Crem gene. Medical search. Frequent questions

and the constitutive transcription factors (CTFs) CREB, CREM, ATF-2 and SRF as they pertain to gene expression in the mammalian nervous system. (nih.gov)
One cAMP-response element (CRE)-like sequence (B/K CLS) was found in the promoter region of B/K DNA, and electrophoretic mobility shift assay indicated its binding to CREM and CREB. (kyobobook.co.kr)
Intracranial mesenchymal tumors with FET-CREB fusions are a recently described group of neoplasms in children and young adults characterized by fusion of a FET family gene (usually EWSR1, but rarely FUS) to a CREB family transcription factor (ATF1, CREB1, or CREM), and have been variously termed intracranial angiomatoid fibrous histiocytoma or intracranial myxoid mesenchymal tumor. (aku.edu)

Name(s)=EWSR1-CREM (PubMed= 23637631 ). (cellosaurus.org)
NGS demonstrated that eight tumors harbored EWSR1-ATF1 fusion, seven had EWSR1-CREB1, four had EWSR1-CREM, and one had FUS-CREM. (aku.edu)

The gene view histogram is a graphical view of mutations across CREM_ENST00000484283. (sanger.ac.uk)
These mutations are displayed at the amino acid level across the full length of the gene by default. (sanger.ac.uk)
This section shows the drugs associated with CREM_ENST00000484283 resistance mutations. (sanger.ac.uk)
Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene. (jax.org)
Excited by this latest progress, they now hope these techniques will enable new treatment options for "those with gene mutations that cause damage to lung airways or alveoli, such as children or adults with familial forms of lung disease. (bu.edu)
Deletion or mutations of their encoding genes usually severely impair either oogenesis or spermatogenesis or both. (ijbs.com)
In human, an array of four DAZ genes ( DAZ 1-4) is located in two clusters on the Y chromosome and mutations of these genes cause severe oligospermia or azospermia [ 1 ]. (ijbs.com)

The protein encoded by this gene is coordinately expressed with activator of cAMP-responsive element modulator (CREM). (wikipedia.org)
Evidence for the effects of cAMP on B1AR regulation has come from a study of members of the cAMP response element (CRE) modulator (CREM) family of transcription factors in transformed cell lines. (thermofisher.com)
Démonstration du rôle majeur de l'expression du gène de CREM (Camp Responsive Element Modulator) dans les mécanismes biologiques de nature rythmique, et sur la structure moléculaire de l'horloge biologique. (cnrs.fr)

Purpose: Gene fusions are important oncogenic drivers and many are actionable. (researchgate.net)
Breakpoint analysis of transcriptional and genomic profiles uncovers novel gene fusions spanning multiple human cancer types. (cellosaurus.org)

The Center for Regenerative Medicine (CReM) iPSC Core was created to expedite the use of iPSC technology by providing essential services and support to on-campus investigators and the broader scientific community. (bu.edu)
The CReM iPSC Catalog is an interactive online catalog of induced pluripotent stem cells (iPSCs) that are available to the scientific research community upon request. (bu.edu)
This iPSC catalog was created by the Center for Regenerative Medicine (CReM) of Boston University and Boston Medical Center and allows users to view, inquire and order iPSCs from the CReM bank of control and disease-specific iPS cell lines including gene-edited and 'knock-in' reporter cell lines. (bu.edu)
The CReM and CReM iPSC Core maintain a state-of-the-art bank of frozen iPSC lines that have been derived by CReM investigators and made readily available to all Boston University and external investigators. (bu.edu)
The CReM iPSC Core is offering basic training in human induced pluripotent stem cell (hiPSC) culture for research investigators working with or planning to work with hiPS cells. (bu.edu)

It is associated with CREM and confers a powerful transcriptional activation function. (wikipedia.org)
Hypoxia-inducible factor 1 (HIF-1) is a master transcriptional regulator of genes regulating oxygen homeostasis. (biomedcentral.com)

CREM proteins are members of the leucine zipper protein superfamily of nuclear transcription factors and act as regulators of cAMP-mediated signal transduction. (co.ke)
These genes, encoding for RNA binding proteins, contain a highly conserved RNA recognition motif and at least one DAZ repeat encoding for a 24 amino acids sequence able to bind other mRNA binding proteins. (ijbs.com)

Yes, I have looked at Ensembl GTF files and they also lack the HGNC gene symbol attribute. (seqanswers.com)
If the GTF file had the gene id in a separate delimited column it would be easy to replace with the HGNC gene symbol using the UNIX join command and a lookup table. (seqanswers.com)

ICER is a member of the CREM family of basic leucine zipper transcription factors that acts as a dominant negative regulator of gene transcription. (uconn.edu)
Four different isoforms of ICER (I, Iγ, II and IIγ) are transcribed from the P2 promoter of the Crem gene. (uconn.edu)

Here we discuss DAZ family genes in a phylogenic perspective, focusing on the common and distinct features of these genes, and their pivotal roles during gametogenesis evolved during evolution. (ijbs.com)

Gene Ontology analysis of genes from the top 200 dataset SNPs for both GWAS datasets showed overrepresentation of LOAD-related terms. (biomedcentral.com)

Differentially expressed genes elsewhere in the genome might share pathways with genes in the QTL region and reflect downstream effects of the QTL. (biomedcentral.com)

Finally, we found that transcription factors Jun , Fos , Atf3 , and Egr1 were upregulated in protective cells, especially Egr1 was predicted to be involved in the regulation of genes related to antioxidant stress and angiogenesis, suggesting a role in promoting differentiation into this cell phenotype. (hindawi.com)

Some of the induced genes, such as CREM, CHOP, and MAP kinase phosphatase-1, may be components of a homeostatic response to excessive stimulation. (jneurosci.org)

In all species, Boule and Dazl are located in single copy on autosomes, while multiple DAZ genes are located on the Y chromosome. (ijbs.com)

Sorry if this question has already been asked, but to get a good annotation with Cuffcompare I need a GTF file with the reference gene symbol name, such as the 'Myog' example given in the Cufflinks manual. (seqanswers.com)
A further step to explore links between DE genes and QTL at the pathway level was largely unsuccessful due to the lack of annotation of the pig genome. (biomedcentral.com)
Search results: The pahtway p1588 has 240 genes in the original annotation. (uth.edu)

It does not carry the causative mutation for prcd-PRA in the PRCD-gene. (richlyred.com)

these effects are thought to involve alterations in gene expression. (jneurosci.org)
Using the 6-hydroxydopamine lesion model of Parkinson's disease and differential display PCR, we have identified a set of more than 30 genes whose expression rapidly increases in response to stimulation of striatal dopamine D 1 receptors. (jneurosci.org)
The induced mRNAs include both novel and previously described genes, with diverse time courses of expression. (jneurosci.org)
these gene expression changes may be responsible for the alterations in striatal physiology. (jneurosci.org)
One example is dynorphin gene expression, which is progressively induced in dorsal striatum by cocaine. (jneurosci.org)
GXD's primary emphasis is on endogenous gene expression during development. (jax.org)
In the first part we consider basic facts about the expression and activity of these transcription factors: the organization of the encoding genes and their promoters, the second messenger cascades converging on their regulatory promoter sites, the control of their transcription, the binding to dimeric partners and to specific DNA sequences, their trans-activation potential, and their posttranslational modifications. (nih.gov)
The main purpose of this study was to characterize the fate of cardiac fibroblasts (CFs) and the dynamic gene expression patterns in a model of cardiac pressure overload using scRNA-seq analysis. (hindawi.com)
Analysis of dynamic gene expression revealed that Gpx3 was significantly upregulated during cell differentiation into protective cells. (hindawi.com)
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression. (cellosaurus.org)
CIRCA: Circadian gene expression profiles. (hogeneschlab.org)
With the advent of 'omics technologies such as gene expression microarrays, new ways of studying genetic variation through so called 'endo-phenotypes' are becoming increasingly popular. (biomedcentral.com)
The general principle of complementing QTL studies with gene expression data is illustrated in Figure 1A . (biomedcentral.com)
Panel A shows the two areas of comparing gene expression results with QTL results: 1) co-location at the genome level between differentially expressed genes and QTL, 2) significant overlap at the pathway level between genes in the QTL region and differentially expressed genes elsewhere in the genome. (biomedcentral.com)
Transcriptomic analysis showed that differentiation of hiPSCs derived from diabetics into KNA+ cells was sufficient to change baseline differences in gene expression caused by the diabetic status and reprogram diabetic cells to a pattern similar to KNA+ cells derived from nondiabetic hiPSCs. (bu.edu)
Abstract Background Tumors have been hypothesized to be the result of a mixture of oncogenic events, some of which will be reflected in the gene expression of the tumor. (co.ke)

We outline various procedures to localize differentially expressed genes on the pig genome and link this with information on published QTL. (biomedcentral.com)
Different approaches to localize the differentially expressed (DE) genes to the pig genome showed different levels of success and a clear lack of concordance for some genes between the various approaches. (biomedcentral.com)
Also, differentially expressed genes underlying QTL for ACTH response were described. (biomedcentral.com)
Using the latest version of the draft sequence, the differentially expressed genes were mapped to the pig genome. (biomedcentral.com)
The goal is to identify overlap between differentially expressed genes and QTL regions at either the genome or the pathway level. (biomedcentral.com)
Differentially expressed genes in the QTL region are obvious positional candidate genes for the QTL. (biomedcentral.com)
Panel B illustrates the steps to test for co-location between differentially expressed genes and QTL regions in the pig example. (biomedcentral.com)
Panel C illustrates the steps that are required to test for significant enrichment at the pathway level between differentially expressed genes and genes in the QTL region. (biomedcentral.com)
The results show a set of genes, differentially regulated in the adult DRG, that are principally involved in immune system modulation. (biomedcentral.com)
Differential analysis reveals a new set of immune related genes in the ganglia, that are differentially regulated in adult neuropathic pain, and that are consistent with the selective activation of macrophages around adult, but not young large A sensory neurons post injury. (biomedcentral.com)

CREM acts as a transcription factor essential for the differentiation of spermatids into mature spermatozoa. (wikipedia.org)
Different cell fates and groups were fully characterized by Gene Set Enrichment Analysis (GSEA) analysis and Transcription factor (TF) activity analysis. (hindawi.com)

Four and a half LIM domains protein 5 is a protein that in humans is encoded by the FHL5 gene. (wikipedia.org)
Deletion of DAZ gene is the most common causes of infertility in humans. (ijbs.com)
DAZ (Deleted in Azoospermia) family genes are important fertility factors in many animals including humans. (ijbs.com)

Is there an easy way to get a GTF file where the reference gene name is the gene symbol? (seqanswers.com)
with Pubmed ID, gene symbol/accession number and viral interacting protein. (polygenicpathways.co.uk)

To view all methylation probes within or in close proximity to CREM_ENST00000484283 please use the COSMIC Genome Browser . (sanger.ac.uk)
This enabled co-location of DE genes and previously studied QTL regions, but the draft genome sequence is still incomplete and will contain many errors. (biomedcentral.com)

The study of genes at the pathway level is also important to identify positional candidate genes in the QTL region that are not represented on the microarray. (biomedcentral.com)
Currently, there are 171 genes in SZGR 2.0 (with evidence in schizophrenia) that are present at this pathway. (uth.edu)

For example, the human gene 'MYOG' is 'NC_000001.10' in RefSeq. (seqanswers.com)
Human induced pluripotent stem cell derived intestinal organoids represent an inexhaustible cellular resource that could serve as a valuable tool to study SARS-CoV-2, as well as other intestinal viruses that infect the intestinal epithelium," explained corresponding author Mostoslavsky, associate professor of microbiology at Boston University School of Medicine (BUSM) and co-director of the CReM. (clinicalomics.com)

Transfected cells containing plasmids having genes oriented in opposing directions and methods of using. (cellosaurus.org)
Taken together, we suggest that the transcription of B/K gene in PC12 cells may be regulated by PKA-dependent mechanism. (kyobobook.co.kr)
This week, Pulmonary Center researchers from the Center for Regenerative Medicine (CReM) report their successes in developing new techniques to implant engineered cells into damaged lung tissue. (bu.edu)

Provide comfort for the family by sending flowers or planting a tree in memory of Eugene Torok. (suncitycenterfuneralhome.com)
The family includes Boule (or Boll ), Dazl (or Dazla ) and DAZ genes. (ijbs.com)
DAZ family genes are highly conserved. (ijbs.com)

Mouse insertional mutagenesis experiments DO NOT support the designation of CREM_ENST00000484283 as a cancer causing gene. (sanger.ac.uk)
In gene-knockout experiments, the majority of mice that lack the B1AR gene die prenatally and those that do survive until adulthood display abnormal cardiac function. (thermofisher.com)

For a focused analysis on 12 genes, overlapping QTL from the public domain were presented. (biomedcentral.com)

It is not found in the Cancer Gene Census . (sanger.ac.uk)
There are multiple polyadenylation sites found in this gene. (wikipedia.org)
Supporting evidence was also found for additional genes from the top 30 dataset SNPs. (biomedcentral.com)

Genes that are regulated in adult rats displaying neuropathic behaviour were compared to those regulated in young rats (10 days old) that did not show the same neuropathic behaviour. (biomedcentral.com)

This section gives an overview of CREM_ENST00000484283, along with links to any related data and resources. (sanger.ac.uk)
Links to bioinformatics resources that are related to CREM_ENST00000484283. (sanger.ac.uk)

Microarray studies can supplement QTL studies by suggesting potential candidate genes in the QTL regions, which by themselves are too large to provide a limited selection of candidate genes. (biomedcentral.com)

It will include hands-on training, lectures, and demonstrations from leading experts and educators in the field of stem cell biology from the Center for Regenerative Medicine (CReM) at Boston University and Boston Medical Center. (bu.edu)

The team was led by Gustavo Mostoslavsky, M.D., Ph.D., at the BU/BMC Center for Regenerative Medicine (CReM) and Elke Mühlberger, PhD, from the National Emerging Infectious Diseases Laboratories (NEIDL) at Boston University. (clinicalomics.com)
RSE et transformation numérique des entreprises artisanales : une étude sur données d'enquête ," Economics Working Paper Archive (University of Rennes 1 & University of Caen) 2019-02, Center for Research in Economics and Management (CREM), University of Rennes 1, University of Caen and CNRS. (repec.org)
The Behavioral Determinants of School Achievement: A Lab in the Field Experiment in Middle School ," Economics Working Paper Archive (University of Rennes 1 & University of Caen) 2022-05, Center for Research in Economics and Management (CREM), University of Rennes 1, University of Caen and CNRS. (repec.org)
Multimarket Contact and Platform Competition: Reassessing the Mutual Forbearance Hypothesis ," Economics Working Paper Archive (University of Rennes 1 & University of Caen) 2019-07, Center for Research in Economics and Management (CREM), University of Rennes 1, University of Caen and CNRS. (repec.org)
Les expériences sur les préférences individuelles et sociales des enfants et des adolescents : une revue de la litterature ," Economics Working Paper Archive (University of Rennes 1 & University of Caen) 2019-11, Center for Research in Economics and Management (CREM), University of Rennes 1, University of Caen and CNRS. (repec.org)
Effets de réseau, effets spatiaux et effets de communautés sur les plateformes de covoiturage : une analyse des leviers de développement de la plateforme iDVROOM ," Economics Working Paper Archive (University of Rennes 1 & University of Caen) 2019-03, Center for Research in Economics and Management (CREM), University of Rennes 1, University of Caen and CNRS. (repec.org)

Involved in ubiquitin conjugation and degradation of CREM isoform ICERIIgamma and ATF15 resulting in abrogation of ICERIIgamma- and ATF5-mediated repression of cAMP-induced transcription during both meiotic and mitotic cell cycles. (icr.ac.uk)

That includes a significant upregulation of interferon-related genes that appear to be conserved across multiple epithelial cell types. (clinicalomics.com)

Because the gene page contains a lot of information, it takes on average 3-5 seconds to load. (uth.edu)

America past, America present: genes and language in the Americas and beyond. (centralparkcarriagesofficial.org)

Efdestined forts to this completion are hindered by the lack of suitable cultured stromal cell copys, especially ones that express buy zebeta no prescription AR at sufficient levels to allow the use of contemporary mass gene expressiveness profiling techniques. (centralparkcarriagesofficial.org)

CREB3

EWSR1-CREM2

Mutations7

Modulator3

Fusions2

IPSC5

Transcriptional2

Proteins2

HGNC2

ICER2

Pivotal1

Ontology1

Pathways1

Regulation1

Kinase1

Chromosome1

Annotation3

Mutation1

Expression16

Differentially10

Transcription factor2

Humans3

Symbol2

Genome2

Pathway2

Human2

Cells3

Family3

Experiments2

Analysis1

Found3

Adult1

Links2

Provide1

Boston Medica1

Center6

CAMP1

Multiple1

Page1

Present1

Lack1