• Characteristics of cultured desmoid cells with different CTNNB1 mutation status. (dtrf.org)
  • Circulating tumour cells (CTCs) can be assessed through a minimally invasive blood sample with potential utility as a predictive, prognostic and pharmacodynamic biomarker. (nature.com)
  • Melanoma tumour cells exhibit pronounced heterogeneity within a single tumour, amongst concurrent tumours within the same patient and amongst tumours from different patients. (nature.com)
  • Circulating tumour cells (CTCs), which are responsible for haematogenous spread of tumours, also reflect this heterogeneity. (nature.com)
  • TAK-285 was examined in a model of breast cancer brain metastasis using direct intracranial injection of BT-474-derived luciferase-expressing cells and showed greater inhibition of brain tumor growth compared to animals treated with lapatinib. (jcancer.org)
  • Tumor tissue or cells can be implanted into the specific orthotopic sites of the mice. (stanford.edu)
  • This is a useful method for cells that lose proliferative capacity after being cultured in plates. (stanford.edu)
  • Tumor cells can be cultured by our staff in preparation for in vivo studies. (stanford.edu)
  • Bone tumors may be classified as "primary tumors", which originate in bone or from bone-derived cells and tissues, and "secondary tumors" which originate in other sites and spread (metastasize) to the skeleton. (wikipedia.org)
  • In cultured keratinocytes, CWO stimulated calcium signaling, resulting in calcineurin-dependent activation of nuclear factor of activated T cells (NFAT). (biorxiv.org)
  • Treatment of syngeneic tumors resulted in CD8 and PD-L1-dependent tumor rejection or growth inhibition and a reduction in myeloid cells endogenously expressing high levels of PD-L1. (elifesciences.org)
  • T cell-based immunotherapy, such as immune checkpoint blockade or adoptive T cell transfer, is limited by the ability of T cells to detect major histocompatibility complex (MHC)-presented antigen by tumor cells. (elifesciences.org)
  • Glioma is the most frequent primary central nerve tumor, which originates from glial progenitor cells [ 1 ]. (hindawi.com)
  • Using mouse models, we validated the metastatic potential of tumor clusters was higher than single cells in vivo . (jcancer.org)
  • Metastatic spread is responsible for the majority of cancer-associated deaths and is affected by a variety of factors, including the deregulation of gene expression, signal transduction, and epigenetic modification, as well as epithelial-to-mesenchymal transition (EMT) and the transformation of tumor cells into stem/progenitor cells. (jcancer.org)
  • In addition to these four pathways, tumors can undergo infiltration around nerve fibers and metastasis along nerves, that is, perineural invasion (PNI), which refers to the phenomenon of perineural invasion by tumor cells filling the perineurial space, wrapping around nerves in a continuous concentric sheath-like pattern, infiltration, and metastasis of extension along nerves around nerve fibers or into perineurium within the perineurium [ 7 ]. (hindawi.com)
  • We explored molecular markers shared between TDEs and circulating tumor cells (CTCs) in the blood of cancer patients to identify candidate genes involved in CRC metastasis. (researchsquare.com)
  • Tumor-derived EV modulates cellular activities in recipient cells by transferring genetic information from cancer cells. (researchsquare.com)
  • Exploring Tumor-Immune Interactions in Co-Culture Models of T Cells and Tumor Organoids Derived from Patients. (bvsalud.org)
  • The use of patient -derived tumor tissues and cells has led to significant advances in personalized cancer therapy and precision medicine . (bvsalud.org)
  • The three-dimensional tumor organoids derived from self -organizing cancer stem cells are valuable ex vivo models that faithfully replicate the structure, unique features, and genetic characteristics of tumors . (bvsalud.org)
  • However, a major limitation of this emerging technology is the absence of a tumor microenvironment that includes immune and stromal cells . (bvsalud.org)
  • The therapeutic efficacy of immune checkpoint inhibitors has underscored the importance of immune cells , particularly cytotoxic T cells that infiltrate the vicinity of tumors , in patient prognosis . (bvsalud.org)
  • To address this limitation, co-culture techniques combining tumor organoids and T cells have been developed, offering diverse avenues for studying individualized drug responsiveness. (bvsalud.org)
  • By integrating cellular components of the tumor microenvironment , including T cells , into tumor organoid cultures , immuno-oncology has embraced this technology , which is rapidly advancing. (bvsalud.org)
  • In the present study, we demonstrate that following exposure to plasma from diabetic patients, the human promonocytic cell line U937 exhibits a significant elevation in core 2 GlcNAc-T activity and increased adherence to cultured retinal capillary endothelial cells. (diabetesjournals.org)
  • The aim of the present study was to investigate whether other cytotoxic metals could be handled by MRPI using MRP1-overexpressing lung tumor GLC4/Sb30 cells. (nih.gov)
  • Human glioma cell lines, U373 and U251 cells, were purchased from the China Academia Sinica Cell Repository (Shanghai, China) and cultured in Dulbecco's Modified Eagle Medium (Gibco) that contained 10% fetal bovine serum (Gibco). (scirp.org)
  • Consistent with this observation, primary tumor explants cultured in a randomly organized collagen matrix realigned the collagen fibers, allowing individual tumor cells to migrate out along radially aligned fibers. (biomedcentral.com)
  • The presentation of these tumor-associated collagen signatures allowed us to identify pre-palpable tumors and see cells at the tumor-stromal boundary invading into the stroma along radially aligned collagen fibers. (biomedcentral.com)
  • Organoids are cultured from stem cells within a 3D medium to provide a more physiologically relevant and realistic view of cellular interactions than can be seen with traditional 2D models. (corning.com)
  • Cancer/testis antigen MAGEC2 (also known as HCA587) is highly expressed in a wide variety of tumors and plays an active role in promoting growth and metastasis of tumor cells. (biomedcentral.com)
  • Co-immunoprecipitation assay was applied for detecting the endogenous interaction of MAGEC2 and TRIM28 in tumor cells. (biomedcentral.com)
  • We demonstrate that MAGEC2 interacts with TRIM28 in melanoma cells and MAGEC2 expression in tumor cells depends on the expression of TRIM28. (biomedcentral.com)
  • The expression level of MAGEC2 protein was significantly reduced when TRIM28 was depleted in tumor cells, and no changes were observed in MAGEC2 mRNA level. (biomedcentral.com)
  • Mechanistic studies indicate that the regulatory role of TRIM28 on MAGEC2 protein expression in tumor cells depends on proteasome-mediated pathway. (biomedcentral.com)
  • In this study, we found that expression of MAGEC2 protein in tumor cells depends on the expression of TRIM28, a reduction in the level of endogenous TRIM28 expression in melanoma cells resulting in significantly decreased expression of MAGEC2 protein. (biomedcentral.com)
  • As has often been the case, hematologic malignancies have led the way in the introduction of this new generation of therapeutics-perhaps because of easy access to tumor samples for pharmacodynamics, and the narrow spectrum of cells of origin. (cancernetwork.com)
  • Cigana C, Assael BM, Melotti P: Azithromycin selectively reduces tumor necrosis factor alpha levels in cystic fibrosis airway epithelial cells. (karger.com)
  • To investigate the chromosomal fragility, we researched by cytogenetic technique in the peripheral blood lymphocytes cultures and in the tumors cells cultures from canines presenting oral and cutaneous warts lesions. (fiocruz.br)
  • Tumors' mutations can encode the seeds of their own destruction, in the form of immunogenic peptides recognized by T cells. (the-scientist.com)
  • New monoclonal antibodies kill both cancer-promoting immunosuppressive cells and tumor cells in culture. (the-scientist.com)
  • Through similar mechanisms, amino acid depletion in culture and cytokine activity in the tumor microenvironment prompt cancer cells to metastasize. (the-scientist.com)
  • This technique has an advantage over routine culture conditions, as the development of cytokine product by individual cells can be localised and measured, which therefore allows for the correlation of cytokine production with cell type. (ersjournals.com)
  • In mice, a fatal brainstem tumor was cleared by injecting it with engineered T cells that recognized the cancer and targeted it for destruction. (stanford.edu)
  • Engineered human immune cells can vanquish a deadly pediatric brain tumor in a mouse model, a study from the Stanford University School of Medicine has demonstrated. (stanford.edu)
  • In mice whose brainstems were implanted with human DIPG, engineered immune cells known as chimeric antigen receptor T cells - or CAR-T cells - were able to eliminate tumors, leaving very few residual cancer cells. (stanford.edu)
  • We gave CAR-T cells intravenously, and they tracked to the brain and cleared the tumor. (stanford.edu)
  • To begin the research, the scientists screened human DIPG tumor cultures for surface molecules that could act as targets for CAR-T cells. (stanford.edu)
  • Crystal Mackall says she is encouraged that the work in mice showed that engineered immune cells called CAR-T cells were able to eradicate the tumors in mice. (stanford.edu)
  • In a dish, Mackall's CAR-T cells killed cultured DIPG cells that carry the H3K27M mutation. (stanford.edu)
  • If the cultured cells were genetically modified to stop expressing the target sugar, the CAR-T cells no longer worked. (stanford.edu)
  • Next, the team tested the GD2 CAR-T cells in mice whose brainstem was implanted with human DIPG tumors, an experimental system that Monje's lab pioneered. (stanford.edu)
  • Seven to eight weeks after the tumor was established, each mouse received one intravenous injection of GD2 CAR-T cells or, as a control treatment, an injection of CAR-T cells that react to a different target. (stanford.edu)
  • Anomalous reactions of mouse alloantisera with cultured tumor cells. (jax.org)
  • Chemotherapy uses drugs to target and kill cancer cells or to shrink tumors and allow a surgeon to use a less invasive procedure. (medicalnewstoday.com)
  • well as cytologic study for tumour cells. (who.int)
  • Objective: We developed a novel, streamlined protocol for generating chondrocytes from bone marrow-derived mesenchymal stem cells (BMSCs) in a 3D culture system that offers. (lu.se)
  • Objective: We developed a novel, streamlined protocol for generating chondrocytes from bone marrow-derived mesenchymal stem cells (BMSCs) in a 3D culture system that offers significant implications for the study of cartilage biology and the discovery of potential therapeutic interventions for cartilage-related and associated disorders. (lu.se)
  • We found that the three Id proteins expressed in neuroblastoma cells (Id1, Id2, and Id3) were down-regulated during induced differentiation, indicating that Id proteins help keep the tumor cells in an undifferentiated state. (lu.se)
  • Matrix metalloproteases (MMPs) are zinc-dependent proteinases that participate in extracellular matrix degradation 1-3 and favor the invasion and proliferation of tumor cells 4 . (bvsalud.org)
  • Tumor necrosis factor (TNF), the first pro-inflammatory cytokine to be released by an inflammatory response, suppresses the translation of the key enzyme of melatonin synthesis (arylalkylamine- N -acetyltransferase, Aanat ). (frontiersin.org)
  • These effects of diabetic plasma on enzyme activity and cell adhesion, mediated by PKCβ2-dependent phosphorylation of the core 2 GlcNAc-T protein, were found to be triggered by increased plasma levels of tumor necrosis factor (TNF)-α. (diabetesjournals.org)
  • The effects of the two macrolides on tumor necrosis factor-α (TNF-α) release were also examined. (karger.com)
  • Tumour necrosis factor (TNF)-α is thought to be a key early cytokine in the pathogenesis of sarcoidosis, despite conflicting data. (ersjournals.com)
  • This study has demonstrated that a subset of mononuclear phagocytes, mature macrophages, are responsible for tumour necrosis factor secretion and this could have implications for targeted management in sarcoidosis in the future. (ersjournals.com)
  • Tumour necrosis factor (TNF)-α is a key early cytokine in a variety of chronic inflammatory responses, including fibrosing alveolitis and granulomatous disease 6 - 8 . (ersjournals.com)
  • The chondrocytes exhibited reduced inflammation, as evidenced by the decreased tumor necrosis factor-α levels, in response to vitamin D, curcumin, and resveratrol treatment. (lu.se)
  • A bone tumor is an abnormal growth of tissue in bone, traditionally classified as noncancerous (benign) or cancerous (malignant). (wikipedia.org)
  • Bone tumors are traditionally classified as noncancerous (benign) or cancerous (malignant). (wikipedia.org)
  • Secondary malignant bone tumors are estimated to be 50 to 100 times as common as primary bone cancers. (wikipedia.org)
  • The most common locations for many primary tumors, both benign and malignant include the distal femur and proximal tibia (around the knee joint). (wikipedia.org)
  • While malignant fibrous histiocytoma (MFH) - now generally called "pleomorphic undifferentiated sarcoma" - primary in bone is known to occur occasionally, current paradigms tend to consider MFH a wastebasket diagnosis, and the current trend is toward using specialized studies (i.e. genetic and immunohistochemical tests) to classify these undifferentiated tumors into other tumor classes. (wikipedia.org)
  • Daily topical treatment with CWO induced dramatic regression of pre-malignant skin tumors and a two-fold reduction in cutaneous squamous cell carcinomas. (biorxiv.org)
  • World Health Organization (WHO) grade IV glioma, which includes glioblastoma multiform (GBM), is a highly invasive and fatal malignant tumor [1]. (scirp.org)
  • These results indicate that ERBB inhibition should be considered for blocking other tumor cell malignant properties besides growth. (aacrjournals.org)
  • There exists a dire need to improve treatments for malignant brain tumors. (mskcc.org)
  • Specifically, ERV-K members were originally identified due to their similarity to the Mouse Mammary Tumor Virus (MMTV) and are subdivided into ten so-called human MMTV-like clades (HML1-10) ( 2 , 3 ). (frontiersin.org)
  • Ma Z, Gibson SL, Byrne MA, Zhang J, White MF and Shaw LM (2006) Suppression of insulin receptor substrate 1 (IRS-1) promotes mammary tumor metastasis. (scielo.br)
  • As little is known about epithelial-stromal interactions in vivo, it is necessary to visualize the stroma surrounding normal epithelium and mammary tumors in intact tissues to better understand how matrix organization, density, and composition affect tumor formation and progression. (biomedcentral.com)
  • Epithelial-stromal interactions in normal mammary glands, mammary tumors, and tumor explants in three-dimensional culture were studied with histology, electron microscopy, and nonlinear optical imaging methodologies. (biomedcentral.com)
  • We used both laser-scanning multiphoton and second harmonic generation microscopy to determine the organization of specific collagen structures around ducts and tumors in intact, unfixed and unsectioned mammary glands. (biomedcentral.com)
  • One important step to elucidating these signaling interactions is to determine the organization of the collagenous stroma surrounding both normal mammary glands and tumors within intact tissue so as to better understand the cell-matrix interaction and how matrix organization, density, and composition affect tumor formation and progression. (biomedcentral.com)
  • Using in vivo mouse models of breast cancer, we test the effects of ERBB1 and ERBB2 inhibitors AC480 and lapatinib, ERBB1 inhibitor gefitinib, and ERBB2 inhibitor AG825 on in vivo tumor cell invasive properties in mammary fat pad tumors. (aacrjournals.org)
  • Circulating tumour DNA (ctDNA) from the same patient blood sample, was assessed by ddPCR targeting tumour-specific mutations. (nature.com)
  • We describe areas where major inroads were initially achieved by targeting angiogenesis and by unraveling pathways in the heterogeneous tumors of mesenchymal origin-spurred by the identification of c-Kit-activating mutations in GIST and the regressions that ensued when tumors harboring these mutations were exposed to the tyrosine kinase inhibitor imatinib (Gleevec). (cancernetwork.com)
  • Here, in Part I, we describe areas where major inroads were initially achieved by targeting angiogenesis (central to the biology of renal cell carcinoma and hepatocellular cancer) and by unraveling pathways in the heterogeneous tumors of mesenchymal origin-spurred by the identification of c-Kit-activating mutations in gastrointestinal stromal tumors (GIST) and the regressions that ensued when tumors harboring these mutations were exposed to the tyrosine kinase inhibitor imatinib (Gleevec). (cancernetwork.com)
  • This study supports ERV-K env as a single prognostic indicator for better survival of RCC, which we propose represents a new tumor antigen. (frontiersin.org)
  • Viral cultures from throat, stool samples, and antigen detection for herpes and respiratory viruses are recommended during the first week. (medscape.com)
  • Treatment of xenograft tumors resulted in PD-L1-dependent tumor growth inhibition. (elifesciences.org)
  • In comparing the clinicopathological features of 451 IMPC patients and 282 IDC-NST patients, our results showed that tumor emboli were significantly higher in IMPC patients and were associated with a high frequency of metastasis. (jcancer.org)
  • Infiltration versus metastasis is one of the most characteristic biological properties of tumors [ 5 ]. (hindawi.com)
  • Generally, it is believed that there are four main pathways between tumor invasion and metastasis, including local invasion, blood, lymphatic, and seeding metastasis [ 6 ]. (hindawi.com)
  • Overexpression of tumor markers in Extracellular vesicles (EV), especially in tumor-derived exosomes (TDEs), is implicated in metastasis. (researchsquare.com)
  • Tumors are generated from human tumor cell lines or tissues, then dissected and digested using an enzyme cocktail of DNase I (Sigma 10104159001), trypsin inhibitor (Sigma T9253-5G), and papain (Worthington LS003126) into a single cell suspension. (stanford.edu)
  • As such, TACS should provide indications that a tumor is, or could become, invasive, and may serve as part of a strategy to help identify and characterize breast tumors in animal and human tissues. (biomedcentral.com)
  • Breast cancer is one of the most common primary tumors to develop associated brain metastases ( 1 , 2 ), and while recent progress in cancer therapy has improved control of primary breast tumors, methods to effectively treat brain metastases from breast cancer remain inadequate. (jcancer.org)
  • Sixteen histological tumor subtypes exist and the most common are papillary, chromophobe and clear cell renal cell carcinoma (ccRCC) representing 85% of all RCC. (frontiersin.org)
  • In this investigation a human RCC tissue microarray (TMA) (n=374) predominantly consisting of the most common histological tumor subtypes was hybridized with an ERV-K env antibody and correlated with patient clinical data. (frontiersin.org)
  • PDGFA and RAF1 mRNA are higher in CSC-EXOs than in HT-29-EXOs, which correlates with higher expression in CSC than the primary tumor. (researchsquare.com)
  • We tested an essential-oil derivative, camphor white oil (CWO), for anti-tumor activity in a mouse model of keratinocyte-derived skin cancer. (biorxiv.org)
  • Imaging of the tumor-stromal interface in live tumor tissue ex vivo was performed with multiphoton laser-scanning microscopy (MPLSM) to generate multiphoton excitation (MPE) of endogenous fluorophores and second harmonic generation (SHG) to image stromal collagen. (biomedcentral.com)
  • The presence of an inflamed disk (discitis) can help distinguish an abscess from a metastatic tumor. (msdmanuals.com)
  • This newer classification categorises bone tumors into cartilage tumors, osteogenic tumors, fibrogenic tumors, vascular tumors of bone, osteoclastic giant cell-rich tumors, notochordal tumors, other mesenchymal tumors of bone, and hematopoietic neoplasms of bone. (wikipedia.org)
  • We sequenced the coding regions surrounding YXXM motifs of IRS1 using tumor samples of 42 NSCLC patients and 40 matching controls and found heterozygote p.S668T mutation in nine of 42 samples and four of nine also had the p.D674H mutation. (scielo.br)
  • On the basis of these preclinical data, the ADC SAR408701 is a promising candidate for development as a potential treatment for patients with CEACAM5-positive tumors. (nih.gov)
  • With the development of tumor molecular heterogeneity theory(12), there are still some patients with GIST who are sensitive to radiotherapy, especially for the patients with advanced stage(13-16).In addition, with the development of imaging technology and modern tissue and organ radiation technology, it has become a reality to concentrate high-dose radiation locally in abdominal cavity tumors(12), which challenges RT's insensitivity to GISTs. (researchsquare.com)
  • Pleural fluid analysis biopsy and lavage has increased the diag- was performed for protein concentration, nostic rate, the cause for many patients with lactic dehydrogenase (LDH), cultures, as exudative PE remains unknown or obscure. (who.int)
  • All patients with encephalitis should have blood cultures to rule out bacterial and fungal infections. (medscape.com)
  • The issue of truth-telling is still approached differently in different countries and cultures and there is a need for an increased awareness of cultural differences to truth-telling among patients from ethnic minorities. (who.int)
  • RÉSUMÉ Un des dilemmes éthiques les plus difficiles auxquels sont confrontés les professionnels de la santé qui travaillent dans le domaine de la cancérologie est de définir s'il faut annoncer le diagnostic et le pronostic aux patients atteints d'un cancer en phase terminale, et à quel moment, de quelle manière et dans quelle mesure leur en parler. (who.int)
  • Le fait de dire la vérité ou non est abordé de manière différente en fonction des pays et des cultures, et une plus grande conscience des différences culturelles est nécessaire avant de dire la vérité aux patients issus de minorités ethniques. (who.int)
  • In vivo , CWO induced transcriptional changes in immune-related genes, resulting in cytotoxic T cell-dependent tumor regression. (biorxiv.org)
  • As such, CEACAM5 is an attractive target for antibody-based therapies designed to selectively deliver cytotoxic drugs to certain epithelial tumors. (nih.gov)
  • The cytotoxic activity of SAR408701 was assessed in CEACAM5-expressing tumor cell lines and using patient-derived xenograft mouse models of CEACAM5-positive tumors. (nih.gov)
  • Subsequently, we used a model of neuroinvasion in nude mice to assess the effect of NGF in vivo on tumor nerve invasion as well as on nociceptive transmission. (hindawi.com)
  • In particular, local cell invasion was found predominantly to be oriented along certain aligned collagen fibers, suggesting that radial alignment of collagen fibers relative to tumors facilitates invasion. (biomedcentral.com)
  • Using gefitinib, ERBB1 inhibition rapidly inhibits tumor cell motility and invasion but not intravasation, whereas ERBB2 inhibition by AG825 rapidly blocks intravasation. (aacrjournals.org)
  • In addition, we differentiate for the first time the contributions of ERBB1 and ERBB2 to the key metastatic properties of in vivo tumor cell invasion and intravasation. (aacrjournals.org)
  • These experiments temporally and molecularly separate two key stages in tumor cell entry into blood vessels: invasion and intravasation. (aacrjournals.org)
  • Koontongkaew S, Monthanapisut P, Saensuk T: Inhibition of arachidonic acid metabolism decreases tumor cell invasion and matrix metalloproteinase expression. (karger.com)
  • citation needed] Primary tumors of bone can be divided into benign tumors and cancers. (wikipedia.org)
  • Some benign tumors are not true neoplasms, but rather, represent hamartomas, namely the osteochondroma. (wikipedia.org)
  • A 2-year interim analysis from the International Ovarian Tumor Analysis Phase 5 (IOTA5) study showed that 80% of ovarian cysts considered benign on ultrasonography either disappeared or required no intervention. (medscape.com)
  • One third of all ovarian tumors are serous, and two thirds of these serous tumors are benign. (medscape.com)
  • Of these tumors, 75% are benign and are found in women aged 30-50 years. (medscape.com)
  • Menounos, 39, shared her news with People magazine this week, revealing that she underwent a seven-hour surgery in June to remove a benign tumor the size of a golf ball. (huffpost.com)
  • Cystourethroscopy showed a 2-cm papillary tumor on the left superior aspect of the posterior wall of the bladder (Fig. 2). (medscape.com)
  • Intraoperative photograph through resectoscope demonstrates 2-cm papillary bladder tumor. (medscape.com)
  • Our studies were designed to evaluate the effect of ERBB inhibition on tumor cell motility and intravasation in vivo using clinically relevant small-molecule inhibitors. (aacrjournals.org)
  • ERBB1 and ERBB2 inhibition rapidly (within 3 h) inhibits both tumor cell motility and intravasation. (aacrjournals.org)
  • ERBB1 and ERBB2 inhibition can rapidly block tumor cell invasive properties. (aacrjournals.org)
  • Molecular features of these tumors have expanded our vision of tumorigenesis and progression and provided abundant specifically targeted pathways [ 5 ]. (hindawi.com)
  • As an important member of the miRNA family, miR-381-3p also mediates tumor progression. (hindawi.com)
  • SUMMARY BLURB Essential oil derived from the camphor tree acts by stimulating immune cell-dependent regression of skin tumors in a mouse model of cutaneous squamous cell carcinoma. (biorxiv.org)
  • Secondary bone tumors are metastatic lesions which have spread from other organs, most commonly carcinomas of the breast, lung, and prostate. (wikipedia.org)
  • Preoperative angiography is required for suspected aneurysms, while arteriography remains helpful in determining lesions responsible for pulsatile tinnitus, such as glomus tumors. (medscape.com)
  • In the studies analyzed, there was a significant positive immunoreactivity for metalloproteases in odontogenic lesions, particularly in keratocystic odontogenic tumors, a finding that may explain KCOT aggressiveness. (bvsalud.org)
  • Some studies about odontogenic cysts and tumors have been conducted to evaluate metalloprotease expression in these lesions. (bvsalud.org)
  • Growing tumors exist in metabolically compromised environments that require activation of multiple pathways to scavenge nutrients to support accelerated rates of growth. (jci.org)
  • A transurethral resection of the bladder tumor was done. (medscape.com)
  • The treatment of non-muscle-invasive bladder cancer (Ta, T1, carcinoma in situ [CIS]) begins with transurethral resection of bladder tumor (TURBT). (medscape.com)
  • Although epigenetically silenced, endogenous retroviral (ERV) genes become activated in tumors and function to ignite immune responses. (frontiersin.org)
  • Research has intensified to understand ERV protein function and their role as tumor antigens and targets for cancer (immune) therapy. (frontiersin.org)
  • For each cancer discussed in the first part of our overview, as well as in Part II, which will deal with more common cancers, we briefly cover the tumor biology, how targeting was achieved, the introduction of immune modulation or immune-conjugates, and the impact these therapies are having in the disease. (cancernetwork.com)
  • Now we need to quantify more protein biomarkers, assess the tumor mutational landscape, and examine immune cell signatures, too. (the-scientist.com)
  • The advent of genomic sequencing technologies has enabled the comprehensive analysis of tumor characteristics. (bvsalud.org)
  • By definition, serous tumors are characterized by a proliferation of epithelium resembling that lining the fallopian tubes. (medscape.com)
  • Tumor fragments from tumor growing in donor mice will be passaged to recepient mice. (stanford.edu)
  • Lack of lung tumor promotion after inhalation of a copper-nickel welding fume in A/J mice. (cdc.gov)
  • Our lab has previously demonstrated that stainless steel welding fumes promote lung tumors in tumor-susceptible A/J mice. (cdc.gov)
  • The aim of this study was to characterize a new copper-nickel (Cu-Ni) fume and then investigate if inhalation of this fume would promote lung tumors in mice using a two-stage (initiation-promotion) model. (cdc.gov)
  • At 30 weeks, mice were sacrificed and lung tumor multiplicity and incidence were evaluated. (cdc.gov)
  • The study , which was published online April 16 in Nature Medicine, represents the first time a severe human brainstem tumor, diffuse intrinsic pontine glioma, has been eradicated in mice. (stanford.edu)
  • They will insert a cutting tool into the bladder to remove small tumors and abnormal tissue. (medicalnewstoday.com)
  • Pathology of resected bladder tumor is shown under low-power microscopy. (medscape.com)
  • A Bladder Tumor in an 18-Year-Old Male - Medscape - Jan 01, 1998. (medscape.com)
  • In mouse and rat xenograft tumor models, TAK-285 showed antitumor activity against cancers that expressed HER2 or EGFR. (jcancer.org)
  • The situation with solid tumors is considerably more complex, and the evolution of targeted therapies for these cancers is still in its infancy. (cancernetwork.com)
  • The epidermal growth factor receptor family (ERBB) is overexpressed in a wide variety of tumor types and is correlated with poor prognosis. (aacrjournals.org)
  • Pain may increase with the growth of the tumor and may be worse at night and at rest. (wikipedia.org)
  • Consistent with the in vitro activities, frankincense essential oil was effective in inhibiting tumor growth and inducing tumor cell apoptosis in a human BC mouse model. (spandidos-publications.com)
  • Clinical studies using ERBB inhibitors have focused on tumor growth effects, but ERBBs can contribute to malignancy independent of their effects on tumor growth. (aacrjournals.org)
  • Moreover, in vivo studies confirm that the CTAC@MSNs-HSA are able to induce cancer cell death and efficiently inhibit tumor growth. (rsc.org)
  • It has also been shown that metformin and phenformin inhibit tumor growth by disrupting mitochondrial complex. (rsc.org)
  • In animal studies, we can often slow the growth of a tumor, shrink a tumor or prevent tumors from forming. (stanford.edu)
  • Excess expression of the sugar is caused by the same mutation, known as the H3K27M mutation, that drives the growth of most DIPG tumors, the team found. (stanford.edu)
  • MMP-1, MMP-2, MMP-3, MMP-8, MMP-9 and MMP-13 have been identified in odontogenic cysts, which suggests that MMPs play an important role in the growth of these tumors 9-10 . (bvsalud.org)
  • High ERV-K env total protein expression of all tumor subtypes significantly correlated with low tumor grading and a longer disease specific survival using multivariable analyses. (frontiersin.org)
  • Cancerous bone tumors usually originate from a cancer in another part of the body such as from lung, breast, thyroid, kidney and prostate. (wikipedia.org)
  • Basically, using one culture dish instead of 10 has allowed us to produce larger batches, faster, whilst using less tissue-culture real estate. (corning.com)
  • The Brain Tumor Center (BTC) at Memorial Sloan Kettering Cancer Center provides a unique opportunity to bring together researchers and clinicians for scientific discovery and development of truly effective brain tumor therapies. (mskcc.org)
  • Gliomas are the most common primary brain tumors. (scirp.org)
  • News" anchor role after recent surgery to remove a brain tumor. (huffpost.com)
  • News" after recently undergoing surgery to remove a brain tumor. (huffpost.com)
  • It's so surreal and crazy and unbelievable that my mom has a brain tumor ― and now I have one too? (huffpost.com)
  • Physician-scientist Ingo Mellinghoff (center) is affiliated with the Brain Tumor Center. (mskcc.org)
  • A systematic review and meta-analysis by Liu et al found that the malignancy rate, including borderline tumors, for simple ovarian cysts in postmenopausal women was approximately 1 in 10,000. (medscape.com)
  • Epithelial cystic tumors account for about 60% of all true ovarian neoplasms. (medscape.com)
  • Mucinous epithelial tumors account for approximately 10-15% of all epithelial ovarian neoplasms. (medscape.com)
  • Through use of a library of close to 70 patient-derived organoids, Tiriac has demonstrated that organoids reflect the molecular details of the tumor from which they were derived. (corning.com)
  • Methods: We developed a streamlined protocol for generating chondrocytes from BMSCs in a 3D culture system using an "in-tube" culture approach. (lu.se)
  • Cultures and sensitivities in bacterial disorders are helpful and are obtained from discharge within the ear canal or through a myringotomy. (medscape.com)
  • Tumor is superficial grade 2, stage Ta transitional cell carcinoma. (medscape.com)
  • Biopsies to determine the origin of the tumour in cases like this are rarely done. (wikipedia.org)
  • Care should be taken to exclude other causes of chronic diarrhea, both infectious and noninfectious (e.g., lymphocytic colitis, collagenous colitis, tumors, drug reactions). (cdc.gov)
  • Together, these studies identify T cell-mediated tumor regression as the mechanism through which a plant-derived essential oil diminishes established tumor burden. (biorxiv.org)
  • Causes regression or oncolysis of various tumors (21). (cdc.gov)
  • These tumor organoids have emerged as innovative tools that are extensively employed in drug testing, genome editing , and transplantation to guide personalized therapy in clinical settings. (bvsalud.org)
  • 10-12 Noticeably, cationic surfactant is more extensively used in tumor treatment than other types of surfactants, such as anionic and nonionic surfactant. (rsc.org)
  • Our data indicate that plakoglobin promotes tumor cluster formation in IMPC and downregulates apoptosis in the cell clusters through activation of PI3K/Akt/Bcl-2 signaling. (jcancer.org)
  • Stereotactic radiation is a relatively new therapeutic tool that offers nonsurgical hope for treating some tumors. (medscape.com)