Crotalus durissus terrificus rattlesnake venom. Medical search. Frequent questions

Convulxin is a snake venom toxin found in a tropical rattlesnake known as Crotalus durissus terrificus. (wikipedia.org)
The Crotalus durissus terrificus is called by many names - tropical rattlesnake, Crotalus durissus, and cascavel or cascabel, as it is called in Brazil. (kidadl.com)

In Latin America, the major prevalence is due to snakes of the family Viperidae , where rattlesnakes ( Crotalus ) are included. (mdpi.com)
Many BPPs were described in the venoms from arthropods, amphibians and snakes, most of them being ACE inhibitors [ 19 ]. (biomedcentral.com)
SVEVs isolated from lyophilized venoms collected from four different species of snakes ( Agkistrodon contortrix contortrix , Crotalus atrox , Crotalus viridis and Crotalus cerberus oreganus ) were analyzed by mass spectrometry-based proteomic, which allowed the identification of proteins belonging to eight main functional protein classes such as SVMPs, serine proteinases, PLA 2 , LAAO, 5′nucleotidase, C-type lectin, CRISP and Disintegrin. (nature.com)
Unlike the snakes of North America, the rattlesnake species are fast and deadly. (kidadl.com)

South American rattlesnakes are represented in Brazil by a single species, Crotalus durissus, which has public health importance due to the severity of its envenomation and to its wide geographical distribution. (bvsalud.org)
venom profile, regardless of the subspecies, as evidenced by PLA2 isoforms complexity, which may explain the increase in venom neurotoxicity from Northeastern through Southern Brazil reported for the species. (bvsalud.org)
Rattlesnakes may be identified in all but one species by a rattle at the tip of the tail. (medscape.com)
All the venomous species have a venom gland that synthesizes, stores and secretes a complex mixture of biological molecules including proteins. (nature.com)

Convulxin is part of the snake venom C-type lectin family, a group of hemorrhagic toxins that disrupt body homeostasis. (wikipedia.org)
In this work, a general biochemical characterization in snake venom of serine proteases (SVSP), phospholipases A 2 (PLA 2 ), metalloproteases (SVMP) and hyaluronidases (SVH) of Crotalus aquilus (Ca), Crotalus polystictus (Cp) and Crotalus molossus nigrescens (Cmn) was done. (mdpi.com)
Crotamine is a natural polypeptide from snake venom which delivers nucleic acid molecules into cells, besides having pronounced affinity for negatively charged membranes and antifungal activity. (bvsalud.org)
Snake venoms are a complex mixture of peptides and proteins, including peptidases. (biomedcentral.com)
Snake venom sPLA 2 s are orthologous to mammalian GIIA, GIIB or GIIE sPLA 2 s, or they belong to the unique GIA sPLA 2 s [ 3 ]. (ijbs.com)
This study evaluated the use of fibrin glue derived from snake venom in the healing process after canine hysterorrhaphy. (scite.ai)
The fibrin gel obtained from the venom of the Crotalus durissus terrificus snake, a rattlesnake, contains serinoprotease, a protein in the venom that has been characterized as thrombin-like and acts in a similar manner as thrombin. (scite.ai)
The fibrin gel developed from the venom of this snake was shown to act as a safe, stable, and durable scaffold for up to seven days, without causing adverse side effects. (scite.ai)
Fibrin gel produced from the venom of the Crotalus durissus terrificus snake possesses many clinical and surgical uses. (scite.ai)
Proteins constitute almost 95% of snake venom's dry weight and are produced and released by venom glands in a solubilized form during a snake bite. (nature.com)
This study shows that proteins can be secreted and confined in snake venom extracellular vesicles (SVEVs) presenting a size distribution between 50 nm and 500 nm. (nature.com)
In addition, the molecular function of some of the described proteins suggests a central role for SVEVs in the cytotoxicity of the snake venom and sheds new light in the envenomation process. (nature.com)
If you would like to explore more about the world and history of rattlesnakes, go ahead and read the interesting facts about other rattlesnake subspecies too such as the ring-necked snake and the timber rattlesnake . (kidadl.com)
The South American rattlesnake is a snake. (kidadl.com)

It should be noted that a retrospective review of 21 cases of male patients with C horridus (timber rattlesnake) envenomation, patient age 19-71, found severe thrombocytopenia despite antivenom administration. (medscape.com)

Due to their high degree of target specificity, venom toxins have been increasingly used as lead compounds in the development of drugs [ 7 ]. (biomedcentral.com)
Finally, the immunorecognition of venom toxins by the crotalic antivenom produced at Butantan Institute was evaluated using Western blotting. (bvsalud.org)
PhTx2 and PhTx3, fractions from P. nigriventer venom, contain toxins acting on sodium and calcium channels, respectively. (scielo.org)
Toxins with hemorrhagic and myonecrotic activity are generally found in the venoms of the Viperidae family due to synergic action of proteolytic enzymes, such as metalloproteinases and serine proteinases 4 . (nature.com)

Rattlesnakes are indigenous from North America to South America. (medscape.com)

Juvenile southern Pacific rattlesnake (Crotalus oreganus helleri). (medscape.com)

In Brazil, the venoms of C. d. terrificus and C. d. collilineatus are used for hyperimmunization of horses for antivenom production, even though the distinction of these two subspecies are mostly by their geographical distribution. (bvsalud.org)

Comparison between venom molecules is also difficult when different techniques are used, and therefore, their identification/characterization using the same methodology is necessary. (mdpi.com)

Moderate rattlesnake envenomation in a toddler after treatment with antivenom. (medscape.com)

Results: The protein profile of individual venoms from C. d. collilineatus and C. d. terrificus showed a comparable overall composition, despite some intraspecific variation, especially regarding crotamine and LAAO. (bvsalud.org)

The C. durissus belongs to the reptile class. (kidadl.com)

The venom (not poison) is primarily neurotoxic, which affects the nervous system and causes blindness, paralysis, and death. (tulsazoo.org)
We examined the effect of crotoxin, the neurotoxic complex from the venom of the South American rattlesnake Crotalus durissus terrificus, on the uptake of ³H-choline in minces of smooth muscle myenteric plexus from guinea pig ileum. (scielo.org)

In this context, we described a comparative compositional and functional characterization of individual C. d. collilineatus and C. d. terrificus venoms from three Brazilian states. (bvsalud.org)

Methods: We compared the compositional patterns of C. d. terrificus and C. d. collilineatus individual venoms by 1-DE and RP-HPLC. (bvsalud.org)
Here we discuss the methods for extraction from South American Rattlesnakes, Crotalus durissus terrificus. (kyreptilezoo.com)

The immunorecognition pattern of individual venoms from C. d. collilineatus and C. d. terrificus by crotalic antivenom produced at Butantan Institute was similar. (bvsalud.org)
[ 5 ] When considering the use of antivenom, the risk of adverse reaction to antivenom must be weighed against the benefits of reducing venom toxicity. (medscape.com)

Biologically active proteins and peptides, as those found in venoms, may have a potential therapeutic use for the correction of hemostatic disorders and cellular adhesion among other applications [ 8 ]. (biomedcentral.com)
Finally, the further GIX sPLA 2 s are found in venom of marine snails, and GXIA and GXIB sPLA 2 s are plant proteins. (ijbs.com)

The neotropical rattlesnake is mostly found in the extreme conditions of tropical regions with a dry and hot climate. (kidadl.com)

The antimalarial effect of a native cationic polypeptide from the venom of a South American rattlesnake named crotamine, with ability of targeting and disrupting the acidic compartments of Plasmodium falciparum parasite, was previously described by us. (bvsalud.org)
Tx1, a neurotoxin isolated from the venom of the South American spider Phoneutria nigriventer, produces tail elevation, behavioral excitation and spastic paralysis of the hind limbs after intracerebroventricular injection in mice. (scielo.org)
What type of animal is a South American rattlesnake? (kidadl.com)
What class of animal does a South American rattlesnake belong to? (kidadl.com)
How many South American rattlesnakes are there in the world? (kidadl.com)
Where does a South American rattlesnake live? (kidadl.com)

Venoms represent a still underexplored reservoir of bioactive components that might mitigate or cure diseases in conditions in which conventional therapy is ineffective. (biomedcentral.com)

Due to the importance of such data for evaluating the quality and efficiency of fibrin gel formulations on its use as a scaffold, this study sought to analyze the heterologous fibrin sealant developed from the venom of Crotalus durissus terrificus using studies in ovine experimental models. (scite.ai)

7. Cross-neutralization of the neurotoxicity of Crotalus durissus terrificus and Bothrops jararacussu venoms by antisera against crotoxin and phospholipase A2 from Crotalus durissus cascavella venom. (nih.gov)
Bothrops jararaca venom (BjV) can induce mast cell degranulation. (bvsalud.org)
The cDNA sequence of hyaluronidase was cloned from the transcriptome of Bothrops pauloensis venom glands. (biomedcentral.com)
The cDNA from Bothrops pauloensis venom gland that corresponds to hyaluronidase comprises 1175 bp and codifies a protein containing 194 amino acid residues. (biomedcentral.com)
The isolation and biological characterization of hyaluronidases from snake venoms, including Bothrops genus, are usually difficult to achieve due to their instability and fast degradation, and because of their relatively low concentration in these biological samples. (biomedcentral.com)

15. Specificity of antibodies to the reconstituted crotoxin complex, from the venom of South American rattlesnake (Crotalus durissus terrificus), using enzyme-linked immunosorbent assay (ELISA) and double immunodiffusion. (nih.gov)
Results We show that the venom mixture containing 20% crotamine and 57% crotoxin produced a strong immunogenic response in horses. (scielo.org)
Antivenom raised against this venom mixture reacted with most venom components including crotamine and crotoxin, in contrast to the antivenom raised against crotamine-negative venom. (scielo.org)

Juvenile southern Pacific rattlesnake (Crotalus oreganus helleri). (medscape.com)

6. Comparison of the biological activities in venoms from three subspecies of the South American rattlesnake (Crotalus durissus terrificus, C. durissus cascavella and C. durissus collilineatus). (nih.gov)

Convulxin is a snake venom toxin found in a tropical rattlesnake known as Crotalus durissus terrificus. (wikipedia.org)
Previous works have shown that crotamine, a toxin found in Crolatus durissus venom, shows marked individual and populational variation. (scielo.org)

These enzymes are widely described in snake venoms, in which they facilitate the spreading of the main toxins in the victim's body during the envenoming. (biomedcentral.com)
This work is the first report of a cDNA sequence of hyaluronidase from Brazilian snake venoms. (biomedcentral.com)
In snake venoms, this enzyme potentiates the toxicity and contributes to local damage at the bite site by affecting the extracellular matrix integrity due to hyaluronate degradation[ 6 - 8 ]. (biomedcentral.com)

9. Identification of crotamine in the venom of Crotalus durissus collilineatus by three different methods. (nih.gov)

Hyaluronidases are often found in a diversity of venoms, such as those from snakes, lizards and arthropods (scorpions, spiders, wasps and bees), in which they act as an immunogen. (biomedcentral.com)

2. Snake venomics of the Central American rattlesnake Crotalus simus and the South American Crotalus durissus complex points to neurotoxicity as an adaptive paedomorphic trend along Crotalus dispersal in South America. (nih.gov)
Rattlesnakes are indigenous from North America to South America. (medscape.com)

3. Snake venomics and antivenomics of Crotalus durissus subspecies from Brazil: assessment of geographic variation and its implication on snakebite management. (nih.gov)
Methods In this work, we used an antivenomics approach to assess the cross-reactivity of crotalic antivenom manufactured by IVB towards crotamine-negative venom and a mixture of crotamine-negative/crotamine-positive venoms. (scielo.org)
Conclusions These results indicate that venomic databases and antivenomics analysis provide a useful approach for choosing the better venom mixture for antibody production and for the subsequent screening of antivenom cross-reactivity with relevant snake venom components. (scielo.org)

Immunization of horses with Crotalus durissus terrificus (South American rattlesnake) venom. (unboundmedicine.com)
To achieve this goal, antivenom production must start from a suitable immunization protocol and proper venom mixtures. (scielo.org)

Abstract Background Snakebite treatment requires administration of an appropriate antivenom that should contain antibodies capable of neutralizing the venom. (scielo.org)

1. Quantification of crotamine, a small basic myotoxin, in South American rattlesnake (Crotalus durissus terrificus) venom by enzyme-linked immunosorbent assay with parallel-lines analysis. (nih.gov)
4. Chemical and functional homology of myotoxin a from prairie rattlesnake venom and crotamine from South American rattlesnake venom. (nih.gov)
8. New view on crotamine, a small basic polypeptide myotoxin from South American rattlesnake venom. (nih.gov)
10. Nucleotide sequence of crotamine isoform precursors from a single South American rattlesnake (Crotalus durissus terrificus). (nih.gov)
11. Structure and chromosomal localization of the gene for crotamine, a toxin from the South American rattlesnake, Crotalus durissus terrificus. (nih.gov)
12. Automated NMR structure determination and disulfide bond identification of the myotoxin crotamine from Crotalus durissus terrificus. (nih.gov)
14. Intraspecific variation of the crotamine and crotasin genes in Crotalus durissus rattlesnakes. (nih.gov)
16. The analgesic activity of crotamine, a neurotoxin from Crotalus durissus terrificus (South American rattlesnake) venom: a biochemical and pharmacological study. (nih.gov)
In addition, serum produced from crotamine-negative venoms fails to recognize this molecule. (scielo.org)

In Brazil, antivenom against South American rattlesnake (Crotalus durissus terrificus) bites is produced by public institutions based on the guidelines defined by the regulatory agency of the Brazilian Ministry of Health, ANVISA. (scielo.org)

5. Geographic and ontogenic variability in the venom of the neotropical rattlesnake Crotalus durissus: pathophysiological and therapeutic implications. (nih.gov)

2. The inoculation schedule used in horses to obtain antivenom serum consisted of sc injections of a 7.5 mg venom starting dose in 5.0 ml sterile saline emulsified with an equal volume of Freund's complete adjuvant. (unboundmedicine.com)
When antigen was emulsified with liposome, the immune serum was ineffective against the lethal effects of C. d. terrificus venom. (unboundmedicine.com)
3. The inoculation schedule used in horses to obtain hyperimmune serum consisted of reimmunization with sc booster injections of 7.5 mg venom in 5.0 ml sterile saline emulsified with an equal volume of Freund's incomplete adjuvant. (unboundmedicine.com)

A hyaluronidase-like isoform from Vespula vulgaris venom was hypothesized to act as a lectin by binding to hyaluronate and/or other related substances without degrading them[ 11 ]. (biomedcentral.com)

[ 5 ] When considering the use of antivenom, the risk of adverse reaction to antivenom must be weighed against the benefits of reducing venom toxicity. (medscape.com)

Convulxin is part of the snake venom C-type lectin family, a group of hemorrhagic toxins that disrupt body homeostasis. (wikipedia.org)

1. A comparative study was carried out on horses immunized with Crotalus durissus terrificus venom using four different inoculation procedures, which included the use of Freund's adjuvant, A1(OH)3 and liposomes as adjuvants. (unboundmedicine.com)

Among these peptides, snake venom cathelicidins are being widely exploited, because the variation in the composition of the venom reflects a range of biological activities that may be of biotechnological interest. (frontiersin.org)

Puno, has been investigated for its protein content and some enzymatic activities, using for it the whole venom as well as the fractions obtained by gel filtration chromatography in Sephadex G-100. (edu.pe)

Over the centuries, researchers have been trying to understand animal venoms, unveiling intricate mixtures of molecules and their biological effects. (scielo.org)
Patients who are believed to have a dry bite in which no venom effects develop should be observed for at least 8 hours. (medscape.com)

Recently, thromboelastography (TEG) has emerged as an enhanced real-time monitoring parameter for snake envenomations that may aid in management of venom-induced consumptive coagulopathy. (bvsalud.org)

Lymphatic constriction bands and pressure immobilization techniques may inhibit the spread of venom, but whether they improve outcome is not clear. (medscape.com)

The sequence, denominated BpHyase, was identified as hyaluronidase-like since it shows high sequence identities (above 83%) with other described snake venom hyaluronidase-like sequences. (biomedcentral.com)

Among venomous animals, Latrodectus Walckenaer, 1805 (widow spiders) have become feared in many cultures worldwide due to their extremely neurotoxic venom. (scielo.org)

Organisms2

Diseases1

Chemicals and Drugs7

Tropical rattlesnake2

Snakes4

Species4

Snake14

Timber rattlesnake1

Toxins4

North America1

Oreganus1

Subspecies1

Molecules1

Envenomation1

Protein1

Belongs1

Neurotoxic2

Characterization1

Methods2

Antivenom2

Proteins2

Found1

South American6

Components1

Study1

Bothrops5

Crotoxin3

Oreganus helleri1

Cascavella1

Toxin found2

Snake Venoms3

Collilineatus1

Immunogen1

South America2

Antivenomics3

Immunization2

Antibodies1

Crotamine9

Bites1

Therapeutic1

Serum3

Isoform1

Toxicity1

Lectin1

Horses1

Biological activities1

Activities1

Effects2

Management1

Spread1

High1

Worldwide1