UbiquitinationUbiquitinUbiquitin-Protein LigasesUbiquitinsProteasome Endopeptidase ComplexUbiquitin-Conjugating EnzymesSKP Cullin F-Box Protein LigasesLigasesProteolysisEndosomal Sorting Complexes Required for TransportF-Box ProteinsLysinePolyubiquitinUbiquitin-Protein Ligase ComplexesCullin ProteinsUbiquitinated Proteinsbeta-Transducin Repeat-Containing ProteinsProtein BindingProto-Oncogene Proteins c-mdm2S-Phase Kinase-Associated ProteinsUbiquitin ThiolesteraseProtein Processing, Post-TranslationalCell LineHEK293 CellsCysteine EndopeptidasesProto-Oncogene Proteins c-cblMultienzyme ComplexesImmunoprecipitationLeupeptinsProtein Structure, TertiaryMutationAmino Acid SequenceAnaphase-Promoting Complex-CyclosomeCell Cycle ProteinsProtein StabilityMolecular Sequence DataProtein TransportSignal TransductionProteasome InhibitorsPhosphorylationAmino Acid MotifsHeLa CellsNuclear ProteinsUbiquitin-Activating EnzymesCarrier ProteinsEndocytosisSaccharomyces cerevisiae ProteinsReceptors, Autocrine Motility FactorRNA, Small InterferingTwo-Hybrid System TechniquesTransfectionDNA-Binding ProteinsMultiprotein ComplexesMultivesicular BodiesCell Line, TumorTumor Suppressor Protein p53Adaptor Proteins, Signal TransducingModels, BiologicalRNA InterferenceTNF Receptor-Associated Factor 6Down-RegulationIntracellular Signaling Peptides and ProteinsPeptide SynthasesImmunoblottingUbiquitin-Specific ProteasesSaccharomyces cerevisiaeRecombinant Fusion ProteinsSumoylationCOS CellsCysteine Proteinase InhibitorsTranscription FactorsLysosomesTumor Suppressor ProteinsEndopeptidasesDNA DamageI-kappa B KinaseSequence Homology, Amino AcidCells, CulturedRING Finger DomainsCell NucleusVon Hippel-Lindau Tumor Suppressor ProteinSUMO-1 ProteinProteinsGene Expression RegulationNucleotide Transport ProteinsEndosomesBlotting, WesternPeptide HydrolasesI-kappa B ProteinsBinding SitesCell CycleNF-kappa BSubstrate SpecificityProtein-Serine-Threonine KinasesProto-Oncogene ProteinsRepressor ProteinsGene Knockdown TechniquesProliferating Cell Nuclear AntigenRecombinant ProteinsCercopithecus aethiops