• The 2,4-diamino-quinazoline and allopurinol-based compounds were also potent growth inhibitors of the related apicomplexan parasite Toxoplasma gondii, and a good correlation was observed in the relative activities of compounds in the allopurinol-based series against T. gondii and C. parvum. (www.gov.uk)
  • Cryptosporidium parvum is an intracellular protozoan parasite of the family Cryptosporidiidae and phylum Apicomplexa Footnote 1 Footnote 3 . (wordpress.com)
  • Taken together, these data illustrate the utility of the Open Access Malaria Box as a source of both potential leads for drug development and chemical probes to elucidate basic biological processes in C. parvum and other apicomplexan parasites. (www.gov.uk)
  • Potency was conserved in a sub-set of compounds from each scaffold with variable physicochemical properties, and two of the scaffolds identified exhibit more rapid inhibition of C. parvum growth than nitazoxanide, making them excellent candidates for further development. (www.gov.uk)
  • C. parvum occurs worldwide and is ubiquitous in the environment Footnote 1 Footnote 9 . (wordpress.com)
  • Drinking water treatment: Both microfiltration and ultrafiltration are the most cost-effective methods to remove C. muris and C. parvum from water. (wordpress.com)
  • c Fraction represents number of mice showing developmental stages of C. parvum in the intestinal epithelium over the total number of mice inoculated, e.g., 4/4 indicates 4 mice were found infected out of 4 mice inoculated. (cdc.gov)