• Signs and symptoms that typically accompany an elevated creatine kinase include cardiac symptoms such as chest pain, breathing trouble, dizziness, excessive sweating and pain that reaches the jaw or the lower arm, according to Healthgrades. (reference.com)
  • A higher creatine kinase level usually manifests a few hours after a heart attack when the heart muscle cells start to die, says Healthgrades. (reference.com)
  • Small volumes of CK-BB elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. (mybiosource.com)
  • The ELISA analytical biochemical technique of the MBS706326 kit is based on CK-BB antibody-CK-BB antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect CK-BB antigen targets in samples. (mybiosource.com)
  • The ELISA Kit is designed to detect native, not recombinant, CK-BB. (mybiosource.com)
  • Clinically, creatine kinase is assayed in blood tests as a marker of damage of CK-rich tissue such as in myocardial infarction (heart attack), rhabdomyolysis (severe muscle breakdown), muscular dystrophy , autoimmune myositides , and acute kidney injury . (wikipedia.org)
  • CK-BB is predominantly expressed in brain and smooth muscle, including vascular and uterine tissue. (wikipedia.org)
  • BB-CK is a cytoplasmic enzyme involved in cellular energy homeostasis, with certain fractions of the enzyme being bound to cell membranes, ATPases, and a variety of ATP-requiring enzymes in the cell. (wikipedia.org)
  • Creatine (Cr) has emerged as a safe nutritional supplement not only to increase muscle mass and performance, prevent disease-induced muscle atrophy and improve rehabilitation, but also to strengthen cellular energetics in general (see Salomons and Wyss 2007). (springer.com)
  • 2008 ). Although Cr effects are likely due to pleiotropic cellular functions, its main role is in the creatine kinase (CK/PCr) system for temporal and spatial energy buffering. (springer.com)
  • KCC2 and NKCC1 functions are also regulated by phosphorylation by enzymes such as PKC, Src-family tyrosine kinases, and WNK1-4 and their downstream effectors STE20/SPS1-related proline/alanine-rich kinase (SPAK)-oxidative stress responsive kinase-1 (OSR1). (frontiersin.org)
  • The concentration gradients of the kit standards or positive controls render a theoretical kit detection range of 3.12 mU/ml-200 mU/ml in biological research samples containing CK-BB, with an estimated sensitivity of 0.78mU/ml. (mybiosource.com)
  • The primary clinical use of CK studies is the diagnosis of Myocardial Infarction , (increased in the MB variant), but CK is also increased in different conditions as muscular diseases and traumas (MM and MB) and brain trauma and brain surgery (BB). (golifescience.com)
  • In clinical diagnostic testing, creatine kinase levels in the blood are measured as part diagnosis of a number of illnesses. (kidneypedia.net)
  • The symptoms, if any, accompanying a clinical test revealing elevated creatine kinase can help to identify the underlying cause or illness. (kidneypedia.net)
  • Clinically, creatine kinase is assayed in blood tests as a marker of myocardial infarction (heart attack), rhabdomyolysis (severe muscle breakdown), muscular dystrophy and in acute renal failure . (wikidoc.org)
  • The exercise protocol promoted slight muscle damage, reflected in significant increases in total creatine kinase in all subjects after exercise. (biomedcentral.com)
  • Normal creatine kinase levels vary by age, gender, muscle mass, and level of activity. (kidneypedia.net)
  • Signs and symptoms that typically accompany an elevated creatine kinase include cardiac symptoms such as chest pain, breathing trouble, dizziness, excessive sweating and pain that reaches the jaw or the lower arm, according to Healthgrades. (reference.com)
  • In addition, activation of these kinases is modulated by humoral factors such as estrogen and taurine. (frontiersin.org)