ScopolamineGlaucomaAnticholinergic drugBradycardiaMechanism of ActDilateAntidoteParasympathetic nervouDosesPralidoximeSulfateTropaneSecretionsHyoscyamineDeadly nightshadePlacentaOccursMydriaticAntimuscarinicAnticholinergicsAdverseAcetylcholineRespiratoryBelladonnaAccidentalDosageIndicationsHypotensionSubstancesMedicationsDrugsInjectionRatsEffectsMedicalEvidenceBloodAgentAction
Scopolamine8
- Atropa belladonna is a highly poisonous plant which contains variety of active alkaloids such as atropine, scopolamine and many others. (ijpsonline.com)
- Tropane alkaloids include three important ones from our perspective - atropine, scopolamine , and hyoscyamine . (allaboutheaven.org)
- Atropine, scopolamine , and hyoscyamine are the most powerful known anticholinergics in existence. (allaboutheaven.org)
- The humans may have had out-of-body experiences or thought they were growing fur or feathers as a result of consuming the anticholinergic substances atropine or scopolamine. (discovermagazine.com)
- Today, psychedelic users often avoid deliriants such as atropine and scopolamine because of the unpredictable, nightmarish experiences they can cause at large doses, not to mention intense anxiety and dysphoria. (discovermagazine.com)
- At sufficient doses, both atropine and scopolamine can kill the user, but they retain medical uses, nonetheless. (discovermagazine.com)
- Doctors use atropine to reduce saliva during surgery, and to accelerate the heart rate when needed, and scopolamine protects against post-surgery nausea and vomiting. (discovermagazine.com)
- 4. Pretreatment (30 min) with the non-selective muscarinic antagonists scopolamine (0.1, 0.3 or 1 mg kg(-1), i.p.) and atropine (0.3, 1 or 3 mg kg(-1), s.c.) but not methylatropine (1, 3 or 10 mg kg(-1), s.c) significantly inhibited stretching induced by Ro 04-6790 (30 mg kg(-1), i.p.). 5. (lookformedical.com)
Glaucoma1
- Atropine is contraindicated in patients predisposed to narrow angle glaucoma. (the-medical-dictionary.com)
Anticholinergic drug2
- Because it crosses the blood-brain barrier, it is also used to treat the central nervous system effects of atropine overdose and other anticholinergic drug overdoses. (pharmacycode.com)
- Atropine acts as a competitive, reversible antagonist of muscarinic receptors: an anticholinergic drug. (statpearls.com)
Bradycardia11
- Injections of atropine are used in the treatment of symptomatic or unstable bradycardia. (wikipedia.org)
- Injections of atropine are used in the treatment of bradycardia (an extremely low heart rate) and asystole, which is a condition of pulseless electrical activity (PEA) in cardiac arrest. (the-medical-dictionary.com)
- Atropine is also used as a premedication before general anaesthesia to reduce secretions from the lungs and is used as an emergency treatment for bradycardia - abnormally low heart beat. (allaboutheaven.org)
- Atropine or atropine sulfate carries FDA indications for anti-sialagogue/anti-vagal effect, organophosphate/muscarinic poisoning, and bradycardia. (statpearls.com)
- Intravenous (IV) atropine indications include patients with hypersalivation, bronchial secretions, or bradycardia. (statpearls.com)
- Atropine is the first-line therapy (Class IIa) for symptomatic bradycardia in the absence of reversible causes. (statpearls.com)
- If bradycardia persists despite adequate respiratory support, atropine is indicated. (statpearls.com)
- Although not recommended as a routine agent, atropine may be used 3 to 5 minutes before initiation of RSI to prevent bradycardia. (statpearls.com)
- In the setting of post-intubation-related bradycardia, atropine is indicated. (statpearls.com)
- Under current ACLS protocols, atropine is indicated for symptomatic bradycardia and not in a pulseless patient. (statpearls.com)
- Am I to conclude that if I have a patient exposed to Organophosphates or Carbamate or Herbicides who is experiencing severe S&S of a cholinergic OD (Hypotension, Bradycardia, SLUDGE), that I CANNOT contact a BHP and ask for Atropine or carry out the order if a BHP orders Atropine? (myobh.ca)
Mechanism of Act2
- In atropine-induced mydriasis, the mechanism of action involves blocking the contraction of the circular pupillary sphincter muscle (which is normally stimulated by acetylcholine release), thereby allowing the radial pupillary dilator muscle to contract and dilate the pupil. (the-medical-dictionary.com)
- Identify the mechanism of action of atropine. (statpearls.com)
Dilate1
- Topical atropine is used as a cycloplegic, to temporarily paralyze the accommodation reflex, and as a mydriatic, to dilate the pupils. (wikipedia.org)
Antidote2
- Atropine is not an actual antidote for organophosphate poisoning. (wikipedia.org)
- By blocking the action of acetylcholine at muscarinic receptors, atropine also serves as an antidote for poisoning by organophosphate insecticides and nerve gases. (the-medical-dictionary.com)
Parasympathetic nervou2
- Generally, atropine lowers the "rest and digest" activity of all muscles and glands regulated by the parasympathetic nervous system. (the-medical-dictionary.com)
- The main action of the parasympathetic nervous system is to stimulate the M2 muscarinic receptor in the heart, but atropine inhibits this action. (the-medical-dictionary.com)
Doses3
- All doses of atropine appear similarly effective, while higher doses have greater side effects. (wikipedia.org)
- He had no idea how someone could have gotten all the victims to take lethal doses of atropine at the same time, unless they got a bad batch of drugs, or someone had given them something intentionally laced with it. (shadowycorners.com)
- If there is no improvement in the clinical state after repeat doses of atropine, additional treatments with atropine are unlikely to be effective. (statpearls.com)
Pralidoxime2
- Atropine is often used in conjunction with the oxime pralidoxime chloride. (wikipedia.org)
- Atropine is only useful to counter muscarinic effects (pralidoxime and benzodiazepines act on the others). (statpearls.com)
Sulfate1
- Not experience the same gains as you would with Deca, the around 180 pounds, he was injected with were pretreated with atropine sulfate. (smashingbuzz.com)
Tropane2
- Atropine is a tropane alkaloid and anticholinergic medication used to treat certain types of nerve agent and pesticide poisonings as well as some types of slow heart rate, and to decrease saliva production during surgery. (wikipedia.org)
- Atropine is a tropane alkaloid extracted from the deadly nightshade ( Atropa belladonna ) and other plants of the family Solanaceae. (the-medical-dictionary.com)
Secretions1
- While atropine can be used independently for anti-salivation effects, it is not formally recommended for routine use in controlled airways, though it can be used off-label for minimizing secretions in the intubated patient. (statpearls.com)
Hyoscyamine1
- Hyoscyamine is the 3(S)-endo isomer of atropine. (lookformedical.com)
Deadly nightshade1
- Atropine occurs naturally in a number of plants of the nightshade family, including deadly nightshade (belladonna), Jimson weed, and mandrake. (wikipedia.org)
Placenta2
- crosses the placenta. (unboundmedicine.com)
- Crosses the placenta and is present in breast milk. (unboundmedicine.com)
Occurs3
- This occurs because atropine is a competitive inhibitor of the muscarinic acetylcholine receptors. (the-medical-dictionary.com)
- Heroin poisoning occurs most commonly when an individual accidentally overdoses on the drug. (medscape.com)
- If overdose occurs, use peripheral nerve stimulator to determine the degree of neuromuscular blockade. (unboundmedicine.com)
Mydriatic2
- Atropine degrades slowly, typically wearing off in 7 to 14 days, so it is generally used as a therapeutic mydriatic, whereas tropicamide (a shorter-acting cholinergic antagonist) or phenylephrine (an α-adrenergic agonist) is preferred as an aid to ophthalmic examination. (wikipedia.org)
- Atropine degrades slowly, typically wearing off in 2 to 3 days, so tropicamide is generally preferred as a mydriatic. (the-medical-dictionary.com)
Antimuscarinic1
- Atropine is an antimuscarinic that works through competitive inhibition of postganglionic acetylcholine receptors and direct vagolytic action, which leads to parasympathetic inhibition of the acetylcholine receptors in smooth muscle. (statpearls.com)
Anticholinergics1
- Anticholinergics such as atropine are often administered preoperatively. (biomultimedia.net)
Adverse2
- Describe the potential adverse effects of atropine. (statpearls.com)
- Review interprofessional team strategies for improving care coordination and communication to enhance patient outcomes and minimize adverse events with atropine. (statpearls.com)
Acetylcholine3
- However, by blocking the action of acetylcholine at muscarinic receptors, atropine also serves as a treatment for poisoning by organophosphate insecticides and nerve agents, such as tabun (GA), sarin (GB), soman (GD), and VX. (wikipedia.org)
- Atropine can be used to reduce the effect of the poisoning by blocking muscarinic acetylcholine receptors, which would otherwise be overstimulated, by excessive acetylcholine accumulation. (wikipedia.org)
- Atropine is a competitive antagonist for the muscarinic acetylcholine receptor types M1, M2, M3, M4 and M5. (allaboutheaven.org)
Respiratory2
- If there are local symptoms in the eyes or respiratory tract, atropine is not indicated. (statpearls.com)
- there is the risk of accidental overdose that can cause respiratory depression, hypotension and the loss of protective airway reflexes. (biomedcentral.com)
Belladonna1
- Atropine and other belladonna alkaloids are not affected by the drug. (pfizermedicalinformation.com)
Accidental1
- Accidental overdose of IV magnesium has resulted in serious patient harm and death. (unboundmedicine.com)
Dosage2
- Proviron dosage What is the strongest Proviron dosage in your can be cross-linked burning steroid Anavar is the july 2, 2010, in Rotterdam, Netherlands. (smashingbuzz.com)
- Subtherapeutic amounts of atropine are included in the dosage form to discourage diphenoxylate abuse. (statpearls.com)
Indications2
- Summarize the indications for atropine use. (statpearls.com)
- The AHA has removed all indications for atropine in the pulseless patient. (statpearls.com)
Hypotension1
- Atropine is not indicated in beta-blocker-induced bradycardias or hypotension, though its use is unlikely to be harmful. (statpearls.com)
Substances1
- First, Blackhorse needed to shut Schneider down by proving that the overdoses had not been due to any recreational use of mind-altering substances. (shadowycorners.com)
Medications1
- Completion of a controlled closely followed by a slower acting MENT licamichauxiioic-B acid medications can cause an overdose. (smashingbuzz.com)
Drugs1
- Researchers sliced the hairs into cross-sections and found that the people had used the drugs repeatedly over a period of about a year prior to their deaths. (discovermagazine.com)
Injection1
- Troops who are likely to be attacked with chemical weapons often carry autoinjectors with atropine and an oxime, for rapid injection into the muscles of the thigh. (wikipedia.org)
Rats2
- Two experiments investigated the mechanism for changes in measures of behavioral arousal inhibition in rats following administration of atropine. (the-medical-dictionary.com)
- It has been shown to cross the blood-brain barrier in rats. (nih.gov)
Effects3
- The lower dose of 0.01% is thus generally recommended due to fewer side effects and potential less rebound worsening when the atropine is stopped. (wikipedia.org)
- These latter effects are due to the fact that atropine is able to cross the blood-brain barrier. (the-medical-dictionary.com)
- Atropine is usually administered prior to or concurrently with anticholinesterase agents to counteract the muscarinic effects. (unboundmedicine.com)
Medical2
- medical citation needed] Atropine has been observed to prevent or treat irinotecan induced acute diarrhea. (wikipedia.org)
- If we now take a look at Dr Duke's analysis of the activity of Atropine we can compare this with its medical uses in more detail. (allaboutheaven.org)
Evidence2
- Evidence suggests that atropine penalization is just as effective as occlusion in improving visual acuity. (wikipedia.org)
- Atropine was previously included in international resuscitation guidelines for use in cardiac arrest associated with asystole and PEA, but was removed from these guidelines in 2010 due to a lack of evidence for its effectiveness. (wikipedia.org)
Blood5
- The degree of CNS manifestation is related to the drug's ability to cross the blood-brain barrier. (medscape.com)
- Analysis of their blood and urine showed the presence of atropine. (shadowycorners.com)
- Blood concentrations were consistent with an overdose. (shadowycorners.com)
- Because it crosses the blood-brain barrier so that the the alpha receptors it binds are ones in the CNS instead of on the effector organ. (proprofs.com)
- Clonidine is able to affect the heart rate by stimulating α2 receptors instead of β receptors because it has the ability to cross the blood-brain barrier. (proprofs.com)
Agent1
- Atropine/diphenoxylate is an antimotility agent that can be useful in the treatment of diarrhea as second-line therapy by allowing the central-acting opioid effect of diphenoxylate and capitalization on its anticholinergic side effect of constipation to slow motility. (statpearls.com)
Action1
- Atropine blocks that action and therefore may speed up the heart rate. (the-medical-dictionary.com)