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  • prognostic technologies market
  • The report pegs the overall value of this global market in 2013 at US$0.43 bn.The research report, titled " Circulating Tumor Cells (CTCs) Prognostic Technologies Market - Global Industry Analysis, Size, Share, Growth, Trends and Forecast, 2014 - 2020 ", further states that the estimated value of the global CTCs prognostic technologies market is expected to reach US$2.16 bn, exhibiting a CAGR of 26.30% between 2014 and 2020. (cnbc.com)
  • According to the report, rapidly increasing prevalence of cancer across the world, coupled with significant advancement of therapeutic monitoring, is stimulating the global CTCs prognostic technologies market. (cnbc.com)
  • The high benefit-cost ratio (BCR) associated with CTCs prognostic technologies has also helped this market to grow extensively.The report, on the other hand, also discusses the challenges, which the global CTCs prognostic technologies market might face such as high cost associated with the diagnosing of CTCs as well as reluctance among people towards adopting highly developed prognostic technologies. (cnbc.com)
  • Tumor cell enrichment and tumor cell detection are the two main components of the global CTCs prognostic technologies market based on technologies. (cnbc.com)
  • On the basis of application, the market study reports that the breast cancer market and the prostate cancer market are likely to register the fastest growth, i.e. 27.10% and 25.20% respectively over the forecast period.The research report cites North America as the biggest regional CTCs prognostic technologies market across the world. (cnbc.com)
  • Contrarily, analysts predict that the CTCs prognostic technologies market in Asia Pacific will exhibit an impressive growth rate on account of the increasing prevalence of cancer, together with rise in the research and development activities in this region, reports the study.Major participants in the global CTCs prognostic technologies market has been profiled in this report in order to analyze the competitive landscape of this industry. (cnbc.com)
  • The primary factors driving the growth of the CTCs prognostic technologies market are increasing demand for diagnostic and prognostic technologies coupled with high incidence and prevalence rates of cancer. (transparencymarketresearch.com)
  • Furthermore, colossal application scope of these technologies and patient safety are also some of the factors driving the growth of the CTCs prognostic technologies market. (transparencymarketresearch.com)
  • The CTCs prognostic technologies market is categorized based on technology and applications. (transparencymarketresearch.com)
  • samples
  • lack of CTCs in blood samples obtained from six control mice without xenografts. (nih.gov)
  • FISH can also be used to detect and localize specific RNA targets (mRNA, lncRNA and miRNA) in cells, circulating tumor cells, and tissue samples. (wikipedia.org)
  • An incisional biopsy or core biopsy samples a portion of the abnormal tissue without attempting to remove the entire lesion or tumor. (wikipedia.org)
  • They also claim a 95% sensitivity rate (in 95% of samples in which CTCs are present, the ISET test will isolate the CTCs sufficiently for cytopathological identification). (wikipedia.org)
  • Specifically, the company focuses on improving the stability of biological materials, such as DNA, RNA, proteins, cells from patient samples used in research, and diagnostic testing reagents. (wikipedia.org)
  • These products include RNAgard Blood, DNAgard Blood, and DNAgard Tissue and Cells, products designed to stabilize biological samples from collection to analytical testing. (wikipedia.org)
  • predictive
  • S. Lankiewicz, S Zimmermann, C Hollmann, T Hillemann, T. F. Greten, (2008) Circulating tumour cells as a predictive factor for response to systemic chemotherapy in patients with advanced colorectal cancer, Mol Oncol, 2(4), 349-355. (scirp.org)
  • The relative number of CTCs is predictive of patient prognosis and treatment efficacy. (slas.org)
  • The final survival analysis of the SUCCESS A trial will give further insight, whether CTCs can be used as early predictive marker for the efficacy of adjuvant zoledronate treatment. (aacrjournals.org)
  • And CTC phenotype was measured by immunofluorescent staining and evaluate the predictive significance on survival in 32 CTCs-positive patients with advanced CRC. (paperity.org)
  • tissue
  • As one of the nuclear receptor (NR) members, VDR is found in both normal breast tissue and breast tumors [ 9 , 10 ]. (mdpi.com)
  • Cells, circulating tumor cells (CTCs), or formalin-fixed paraffin-embedded (FFPE) or frozen tissue sections are fixed, then permeabilized to allow target accessibility. (wikipedia.org)
  • In situ hybridization (ISH) is a type of hybridization that uses a labeled complementary DNA, RNA or modified nucleic acids strand (i.e., probe) to localize a specific DNA or RNA sequence in a portion or section of tissue (in situ), or, if the tissue is small enough (e.g., plant seeds, Drosophila embryos), in the entire tissue (whole mount ISH), in cells, and in circulating tumor cells (CTCs). (wikipedia.org)
  • RNA ISH (RNA in situ hybridization) is used to measure and localize RNAs (mRNAs, lncRNAs, and miRNAs) within tissue sections, cells, whole mounts, and circulating tumor cells (CTCs). (wikipedia.org)
  • In situ hybridization is a powerful technique for identifying specific mRNA species within individual cells in tissue sections, providing insights into physiological processes and disease pathogenesis. (wikipedia.org)
  • When a sample of tissue or fluid is removed with a needle in such a way that cells are removed without preserving the histological architecture of the tissue cells, the procedure is called a needle aspiration biopsy. (wikipedia.org)
  • 2017
  • The now chief scientific officer for Vortex Biosciences earned the 2017 SLAS Innovation Award winner for her presentation, " Classification of Large Circulating Tumor Cells Isolated with Ultra-High-Throughput Microfluidic Vortex Technology ," built from those early interests. (slas.org)
  • OncologyPRO has evolved in July 2017 to offer you direct access to our rich content either by tumour site or according to the objectives of your visit. (esmo.org)
  • enabled viable
  • We demonstrated that our MDA-MB-231 xenograft model shed CTCs into mouse circulation using a new technology that enabled viable human CTC capture from mouse blood (Talasaz et al, 2009). (nih.gov)
  • gene
  • Hypoxia induced ATF4 and the HIF1alpha target gene apelin in CTCs, but not in parental cells. (nih.gov)
  • D) Expression of ATF4 and its target gene ASNS in CTCs, compared with parental MDA-MB-231 cells. (nih.gov)
  • This research includes also analysis of the tumor gene profiling. (knowcancer.com)
  • Through the EMT process, epithelial cells lose cell-cell contacts and cell polarity, downregulate epithelial-associated genes, acquire mesenchymal gene expression and undergo major changes in their cytoskeleton. (aacrjournals.org)
  • Prior to that, he served as a scientific director at HK Pharmaceuticals and Digital Gene Technologies, as well as a scientist at the Salk Institute studying cell signaling and viral based gene therapy approaches. (wikipedia.org)
  • Survival
  • In recent years, an increasing number of clinical studies have suggested that an optimal vitamin D status has a protective effect against BC development and that high Vitamin D receptor (VDR) expression in breast tumors is associated with a better survival rate [ 5 , 6 , 7 , 8 ]. (mdpi.com)
  • therefore
  • CTCs have been shown to have prognostic value in a number of cancer types and therefore there is extensive research and development activity to develop methodologies for CTC enumeration as well as analysis. (selectbiosciences.com)
  • Qualitative and quantitative analysis of product vendors and their market penetrance, markers utilized for the capture/study of CTCs and CSCs as well as cancer classes wherein there is current research activity vis-à-vis CTCs and CSCs are described in this dataset derived from worldwide pools of researchers in November and December 2012-therefore these data reflect an up-to-date market landscape. (selectbiosciences.com)
  • The treatment response can be immediately assessed by serial quantitation of CTCs after chemotherapy, and therefore this method highlights an alternative approach to rapidly access the patient's response to treatment. (scirp.org)
  • Aim of this study was therefore to evaluate CTCs in the context of two different zoledronate regimens. (aacrjournals.org)
  • patients
  • Patients with tumors that have spread to other parts of the body and who are about to start systemic treatment will be eligible to take part in this study. (knowcancer.com)
  • Consequently, an evaluation of VDR expression in the CTCs of BC patients may allow optimization of their treatment. (mdpi.com)
  • As an attempt to profile and subtype the CTCs of metastatic patients, we established an innovative fluorescence technique using nine BC cell lines to visualize, define, and compare their individual VDR status. (mdpi.com)
  • The results demonstrated major differences in the VDR levels among the nine cell lines, and VDR positive CTCs were detected in 46% of CTC-positive patients, with a total of 42 CTCs individually analyzed. (mdpi.com)
  • In order to develop a new standard of curative effect, this study was de-signed to track the number of CTCs in patients with lung cancer during chemotherapy. (scirp.org)
  • The level of CK19 mRNA in pa-tients with small cell lung cancer (SCLC) was higher than that of patients with non-small cell lung cancer (NSCLC) (t=1.944, P=0.061). (scirp.org)
  • But to convince researchers, clinicians and patients of the usefulness of the CTCs, we need a technology that must be low cost, simple to use, reproducible and fast. (slas.org)
  • Circulating tumor cells (CTCs) as prognostic biomarker in patients with advanced chemorefractory, RAS wild-type colorectal cancer (CRC) treated with. (esmo.org)
  • Results Forty-eight of 98 patients were CTCs-positive, including 18 CTM-positive patients, and CTC detection was positively correlated with lymphatic invasion (P = 0.049), TNM stage (P = 0.023), and serum CEA level (P = 0.014). (paperity.org)
  • detectable
  • Those results were made possible by exquisitely sensitive magnetic separation technology employing Ferrofluids (colloidal magnetic nanoparticles) and high gradient magnetic separators invented by Paul Liberti and motivated by theoretical calculations by Liberti and Leon Terstappen that indicated very small tumors shedding cells at less than 1.0% per day should result in detectable cells in blood. (wikipedia.org)
  • After the tumor cells come to rest at another site, they re-penetrate the vessel or walls and continue to multiply, eventually forming another clinically detectable tumor. (wikipedia.org)
  • efficacy
  • Measuring the ratio of traditional CTC to apoptotic CTCs - from baseline to therapy - provides clues to a therapy's efficacy in targeting and killing cancer cells. (wikipedia.org)