Cross desensitization. Medical search. Frequent questions

Budd , David C. et al "Cross Talk Between m3-Muscarinic and β 2 -Adrenergic Receptors at the Level of Receptor Phosphorylation and Desensitization. (aspetjournals.org)
The beta-adrenergic receptor kinase 1 (beta ARK1) is a member of the G protein-coupled receptor kinase (GRK) family that mediates the agonist-dependent phosphorylation and desensitization of G protein-coupled receptors. (duke.edu)

We sought to extend the receptor-desensitization paradigm for use with a cultured cell system, in which an intracellular calcium signal rather than a contractile response might be used as an index of receptor activation. (aspetjournals.org)
The beta-adrenergic receptor kinase (beta ARK) phosphorylates its membrane-associated receptor substrates, such as the beta-adrenergic receptor, triggering events leading to receptor desensitization. (duke.edu)

These evidence-based methods include cognitive behavioral therapy, eye movement desensitization reprocessing (EMDR), emotionally focused therapy (EFT), dialetical behavioural therapy (DBT), psychodynamic, family systems, solution-focused therapy and mindfulness practices. (health-local.com)

1996 ) Reciprocal cross-desensitization of locus coeruleus electrophysiological responsivity to corticotropin-releasing factor and stress. (neurotree.org)

BACKGROUND In liver transplantation (LT), preoperative desensitization therapy is considered necessary in patients positive for donor-specific anti-human leukocyte antigen antibodies (DSAs). (bvsalud.org)
Cross-reactive epitope group antigen (CREG)-alone-positive cases were also treated with preoperative MMF when lymphocyte cross-matching was positive. (bvsalud.org)

The mechanism of opiate desensitization is only poorly understood. (tau.ac.il)

Cross tolerance within classes of drugs. (freezingblue.com)
It's merely creating a tolerance so that peanut allergy sufferers can worry less about cross contamination or accidental ingestion of small amounts of peanut protein. (bestallergysites.com)
Abstract: Desensitization or tolerance is a major consequence of long‐term opiate exposure. (tau.ac.il)
Tnis molecular event could underlie the development of tolerance and cross‐tolerance to opiates. (tau.ac.il)

Take every opportunity to trail ride with a group or go somewhere new to ride, since exposure and desensitization are important parts of your cross-country training. (horseillustrated.com)

population-based studies have suggested that having a cat in the house could decrease the risk of sensitisation and Methods We did a population-based cross-sectional study of asthma.8-11 Simple explanations for this finding include the children (aged 12-14 years), some of whom had symptoms of possibility that families affected by allergy avoid having asthma and bronchial hyper-reactivity. (cdc.gov)

Treatment modalities are depending on the clinical phenotypes of NH and they will embrace for each patient: the avoidance of culprit NSAID, the finding of well-tolerated NSAID and in certain cases, desensitization procedures when the NSAID treatment was absolutely needed as well as the control of associated diseases such as spontaneous chronic urticarial or allergic respiratory diseases. (intechopen.com)
Mycophenolate mofetil (MMF) was administered preoperatively in DSA-positive cases with positive lymphocyte cross-matching who underwent LDLT. (bvsalud.org)
Of 9 DSA-positive cases, desensitization therapy was performed in 7, among which rituximab administration was performed in 3 strongly DSA-positive cases. (bvsalud.org)
Of 7 CREG-alone-positive cases, 2 were lymphocyte cross-match-positive and underwent desensitization therapy. (bvsalud.org)
CONCLUSIONS Satisfactory LDLT results were achieved in DSA- and CREG-alone-positive cases following desensitization therapy. (bvsalud.org)

However, the relationship between DSA intensity and the necessary desensitization therapy is unclear. (bvsalud.org)

We developed a calcium signaling-based assay, using cultured human embryonic kidney cells (HEK), that evaluates simultaneously, the activation/desensitization or blockade of the proteinase-activated receptors, PAR 1 and PAR 2 . (aspetjournals.org)
These data, coupled with previous observations on the absence of heterologous desensitization between PAF and sIgM receptors, may delineate distinct signaling pathways in human B cells. (jci.org)

The toxins blocked both PAF-induced transmembrane uptake of Ca2+ as well as release of Ca2+ from internal stores, and were selective in that activation events after cross-linking of surface IgM were not affected. (jci.org)

In contrast, we found that CPZ exerts its anti-inflammatory effects via profound desensitization of TRPA1. (nature.com)

2000). "State-dependent cross-inhibition between transmitter-gated cation channels" (PDF). (wikipedia.org)

We demonstrate a novel dual strategy against inflammation and pain through body-wide desensitization of nociceptors via TRPA1. (nature.com)
Thus, systemic desensitization through TRPA1 may provide a novel strategy for medicinal treatment of various chronic inflammatory and pain states. (nature.com)

Lt. Cross can not keep his mind off of the girl that he loves back home, even while on duty. (ipl.org)
Moreover when Ted Lavender got shot in the head, Cross felt responsible for his death because he was the lieutenant and all he has been doing is daydreaming about a girl that doesn't love him back. (ipl.org)

Although GABA activates synaptic (αβγ) GABA A receptors with high efficacy, partial agonist activation of αβγ isoforms and GABA activation of the primary extrasynaptic (αβδ) GABA A receptors are limited to low-efficacy activity, characterized by minimal desensitization and brief openings. (jneurosci.org)

Intriguingly, colonic and systemic administration of CPZ or AITC induced a profound body-wide, TRPA1-mediated desensitization of nociception in mice. (nature.com)

Before tackling true cross-country schooling or competition out in the open, your horse will need some mental preparation in order to proceed safely. (horseillustrated.com)

Specific fear focused in a phobia can vary cross culturally. (oneclass.com)

This pilot study examined eye movement desensitization and reprocessing (EMDR)-based group treatment for preschool refugee children in German daycare centers. (emdria.org)
On his plan now, we've added a trauma exposure, while we wait on an Eye Movement Desensitization and Reprocessing (EMDR) therapist. (youthvillages.org)
I am also trained in EMDR (Eyes Movement Desensitization and Reprocessing. (sophie-dubois.com)
Bilateral stimulation is commonly used in EMDR (eye movement desensitization and reprocessing) which is routinely used to heal and process traumas. (in5d.com)
My training in therapeutic modalities includes Eye Movement Desensitization and Reprocessing (EMDR), Trauma-Focused Cognitive Behavior Therapy (TF-CBT), Functional Family Therapy (FFT), Dialectical Behavior Therapy (DBT), and Motivational Interviewing (MI). (goodlifetherapyia.com)
Depending on my client's needs, I employ evidence-based interventions from Solution Focused Therapy (SFT), Cognitive Behavior Therapy (CBT), Dialectical Behavior Therapy (DBT), Emotion Focused Therapy (EFT), Gestalt, and Eye Movement Desensitization and Reprocessing (EMDR). (horizonpsychology.ca)

The second process is distal to receptor/G-protein interaction and utilizes an undefined pathway to cross-desensitize the Ca2+ mobilization response to all peptide chemoattractants. (duke.edu)
We propose that receptor cross-desensitization in leukocytes is orchestrated at several levels by mechanisms with selectivity for types of chemoattractant receptors. (duke.edu)
We hypothesized that the attenuation of the GIRK current would lead to a recovery of neuronal excitability whereby desensitization of the receptor would lead to a new steady state of POMC neuron activity reflecting the sustained GIRK current observed after the initial decline from peak with continued agonist exposure. (jneurosci.org)
Altogether, the data show that somatodendritic MORs in POMC neurons inhibit neuronal activity through at least two effectors with distinct levels of receptor reserve and that differentially reflect receptor desensitization. (jneurosci.org)
SIGNIFICANCE STATEMENT Desensitization of the μ-opioid receptor (MOR) is thought to underlie the development of cellular tolerance to opiate therapy. (jneurosci.org)
The data show that somatic MORs in POMC neurons couple to multiple effectors that have differential sensitivity to desensitization of the receptor. (jneurosci.org)
It is the most structurally and functionally distinct P2X subtype, containing a unique cytoplasmic domain critical for the receptor to initiate apoptosis and not undergo desensitization. (nih.gov)
Scholars@Duke publication: Unidirectional, heterologous desensitization of the pertussis toxin receptor by the CD3/TCR complex. (duke.edu)
When this occurs after stimulation by the primary agonist for a given receptor it is termed homologous desensitization, and heterologous desensitization when to an agonist binding to a different type of receptor. (duke.edu)
If two cysteine residues come into close proximity, we predict they will be cross-linked and result in ∼66% of the receptor subunits running on a Western blot as dimers. (rupress.org)

Our data show that all receptors studied underwent homologous desensitization. (duke.edu)
Whereas all peptide receptors underwent homologous desensitization, C5a and IL-8, but not fMLP, receptors were cross-desensitized by other peptide chemoattractants. (duke.edu)
These data suggest that in addition to homologous desensitization, peptide chemoattractant receptors cross-desensitize one another by at least two processes. (duke.edu)
Unlike histamine-induced rises in [Ca2+]i, those induced by CPH were not desensitized in a homologous manner, and there was no cross-desensitization between CPH and histamine. (uni-regensburg.de)

Scholars@Duke publication: Cross-desensitization of receptors for peptide chemoattractants. (duke.edu)

Cross-desensitization of receptors for peptide chemoattractants. (duke.edu)
The formylpeptide (fMLP) and C5a chemoattractants were previously shown to cross-desensitize each other's ability to mobilize Ca2+ in leukocytes but not to affect nonchemoattractant Ca(2+)-mobilizing receptors, and vice versa. (duke.edu)
In the presence of cytochalasin B, only fMLP and C5a caused the activation of phospholipase D in intact leukocytes and enhanced desensitization of IL-8 and C5a but not fMLP receptors. (duke.edu)
Activation of somatic μ-opioid receptors (MORs) in hypothalamic proopiomelanocortin (POMC) neurons leads to the activation of G-protein-coupled inward rectifier potassium (GIRK) channels and hyperpolarization, but in response to continued signaling MORs undergo acute desensitization resulting in robust reduction in the peak GIRK current after minutes of agonist exposure. (jneurosci.org)
Thus, continued signaling of opioid receptors can proceed in the following three phases: first reaching a peak, then undergoing desensitization, and finally reaching a fully desensitized state. (jneurosci.org)
Cross-linking of these receptors on the surface of effector cells such as basophilic and eosinophilic granulocytes or mast cells by allergen contact results in consecutive cell activation with the release of histamine and other proinflammatory mediators. (uni-marburg.de)

In network with Aetna, Anthem Blue Cross Blue Shield, United Health Care (UHC), UHC All Savers, UHC Optum, UHC Optum Behavioral Health, UHC UMR (UBH & UHC Choice Plus Network). (christiancounselingconnection.com)
Anna accepts Blue Cross Blue Shield insurance and also offers a direct rate. (goodlifetherapyia.com)
Green Door Counseling accepts Anthem/Blue Cross Blue Shield Insurance, United Healthcare and private pay. (susanwolfetherapist.com)

11. Hypersensitivity Reactions to Oxaliplatin: Identifying the Risk Factors and Judging the Efficacy of a Desensitization Protocol. (nih.gov)
Data submitted to the Australian TGA was generated in Hansa's phase 2 studies that demonstrated the efficacy and safety of imlifidase as a desensitization treatment to enable incompatible kidney transplantation for highly sensitized patients. (hansabiopharma.com)

Choices to consider as desensitization therapies include IV immunoglobulin (Ig) infusion, plasmapheresis, either alone or combined, rituximab (Rituxan®), and in very selected cases, splenectomy. (bcbsnd.com)
Cross-culturally effective, low-threshold therapies for refugees that can be carried out quickly are urgently required. (emdria.org)

These observations suggest a model in which T cells can regulate amplification of a non-AgR stimulatory pathway by heterologous desensitization. (duke.edu)

The current data show that desensitization of neutrophils to any two CEACAMs results in selective desensitization to those two CEACAMs, while the cells remain responsive to the other two neutrophil CEACAMs. (biomedcentral.com)
On the other hand, it is important to note that there are other NSAIDs that either partially inhibit COX-1 or are selective for COX-2, such as celecoxib, which lacks cross-reactivity with COX-1 inhibitors ( Table 1 ). (midwestsinus.com)

HLA-sensitized individuals are difficult to match for donor organs because of high risks of hyperacute rejection and graft loss with cross-matched organs. (bcbsnd.com)
It does, however, facilitate the implementation of cross-over donation programs by increasing the number of living donor/recipient pairs eligible to participate in the program. (bvsalud.org)
In order to mitigate the risk of a donor withdrawing and to facilitate the matching, the legislator has chosen to integrate a deceased donor organ to initiate the cross-donation program. (bvsalud.org)
The provisional approval has a duration of two years and was based on data from Hansa's phase 2 studies 1-4 that included highly sensitized patients who received a kidney from either a living (17%) or deceased donor (83%) following desensitization treatment with imlifidase. (hansabiopharma.com)
1-4 The submitted data included a sub analysis of highly sensitized patients that received a kidney transplant from a living donor following desensitization treatment using imlifidase. (hansabiopharma.com)

The cells were not refractory to further stimulation of the AgR because cross-linking with rabbit anti-mIg resulted in the standard maximal stimulation. (duke.edu)
To examine potential interactions of CEACAMs in neutrophil signaling, the effects on neutrophil adhesion to human umbilical vein endothelial cells of a set of CD66 mAbs was tested following desensitization to stimulation by various combinations of these mAbs. (biomedcentral.com)
Addition of a CD66 mAb in the absence of calcium results in desensitization of neutrophils to stimulation by that CD66 mAb. (biomedcentral.com)

14. Rituximab Hypersensitivity: Evaluation, Desensitization, and Potential Mechanisms. (nih.gov)

The use of a desensitization treatment protocol that does not meet these criteria or for any other transplant other than heart or renal is considered experimental/investigational, and therefore, non-covered. (bcbsnd.com)
Specific immunotherapy (SIT), also termed hypo- or desensitization, is known for almost a century as a treatment for immediate type reactions. (uni-marburg.de)
In the control construct (C349A) that removed the free cysteine C349, and some cysteine-containing mutants, cross-linker treatment does not result in dimerization. (rupress.org)
Hansa Biopharma, "Hansa" (Nasdaq Stockholm: HNSA), a pioneer in enzyme technology for rare immunological conditions, today announced that the Australian Therapeutic Goods Administration ("TGA") has provisionally approved Idefirix (imlifidase) as desensitization treatment for highly sensitized patients prior to kidney transplantation from both living and deceased donors. (hansabiopharma.com)
This review article focuses on the management of AERD patients with a particular emphasis on aspirin desensitization and continuous treatment with aspirin. (midwestsinus.com)

8. Indications, protocols, and outcomes of drug desensitizations for chemotherapy and monoclonal antibodies in adults and children. (nih.gov)
however, adults that have a systemic reaction and children that have systemic symptoms involving the respiratory, gastrointestinal or cardiovascular system must be tested and need desensitization. (thedoctorsclinic.com)

In contrast, desensitization of cells to CEACAM1 and any two of the other CEACAMs left the cells unresponsive to all CD66 mAbs. (biomedcentral.com)

2. Hypersensitivity and desensitization to antineoplastic agents: outcomes of 189 procedures with a new short protocol and novel diagnostic tools assessment. (nih.gov)
6. Hypersensitivity reactions to oxaliplatin and the application of a desensitization protocol. (nih.gov)

7. Risk stratification for desensitization of patients with carboplatin hypersensitivity: clinical presentation and management. (nih.gov)
My university background is in clinical and cross-cultural psychology and was strongly inspired by psychoanalysis. (sophie-dubois.com)
These three distinct ways of stimulations of immune or inflammatory cells differ substantially in clinical manifestations, time of appearance, dose dependence, predictability, and cross-reactivity, and thus need to be differentiated. (karger.com)

The study was also limited by lack of randomization and by the inability to look at cross-reactivity in multiallergic participants. (medscape.com)

4. Carboplatin-, oxaliplatin-, and cisplatin-specific IgE: cross-reactivity and value in the diagnosis of carboplatin and oxaliplatin allergy. (nih.gov)

I gave in to the temptation of providing a quick response: "Definitely not, American voters, on balance, are tolerant, but when a politician crosses the line, he will pay the price," I cited a few examples. (smerconish.com)

The movement of water can be unpredictable and may cause the horse to lose its footing or become unbalanced, leading to fear and reluctance to cross. (pettime.net)

China has issued for public comment draft standard-like guidelines to govern cross-border data flows to further implement China's heightened concern over national security and cybersecurity, as embodied in the National Security Law (2015), Cybersecurity Law (effective June 1, 2017) and related laws and regulations. (wilmerhale.com)
They would subject cross-border data flows covering a very wide range of subject matters to security assessments and privacy consents. (wilmerhale.com)
The Guidelines, termed the Information Security Technology-Guidelines for Data Cross-Border Transfer Security Assessment (the Guidelines), set forth the procedures, principal assessment concerns, and methods for cross-border data transfer security assessments. (wilmerhale.com)
The Guidelines would be applicable to Network Operators for the conduct of security assessments of cross-border transfers of personal information and important data, and be applicable to industry regulators and supervisors to guide and supervise Network Operators in their security assessments of cross-border transfers of personal information and important data [Article 1]. (wilmerhale.com)
The Guidelines define such terms as Important Data, Sensitive Personal Information, Data Cross-Border Transfer (sic), Provide [Provision] and Data Desensitization. (wilmerhale.com)
Important Data includes data related to national security, economic development, and societal and public interests, as further detailed in the 28 industry sectors listed in Appendix A. Cross-border data transfers would not include overseas data transiting China without being modified, processed or disposed of in China [Article 3.6]. (wilmerhale.com)

Prolonged activation of somatic MORs in POMC neurons robustly inhibited action potential firing and Ca 2+ activity despite desensitization of the MOR and reduced activation of a potassium current over the same time course. (jneurosci.org)

1. Oxaliplatin hypersensitivity: evaluation, implications of skin testing, and desensitization. (nih.gov)
Desensitization with insect venom is recommended to those who reacted to skin testing. (thedoctorsclinic.com)

13. Hypersensitivity reactions to chemotherapy: outcomes and safety of rapid desensitization in 413 cases. (nih.gov)

10. Hypersensitivity reactions to oxaliplatin: cross-reactivity to carboplatin and the introduction of a desensitization schedule. (nih.gov)

17. Desensitization with oxaliplatin in patients intolerant of carboplatin desensitization. (nih.gov)

OIT consists of administering small amounts of allergen, followed by escalating doses over time to induce desensitization. (medscape.com)

The present studies focused on MOR desensitization in hypothalamic proopiomelanocortin (POMC) neurons as these neurons produce the endogenous opioid β-endorphin and are heavily regulated by opioids. (jneurosci.org)
Alpha-gal allergy is the sensitization to Alpha-gal present in saliva when a tick bites and the development of an IgE-mediated reaction to Alpha-gal also present in red meat by cross-reactivity. (qxmd.com)

I have been teaching for over 7 years now cross-culturally and in Canada. (horizonpsychology.ca)

This can make them more hesitant to cross water, as they sense their rider's fear and uncertainty. (pettime.net)

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