AnatomyOrganismsChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesInformation Science
Cyclic AMP Response Element-Binding ProteinPhosphorylationPromoter Regions, GeneticTranscription, GeneticCyclic AMPCyclic AMP Response Element ModulatorCREB-Binding ProteinResponse ElementsTranscription FactorsSterol Regulatory Element Binding Protein 1Activating Transcription Factor 2DNA-Binding ProteinsBase SequenceActivating Transcription Factor 1Molecular Sequence DataActivating Transcription FactorsGene Expression RegulationCyclic AMP-Dependent Protein KinasesSterol Regulatory Element Binding Protein 2Nuclear ProteinsTranscriptional ActivationRNA, MessengerCell LineSignal TransductionBinding SitesLeucine ZippersRegulatory Sequences, Nucleic AcidCells, CulturedTransfectionDNAProtein BindingProto-Oncogene Proteins c-fosSterol Regulatory Element Binding ProteinsCCAAT-Enhancer-Binding ProteinsGene Products, taxColforsinGene Expression Regulation, EnzymologicGenes, ReporterG-Box Binding FactorsEnhancer Elements, GeneticAmino Acid SequenceTranscription Factor AP-1Rats, Sprague-DawleyProto-Oncogene Proteins c-junEnzyme ActivationChloramphenicol O-AcetyltransferaseTrans-ActivatorsMitogen-Activated Protein KinasesTumor Cells, CulturedBrain-Derived Neurotrophic FactorDNA PrimersNF-kappa BBlotting, WesternElectrophoretic Mobility Shift Assay
CREBKinaseSerineAndrogenPhosphorylationTranscription factorTumorMRNASubunitPathwayActivatesAKT1ReceptorPromotersAdditionallyReceptorsPromoterGene expressionPutativeApoptosisMolecularBovineCAMPTranscriptPhosphorylatesAntibodySynthesisFamilyHUMANCellDetectionWesternProcessFoundDomainTargetComplexExpressionPresenceNormal
CREB9
  • CAMP responsive element binding protein 1, also known as CREB-1, is a protein that in humans is encoded by the CREB1 gene. (wikipedia.org)
  • This protein is a CREB transcription factor that is a member of the leucine zipper family of DNA-binding proteins. (wikipedia.org)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human CREB Binding Protein (CREBBP) in Tissue homogenates and other biological fluids. (hudsen.org)
  • Description: A sandwich ELISA for quantitative measurement of Rat CREB binding protein(CREBBP) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (hudsen.org)
  • One example is the activating transcription factor/cyclicAMP response element-binding protein (ATF/CREB) family that is defined by the ability of its members to bind to the cyclicAMP response element (CRE) in target promoters. (biomedcentral.com)
  • Inhibition of Gα s with NF449 attenuated the phosphorylation of cAMP response element-binding protein-1 (CREB-1) and the induction of cPLA 2α by cortisol in amnion fibroblasts. (elsevierpure.com)
  • Both glucocorticoid receptor (GR) and CREB-1 were found bound to the GRE upon cortisol stimulation of amnion fibroblasts. (elsevierpure.com)
  • The induction of cPLA 2α by cortisol was blocked by GR antagonist RU486 or protein kinase A inhibitor H89 or dominantnegative CREB-1. (elsevierpure.com)
  • In conclusion, cortisol activates the cAMP/protein kinase A/CREB-1 pathway via Gα s induction, and the phosphorylated CREB-1 interacts with GR at the GRE to promote cPLA 2α expression in amnion fibroblasts. (elsevierpure.com)
Kinase4
  • Mediates survival signals downstream of PI3 kinase and several growth factor receptors by phosphorylating AP0pototic proteins. (affbiotech.com)
  • Synthetic peptide taken within amino acid region 430-480 on human Rac protein kinase-alpha protein. (stjohnslabs.com)
  • AKT1 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. (stjohnslabs.com)
  • cAMP then activates protein kinase A (PKA) which phosphorylates downstream effectors that lead to a specific cellular response. (smpdb.ca)
Serine1
  • This protein has been shown to form a stable complex with inter-alpha-inhibitor (I alpha I), and thus enhance the serine protease inhibitory activity of I alpha I, which is important in the protease network associated with inflammation. (appliedbioinfo.com)
Androgen1
  • Western blot was used to evaluate protein expression of LGR4, RSPO1-4, androgen receptor (AR), cyclic AMP response-element binding protein (CREB1), γH2A.X, and H2A.X. Cell proliferation was detected by CCK-8 assay and apoptosis was assayed by flow cytometry. (physiciansweekly.com)
Phosphorylation4
  • Phosphorylation of TBC1D4 triggers the binding of this effector to inhibitory 14-3-3 proteins, which is required for insulin-stimulated glucose transport. (stjohnslabs.com)
  • AKT mediates insulin-stimulated protein synthesis by phosphorylating TSC2 at 'Ser-939' and 'Thr-1462', thereby activating mTORC1 signaling and leading to both phosphorylation of 4E-BP1 and in activation of RPS6KB1. (cusabio.com)
  • AKT is involved in the phosphorylation of members of the FOXO factors (Forkhead family of transcription factors), leading to binding of 14-3-3 proteins and cytoplasmic localization. (cusabio.com)
  • Western blotting was used to detect the expressions of cyclinD1, CDK2, Bcl2, β-catenin and phosphorylation of the key proteins in the MAPK signaling pathway. (bvsalud.org)
Transcription factor1
  • It has been supported that cAMP response element binding protein 1 (CREB1), a common transcription factor, extensively participates in osteogenic differentiation. (bvsalud.org)
Tumor4
  • Additionally, LGR4 knockdown further suppressed tumor growth and AR/CREB1 expression but enhanced γH2A.X expression in xenografts. (physiciansweekly.com)
  • described a gene, which they designated TSG6, that is transcribed in normal fibroblasts and activated by binding of the cytokines tumor necrosis factor alpha (TNF-alpha) and interleukin-1 (IL1) at AP-1 and NF-IL6 sites in its promoter. (appliedbioinfo.com)
  • Regulation of bovine tumor necrosis factor alpha induced protein 6 in ovarian follicles during the ovulatory process and promoter activation in granulosa cells. (appliedbioinfo.com)
  • To study the regulation of bovine tumor necrosis factor alpha induced protein 6 (TNFAIP6) prior to ovulation, preovulatory follicles obtained after the treatment with human chorionic gonadotropin (hCG) were used. (appliedbioinfo.com)
MRNA3
  • In addition, Atf3 mRNA levels are increased in response to cytochalasin D treatment, an inducer of chondrocyte maturation. (biomedcentral.com)
  • mRNA and protein expressions of Ngb and HIF-1α showed positive in different tissues of the yak and cattle telencephalon. (bvsalud.org)
  • Mechanistic studies demonstrated that NRF2 transcriptionally regulated SMN mRNA expression by binding to two antioxidant response elements in the SMN1 promoter. (bvsalud.org)
Subunit1
  • Harris BA: Complete cDNA sequence of a human stimulatory GTP-binding protein alpha subunit. (smpdb.ca)
Pathway1
  • The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. (wikipedia.org)
Activates1
  • The FSH receptor activates G(s) proteins which leads to the activation of adenylyl cyclase and produces the secondary messenger cAMP. (smpdb.ca)
AKT11
  • Phospho-AKT1-protein if for use in research applications. (stjohnslabs.com)
Receptor5
  • PKA signaling also affects NMDA receptor activity and may play an important role in neuroadaptation in response to chronic alcohol exposure. (genome.jp)
  • The follicle-stimulating hormone receptor (FSHR) is a transmembrane G protein-coupled receptor located in the ovary, testis, and uterus. (smpdb.ca)
  • Tilly JL, Aihara T, Nishimori K, Jia XC, Billig H, Kowalski KI, Perlas EA, Hsueh AJ: Expression of recombinant human follicle-stimulating hormone receptor: species-specific ligand binding, signal transduction, and identification of multiple ovarian messenger ribonucleic acid transcripts. (smpdb.ca)
  • TSG6 is a member of the hyaluronan-binding protein family, which includes cartilage link protein ), proteoglycan core protein , and the adhesion receptor CD44. (appliedbioinfo.com)
  • The type I IFNs (IFNα/β) bind to a specific IFN-α/β receptor (IFNAR) that consists of IFNAR1 and IFNAR2 chains [ 24 ]. (biomedcentral.com)
Promoters1
  • This protein binds the cAMP response element, a DNA nucleotide sequence present in many viral and cellular promoters. (wikipedia.org)
Additionally1
  • Additionally, CREB1 bond to VEGF promoter and transcriptionally activated VEGF expression. (bvsalud.org)
Receptors1
  • believed the expression of TSG-6 is an integral part of the cascade of inflammatory-like changes that occur in an ovulatory follicle in response to a trophic hormone that couples with luteinizing hormone/hCG receptors. (appliedbioinfo.com)
Promoter3
  • The induction of cPLA 2α by cortisol was abolished by mutagenesis of a glucocorticoid response element (GRE) in the promoter. (elsevierpure.com)
  • JASPAR predicted the potential binding of CREB1 with VEGF promoter, which was then testified by ChIP and luciferase reporter assays. (bvsalud.org)
  • Mutant studies identified the minimal region conferring full-length promoter activity, in which AP1 and CRE elements were required for promoter activity. (appliedbioinfo.com)
Gene expression2
  • In contrast, RSPO1 stimulation augmented cell viabilities, promoted AR and CREB1 expression, and upregulated DNA repair gene expression, which could be reversed by enzalutamide, except for AR expression. (physiciansweekly.com)
  • The Sox9 gene is required for the differentiation of mesenchymal precursor cells to chondrocytes and, together with the related L-Sox5 and Sox6 proteins, controls chondrocyte-specific gene expression [ 4 , 5 ]. (biomedcentral.com)
Putative1
Apoptosis5
  • Following CREB1 elevation or/and vascular endothelial growth factor (VEGF) silencing in ZA-treated PDLSCs, CCK-8 and TUNEL assays separately estimated cell viability and apoptosis. (bvsalud.org)
  • Western blotting tested the expression of apoptosis- and osteogenic differentiation-associated proteins. (bvsalud.org)
  • CREB1 expression was declined in ZA-exposed PDLSCs and CREB1 elevation exacerbated the viability and osteogenic differentiation while obstructed the apoptosis of PDLSCs. (bvsalud.org)
  • Further, VEGF absence partially stimulated the apoptosis while suppressed the osteogenic differentiation of CREB1-overexpressing PDLSCs treated by ZA. (bvsalud.org)
  • To be concluded, CREB1 might activate VEGF transcription to obstruct the apoptosis while contribute to the osteogenic differentiation of ZA-treated PDLSCs. (bvsalud.org)
Molecular1
  • Prolonged incubation with TSG-6 and IaI leads to HA films that contain, in addition to covalently HA-bound HCs, several tightly but non-covalently bound molecular species. (appliedbioinfo.com)
Bovine1
  • Codina J, Stengel D, Woo SL, Birnbaumer L: Beta-subunits of the human liver Gs/Gi signal-transducing proteins and those of bovine retinal rod cell transducin are identical. (smpdb.ca)
CAMP2
  • This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. (wikipedia.org)
  • cAMP responsive element binding pro. (gsea-msigdb.org)
Transcript1
  • Further analyses and immunohistochemistry indicated that this increase in transcript and protein levels occurred in theca and granulosa cells. (appliedbioinfo.com)
Phosphorylates1
  • Activated TNK2 phosphorylates it on Tyr-176 resulting in its binding to the anionic plasma membrane phospholipid PA. (stjohnslabs.com)
Antibody1
  • Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. (affbiotech.com)
Synthesis1
  • Using cultured human amnion fibroblasts, we found that the induction of cPLA 2α by cortisol required ongoing transcription and synthesis of at least one other protein. (elsevierpure.com)
Family4
  • One member of this family, Activating Tanscription Factor 3 (ATF3), is expressed during skeletogenesis and acts as a transcriptional repressor, but the function of this protein in chondrogenesis is unknown. (biomedcentral.com)
  • The protein encoded by this gene is a secretory protein that contains a hyaluronan-binding domain, and thus is a member of the hyaluronan-binding protein family. (appliedbioinfo.com)
  • DnaJ heat shock protein family (Hsp. (gsea-msigdb.org)
  • guanylate binding protein family me. (gsea-msigdb.org)
HUMAN2
  • After human periodontal ligament stem cells (PDLSCs) were challenged with zoledronic acid (ZA), CREB1 expression was examined with RT-qPCR and western blotting. (bvsalud.org)
  • MEX3A is a protein that is known to be highly expressed in various human malignant tumors, including thyroid cancer, and it has been linked to patient prognosis. (bvsalud.org)
Cell1
  • The hyaluronan-binding domain is known to be involved in extracellular matrix stability and cell migration. (appliedbioinfo.com)
Detection1
  • WB: For western blot detection of denatured protein samples. (affbiotech.com)
Western1
  • Review: the total protein of unphosphorylated PI3K (t-PI3K), phosphorylated PI3K (p-PI3K), unphosphorylated AKT protein (t-AKT), and phosphorylated AKT protein (p-AKT) were detected and analysed using western blot in the presence of housekeeping protein β-Actin as a loading control at 4, 6, and 24 h intervals. (cusabio.com)
Process1
  • Here, the current study was to look into the impacts of CREB1 on the process of periodontitis and its possible action mechanism. (bvsalud.org)
Found1
  • Enhanced levels of this protein are found in the synovial fluid of patients with osteoarthritis and rheumatoid arthritis. (appliedbioinfo.com)
Domain1
Target1
  • Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. (affbiotech.com)
Complex1
Expression1
  • Likewise, LGR4 ablation diminished AR and CREB1 expression induced by radiation. (physiciansweekly.com)
Presence1
  • We demonstrate that TSG-6 mediated cross-linking of HA films is impaired in the presence of IaI, and that this effect suppresses the TSG-6-mediated enhancement of HA binding to CD44 positive cells. (appliedbioinfo.com)
Normal1
  • Expressed in prostate cancer and levels increase from the normal to the malignant state (at protein level). (affbiotech.com)