)

Multiple preclinical studies in vitro and in vivo have proven curcumin to be effective against various cancers. (hindawi.com)

Curcumin has significantly higher glass transition temperature Tg (≈ 347 K) than the polymer matrix (≈274-277 K depending on the molecular weight), and dispersions displayed Tg's intermediate between those of the pure amorphous components, implying that curcumin acts as an effective antiplasticizer for PADAS. (ibecbarcelona.eu)

A key active site of curcumin for biological reactions is the diketo group, which acts as the primary hydrogen affinity site at physiological pH [ 1 , 12 ]. (hindawi.com)
Numerous biological responses involve Ca+2 influx as an intracellular messenger. (activeskincare.ca)

Curcumin causes cell death and primarily initiates an autophagic step (mitophagy). (hindawi.com)

Curcumin is a weak Brönsted acid, with three labile protons and accordingly three pKa values-which can be estimated by both NMR and absorption spectrometry-corresponding to three prototropic equilibria (Figure 2(b) ). (hindawi.com)
In this study, polymer dispersions of curcumin were obtained in PADAS, a biodegradable semicrystalline copolymer based on 1,12-dodecanediol, sebacic acid and alanine. (ibecbarcelona.eu)

In previous blog entries I have discussed a number of traditional Chinese herbal medicines such as curcumin, ginger, danshen root and epimedium. (anti-agingfirewalls.com)

Fisetin signifcantly increases antioxidants in membranes and activates the redox protection system. (geresdengle.com)

RESULTS Effect of miltefosine within the intracellular Ca2+ concentration of promastigotes. (icsv20.org)
In order to determine the Rabbit polyclonal to HCLS1 effect of miltefosine within the [Ca2+]i (intracellular Ca2+ concentration) in promastigotes, the parasites were loaded with the fluorescent Ca2+ indication Fura-2. (icsv20.org)

Purpose Although curcumin (Cur) has powerful pharmacological effects, its use in medicine has not been established yet. (researchgate.net)

In fact, a plasma membrane Ca2+ channel homolog to the human being L-type voltage-gated Ca2+ channel (VGCC) has been explained in (29). (icsv20.org)
In the present work we display new mechanisms of action of miltefosine, demonstrating that this drug is able to activate a Ca2+ channel in the plasma membrane of similar to the sphingosine-activated channel mentioned above for acidocalcisomes. (icsv20.org)

In this article, after a brief review of the physicochemical properties and pharmacokinetic profiles of curcumin, recent advances in curcumin oral delivery systems are discussed. (researchgate.net)

Histopathological examination furthers confirmed the kidney damage protection effect of curcumin. (thieme-connect.com)
Hence, curcumin may be useful for preventing kidney damage against cisplatin administration. (thieme-connect.com)

That post also at least partially explains why certain familiar substances like aspirin, coffee, curcumin, resveratrol and green tea may convey both protection against cancers and a longevity benefit. (anti-agingfirewalls.com)

Transmission electron microscopy demonstrated that Ery PDT altered the C. albicans cell morphology by inducing cell wall/membrane rupture. (thieme-connect.de)

The results demonstrate that 0.25% curcumin extract is as effective, but safe! (activeskincare.ca)

Even after arriving at their sites of action, prior to the release of their cargo and clearance, NPs must effectively penetrate through the cell membrane and navigate intracellular compartment networks to get to their subcellular mark. (biomedcentral.com)

My Google research led me to a curcumin program a while back and that has brought back my original dark brown hair color, and recently I found that I now longer had to get up to go to the bathroom every night(as has been the case for years). (teebrasil.com)

Dielectric spectroscopy was employed to assess the relaxation dynamics of the binary dispersion with 30 wt% curcumin, as well as that of each (amorphous) component separately. (ibecbarcelona.eu)

Anatomy54

Organisms13

Chemicals and Drugs108

Analytical, Diagnostic and Therapeutic Techniques and Equipment24

Phenomena and Processes52

Disciplines and Occupations1

Technology, Industry, Agriculture5

Information Science3

Health Care1

Apoptosis9

Oxidative4

Extracellular3

Depolarization1

Reactive oxygen1

Proteins3

Homeostasis2

Quantification1

Glutathione2

Lipid peroxidation1

Mitochondrial2

Turmeric3

Permeability1

Outer membrane1

Antioxidant1

Amiodarone2

Fluorescence1

Cellular3

Molecule4

Tissues1

Protein1

Transporters2

Aimed to investigate1

Synthesis2

Efficacy2

Inflammatory1

Proven1

Significantly1

Biological2

Autophagic1

Acid2

Medicines1

Increases1

Concentration2

Effects1

Plasma2

Delivery1

Damage2

Protection1

Cell wall1

Effective1

Release1

Research1

Component1