• The significant growth inhibition by the steroid sulfatase and aromatase inhibitors were also observed in the co-culture system. (scirp.org)
  • Here, we demonstrate that widely used pyrazinoylguanidine-type NHE1 inhibitors potently inhibit growth and survival of cancer cell spheroids, in a manner unrelated to NHE1 inhibition. (ku.dk)
  • citation needed] Some common components of human diets also act as mild angiogenesis inhibitors and have therefore been proposed for angioprevention, the prevention of metastasis through the inhibition of angiogenesis. (wikipedia.org)
  • 1998). p21(WAF1) is required for butyrate-mediated growth inhibition of human colon cancer cells. (nature.com)
  • 2004). Inhibition of cell growth by EGR-1 in human primary cultures from malignant glioma. (nature.com)
  • PHI1 exhibits discrete cellular selectivity for BRAF dimers, with enhanced inhibition of the second protomer when the first protomer is occupied, comprising a novel class of dimer selective inhibitors. (nature.com)
  • Here we provide evidence that there may be a direct link between inhibition of intestinal cancer growth and selective inhibition of the COX-2 pathway. (nih.gov)
  • It was also shown that inhibition of the p16 tumour suppressor gene delays growth arrest and therefore senescence of MSC [ 16 ]. (hindawi.com)
  • Recent reports have shown that the sensitivity of non-small-cell lung cancer cell lines to EGFR inhibitors such as erlotinib (Tarceva, OSI Pharmaceuticals) is dependent on inhibition of the phosphatidylinositol 3′-kinase-phosphoinositide-dependent kinase 1-Akt-mTOR pathway. (aacrjournals.org)
  • Using tumor cells (HeLa), the researchers demonstrated in cell culture that inhibition of HDAC10 by DKFZ-748 curbed cancer cell growth when sufficient polyamines were not available. (dkfz.de)
  • 1975. Tumor growth inhibition by ammonium chloride-induced acidosis. (cdc.gov)
  • We show that topical treatment of mouse and human skin with small-molecule inhibitors of the Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway results in rapid onset of anagen and subsequent hair growth. (nextbigfuture.com)
  • Our laboratory uses molecular, biochemical, physiological, pharmacologic (small molecule inhibitors), cell and tissue culture, and combined optical and biomechanical engineering approaches to analyze cell/tissue/organ-specific conditional/inducible gene knockout and transgenic mouse models. (sc.edu)
  • Herein, we report on a specific oligonucleotide-based RNA inhibitor targeting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). (mdpi.com)
  • Strategies to inhibit the VEGF pathway include antibodies directed against VEGF or VEGFR, soluble VEGFR/VEGFR hybrids, and tyrosine kinase inhibitors. (wikipedia.org)
  • This induction was also inhibited by a tyrosine kinase inhibitor, tyrphostin RG-50864, suggesting the role of receptor tyrosine kinase activation in this process. (jneurosci.org)
  • The American Association of Cancer Research (AACR) developed the multiplex immunoassay that helped in the examination of acquired resistance to receptor tyrosine kinase (RTK) inhibitors. (alliedmarketresearch.com)
  • Although tyrosine kinase inhibitors (TKIs) are effective in treating chronic myeloid leukemia (CML), they often fail to eradicate the leukemia-initiating stem cells (LSCs), causing disease persistence and relapse. (lu.se)
  • However, its proliferation was significantly decreased by the treatment of steroid sulfatase or aromatase inhibitors. (scirp.org)
  • We evaluated the effects of STS inhibitor and aromatase inhibitors on the proliferation of estrogen-dependent endometrial cancer cells. (scirp.org)
  • Angiogenesis inhibitors are also used to effectively treat macular degeneration in the eye, and other diseases that involve a proliferation of blood vessels. (wikipedia.org)
  • In addition, their osteogenic differentiation potential was increased, and genes involved in cell adhesion, FGF-2 signalling, cell cycle, stemness, cell differentiation, and cell proliferation were upregulated, compared to that of the MSCs cultured on uncoated plates. (hindawi.com)
  • We demonstrate that UCN-01, at concentrations lower than those necessary to inhibit cancer cell growth, inhibit proliferation of human endothelial cells in vitro. (karger.com)
  • Supplementation of HA to the MSC culture supernatant resulted in an increased proliferation rate. (europa.eu)
  • In contrast, addition of the known HAS inhibitor 4-methylumbelliferone (4-MU) to MSC led to a reversible proliferation arrest. (europa.eu)
  • However, the therapeutic use of endogenous inhibitors has disadvantages. (wikipedia.org)
  • The most widely used VEGF pathway inhibitor on the market today is Bevacizumab. (wikipedia.org)
  • Taken together, our findings indicate that SS18-SSX-mediated attenuation of an EGR1-PTEN network regulates synovial sarcoma cell survival, and that HDAC inhibitor-mediated apoptosis operates at least in part through reactivation of this pathway. (nature.com)
  • Inhibitors of histone deacetylase (HDAC) restore the p53 pathway in neuroblastoma cells. (nature.com)
  • Akt also regulates the mammalian target of rapamycin (mTOR)-S6K-S6 pathway to control cell growth in response to growth factors and nutrients. (aacrjournals.org)
  • Furthermore, such approaches allow for predicting the Transforming Growth Factor b (TGF-b) pathway in quantities not yet measured. (lu.se)
  • Inhibitors of these enzymes have long been used to treat depression, certain other psychiatric and emotional disorders, and Parkinson's disease. (sciencedaily.com)
  • In experiments with mouse and human hair follicles, Angela M. Christiano, PhD, and colleagues found that drugs that inhibit the Janus kinase (JAK) family of enzymes promote rapid and robust hair growth when applied to the skin. (nextbigfuture.com)
  • Inhibiting a family of enzymes inside hair follicles that are suspended in a resting state restores hair growth, a new study from researchers at Columbia University Medical Center has found. (nextbigfuture.com)
  • Based on this specificity, the DKFZ team succeeded in synthesizing a highly specific HDAC10 inhibitor on the basis of an already known drug that does not selectively block HDAC enzymes. (dkfz.de)
  • Malnutrition results in a relative deficiency of enzymes, such as beta-glucuronidase inhibitor glucaro-1,4-lactone, that inhibit deconjugation of conjugated bilirubin. (medscape.com)
  • Endogenous inhibitors are often derived from the extracellular matrix or basement membrane proteins and function by interfering with endothelial cell formation and migration, endothelial tube morphogenesis, and down-regulation of genes expressed in endothelial cells. (wikipedia.org)
  • The extracellular matrix (ECM) provides structural and biochemical support to the surrounding cells, and it has been used as a coating substrate for cell culture. (hindawi.com)
  • Poly-L-lysine (PLL) of extracellular matrix proteins is a small natural homopolymer of the essential amino acid L-lysine that is used to coat culture substrates. (hindawi.com)
  • Since heparan sulfate-proteoglycan is a major component of the extracellular matrix of skeletal muscle, factors that are bound to this proteoglycan, such as basic fibroblast growth factor (bFGF), are in a strategic position for neuronal signaling. (jneurosci.org)
  • NV556 treatment in an in vitro 3D human liver Extracellular Matrix (ECM) cultured with a TGFβ1-activated human hepatic stellate cell line led to decreased collagen production. (lu.se)
  • Unlike embryonic stem cells, adult stem cells (MSCs) have a limited lifespan and stop proliferating during in vitro culture due to replicative senescence [ 8 ]. (hindawi.com)
  • The TMDU-led research team set out to investigate the effects of low oxygen conditions within the neural stem cell niche using a cell culture model of NSPCs isolated from the forebrains of embryonic mice. (news-medical.net)
  • The receptor for epidermal growth factor (EGFR) is overexpressed in many cancers. (aacrjournals.org)
  • On the contrary, EGR1 knockdown leads to a decrease in HDAC inhibitor-induced apoptosis. (nature.com)
  • Using a combination of gain- and loss-of-function approaches, we show that EGR1 modulation of PTEN contributes to HDAC inhibitor-induced apoptosis in synovial sarcoma. (nature.com)
  • UCN-01, a protein kinase C (PKC) inhibitor, induces growth arrest and apoptosis in cancer cells and was recently introduced in a phase I clinical trial. (karger.com)
  • In this study, we tested the effects of several potential inhibitors of microbial growth. (usda.gov)
  • This work shows that Ponatinib and BRAF dimer selective inhibitors will be useful in treating BRAF-dependent tumors. (nature.com)
  • Scientists from the German Cancer Research Center (DKFZ) have now for the first time synthesized a highly selective inhibitor that can be used to study the function of HDAC10. (dkfz.de)
  • An angiogenesis inhibitor is a substance that inhibits the growth of new blood vessels (angiogenesis). (wikipedia.org)
  • More work needs to be done to test if JAK inhibitors can induce hair growth in humans using formulations specially made for the scalp. (nextbigfuture.com)
  • It's likely that the drugs act on the same pathways in human follicles as they do in mice, suggesting they could induce new hair growth and extend the growth of existing hairs in humans. (nextbigfuture.com)
  • Several forms of hair loss in humans are characterized by the inability of hair follicles to enter the growth phase (anagen) of the hair cycle after being arrested in the resting phase (telogen). (nextbigfuture.com)
  • Considering that intratumoral estrogen metabolism plays an important role, our co-culture systems provide an environment similar to that of the tumor in living patients in terms of metabolism and synthesis of intratumoral estrogens. (scirp.org)
  • Conversely, SC-58125 had no effect on HCT-116 implants in nude mice or colony formation in culture. (nih.gov)
  • Conversely, blocking VEGF-A with a drug inhibitor diminished the increase in neurosphere formation under low oxygen conditions. (news-medical.net)
  • Conversely, technological development of automated immuno-oncology assay is projected to create lucrative opportunities for the market growth during the forecast period. (alliedmarketresearch.com)
  • PD 0325901 is a potent MKK1 (MEK1) and MKK2 (MEK2) inhibitor. (sigmaaldrich.com)
  • In addition to dietary treatment, some advise the use of NTBC, which is a highly potent inhibitor of the enzyme 4-hydroxyphenylpyruvate dioxygenase. (medscape.com)
  • Highly potent reversible inhibitor of the enzyme 4-hydroxyphenylpyruvate dioxygenase. (medscape.com)
  • We investigated the antifibrotic effect of NV556, a novel potent sanglifehrin-based cyclophilin inhibitor in vitro and in vivo. (lu.se)
  • Treatment with the novel cyclophilin inhibitor NV651, presented a potent antiproliferative effect in HCC cell lines via cell cycle perturbations arresting cells in the mitotic phase. (lu.se)
  • The Na+/H+ exchanger-1 (NHE1) supports tumour growth, making NHE1 inhibitors of interest in anticancer therapy, yet their molecular effects are incompletely characterized. (ku.dk)
  • In addition, NV651 decreased tumour growth in xenograft-mouse model. (lu.se)
  • Meriolin 3 potently inhibits tumor growth in two mouse xenograft cancer models, namely, Ewing's sarcoma and LS174T colorectal carcinoma. (rcsb.org)
  • Endogenous inhibitors are attractive targets for cancer therapy because they are less toxic and less likely to lead to drug resistance than some exogenous inhibitors. (wikipedia.org)
  • A new study shows that an enzyme involved in appropriately repressing sets of neuronal genes in non-neuronal cells is also a target for certain monoamine oxidase inhibitors used to treat depression. (sciencedaily.com)
  • Now, in a study published online today in the June 26 issue of Chemistry & Biology, Shiekhattar and his team show that the enzyme is itself a target for certain monoamine oxidase inhibitors used to treat depression. (sciencedaily.com)
  • Inhibitors of that second enzyme are currently in clinical trails as cancer therapies. (sciencedaily.com)
  • Because the primary role of the enzyme is to repress sets of related genes, many other areas of potential influence for the monoamine oxidase inhibitors are possible too, according to Shiekhattar. (sciencedaily.com)
  • Although histone deacetylase (HDAC) inhibitors are known to suppress synovial sarcoma in vitro and in vivo , the exact mechanism is not clear. (nature.com)
  • In vitro, tenocyte-like cells extracted from the rotator cuff were able to mineralize in osteogenic cultures, and expressed , , and , which are hypertrophic chondrocytes markers. (iasp-pain.org)
  • Biochemical data consistently demonstrated that αC-IN inhibitors are more effective in inhibiting dimeric RAF activity compared to αC-OUT inhibitors 11 , 12 . (nature.com)
  • The results of this study may aid in achieving improved clinical responses from patients treated with STS inhibitors. (scirp.org)
  • Numerous compounds have been found to decrease the levels of cystine in cultured cells, but only a few were proven effective in clinical trials. (medscape.com)
  • In addition, fascial fibroblasts express transforming growth factor-beta I and connective-tissue growth factor mRNA, which may account for the clinical fibrosis. (medscape.com)
  • In addition, assessment of anti-FVIII antibody levels has the potential to improve inhibitor surveillance and clinical decision-making related to the progress of ITI. (cdc.gov)
  • 2006). Anticancer activities of histone deacetylase inhibitors. (nature.com)
  • Estrogen receptor and steroid sulfatase mRNA levels in cancer cells were significantly higher in the co-cultures compared with the monocultures of endometrial cancer cells. (scirp.org)
  • The SS18-SSX oncoprotein, characteristic of synovial sarcoma, maintains EGR1 expression at low levels, whereas it is significantly increased after HDAC inhibitor treatment. (nature.com)
  • When the research team added VEGF-A to the NSPC cultures, neurosphere formation was significantly increased. (news-medical.net)
  • Next we examined the effects of steroid sulfatase inhibitor and aromatase inhibitor in monoculture of endometrial cancer cell line (Ishikawa) and in a co-culture system involving an Ishikawa cells and stromal cells. (scirp.org)
  • Estradiol and androstenediol concentrations were also significantly higher in the co-cultured cells. (scirp.org)
  • Cancer and non-cancer cells were grown as 3-dimensional (3D) spheroids and treated with pyrazinoylguanidine-type (amiloride, 5-(N-ethyl-N-isopropyl)-amiloride (EIPA), 5-(N,N-dimethyl)-amiloride (DMA), and 5-(N,N-hexamethylene)-amiloride (HMA)) or benzoylguanidine-type (eniporide, cariporide) NHE1 inhibitors for 2-7 days, followed by analyses of viability, compound accumulation, and stress- and death-associated signalling. (ku.dk)
  • Specifically, tumor cells release various pro-angiogenic paracrine factors (including angiogenin, vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF), and transforming growth factor-β (TGF-β). (wikipedia.org)
  • SC-58125 also inhibited colony formation of cultured HCA-7 cells. (nih.gov)
  • Cellular senescence refers to active cells that eventually enter a state of irreversible growth arrest. (hindawi.com)
  • Our results demonstrate that tumor growth, peritoneal dissemination and peritoneum or organ metastasis implanted MKN45 cells were significantly decreased in shAhR and Biseugenol-treated mice and that endoplasmic reticulum (ER) stress was caused. (oncotarget.com)
  • They cultured these cells into neurospheres, or free-floating stem cell clusters, under low-oxygen and normal-oxygen conditions. (news-medical.net)
  • Removing the acetyl group makes the polyamines usable by tumor cells, which rely on these compounds for growth," said Raphael Steimbach, lead author of the study, explaining a newly discovered function of HDAC10. (dkfz.de)
  • R.I. FRESHNEY: "Culture of Animal Cells: A Manual of Basic Technique", 1987, ALAN R. LISS, INC. (sumobrain.com)
  • For instance, xMAP multiplex assay provides a platform for cancer biomarker assays, which are compatible with plasma, serum, cultured cells, and other biological samples. (alliedmarketresearch.com)
  • Long-term culture initiating cell assay showed that the mesenchymal stem cells from patients with CML displayed an enhanced supporting capacity for normal and CML BM CD34 + CD38 - cells. (lu.se)
  • Ultra-sensitive Histamine ELISA kit enabling detection of Histamine in serum, plasma, urine, and tissue culture media in just 2.5 hours. (enzolifesciences.com)
  • Other studies have shown elevated serum levels of manganese superoxide dismutase and tissue inhibitor of metalloproteinase (TIMP-1). (medscape.com)
  • 2. Virkon and tissue culture hood with UV-light. (lu.se)
  • 3. 15-cm tissue culture-treated plastic dishes. (lu.se)
  • To test this idea, we applied bFGF to cultured Xenopus spinal cord neurons and monitored the change in intracellular Ca2+ level with fura-2 ratio imaging. (jneurosci.org)
  • reseeded for the progenitor expansion phase at D12 and D19 in neural stem cell culture media with EGF and bFGF, and finally at D26 for neural differentiation with neurogenic/neurotrophic factors BDNF, GDNF, NT3, and cAMP. (nih.gov)
  • In this study, we report a central role of the transcription factor, early growth response-1 (EGR1), in the regulation of HDAC inhibitor-induced apoptotic cell death in synovial sarcoma. (nature.com)
  • Christiano and her colleagues serendipitously discovered the effect of JAK inhibitors have on hair follicles when they were studying alopecia areata, a form of hair loss that's caused by an autoimmune attack on the hair follicles. (nextbigfuture.com)
  • To further analyze neurotrophin regulation of growth cone behaviors, we examined the role of p75 NTR in regulating filopodial dynamics in peripheral and CNS neurons. (jneurosci.org)
  • We also work closely with farmers on controlling inhibitors which prevent the growth of bacteria and cultures, hindering the fermentation process. (danone.de)
  • Utilizing Free Fatty Acids as Bacteria Inhibitors: Recently a strain of antibiotic resistant bacteria contaminated a common eye drop brand. (hputx.edu)
  • This project will study free fatty acids (FFA's) have the ability to inhibit the growth of common bacteria in preservative free eye drops. (hputx.edu)
  • Calcific deposits were composed of apatite crystals associated with proteins involved in bone and cartilage development and endochondral bone growth. (iasp-pain.org)
  • It is a procedure in which various analytes such as proteins, biomolecules, growth factors, cytokines, and chemokines are profiled by detecting and quantifying them simultaneously. (alliedmarketresearch.com)
  • Currently, angiogenesis inhibitors are recognized for their improvement of cancer immunotherapy by overcoming endothelial cell anergy. (wikipedia.org)
  • Meriolins display better antiproliferative and proapoptotic properties in human tumor cell cultures than their parent molecules, meridianins and variolins. (rcsb.org)
  • We report that, in addition to direct inhibitory effects on endothelial cell growth, UCN-01 abrogates hypoxia-mediated transactivation of HIF-1-responsive promoters in a prostate cancer cell line. (karger.com)
  • Herein, we sought to determine if rapamycin, an inhibitor of mTOR, could enhance erlotinib sensitivity for cell lines derived from a variety of tissue types (non-small-cell lung, pancreatic, colon, and breast). (aacrjournals.org)
  • To generate single cell suspensions, hESC-derived cultures were dissociated from plates using Accutase (ThermoFisher) at 37°C. Light trituration using a P1000 pipette was done every 5 min until nearly all clumps had been dissociated (up to 1 h). (nih.gov)
  • Skills learned will be common laboratory techniques, cell cultures and microscopic imaging. (hputx.edu)
  • Optimized cell-based assays deliver crucial information to confirm the efficiency of a drug or a compound in simple and progressively complex co-culture assays. (alliedmarketresearch.com)
  • Genes required for degradation of and growth on the carbon source pectin were down-regulated, whereas transcripts involved in redox processes were up-regulated. (frontiersin.org)
  • Of 60 blood cultures positive for Gram-positive cocci in clusters, LAMP (via detection of the Fem A and Mec A genes) showed 100% sensitivity and specificity for identification of MRSA/MSSA. (who.int)
  • However, drug resistance to these inhibitors is developed resulting in only short-term improvement of patients' survival 15 . (nature.com)
  • A 4-mo regimen of isoniazid and rifampin is acceptable therapy for adults who have active tuberculosis and who are sputum-smear and culture negative, if there is little possibility of drug resistance (see Section 1 above). (cdc.gov)
  • should not be cultured from sites where they are part of the normal flora because differentiation of pathogens from normal flora may be impossible. (msdmanuals.com)
  • While angiogenesis is a critical part of wound healing and other favorable processes, certain types of angiogenesis are associated with the growth of malignant tumors. (wikipedia.org)
  • We found that the potential for formation of bacterial lipopeptide syringomycin resulted in stronger growth reduction effects on saprophytic Aspergillus nidulans compared to Verticillium spp. (frontiersin.org)
  • Some fungi, particularly molds (eg, Aspergillus species), usually cannot be cultured from blood. (msdmanuals.com)
  • ABSTRACT We evaluated the utility of 2 methods for detection of methicillin-resistant Staphylococcus aureus (MRSA) directly from signal-positive blood culture bottles: loop-mediated isothermal amplification (LAMP) assay, and direct cefoxitin disk diffusion (DCDD) test using a 30 g cefoxitin disk. (who.int)
  • The immuno-oncology assay market is witnessing significant growth, owing to increase in R&D activities in pharmaceuticals for the treatment of cancer. (alliedmarketresearch.com)
  • In addition, they offer easier & faster analysis of cancer, and are automated as compared to conventional methods, thus fueling the immune-oncology assay market growth. (alliedmarketresearch.com)
  • The effects of different fluorescent pseudomonads, including some known biocontrol agents of other plant pathogens, on fungal growth of the haploid Verticillium dahliae and/or the amphidiploid Verticillium longisporum were compared on pectin-rich medium, in microfluidic interaction channels, allowing visualization of single hyphae, or on Arabidopsis thaliana roots. (frontiersin.org)
  • Results showed that when tested against pure and mixed cultures of some hardy opportunistic bacterial pathogens, the free and glycerol-bound forms of the natural fatty acid lauric acid were most inhibitory. (usda.gov)
  • We also assessed the biological effects of inhibitors of steroid sulfatase and aromatase in the co-culture system compared with usual monocultures. (scirp.org)
  • My research focus is on gaining an understanding of the unique and redundant biological function and properties of the three transforming growth factor beta (TGFβ) ligands and their signaling mechanisms in cardiovascular development and homeostasis and in disease pathogenesis. (sc.edu)
  • In the literature this growth arrest was so far described being caused by the depletion of one of the two uridine diphosphate (UDP) precursor sugars needed for HA synthesis. (europa.eu)
  • An imbalance in the structural and signaling properties of β-catenin often leads to disease and unregulated growth associated with cancer and metastasis. (chemdiv.com)
  • Growth cone behaviors change in a region-specific manner as axons extend to their targets ( Mason and Erskine, 2000 ), suggesting that guidance cues regulate growth cone motility. (jneurosci.org)
  • The growth of bone and cartilage may be affected in children. (who.int)
  • Thus angiogenesis inhibitors have been closely studied for possible cancer treatment. (wikipedia.org)
  • When the researchers looked more closely at normal mouse hair follicles, they found that JAK inhibitors rapidly awakened resting follicles out of dormancy. (nextbigfuture.com)
  • Little to no hair growth occurred in control mice during the same timeframe (left photo). (nextbigfuture.com)
  • Mice treated for five days with one of two JAK inhibitors sprouted new hair within 10 days, greatly accelerating the onset of hair growth. (nextbigfuture.com)
  • The drugs also produce longer hair from human hair follicles grown in culture and on skin grafted onto mice. (nextbigfuture.com)
  • Furthermore, retinal and dorsal root ganglion growth cones from p75 mutant mice are insensitive to neurotrophins but display enhanced filopodial lengths comparable with neurotrophin-treated wild-type growth cones. (jneurosci.org)
  • Bypassing agents (BPA), a class of therapeutics given to patients who have inhibitors, bypass the need for FVIII in the coagulation cascade, and long-term inhibitor eradication is accomplished using immune tolerance induction therapy (ITI). (cdc.gov)
  • This suggested JAK inhibitors might be doing something to the hair follicles in addition to stopping the immune attack. (nextbigfuture.com)
  • [ 2 ] One report described eosinophilic fasciitis in association with the immune checkpoint inhibitor cemiplimab. (medscape.com)
  • The specimen must be transported rapidly, in the correct medium, and in conditions that limit growth of any potentially contaminating normal flora. (msdmanuals.com)
  • Some angiogenesis inhibitors are endogenous and a normal part of the body's control and others are obtained exogenously through pharmaceutical drugs or diet. (wikipedia.org)
  • Angiogenesis inhibitors were once thought to have potential as a "silver bullet" treatment applicable to many types of cancer, but the limitations of anti-angiogenic therapy have been shown in practice. (wikipedia.org)
  • Angiogenesis is regulated by the activity of endogenous stimulators and inhibitors. (wikipedia.org)
  • During tumor growth, the action of angiogenesis stimulators surpasses the control of angiogenesis inhibitors, allowing for unregulated or less regulated blood vessel growth and formation. (wikipedia.org)
  • The researchers evaluated a protein called vascular endothelial growth factor -A (VEGF-A) as a potential candidate. (news-medical.net)
  • The miRIDIAN microRNA Hairpin Inhibitor Library is a complete collection of microRNA inhibitors arrayed in 96-well plates to allow high-throughput phenotypic screening applications in human, mouse, or rat. (horizondiscovery.com)
  • miRIDIAN microRNA Hairpin Inhibitor libraries contain microRNA inhibitors for every human, mouse, and rat microRNA in the miRBase sequence database v 21.0 Successful microRNA phenotypic screening requires best-in-class reagents to minimize false or misleading effects and achieve high-confidence data. (horizondiscovery.com)
  • Prominent among the effective drugs is cysteamine, which has been shown to decrease the tissue levels of cystine, delay the progression of renal disease, and improve linear growth, particularly when treatment is started in children younger than 2 years. (medscape.com)