• It is a signal transducing adaptor protein that undergoes tyrosine PHOSPHORYLATION in signaling pathways that regulate CELL MIGRATION and CELL PROLIFERATION. (ucdenver.edu)
  • AND-34/BCAR3 (Breast Cancer Anti-Estrogen Resistance 3) associates with the focal adhesion adaptor protein, p130CAS/BCAR1. (molvis.org)
  • Several phosphorylation sites have been described in p130Cas upon Fibroblast Growth Factor stimulation, and phosphorylated tyrosine (Y249) might function as a binding site for the Crk-adaptor molecule. (bdbiosciences.com)
  • Nod Signaling Adaptor Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uchicago.edu)
  • Cytosolic signaling adaptor proteins that were initially discovered by their role in the innate immunity (IMMUNITY, INNATE) response of organisms that lack an adaptive immune system. (uchicago.edu)
  • Below are the most recent publications written about "Nod Signaling Adaptor Proteins" by people in Profiles. (uchicago.edu)
  • Below are the most recent publications written about "Adaptor Proteins, Signal Transducing" by people in Profiles. (childrensmercy.org)
  • A signal transducing adaptor protein that links extracellular signals to the MAP KINASE SIGNALING SYSTEM. (uchicago.edu)
  • The insulin-receptor substrate (IRS), SHC, GRB2, CRKII and CRKL adaptor proteins have all been implicated in transmitting signals to the nucleus of the cell. (nih.gov)
  • NCK is a major adaptor protein involved in membrane receptor signalling and modulation of actin cytoskeleton dynamics. (eu.org)
  • Discs Large Homolog 1 Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (umassmed.edu)
  • This graph shows the total number of publications written about "Discs Large Homolog 1 Protein" by people in this website by year, and whether "Discs Large Homolog 1 Protein" was a major or minor topic of these publications. (umassmed.edu)
  • Below are the most recent publications written about "Discs Large Homolog 1 Protein" by people in Profiles. (umassmed.edu)
  • CRKL or v-crk sarcoma virus CT10 oncogene homolog (avian)-like is a protein kinase containing SH2 and SH3 (src homology) domains that activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion (1). (rockland.com)
  • Activation of protein serine/threonine kinases and pathways coupled to small G proteins, and elevation of intracellular calcium, are examples of the events that follow. (nih.gov)
  • Recent studies on the involvement of the G12 family of heterotrimeric G proteins (Gα12 and Gα13, the products of the GNA12 and GNA13 genes, respectively) in oncogenic pathways have uncovered a link between G12 signaling and cancer progression. (biomedcentral.com)
  • Heterotrimeric guanine nucleotide-binding proteins (G proteins) mediate extracellular signals from transmembrane G protein-coupled receptors (GPCRs) to activate intracellular effector molecules, triggering signaling pathways that lead to a variety of cellular responses [ 1 , 2 ]. (biomedcentral.com)
  • The tyrosine kinase Src is a member of a family of related kinases known as the Src family kinases (SFKs) that share a common structural organization and function as key regulators of signal transduction pathways triggered by a wide variety of surface receptors, including receptor tyrosine kinases, integrins, G-protein-coupled receptors, and antigen receptors (Thomas and Brugge 1997). (mdm2-receptor.com)
  • A SH2 DOMAIN-containing protein that mediates SIGNAL TRANSDUCTION pathways from multiple CELL SURFACE RECEPTORS , including the EPHB1 RECEPTOR . (nih.gov)
  • They play a role in cell signaling pathways such as those involving G-PROTEINS and the HIPPO-SIGNALING PATHWAY . (nih.gov)
  • We will exploit the use of substrate specific variants of the Met receptor to dissect signaling pathways essential for tumor induction and metastasis and will dissect signals that promote tumor angiogenesis. (mcgill.ca)
  • Src Homology 2 (SH2) domains are small modular domains found within a great number of proteins involved in different signalling pathways. (eu.org)
  • Kim E, Cho KO, Rothschild A, Sheng M. Heteromultimerization and NMDA receptor-clustering activity of Chapsyn-110, a member of the PSD-95 family of proteins. (umassmed.edu)
  • Insulin receptor substrate-1 (IRS-1) and Golgi phosphoprotein 3 (GOLPH3) were overexpressed in ESCC. (spandidos-publications.com)
  • Receptor-facilitated antigen presentation requires the recruitment of B cell linker protein to Igalpha. (uchicago.edu)
  • Little is known about the transcriptional regulation of EFS, but several transcriptional regulators for EFS have been proposed based on consensus binding sites in its promoter region for ATF (Activating transcription factor), NF-κβ, NF-κβ1, GATA-3, C/EBPα (CCAAT/enhancer-binding protein alpha), glucocorticoid receptors α and β, and p53. (wikipedia.org)
  • Podosomes are structurally divided into a core, which mainly contains proteins involved in actin polymerization (such as WASP, the Arp2/3 complex and cortactin ), and a surrounding ring populated by integrin receptors and adhesion proteins (for example, paxillin and focal adhesion kinase (FAK/Pyk2) ) [15] . (cellmigration.org)
  • Following binding of the antigen-HLA complex to the TCR, receptors aggregate, associated protein tyrosine kinases (PTK) are activated, and TCR subunits and a number of linker or adapter molecules are phosphorylated on tyrosine residues. (nih.gov)
  • Once phosphorylated by SRC or other kinases, these tyrosine motifs are bound by the SH2 domains of signaling proteins. (wikipedia.org)
  • Protein tyrosine kinases of the Src family, Fyn and Lck, are associated with the TCR and TCR coreceptors, respectively. (nih.gov)
  • CRKL Protein is suitable for use in Western Blot. (rockland.com)
  • p47v-crk (v-Crk) is the product of a transforming gene, v-crk, that was isolated from avian sarcoma viruses. (bdbiosciences.com)
  • According to the Human Genome Organization (HUGO) Gene Nomenclature Committee (HGNC) its approved symbol is EFS and its synonyms are "Cas scaffolding protein family member 3", CASS3, EFS1, EFS2, HEFS and SIN. (wikipedia.org)
  • We detected PTK6 mRNA and protein expression in the immortalized normal MCF-10A human mammary gland epithelial cell line, and examined PTK6 expression and activation in a normal human breast tissue microarray, as well as in human breast tumors. (oncotarget.com)
  • We will establish the molecular basis through which the Crk adapter protein induces epithelial cell migration using a proteomic approach to identify Crk associated proteins and using cell biology and mouse models for cell invasion. (mcgill.ca)
  • Crk-associated substrate was originally identified as a highly phosphorylated 130 kDa protein that associates with ONCOGENE PROTEIN CRK and ONCOGENE PROTEIN SRC. (ucdenver.edu)
  • EFS (Embryonal Fyn-associated Substrate), also known as SIN (Src INteracting or Signal Integrating protein) was originally identified using cDNA library screening of mouse embryonal libraries for proteins containing SH3-interacting domains, or interacting with the SRC SH3 domain, in two independent studies by Ishino et al. (wikipedia.org)
  • A class of intracellular signaling proteins that were originally identified as inhibitors of ANGIOSTATIN activity. (nih.gov)
  • Adhesion complexes (i.e., focal adhesions and focal complexes) and cell-cell contacts are specialized structures that harbor a large number of cytoskeletal proteins and one of the highest concentrations of signaling molecules in cells ( Ruoslahti and Obrink, 1996 ). (rupress.org)
  • Genetic interaction of mammalian IFT-A paralogs regulates cilia disassembly, ciliary entry of membrane protein, Hedgehog signaling, and embryogenesis. (childrensmercy.org)
  • Because the egg protein and the total amino acid contents declined with development, it is concluded that the rate of breakdown of yolk protein was higher than the anabolic and catabolic processes during embryogenesis. (alr-journal.org)
  • Data also suggest that in freshwater fish FAA are an unlikely primary energy substrate during embryogenesis. (alr-journal.org)
  • General, our outcomes demonstrate the effectiveness of MI-773 such an instant testing for the recognition of significant developmental ramifications of EDCs promoter travel the manifestation of improved green fluorescent proteins (EGFP) in every arteries throughout embryogenesis [25]. (thetechnoant.info)
  • Protein tyrosine kinase 6 (PTK6, also called BRK) is a SRC-related intracellular tyrosine kinase expressed in normal epithelia and cancer. (oncotarget.com)
  • All NSP proteins contain an NH 2 -terminal SH2 (Src homology domain 2) domain, a central proline/serine-rich domain, and a COOH-terminal domain with modest homology to Ras subfamily GDP-exchange factors (GEFs). (molvis.org)
  • The mechanistic basis for the ability of class II PI3Ks to recognize PI(4)P as a substrate to directly produce local pools of PI(3,4)P 2 at defined endocytic membrane nanodomains is unknown. (nature.com)
  • These initial events lead to the generation of multiple protein complexes that localize at the TCR and the plasma membrane. (nih.gov)
  • These complexes contain enzymes that are regulated by protein phosphorylation and whose substrates are located at the membrane. (nih.gov)
  • LAT, initially characterized by this laboratory, is an integral membrane protein with multiple tyrosine residues. (nih.gov)
  • Ras proteins are attached by a fatty tail to the inner surface of the cell membrane. (elifesciences.org)
  • Complexes of Vps34, the sole class III PI3K member, produce PI 3-phosphate (PI(3)P) in the endolysosomal system and during autophagy to regulate vesicle-mediated sorting en route to lysosomes 1 . (nature.com)
  • Although focal adhesions are similar, in terms of molecular composition, to nascent adhesions and focal complexes, several adhesion proteins appear to change as focal adhesions evolve in response to tension, e.g., zyxin and vinculin . (cellmigration.org)
  • We are currently using a multidisciplinary approach to study LAT as well as the multi-protein complexes that form at phosphorylated LAT. (nih.gov)
  • Crk-Associated Substrate Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (ucdenver.edu)
  • Crk-associated substrate p130(Cas) interacts with nephrocystin and both proteins localize to cell-cell contacts of polarized epithelial cells. (ucdenver.edu)
  • SH3 domains bind to proline-rich motif containing proteins. (wikipedia.org)
  • The amino acid sequences of the SH3 domains are 70% identical among human EFS, BCAR1, and NEDD9, making this the most highly conserved domain for the whole protein family. (wikipedia.org)
  • The v-Crk protein is a fusion product of viral Gag protein and a part of cellular Crk that includes SH2 and SH3 domains. (bdbiosciences.com)
  • This class of proteins contains three domains, a C-terminal ligand recognition domain, an N-terminal effector-binding domain, and a centrally located nuclear-binding oligomerization domain. (uchicago.edu)
  • The interaction between SH2 domains and their substrates is however dependent also on cooperative contacts of other surface regions. (eu.org)
  • The Tir protein of EPEC binds NCK1/NCK2 SH2 domains through a high affinity pYDEV motif ( Frese,2006 ). (eu.org)
  • They are able to bind specific motifs containing a phosphorylated tyrosine residue, propagating the signal downstream by promoting protein-protein interactions and/or modifying enzymatic activities. (eu.org)
  • In humans, the 561 amino acid EFS protein acts as a scaffolding protein for cell signaling based on interactions with SRC, FAK, and other proteins, and has been linked to roles in the function of the immune system, and the development of cancer. (wikipedia.org)
  • Engagement of the TCR by antigenic peptide bound to a histocompatibility molecule (in humans, an HLA molecule) leads to a complex set of biochemical events in which the initial activation of protein phosphorylation is critical. (nih.gov)
  • Both the transforming ability and the impact on cell invasion and metastasis of G12 proteins appear to be dependent, at least in part, on their ability to engage Rho GTPases. (biomedcentral.com)
  • Central "substrate domain" containing multiple repeats of tyrosine residues embedded within specific conserved sequences (YxxP) (amino acids 69-350 for human EFS). (wikipedia.org)
  • i) which Gab1 dependent signals are required for morphogenesis, by assessing known Gab1 associated proteins and Gab1 associated proteins identifid by tandem mass spectroscopy, ii) the molecular basis through which the tyrosine phosphatase SHP-2 is required for morphogenesis. (mcgill.ca)
  • The Ras family of proteins play an important role in relaying signals from the outside to the inside of the cell. (elifesciences.org)
  • Mutations identified in many SH2 domain-containing proteins as well as the SH2 domain itself are associated with human diseases ranging from cancers, diabetes, to immunodeficiencies. (eu.org)
  • Mutations in Ras proteins occur in around a third of all cancers, so a better understanding of their dynamics could help with future drug discovery. (elifesciences.org)
  • There are three protein isoforms of human Efs. (wikipedia.org)
  • Protein Tyrosine kinase 6 (PTK6/BRK) is overexpressed in the majority of human breast tumors and breast tumor cell lines. (oncotarget.com)
  • Up to 30% of human protein-coding genes may be regulated by miRNAs ( 8 , 9 ). (spandidos-publications.com)
  • Functional proteomics identifies protein-tyrosine phosphatase 1B as a target of RhoA signaling. (ucdenver.edu)
  • It contains an N-terminal RING FINGER DOMAIN and is a PROTEIN PHOSPHATASE 1 regulatory subunit. (jefferson.edu)
  • More than 300 peptidases (protein-degrading enzymes) are known, but despite the fact that many investigators have extensively studied the ecology and geochemistry of peptidases (protein-degrading enzymes) in aquatic ecosystems, all previous research in freshwater systems are limited to the analysis of a single peptidase, leucyl aminopeptidase. (overleaf.com)
  • Enzymes hydrolyzing proteins containing terminal pyroglutamic acid were not observed. (overleaf.com)
  • Notably, we are unaware of any studies of freshwater in which activities of peptidases (protein-degrading enzymes) were assayed using any compound other than leucine 7-amido-4-methylcoumarin (or related leucine-based compounds), which reports the activity of an enzyme called leucyl aminopeptidase (E.C. 3.4.11.1). (overleaf.com)
  • EFS is a member of the CAS (Crk-Associated Substrate) family of proteins. (wikipedia.org)
  • As the member of CAS protein family, EFS shares common structural characteristics with other members of the family. (wikipedia.org)
  • A family of endogenous regulatory proteins that associate with RETINOBLASTOMA PROTEIN via a specific high-affinity binding domain. (bvsalud.org)
  • Directed network wiring identifies a key protein interaction in embryonic stem cell differentiation. (uchicago.edu)
  • This paper aims to address the relation extraction task, which identifies selected types of relationships among entities (e.g., proteins) reported in text. (springer.com)
  • Factors secreted by cells expressing dominant-active Gα12 were identified by protein array, and their involvement in breast cancer cell invasion was assessed through both RNAi-mediated knockdown and antibody neutralization approaches. (biomedcentral.com)
  • The finding that activation of G12 proteins promotes cancer cell migration and invasion has highlighted the need to understand the biologic processes underlying this phenomenon. (biomedcentral.com)
  • The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. (affbiotech.cn)
  • In normal cells the BRCA1 protein is localized in the nucleus, whereas in the majority of breast cancer cell lines and in malignant pleural effusions from breast cancer patients, it is localized mainly in the cytoplasm. (jefferson.edu)
  • Park T, Large N, Curran T. Quantitative assessment of glioblastoma phenotypes in?vitro establishes cell migration as a robust readout of Crk and CrkL activity. (childrensmercy.org)
  • miR-126 mimics downregulated the expression of IRS-1 and GOLPH3 protein and suppressed the proliferation, migration and invasion of ESCC cells, whereas miR-126 inhibitors led to the opposite results. (spandidos-publications.com)
  • Tissue culture supernatant is purified by either protein A/G or affinity purification methods. (bdbiosciences.com)