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  • adjuvant
  • The adsorption of (A) MenC-CRM197 and (B) Hib-TT and MenC-TT to aluminum phosphate and aluminum hydroxide were studied as a function of adjuvant concentration. (nih.gov)
  • conjugates
  • Fig. 1 shows the adsorption of the MenC-CRM197, MenC-TT and Hib-TT bulk conjugates to aluminum phosphate and aluminum hydroxide in a non-phosphate-containing saline solution at concentrations ranging from 0.06 to 2 mg Al3+/ml. (nih.gov)
  • mice
  • The investigators conducted studies in which CRM197 and paclitaxel (Taxol®) were tested against ovarian cancer cell cultures ( in vitro ) and overexpressing HB-EGF ovarian cancer cells which were injected into mice. (libbyshope.com)
  • The investigators also noted that in the mice with ovarian cancer xenografts , paclitaxel and CRM197 completely blocked tumor formation at doses of 10 mg/kg paclitaxel and 5 mg/kg CRM197. (libbyshope.com)
  • clinical
  • Phase 1 [clinical] study of the use of CRM197 has already started at Fukuoka University for patients with advanced ovarian cancer under the approval of the ethical committee," the investigators added. (libbyshope.com)
  • facility
  • The comments come following an announcement by Reagent Proteins - a division of Pfenix - that its manufacturing partner, Serum Institute of India, has begun construction on a new facility dedicated to the production of CRM197. (in-pharmatechnologist.com)
  • Cell
  • MMP-9 expression on reverse transcription polymerase chain reaction (RT-PCR) revealed that MMP-9 was suppressed in oral squamous cell carcinoma cells treated with CRM197. (nii.ac.jp)
  • In addition, the peptide is capable of priming T-cells in vivo for a subsequent in vitro T-cell response to itself or to the intact CRM197 molecule. (springer.com)