Creb cyclic amp response element binding protein a. Medical search. Frequent questions

Mechanistically, MTX treatment led to cyclic AMP response element-binding protein (CREB) Ser133 phosphorylation, while AMPK depletion attenuated this response and the induction of MnSOD and HO-1. (bmj.com)
Of note, ApoE4-TR mice, unlike age-matched ApoE3-TR mice, displayed impaired spatial cognitive abilities, loss of GABAergic neurons, decreased expression of Reelin, PSD95, SYN and Fyn, and reduced phosphorylation of NMDAR2B and CREB. (biomedcentral.com)
These results suggest that NO contributes to L-LTP by stimulating guanylyl cyclase and cGMP-dependent protein kinase, which acts in parallel with PKA to increase phosphorylation of the transcription factor CREB. (jneurosci.org)
Our findings indicated that the tianeptine antidepressant effect may occur by induction of NCAM140 expression and CREB phosphorylation. (psychiatryinvestigation.org)
Tyrosine kinases Fyn and FAK interact with NCAM and undergo phosphorylation and this transiently activates the MAPK, ERK 1 and 2, cAMP response element binding protein (CREB) and transcription factors ELK and NFkB. (uni-freiburg.de)
Since phosphorylation of cyclic AMP response element binding protein (CREB) is regulated by NMDA receptors and pCREB-like immunoreactivity (lir) is increased after predator stress, we examined the effects of CPP on predator stress-induced changes in pCREB-lir in Chapter 3. (mun.ca)
CREB phosphorylation involved c-Src-dependent extracellular signal-regulated kinase 1/2 activation, but not protein kinase A, protein kinase C, or calmodulin-dependent kinase II, and occurred also in cells transfected with AR or estrogen receptor mutants that do not localize into the nucleus. (unical.it)

Mechanistically, FSH, via binding to hepatic FSHRs, activates the Gi2α/β-arrestin-2/Akt pathway and subsequently inhibits the binding of FoxO1 with the SREBP-2 promoter, thus preventing FoxO1 from repressing SREBP-2 gene transcription. (nature.com)
MTX increases intracellular accumulation of adenosine monophosphate (AMP) and 5-aminoimidazole-4-carboxamide ribonucleotide which activates AMP-activated protein kinase (AMPK). (bmj.com)
These findings suggest a potential molecular mechanism of how mutant HTT activates DNA damage-response pro-degenerative pathways and impairs transcription, triggering neurotoxicity and functional decline in HD. (elifesciences.org)
CREB activates transcription of genes which are important for axonal growth, survival, and synaptic plasticity in neurons.NCAM1 mediated intracellular signal transduction is represented in the figure below. (uni-freiburg.de)
After a ligand binds to the GPCR, it activates a heterotrimeric G-protein, which is composed of three subunits: a guanine nucleotide binding α-subunit, and a βγ-heterodimer (98). (pancreapedia.org)
2 , 3 Tax activates viral transcription through the HTLV-1 long terminal repeat and induces cellular genes through signaling pathways, including nuclear factor-κB (NF-κB), serum response factor/activator protein 1, and cyclic-AMP response element-binding protein (CREB). (ashpublications.org)

We previously demonstrated that exposure to an appetitive CS causes an increase in the activation of extracellular signal-regulated kinase (ERK) and cyclic-AMP response-element binding protein (CREB) in the nucleus accumbens (NAc) of rats, and that CS-evoked ERK activation is critical for CS control over reward seeking. (ed.gov)
We report that HTT forms a transcription-coupled DNA repair (TCR) complex with RNA polymerase II subunit A (POLR2A), ataxin-3, the DNA repair enzyme polynucleotide-kinase-3'-phosphatase (PNKP), and cyclic AMP-response element-binding (CREB) protein (CBP). (elifesciences.org)
Three-train L-LTP was also blocked by inhibitors of guanylyl cyclase or cGMP-dependent protein kinase (PKG). (jneurosci.org)
this, we discovered that a kinase-inactive human being ATM G2870A mutant protein, expressed in cells that do not express endogenous ATM, is recruited to sites of laser-induced DNA damage (Fig. S2). (ecologicalsgardens.com)
The explanation behind concentrating on BRAFV600E kinase is normally that this proteins is normally specific to cancers cells and drives the growth-promoting MAPK pathway. (imacst.com)

3 hr, and is reduced by inhibitors of PKA and of protein or RNA synthesis. (jneurosci.org)
Conversely, either NO or cGMP analogs paired with one-train tetanization produced late-phase potentiation, and the cGMP-induced potentiation was blocked by inhibitors of protein or RNA synthesis and an inhibitor of PKG, but not by an inhibitor of PKA. (jneurosci.org)
Docking calculations revealed that the five inhibitors bind at the DD2-HDAC6 binding site with the lowest binding free energy, the same binding mode is maintained along the 100 ns-long MD simulations. (barbascoinhibitor.com)

In contrast, calcium entry through extrasynaptic NMDA receptors, triggered by bath glutamate exposure or hypoxic/ischemic conditions, activated a general and dominant CREB shut-off pathway that blocked induction of BDNF expression. (nih.gov)
We have recently identified, for the first time, that bronchial epithelial cells are its novel cell source in response to IL-33 via ST2-ERK1/2-MSK1 signaling pathway. (hindawi.com)
Our findings suggest that activation of the NMDAR-D1R/ERK/CREB signal transduction pathway plays a critical role in the control of reward-seeking behavior by reward-predictive cues. (ed.gov)
This event induces the formation of a heterodimer of TLR4 and TLR6, which is rapidly internalized and triggers inflammatory response, leading to the NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion. (cusabio.com)
We have identified CREB-mediated activation of Cox-2 as a potential signaling pathway in prostate cancer which can be blocked with a nontoxic, cost-effective dietary supplement like Nexrutine, demonstrating a prospective for development of Nexrutine for prostate cancer management. (nih.gov)

The cAMP response element sites can be found in the promoter region of some postmeiotic genes, so that the CREM can target and regulate these genes. (wikipedia.org)
CREB siRNA inhibited upregulation of both cytoprotective genes by MTX, while chromatin immunoprecipitation demonstrated CREB binding to the MnSOD promoter in MTX-treated EC. (bmj.com)
Abrogated PNKP activity results in persistent DNA break accumulation, preferentially in actively transcribed genes, and aberrant activation of DNA damage-response ataxia telangiectasia-mutated (ATM) signaling in HD transgenic mouse and cell models. (elifesciences.org)
Elevated intracellular Ca 2+ can activate the transcription factor cyclic AMP response element binding protein (CREB), thereby potentially initiating the expression of genes that are important for synaptic plasticity, neurite growth and dendritic spine development [ 20 - 22 ]. (biomedcentral.com)
CREB is subsequently inactivated and the transcription of a number of 'memory' genes is checked. (proteinspotlight.org)

The results demonstrated that two cyclic AMP responsive elements (CREs) in the proximal promoter region of C/EBPβ were involved in the positive regulation of C/EBPβ transcription during granulocyte-macrophage colony-stimulating factor (GM-CSF)-induced differentiation of bone marrow cells. (harvard.edu)
We also showed that CREB binds to IGF-IR promoter region and identified the relevant CREB-binding site at the 5'-untranslated region fragment of IGF-IR promoter. (unical.it)

Here we show that transgenic mice expressing a dominant-negative form of the CREB transcription factor (CREBA133) under the control of the cardiac myocyte-specific alpha-MHC promoter develop dilated cardiomyopathy that closely resembles many of the anatomical, physiological, and clinical features of human IDC. (nih.gov)
Retroviral transduction of a dominant negative CREB mutant reduced C/EBPβ mRNA levels and significantly impaired the proliferation/differentiation of granulocyte precursors, while a constitutively active form of CREB facilitated C/EBPβ transcription. (harvard.edu)

This cyclic conformation allows cyclic nucleotides to bind to proteins to which other nucleotides cannot. (pancreapedia.org)
Vemurafenib binds towards the energetic site of BRAFV600E proteins selectively, which differs in conformation from wild-type BRAF, and inhibits downstream MAPK signaling [7]. (imacst.com)

Binding of Reelin to the receptors induces feed-forward activation of DAB1, an adaptor protein that interacts with NPxY motifs in both receptor tails [ 20 ]. (biomedcentral.com)
Cyclooxygenase (Cox-2), a pro-inflammatory mediator, is a CREB target that induces prostaglandin E(2) (PGE(2)) and suppresses apoptosis. (nih.gov)

cAMP responsive element modulator is a protein that in humans is encoded by the CREM gene, and it belongs to the cAMP-responsive element binding protein family. (wikipedia.org)
This gene encodes a bZIP transcription factor that binds to the cAMP responsive element found in many viral and cellular promoters. (wikipedia.org)
The chromosomal location of CREM gene is at 10p11.21, where it starts at 35415769 and ends at 35501886 bp from pter ( according to hg19-Feb_2009) CAMP responsive element modulator has been shown to interact with FHL5. (wikipedia.org)

A negative regulator of AMPK is the protein phosphatase 2C (PP2C), which dephosphorylates and inactivates the α-subunit of AMPK, causing the dissociation of the αβγ-heterotrimeric complex. (encyclopedia.pub)
PP1 binds to the gene transcription factor CREB (cyclic AMP-dependent response element binding) and dephosphorylates it. (proteinspotlight.org)

Conclusions These data suggest that MTX therapeutically conditions vascular endothelium via activation of AMPK-CREB. (bmj.com)
To determine whether CS-driven ERK and CREB activation are linked, we selectively blocked ERK signaling in the NAc. (ed.gov)
We found that both NMDA and D1 receptors are critical for CS-driven ERK signaling in the NAc, and that this recruitment of the ERK cascade is responsible for increased CREB activation in the presence of the CS. (ed.gov)
Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. (cusabio.com)
3 , 4 Activation of CREB by Tax is involved in immortalization of primary human T cells. (ashpublications.org)
We now show that, in prostate cancer cells, stimulation with either androgens or estrogens up-regulates IGF-IR by inducing cyclic AMP response element-binding protein (CREB) activation. (unical.it)
CREB silencing abrogated IGF-IR up-regulation and promoter activation. (unical.it)
In conclusion, we describe a novel mechanism of IGF-IR up-regulation and promoter activity by CREB activation, induced by sex steroids, through a nongenotropic signaling. (unical.it)

Enzymes that modify chromatin and associated proteins by the addition or removal of acetyl or methyl groups play a key role in genome regulation [ 1 ]. (biomedcentral.com)

Hebb developed the theory which states that synapses are the key elements of memory, and the term 'synaptic plasticity' was coined. (proteinspotlight.org)
PP1 hinders the synthesis of proteins involved in synaptic plasticity, and hence in the process of memory. (proteinspotlight.org)

Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human CREB Binding Protein (CREBBP) in Tissue homogenates and other biological fluids. (hudsen.org)
This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated. (thermofisher.com)
Western blot was performed using Anti-ATF2 Recombinant Rabbit Monoclonal Antibody (SZ17-01) (Product # MA5-32022) and 60kDa and 40kDa bands corresponding to Cyclic AMP-dependent transcription factor ATF-2 was observed across all the tested cell lines and tissues, except Mouse Skeletal Muscle. (thermofisher.com)

Here we report that synaptic and extrasynaptic NMDA (N-methyl-D-aspartate) receptors have opposite effects on CREB (cAMP response element binding protein) function, gene regulation and neuron survival. (nih.gov)
Calcium entry through synaptic NMDA receptors induced CREB activity and brain-derived neurotrophic factor (BDNF) gene expression as strongly as did stimulation of L-type calcium channels. (nih.gov)

These data suggest that CREB proteins are involved in the regulation of granulopoiesis via C/EBPβ upregulation. (harvard.edu)

In addition, the transcripts of CRE binding (CREB) family proteins were readily detected in hematopoietic stem/progenitor cells. (harvard.edu)
The Sox9 gene is required for the differentiation of mesenchymal precursor cells to chondrocytes and, together with the related L-Sox5 and Sox6 proteins, controls chondrocyte-specific gene expression [ 4 , 5 ]. (biomedcentral.com)
NCAM protein expression was measured in human neuroblastoma SH-SY5Y cells that were cultivated in serum-free media and treated with 0, 10, or 20 µM tianeptine for 6, 24, or 72 hours. (psychiatryinvestigation.org)
The C protein has been purified from cells carrying the Ptrp-C plasmid, and a preliminary study of C protein-DNA binding properties has been carried out. (shengsci.com)
Cells continuously monitor protein synthesis to prevent accumulation of aberrant polypeptides. (shengsci.com)
In search of novel biomarkers with relevance to oncogenesis, we identified the tumor marker and actin-bundling protein Fascin (FSCN1) to be specifically and strongly up-regulated in both HTLV-1-transformed and adult T-cell leukemia/lymphoma patient-derived CD4 + T cells. (ashpublications.org)
Both sex steroids phosphorylated CREB at Ser(133) in a dose-dependent manner in androgen receptor (AR)-positive LNCaP cells, whereas only estrogens phosphorylated CREB in AR-negative PC3 cells. (unical.it)
Oddly enough, vemurafenib-resistant BCPAP cells were totally resistant to metformin also, as there is no significant transformation within their viability in response to treatment with this medication as an individual agent. (imacst.com)

In addition, Atf3 mRNA levels are increased in response to cytochalasin D treatment, an inducer of chondrocyte maturation. (biomedcentral.com)

and forgetfulness is still very much in its infancy, but we do know of one protein, protein phosphatase 1, which certainly seems to be at the heart of this primordial sift. (proteinspotlight.org)
And this change is the work of complex biochemical pathways - one of which protein phosphatase 1 (PP1) belongs to. (proteinspotlight.org)

Cyclic nucleotides, like other nucleotides, are composed of three functional groups: a ribose sugar, a nitrogenous base, and a single phosphate group. (pancreapedia.org)
A cyclic nucleotide, unlike other nucleotides, has a cyclic bond arrangement between the ribose sugar and the phosphate group. (pancreapedia.org)
Cyclic nucleotides form when the phosphate group of the molecule of nucleotide triphosphate (ATP or GTP) is attacked by the 3' hydroxyl group of the ribose, forming a cyclic 3',5'-phosphate ester with release of pyrophosphate. (pancreapedia.org)

CREB and pCREB expression was identified after treatment with 20 µM tianeptine for 6, 24, and 72 hours by Western blot. (psychiatryinvestigation.org)
In Chapter 4, we examined pCREB changes in response to other stressors, such as the EPM, in brain areas implicated in fear and anxiety. (mun.ca)

CREB family is important for in regulating transcription in response to various stresses, metabolic and developmental signals. (wikipedia.org)
Structurally, the IL-17 cytokine family members have no sequence similarity to any other known cytokine or other mammalian proteins [ 2 ]. (hindawi.com)
One member of this family, Activating Tanscription Factor 3 (ATF3), is expressed during skeletogenesis and acts as a transcriptional repressor, but the function of this protein in chondrogenesis is unknown. (biomedcentral.com)
One example is the activating transcription factor/cyclicAMP response element-binding protein (ATF/CREB) family that is defined by the ability of its members to bind to the cyclicAMP response element (CRE) in target promoters. (biomedcentral.com)
These pumps have broad drug specificity and belong to a family of ATP-binding cassette (ABC) transporters, of which P-glycoprotein (PGP) is one of the most important members. (savedelicious.com)
Depending on which family the G protein is, it goes on to activate (G αs protein subunit) or inhibit (G αi protein subunit) the membrane-bound cyclase. (pancreapedia.org)
The functions of the bromodomain and extra terminal (BET) family of proteins have been proved to be involved in various diseases, particularly the acute myeloid leukemia (AML). (bvsalud.org)
The transcription factor ATF-2 (also called CRE-BP1) binds to both AP-1 and CRE DNA response elements and is a member of the ATF/CREB family of leucine zipper proteins. (thermofisher.com)
HDAC are a family of proteins involved in the deacetylation of histones and other non-histones substrates. (barbascoinhibitor.com)
family (pRb's) binding domains and the p300/400-binding pocket are absolutely required for this transformation process [7]. (ecologicalsgardens.com)

Muscleblind-like proteins (MBNLs) are regulators of RNA metabolism. (shengsci.com)

Instead, synaptic enhancement is due to correlated activity brought about by chemical substances between the pre-synaptic and post-synaptic elements. (natural-universe.net)

It is thought that in the event of massed learning, the synthesis of PP1 increases, thereby checking CREB function and putting a constraint on what we learn and remember. (proteinspotlight.org)

The second signaling mechanism involves the binding of a small signaling molecule to a soluble cyclase. (pancreapedia.org)

Regulation of Cox-2 by cyclic AMP response element binding protein in prostate cancer: potential role for nexrutine. (nih.gov)

Histone modifications act as signals that are 'read' by sensory proteins containing bromodomains, PHD fingers and other domains, many of which function as coregulators of DNA-binding transcription factors [ 4 ]. (biomedcentral.com)

Taken together, these results implicate CREB as an important regulator of cardiac myocyte function and provide a genetic model of dilated cardiomyopathy which should facilitate studies of both the pathogenesis and therapy of this clinically important disorder. (nih.gov)

One mechanism is the binding of an extracellular ligand to a transmembrane G-protein-coupled receptor (GPCR). (pancreapedia.org)
The receptor protein has seven transmembrane α-helices connected by alternating cytosolic and extracellular loops. (pancreapedia.org)

Two aspartic acid residues in the active site of the cyclase (AC or GC) promotes the binding of ATP. (pancreapedia.org)

Transcription factors binding to the cyclicAMP response element (CRE) are known to regulate these processes. (biomedcentral.com)
Stringent control of the NF-B and type I interferon pathways is usually crucial to effective host immune responses, yet the molecular mechanisms that negatively regulate these pathways are poorly comprehended. (ecologicalsgardens.com)

The ligand-binding site is in the extracellular domain and the cytosolic domain has a heterotrimeric G protein-binding site (127). (pancreapedia.org)

Proteotoxic stress promotes entrapment of ribosomes and misfolded proteins in a shared cytosolic compartment. (shengsci.com)
At the lysosomal surface, free aldolase promotes the formation of a multiprotein complex, including the vacuolar H + -ATPase and the scaffold protein AXIN, and this complex ensures the effective binding between AMPK and LKB1, thereby activating AMPK [ 25 ] [ 26 ] . (encyclopedia.pub)
In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. (cusabio.com)

It is believed that memory is the result of a synaptic change in size, shape and sensitivity brought on by the synthesis of various proteins. (proteinspotlight.org)
In the event of distributed learning, PP1 synthesis does not have the chance to increase so sharply and its effect on CREB is weaker. (proteinspotlight.org)

Meanwhile, macrophage inflammatory protein 2 (MIP-2) expression levels were upregulated in nontumoral liver tissue from the end of Week 13 of CDAA-HF-T(-) feeding to the end of Week 63. (bvsalud.org)

Between 2 and 20 wk of age, these mice develop four chamber cardiac dilatation, decreased systolic and diastolic left ventricular function, and attenuated contractile responses to the beta-adrenergic agonist, isoproterenol. (nih.gov)

Single-molecule kinetics reveal microscopic mechanism by which High-Mobility Group B proteins alter DNA flexibility. (shengsci.com)

A cyclase enzyme (lyase) catalyzes the formation of the cyclic nucleotide from its nucleotide triphosphate precursor ( Figure 1 ). (pancreapedia.org)

The X-ray cocrystal structure proved that 10 occupied the acetylated lysine (KAc) binding cavity and the WPF shelf of BRD4 BD1. (bvsalud.org)

The miniF plasmid C protein: sequence, purification and DNA binding. (shengsci.com)

The four conserved cysteines in the C-terminal half of the IL-17F sequence are shown to form a cystine knot structural motif in the crystal structure, and, interestingly, this cystine knot structure is similar to a common structural motif seen in several growth factors, such as bone morphogenic proteins (BMPs), TGF- β , nerve growth factor (NGF), and platelet-derived growth factor (PDGF) [ 9 ]. (hindawi.com)

Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request. (cusabio.com)

C protein binds strongly to pifO, and weakly to sequences in the ori-1 region. (shengsci.com)

Another study published this year found that maternal exposure to fluoride significantly reduced the expression of camp-response element binding protein (CREB) in the developing brains of offspring [Chemosphere. (planttrees.org)
Low expression of CREB is implicated is the pathophysiology of depression and suicide. (planttrees.org)

Elevated levels of AMP lead to an inhibition of PP2C activity, which allows AMPK to remain stable in the active Thr 172 -phosphorylated state [ 27 ] [ 28 ] . (encyclopedia.pub)

There are two main groups of cyclic nucleotides: the canonical or well-established and the non-canonical or unknown-function cyclic nucleotides. (pancreapedia.org)
What is more, the longer the interval between two sessions, the better the imprint of the memory, probably because the level of PP1 decreases and CREB is given time to settle and function as it should. (proteinspotlight.org)

High response rates at most sites (median 62%) suggest that this strategy was successful. (sirna-library.com)

The CREM bound to the -180 site of the IL-2 promoter to repress its transcription. (wikipedia.org)

To test a possible downstream target of PKG, we examined changes in phospho-CRE-binding protein (phospho-CREB) immunofluorescence in the CA1 cell body area and obtained results similar to those of the electrophysiology experiments. (jneurosci.org)

Regarding protein levels, IL-6 and NO release were increased by 41.5-EVi1. (bvsalud.org)

Additionally, two specific case reports noted tumor regression in response to vemurafenib in an individual with anaplastic thyroid cancers and an individual with advanced papillary thyroid cancers [12, 13]. (imacst.com)

In contrast to the definitive role of the transcription factor, CCAAT/Enhancer binding protein α (C/EBPα), in steady-state granulopoiesis, previous findings have suggested that granulopoiesis during emergency situations, such as infection, is dependent on C/EBPβ. (harvard.edu)

Anatomy3

Organisms1

Chemicals and Drugs29

Analytical, Diagnostic and Therapeutic Techniques and Equipment3

Phenomena and Processes18

Information Science3

Phosphorylation7

Activates6

Kinase5

Inhibitors3

Pathway5

Genes5

Promoter region2

Dominant-negative2

Conformation2

Induces2

Responsive3

Dephosphorylates2

Activation8

Chromatin1

Synaptic plasticity2

Antibody3

Receptors2

Upregulation1

Cells8

MRNA levels1

Phosphatase2

Phosphate3

PCREB2

Family10

Metabolism1

Substances1

Increases1

Small signalin1

Regulation1

Histone1

Regulator1

Receptor2

Residues1

Regulate2

Extracellular domain1

Promotes3

Synthesis2

Tissue1

Cardiac1

Mechanism1

Enzyme1

Lysine1

Purification1

Form1

Sequence1

Strongly1

Expression2

AMPK1

Function2

Suggest1

Site1

Results1

Levels1

Tumor1

Findings1