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  • domain-contain
  • The core inhibitory kinase module is composed of two groups of kinases, the mammalian STE20-like protein kinase 1 (MST1) and MST2, and the large tumour suppressor 1 (LATS1) and LATS2, in combination with their activating adaptor proteins, salvador family WW domain-containing protein 1 (SAV1), MOB kinase activator 1A (MOB1A) and MOB1B. (nih.gov)
  • PMID25639508}} "SCUBE2 (signal peptide-CUB-EGF domain-containing protein 2) belongs to a secreted and membrane-tethered multi-domain SCUBE protein family composed of 3 members found in vertebrates and mammals. (edu.au)
  • In mammals, the Hippo pathway is a kinase cascade, wherein Macrophage Stimulating 1/2 (MST1/2), in a complex with its regulatory protein Salvador Family WW Domain Containing Protein 1 (SAV1), phosphorylates and activates Large Tumor Suppressor Kinase 1/2 (LATS1/2). (springer.com)
  • kinase
  • The liver kinase B1 (LKB1)-microtubule affinity-regulating kinase (MARK) pathway inhibits YAP and TAZ through scribble homologue (SCRIB)-mediated activation of mammalian STE20-like protein kinase 1 (MST1), MST2, large tumour suppressor 1 (LATS1) and LATS2. (nih.gov)
  • LATS1
  • Recombinant LMO3 (rLMO3) protein administration decreased the phosphorylation of YAP and LATS1, and increased Rho GTPases activities. (springer.com)
  • significance
  • However, the prognostic significance of Cyr-61 in gastric cancer has not been fully determined. (biomedcentral.com)
  • Thus, in the current study, we evaluated the clinical significance of Cyr-61/COX-2 co-expression in determining the clinicopathologic features of gastric cancer and further explored their combined prognostic significance. (biomedcentral.com)
  • survival
  • Crude survival curves were constructed by the Kaplan-Meier method and Cox proportional hazards regression analysis was performed to confirm the prognostic roles of Cyr-61/COX-2 as well as sex and histological grade. (biomedcentral.com)
  • known
  • CTGF expression is known to be upregulated in the extra-capillary and mesangial lesions of glomerulonephritis in human kidney biopsy samples. (biomedcentral.com)
  • expression
  • This retrospective study examined the expressions of Cyr-61 and COX-2 in 82 surgically removed gastric cancer specimens and 43 non-tumor gastric mucosa specimens by immunohistochemical staining to identify the abnormal expression of Cyr-61 or COX-2 in gastric cancer. (biomedcentral.com)
  • Both Cyr-61 and COX-2 high expressions [hazard ratio (HR) = 31.8, 95 % confidence interval (CI) 4.09-246.was associated the higher risk of death during 5 years follow up than single Cyr-61 high expression (HR = 4.1, 95 % CI 1.5-11.6) or COX-2 high expression (HR = 2.9, 95 % CI 1.06-7.8). (biomedcentral.com)
  • Additionally, combined expressions of Cyr-61 and COX-2 has a higher prognostic value than single expression. (biomedcentral.com)
  • In addition to fibrotic markers, the glomerular mRNA expression of Ccl2 is increased in the control mice with anti-GBM glomerulonephritis, and this increase is reduced in Rosa-CTGF cKO mice with nephritis. (biomedcentral.com)
  • CTGF expression and accumulation of macrophages in the mesangial area have been documented in these glomerular diseases. (biomedcentral.com)
  • cancer
  • In this Progress article, we summarize the current understanding of the biological functions of YAP and TAZ, and how the regulation of these two proteins can be disrupted in cancer. (nih.gov)
  • current
  • In this review, we present the current knowledge of the involvement of CTGF in kidney disease, especially glomerulonephritis. (biomedcentral.com)