Cryptococcus neoformans and cryptococcus. Medical search. Frequent questions

grubii and C. neoformans var. (cdc.gov)
grubii , serotype A (3), C. neoformans var. (cdc.gov)
grubii / neoformans has been isolated worldwide ratories, and 3) to apply PCR fingerprinting and URA5 RFLP from soil enriched with avian excreta (4,5). (cdc.gov)
grubii, 150 C. neoformans var. (uludag.edu.tr)

A total of 476 European isolates (310 Cryptococcus neoformans var. (uludag.edu.tr)
The aim of this study was to examine three serial isolates of Cryptococcus neoformans from a patient with AIDS for genotypical and phenotypical characteristics. (unipg.it)
In conclusion, in serial Cryptococcus neoformans isolates from a patient with AIDS, phenotypical changes but not molecular changes were documented, thus supporting the role of microevolution as a pathogenetic mechanism(s) for persistence/reactivation of fungal organisms. (unipg.it)
One hundred and twenty-two clinical isolates, from distinct patients, were identified as C. neoformans and genotyped by URA5-RFLP, with the molecular types VNI (45.5 %) and VNIII (30.9 %) being the most commonly found ones. (unl.pt)
Microevolution of Serial Clinical Isolates of Cryptococcus neoformans var. (broadinstitute.org)
Fungi that require special media include Cryptococcus neoformans (bird seed agar), Candida (chromogenic agar for its differentiation of isolates), dermatophytes (dermatophytes test medium), and Malassezia furfur (need long-chain fatty acid supplementation). (medscape.com)

Infection with C. neoformans is termed cryptococcosis. (wikipedia.org)
However, fungal meningitis and encephalitis, especially as a secondary infection for AIDS patients, are often caused by C. neoformans, making it a particularly dangerous fungus. (wikipedia.org)
In human infection, C. neoformans is spread by inhalation of aerosolized basidiospores, and can disseminate to the central nervous system, where it can cause meningoencephalitis. (wikipedia.org)
People who are immunocompromised-their immune system is not functioning properly due to infection with, for example, the human immunodeficiency virus (HIV) or deliberate suppression to lessen the rejection of a transplanted organ-can are at particular risk for a potentially fatal infection with C. neoformans . (encyclopedia.com)
However, the cellular constituents of the innate immune response that promote clearance versus progression of infection upon respiratory acquisition of C. neoformans remain poorly defined. (listlabs.com)
In this study, we found that during acute C. neoformans infection, CCR2+ Ly6Chi inflammatory monocytes (IM) rapidly infiltrate the lungs and mediate fungal trafficking to lung-draining lymph nodes. (listlabs.com)
Overall, our findings indicate that C. neoformans can subvert the fungicidal potential of IM to enable the progression of infection through a mechanism that is not dependent on lymphocyte priming, eosinophil recruitment, or downstream M2 macrophage polarization pathways. (listlabs.com)
Fundamental niche prediction of Cryptococcus neoformans and Cryptococcus gattii in Europe is an important tool to understand where these pathogenic yeasts have a high probability to survive in the environment and therefore to identify the areas with high risk of infection. (pasteur.fr)
Depending on the virulence of the yeast strain and the immune status of the host, Cryptococcus neoformans can cause either no infection, latent infection, or symptomatic disease. (cdc.gov)
Because C. neoformans enters the body through the respiratory route, infection can present as pneumonia-like illness, with symptoms such as cough, fever, chest pain, and weight loss. (cdc.gov)
C. neoformans infection is acquired through inhalation of basidiospores or desiccated yeast cells from the environment. (cdc.gov)
We investigated the pathogenesis of pulmonary Cryptococcus neoformans infection and passive Ab efficacy in mice deficient in inducible NO synthase (NOS2 -/- ) and the parental strain. (elsevierpure.com)
C. neoformans infection in NOS2 -/- mice resulted in significantly higher levels of IFN-γ, monocyte chemoattractant protein-1, and macrophage-inflammatory protein-1α than parental mice. (elsevierpure.com)
To test this hypothesis, we have studied the influence of murine cerebral infection with C. neoformans and the inhibition of efflux by intraperitoneal injection of a P-glycoprotein inhibitor, GF120918 [N-(4-[2-(1,2,3,4-tetrahydro-6,7-dimethoxy-2-isoquinolinyl)-ethyl]-phenyl)9,10-dihydro-5-methoxy-9-oxo-4-acridine carboxamide], on the pharmacokinetics of itraconazole in plasma and brain after a single intraperitoneal itraconazole injection. (pasteur.fr)
Moreover, the pretreatment of infected mice with GF120918 significantly increased cerebral itraconazole values of area under the curve and decreased weight loss in the treatment with itraconazole of a cerebral infection with C. neoformans. (pasteur.fr)
We are interested in elucidating the process of melanogenesis in Cryptococcus neoformans, where melanin plays a key role during infection. (jhu.edu)
Macrophage recruitment into the lungs of mice after infection with C. neoformans strain H99γ was comparable with that observed in mice challenged with wild-type C. neoformans. (elsevierpure.com)
However, pulmonary infection in mice with C. neoformans strain H99γ was associated with reduced pulmonary fungal burden, increased pulmonary Th1-type and interleukin-17 cytokine production, and classical macrophage activation as evidenced by increased inducible nitric oxide synthase expression, histological evidence of enhanced macrophage fungicidal activity, and resolution of inflammation. (elsevierpure.com)
In contrast, progressive pulmonary infection, enhanced Th2-type cytokine production, and the induction of alternatively activated macrophages expressing arginase-1, found in inflammatory zone 1, Ym1, and macrophage mannose receptor were observed in the lungs of mice infected with wild-type C. neoformans. (elsevierpure.com)
Our results demonstrate that pulmonary infection with C. neoformans strain H99γ results in the induction of classically activated macrophages and promotes fungal clearance. (elsevierpure.com)
These studies indicate that phenotype, as opposed to quantity, of infiltrating macrophages correlates with protection against pulmonary C. neoformans infection. (elsevierpure.com)
Cryptococcosis is infection with the fungi Cryptococcus neoformans or Cryptococcus gattii . (medlineplus.gov)
Infection with C neoformans is seen worldwide. (medlineplus.gov)
Cryptococcus is the most common fungus that causes serious infection worldwide. (medlineplus.gov)
C neoformans is the most common life-threatening cause of fungal infection in people with HIV/AIDS. (medlineplus.gov)

C. neoformans causes cryptococcosis. (encyclopedia.com)
Cryptococcus neoformans is the causative agent of pulmonary cryptococcosis and cryptococcal meningoencephalitis, which are major clinical manifestations in immunosuppressed patients. (unifesp.br)
Two of the species, Cryptococcus neoformans and Cryptococcus bacillisporus , are the casual agents of the majority of human and animal cryptococcosis . (doe.gov)
Cryptococcosis is an acute, subacute or chronic fungal disease caused by an encapsulated yeast Cryptococcus neoformans. (journalcra.com)
This study provides a comprehensive picture of the C. neoformans/C. gattii molecular types most often associated with human cryptococcosis in Portugal and assesses the impact of C. gattii in these infections. (unl.pt)
Cryptococcus neoformans is the most common causative agent of cryptococcosis. (dergipark.org.tr)
Perfect JR. Cryptococcosis ( Cryptococcus neoformans and Cryptococcus gattii ). (medlineplus.gov)
C. neoformans causes cryptococcosis and is often found in bird manure accumulations. (cdc.gov)
Cryptococcosis is a systemic mycosis whose etiological agent is called Cryptococcus. (bvsalud.org)

Candida albicans and Cryptococcus neoformans can cause life-threatening infections, especially in immune-compromised patients. (japsonline.com)
Shehu A, Ismail S, Rohin MAK, Harun A, Aziz AA, Haque M. Antifungal Properties of Malaysian Tualang Honey and Stingless Bee Propolis against Candida albicans and Cryptococcus neoformans. (japsonline.com)
Antifungal activity of EO and fractions were tested by a broth microdilution method, whereby minimum inhibitory concentration (MIC) was determined against several fungal organisms (Candida albicans, Candida krusei, Candida parapsilosis, Candida tropicalis, Cryptococcus gattii, and Cryptococcus neoformans). (researchgate.net)
The aim of this study was to evaluate the presence of Candida and Cryptococcus in Chilean psittacine birds. (scielo.cl)
The most frequent yeasts isolated included Candida famata (8/28 samples), followed by Candida tropicalis (7/28), Cryptococcus albidus (3/28), Cryptococcus laurentii (2/28 ), Rhodotorula sp. (scielo.cl)
2/28), Candida glabrata (1/28) and Cryptococcus neoformans (1/28). (scielo.cl)
Though a wide range of organisms and diseases is considered, the most extensive information centers on common mycoses associated with invasive fungal infections, including Candida albicans, Cryptococcus neoformans, and Aspergillus spp. (who.int)

Most commonly, C. neoformans causes the form of meningitis called cryptococcal meningitis. (encyclopedia.com)
C. neoformans meningitis may lead to permanent neurologic damage. (cdc.gov)
Dr Ballou said: "Cryptococcus is now the most common cause of adult meningitis in sub-Saharan Africa and worldwide it kills around 625,000 people every year. (abdn.ac.uk)
The combined administration of an efflux inhibitor with itraconazole should increase cerebral itraconazole concentrations and therefore, improve the treatment of Cryptococcus neoformans meningitis with this antifungal agent. (pasteur.fr)
Cryptococcus is a ubiquitous fungal pathogen that causes primarily meningitis and pneumonia. (cdc.gov)
Describir epidemiológicamente a los pacientes con meningitis criptocócica asociada al VIH del Instituto de Medicina Tropical en el año 2019. (bvsalud.org)
Estudio observacional descriptivo, retrospectivo en el que se incluyeron pacientes de ambos sexos, sin límite de edad con diagnóstico de meningitis criptocócica infectados por el VIH del Instituto de Medicina tropical (IMT) en el año 2019. (bvsalud.org)
Se estudió una muestra de 43 pacientes con diagnóstico de meningitis criptocócica asociado al VIH, de estos el 72,1% era del sexo masculino, el grupo etario más frecuente entre los 20 a 34 años (promedio de edad: 37,9 ± 13,6 años) y la procedencia en el 46,5% el departamento Central. (bvsalud.org)

Using standard fungal culturing methods, each sample was analyzed for three potentially infectious microorganisms: Blastomyces dermatitidis Cryptococcus neoformans, and Histoplasma capsulatum. (cdc.gov)

Previous studies demonstrated that mitochondrial DNA (mtDNA) was uniparentally transmitted in laboratory crosses of the pathogenic yeast Cryptococcus neoformans. (singerinstruments.com)

The interaction between the fungal pathogen Cryptococcus neoformans and human fibronectin (HFN) was examined in this study. (unifesp.br)
The genome of the basidiomycetous yeast and human pathogen Cryptococcus neoformans. (doe.gov)

The objective of this study was to evaluate the antifungal properties of MTH and SBP against C. albicans and C. neoformans . (japsonline.com)
Early data from endemic areas suggested that C. gattii differed not only in epidemiology and clinical presentation from C. neoformans , but might also have different susceptibilities to antifungal agents and require more aggressive and lengthier antifungal therapy than C. neoformans infections. (cdc.gov)

gattii , serotypes B and lates agrees with the fact that C. neoformans var. (cdc.gov)
Based on the differences in capsule polysaccharides, Cryptococcus is traditionally subdivided into 5 serotypes - A, B, C, D and AD. (doe.gov)
Binding of complement component C3 and Factor B to Cryptococcus neoformans serotypes A through D via the alternative complement pathway was measured in a system containing fresh nonimmune human serum. (johnshopkins.edu)
Serotypes B and C (C. neoformans var. (johnshopkins.edu)
gattii) bound approximately half as many molecules of both complement components as serotypes A and D (C. neoformans var. (johnshopkins.edu)
Most are caused by C. neoformans(serotypes A and D). C. neoformansis an opportunistic pathogen in AIDS patients. (bvsalud.org)

Confirmation of the fact that C. neoformans is a facultative intracellular pathogen could provide new insights into several poorly understood areas of cryptococcal pathogenesis, including mechanisms for latency and persistence and the lack of efficacy of humoral immunity. (elsevierpure.com)
A major research area of the department is focused on understanding the ecology and pathogenesis of Cryptococcus neoformans . (jhu.edu)

Following changes to the International Code of Nomenclature for algae, fungi, and plants, the practice of giving different names to teleomorph and anamorph forms of the same fungus was discontinued, meaning that Filobasidiella neoformans became a synonym of the earlier name Cryptococcus neoformans. (wikipedia.org)
Studies suggest that colonies of C. neoformans and related fungi growing on the ruins of the melted down reactor of the Chernobyl nuclear power plant may be able to use the energy of radiation for "radiotrophic" growth. (wikipedia.org)
C neoformans and C gattii are the fungi that cause this disease. (medlineplus.gov)

Cryptococcus neoformans is the only pathogenic yeast known to have a polysaccharide capsule. (microbeonline.com)

Infections with this fungus are rare in people with fully functioning immune systems, hence C. neoformans is often referred to as an opportunistic pathogen. (wikipedia.org)
Cryptococcus neoformans is an opportunistic pathogenic fungus of human beings that infects mainly immunocompromised patients. (unifesp.br)
Filobasidiella neoformans ) is an opportunistic pathogenic fungus found world-wide. (doe.gov)

Cell-wall dyes interfere with Cryptococcus neoformans melanin deposition. (jhmi.edu)
Perez-Dulzaides R , Camacho E, Cordero RJB, Casadevall A. Cell-wall dyes interfere with Cryptococcus neoformans melanin deposition. (jhmi.edu)
Deletion of CGP1 also reduces production of melanin pigment and attenuates the virulence of C. neoformans. (elsevierpure.com)
One aspect of this research is C. neoformans melanin production and how it relates to virulence. (jhu.edu)
Melanin, a pigment of undefined chemical structure and with a tremendous physical stability, accumulates in the cell wall of C. neoformans and enables growth and budding. (jhu.edu)

Its teleomorph is a filamentous fungus, formerly referred to Filobasidiella neoformans. (wikipedia.org)
citation needed] The teleomorph was first described in 1975 by K.J. Kwon-Chung, who obtained cultures of Filobasidiella neoformans by crossing strains of the yeast C. neoformans. (wikipedia.org)
Its teleomorph is Filobasidiella neoformans , a filamentous fungus belonging to the class Tremellomycetes. (ensembl.org)

Cryptococcal disease is acquired via inhalation of haploid yeast or basidiospores from the environment.Genus Filobasidiella contains approximately 38 Cryptococcus species. (doe.gov)

It formerly contained two varieties: C. neoformans var. (wikipedia.org)
In conclusion, we produced for the first time detailed prediction maps of the species and varieties of the C. neoformans and C. gattii species complex in Europe and Mediterranean area. (pasteur.fr)

Cryptococcus neoformans is a leading cause of invasive fungal infections among immunocompromised patients. (listlabs.com)
These results give us new insight into the plasticity of IM function during fungal infections and the level of control that C. neoformans can exert on host immune responses. (listlabs.com)

Most infections with C. neoformans occur in the lungs. (wikipedia.org)
C. neoformans variety neoformans causes most of the cryptococcal infections in humans. (encyclopedia.com)
Prior to the explosion of the number of cases of AIDS and the more routine use of immunosuppressant drugs, C. neoformans infections were rare. (encyclopedia.com)
Cryptococcus is very drug resistant and infections can last a long time with patients receiving antibiotic treatments for more than six months. (abdn.ac.uk)
X-linked hyper-IgM syndrome associated with Cryptosporidium parvum and Cryptococcus neoformans infections: the first case with molecular diagnosis in Korea. (lu.se)
C. neoformans has a clear predilection for causing disease in persons in whom the immune system is impaired, and today an overwhelming proportion of C. neoformans infections occur in immunocompromised persons. (cdc.gov)

gattii, was later defined as a distinct species, Cryptococcus gattii. (wikipedia.org)
A new species name, Cryptococcus deneoformans, is used for the former C. neoformans var. (wikipedia.org)
Cryptococcus neoformans is a yeast that is the sole species of the genus capable of causing mycotic (fungal) disease. (encyclopedia.com)
A few are pathogenic and constitute the pathogenic Cryptococcus species cluster. (doe.gov)
neoformans, and 16 C. gattii species complex) from both clinical and environmental sources were analyzed by multi-locus sequence typing. (uludag.edu.tr)

Morphological and cultural characteristics of C. neoformans Sanf. (journalcra.com)

Analyses of mating-type alleles and mtDNA genotypes of natural hybrids from clinical and natural samples were consistent with the hypothesis that mtDNA is inherited from the MATa parent in C. neoformans. (singerinstruments.com)

In the lungs, C. neoformans cells are phagocytosed by alveolar macrophages. (wikipedia.org)
However, some C. neoformans cells can survive intracellularly in macrophages. (wikipedia.org)
We ascertained that IM in the lungs upregulated transcripts associated with alternatively activated (M2) macrophages in response to C. neoformans, consistent with the model that IM assume a cellular phenotype that is permissive for fungal growth. (listlabs.com)
For survival in macrophages, C. neoformans utilizes a novel strategy for intracellular parasitism that includes the accumulation of intracellular polysaccharide in cytoplasmic vesicles. (elsevierpure.com)
The finding that C. neoformans replicates inside macrophages in vitro in a manner similar to that observed in vivo provides an excellent system to dissect the molecular mechanisms responsible for this unique pathogenic strategy. (elsevierpure.com)
These alternatively activated macrophages were also shown to harbor highly encapsulated, replicating cryptococci. (elsevierpure.com)

The recognition of C. neoformans in Gram-stained smears of purulent exudates may be hampered by the presence of the large gelatinous capsule which apparently prevents definitive staining of the yeast-like cells. (wikipedia.org)
When grown as a yeast, C. neoformans has a prominent capsule composed mostly of polysaccharides. (wikipedia.org)
There are three versions of C. neoformans , based on differences in the capsule that surrounds the yeast, in the use of various sugars as nutrients, and in the shape of the environmentally resilient structures called spores that can be produced by the yeast. (encyclopedia.com)
Like the capsule produced by some bacteria, the capsule of C. neoformans is made of sugars. (encyclopedia.com)
Cryptococcus neoformans is a yeast with a prominent polysaccharide capsule. (microbeonline.com)

INTRODUCTION: Cryptococcus neoformans and Cryptococcus gattii are encapsulated basidiomycetous yeasts with worldwide distribution. (unifesp.br)

Cryptococcus neoformans, an encapsulated fungal pathogen, causes meningoencephalitis in immunocompromised patients. (elsevierpure.com)
However, there has been a dearth of research on CAP-Gly proteins in fungal pathogens, including Cryptococcus neoformans, which is a global cause of fatal meningoencephalitis in immunocompromised patients. (elsevierpure.com)

Fundamental niche prediction of the pathogenic yeasts Cryptococcus neoformans and Cryptococcus gattii in Europe. (pasteur.fr)

Cryptococcus neoformans is an encapsulated fungal organism and it can cause disease in apparently immunocompetent, as well as immunocompromised, hosts. (ensembl.org)
Antibiotic activities of some commercially available 11 antibiotics were assayed against C. neoformans and chloramphenical alone inhibited the growth of the test organism. (journalcra.com)

The results indicate that NO is involved in the regulation of cytokine expression in response to cryptococcal pneumonia and is necessary for Ab efficacy against C. neoformans in mice. (elsevierpure.com)

Please confirm that you want to SAVE all your changes for 'Cryptococcus neoformans var neoformans JEC21' . (doe.gov)
The genome of Cryptococcus neoformans JEC21 (serotype D) was not sequenced by the JGI, but by TIGR. (doe.gov)

sendo um de Cryptococcus laurentii , dois de Cryptococcus neoformans e um de Cryptococcus gattii . (ufrgs.br)
Com este trabalho, obteve-se o primeiro isolamento descrito de Cryptococcus laurentii de sistema nervoso central de cão. (ufrgs.br)

The first genome sequence for a strain of C. neoformans (var. (wikipedia.org)
Analysis of the genome and transcriptome of Cryptococcus neoformans var. (bvsalud.org)

The department's mycology program has a major focus on Cryptococcus neoformans, a ubiquitous environmental microbe frequently affecting individuals with impaired immunity. (jhu.edu)

The present study evaluated the efficacy of interferon-γ transgene expression by Cryptococcus neoformans strain H99γ in abrogating alternative macrophage activation in infected mice. (elsevierpure.com)

Evidence from laboratory studies indicates that C. neoformans is not only capable of evading the host's immune response, but may also actively impair the response. (encyclopedia.com)

FR5 moderately inhibited strains of C. gattii and C. neoformans (MIC 0.62 mg/mL). (researchgate.net)

The research program of the Casadevall laboratory seeks to elucidate host defenses against C. neoformans , and how the fungus' virulence contributes to disease. (jhu.edu)

EO showed moderate inhibition of C. neoformans (MIC 0.62 mg/mL), and strongly inhibited of C. gattii (MIC 0.31 mg/mL). (researchgate.net)

The larger number of genotype VNI iso- mans , serotype D, C. neoformans var. (cdc.gov)

Our findings indicate a complex relationship between Ab efficacy against C. neoformans and cytokine expression, underscoring the interdependency of cellular and humoral defense mechanisms. (elsevierpure.com)

citation needed] Cryptococcus neoformans typically grows as a yeast (unicellular) and replicates by budding. (wikipedia.org)

The case mans (serotype D) and C. neoformans var. (who.int)

Cryptococcus neoformans was the first intracellular pathogen for which the non-lytic escape process termed vomocytosis was observed. (wikipedia.org)
Our results indicate that in C. neoformans, Amphotericin B causes intracellular damage mediated through the production of free radicals before damage on the cell membrane, measured by propidium iodide uptake. (unesp.br)
Recent in vivo studies have demonstrated that C. neoformans is a facultative intracellular pathogen, as was previously suggested by in vitro studies. (elsevierpure.com)

neoformans (VNIV), 65 among C. neoformans var. (uludag.edu.tr)

C. neoformans can also disseminate to the central nervous system (CNS) and cause meningoencephalitis. (cdc.gov)

Sabouraud's dextrose agar ) at room temperature or 37 °C. Cryptococcus neoformans are sensitive to cycloheximide so media containing cycloheximide should be avoided. (microbeonline.com)

Anatomy10

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