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  • 1989
  • 1989). We now show, by using electrophysiological techniques in three different types of smooth muscle, that a large-conductance voltage and Ca 2+ -sensitive channel, otherwise indistinguishable from the large-conductance Ca 2+ -activated K + channel (BK channel), is also sensitive to cytoplasmic ATP and cromakalim. (royalsocietypublishing.org)
  • glibenclamide
  • In the present study performed in the porcine epicardial coronary artery, the effect of levosimendan (0.009-3.2 μM) was compared to cromakalim (0.0125-5 μM), the known activator of ATP-sensitive potassium (K ATP ) channels, in the presence of glibenclamide (GLI), an inhibitor of K ATP channels and tetraethylammonium (TEA), the non-selective inhibitor of potassium channels. (springer.com)
  • cerebral
  • The authors tested the efficacy of locally delivered intrathecal cromakalim, a PCO, incorporated into a controlled-release system to prevent cerebral vasospasm in a rat model of SAH. (thejns.org)
  • group
  • Controlled release of cromakalim from the cromakalim/hyaluronan implant at a dose of 0.055 mg/kg significantly increased lumen patency in a dose-dependent manner up to 94 ± 8% (mean ± standard error of the mean) of the basilar arteries of the sham group compared with the empty polymer group (p = 0.006). (thejns.org)
  • Lumen patencies of the cromakalim-only groups did not differ in statistical significance at low (64 ± 9%) or high (66 ± 7%) doses compared to the SAH-only group. (thejns.org)
  • treatment
  • While clinical trials have indicated that cromakalim may be of benefit in the treatment of nocturnal asthma, it remains to be determined whether KCOs will find a place in our armamentarium of clinically useful anti-asthma agents. (curehunter.com)