AnatomyOrganismsChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and Processes
Creatine KinaseCreatine Kinase, BB FormIsoenzymesCreatineCreatine Kinase, MM FormCreatine Kinase, Mitochondrial FormCreatine Kinase, MB FormPhosphatidylinositol 3-KinasesClinical Enzyme TestsPhosphocreatineMAP Kinase Signaling SystemRats, Inbred BBProtein KinasesProtein-Serine-Threonine KinasesArginine KinaseMusclesProtein Kinase InhibitorsCalcium-Calmodulin-Dependent Protein Kinases4-1BB Ligandsrc-Family KinasesL-Lactate DehydrogenaseMyocardium
IsoenzymesEnzymePhosphokinaseIsoenzymeMyocardial infarctionHigh-energy phLactateProteinPhosphocreatineSerumCytosolicIsozymesLiverMuscleIsoformsSupplementsSupplementationMonohydrateLevelsTissueRefersPhosphateBleeding disordersMolecularReactionTest measuresDiseasesIncludeTypeAdulthoodLungsFoundReference RangeImportantLevelTotalPeopleBody
Isoenzymes10
  • In addition to those three cytosolic CK isoforms, there are two mitochondrial creatine kinase isoenzymes, the ubiquitous form and the sarcomeric form. (wikipedia.org)
  • CK-MM, CK-MB, and CK-BB isoenzymes. (online-sciences.com)
  • Creatine kinase (CK) is an enzyme, found primarily in muscle and brain tissue, which exists as three dimeric isoenzymes: CK-MM (CK-3), CK-MB (CK-2), and CK-BB (CK-1) − built from subunits designated M and B. The CK-MB isoenzyme, which has a molecular mass of approximately 87 kilodaltons, accounts for 5% to 50% of total CK activity in myocardium. (evexiadiagnostics.com)
  • Diagnosis of acute myocardial infarction when skeletal muscle damage is present: A caveat regarding use of creatine kinase isoenzymes. (evexiadiagnostics.com)
  • The CK-MB is one of three forms (isoenzymes) of the enzyme in creatine kinase (CK). (orangehealth.in)
  • These isoenzymes include CK-MM (found in skeletal muscles and the heart), CK-MB (found mostly in the heart, but small amounts are found in skeletal muscles), and CK-BB (mostly found in the brain and smooth muscles, such as the intestines and uterus). (orangehealth.in)
  • Creatine Kinase MB (CK-MB) is an enzyme present in the cardiac muscle with a molecular weight of 87.0 kDa.1 Creatine Kinase is a dimeric molecule formed from two subunits designated as "M" and "B" which combine to form three different isoenzymes, CK-MM, CK-BB, and CK-MB. (nal-vonminden.com)
  • Three cytoplasmic ISOENZYMES have been identified in human tissues: the MM type from SKELETAL MUSCLE, the MB type from myocardial tissue and the BB type from nervous tissue as well as a mitochondrial isoenzyme. (ucdenver.edu)
  • Creatine kinase and its isoenzymes in neoplastic disease. (shengsci.com)
  • The creatine phosphokinase (CPK) isoenzymes test measures the different forms of CPK in the blood. (adam.com)
Enzyme13
  • Creatine kinase (CK), also known as creatine phosphokinase (CPK) or phosphocreatine kinase, is an enzyme (EC 2.7.3.2) expressed by various tissues and cell types. (wikipedia.org)
  • Thus creatine kinase is an important enzyme in such tissues. (wikipedia.org)
  • Creatine kinase-MB (CK-MB) is a form of an enzyme that is found primarily in the heart muscles. (orangehealth.in)
  • The Creatine Phosphokinase (CPK)-MB test measures:The creatine kinase MB (CK-MB) test analyses the amount of CK-MB enzyme. (orangehealth.in)
  • In our body, creatine can bind a high-energy phosphate group (Pi) forming phosphocreatine (Pcr) (or creatine phosphate (CP)) with help of an enzyme called creatine kinase (CK). (cregaatine.com)
  • In the next step, one methyl group is added to GAA forming creatine with help of an enzyme S-adenosyl-L-methionine:N-guanidinoacetate methyltrasferase (GAMT) (Picture 2). (cregaatine.com)
  • Creatine kinase (CK) is a dimer enzyme with four different forms: mitochondrial isoenzyme and cytosolic isoenzyme CK-MM (muscle type), CK-BB (brain type) and CK-MB. (xhfhj.com)
  • CK is made up of 3 enzyme forms. (fbscan.com)
  • Creatine phosphokinase (CPK) is an enzyme in the body. (adam.com)
  • Creatine kinase, also known as phosphocreatine kinase or creatine phosphokinase, is an enzyme or type of protein that is found in several tissue types of the human body, including the muscle and the brain. (creatinejournal.com)
  • The function of this enzyme is to catalyze the conversion of creatine to phosphocreatine by applying itself in the consumption of adenosine triphosphate, the generation of adenosine diphosphate, and the reverse reaction. (creatinejournal.com)
  • In the CPK test, the total creatine phosphokinase (CPK) enzyme level is measured in the blood serum when a muscle is under stress or injured, CPK leaks into the blood and elevated levels. (mfine.co)
  • They work by inhibiting a particular enzyme ([http://en.wikipedia.org/wiki/Cyclooxygenase Cyclooxygenase]) which reduces pain, fever and inflammation. (fellrnr.com)
Phosphokinase12
Isoenzyme6
  • Apart from the two mitochondrial CK isoenzyme forms, that is, ubiquitous mtCK (present in non-muscle tissues) and sarcomeric mtCK (present in sarcomeric muscle), there are three cytosolic CK isoforms present in the cytosol, depending on the tissue. (wikipedia.org)
  • CK-BB is the predominant isoenzyme found in the brain , colon, ileum, stomach , and urinary bladder. (online-sciences.com)
  • Comparable detection of acute myocardial infarction by creatine kinase MB isoenzyme and cardiac troponin I. Clin Chem. (evexiadiagnostics.com)
  • CK-MB is the isoenzyme of Creatine Kinase most involved in the metabolism of cardiac muscle tissue.2 The release of CK-MB into the blood following MI can be detected within 3-8 hours after the onset of symptoms. (nal-vonminden.com)
  • The CK-BB isoenzyme is ubiquitous in neoplastic tissue, but with low activity. (shengsci.com)
  • Evaluation of BB isoenzyme in serum might indicate the extent of diseases or the response to therapy. (shengsci.com)
Myocardial infarction4
  • Clinically, creatine kinase is assayed in blood tests as a marker of damage of CK-rich tissue such as in myocardial infarction (heart attack), rhabdomyolysis (severe muscle breakdown), muscular dystrophy, autoimmune myositides, and acute kidney injury. (wikipedia.org)
  • Creatine kinase-MB: Detection of myocardial infarction and monitoring reperfusion. (evexiadiagnostics.com)
  • Diagnostic evaluation of creatine kinase-2 mass and creatine kinase-3 and -2 isoform ratios in early diagnosis of acute myocardial infarction. (evexiadiagnostics.com)
  • Creatine Kinase (CK) is internationally accepted as a sensitive and specific indicator of acute myocardial infarction (AMI). (randox.com)
High-energy ph3
  • Creatine kinase acts as a regulator of high-energy phosphate production and utilization within contractile tissues. (online-sciences.com)
  • It stores high-energy phosphate groups in the form of phosphocreatine and converts it into ATP, which is the main energy source. (healthandmedicine.net)
  • Cellular ATP is buffered by specialized equilibrium-driven high-energy phosphate (~P) transferring kinases. (molvis.org)
Lactate1
  • Confocal studies showed differential cellular and compartmental distribution of isozymes involved in glucose, glutamate, glutamine, lactate, and creatine metabolism. (molvis.org)
Protein5
  • The first structure of a creatine kinase solved by X-ray protein crystallography was that of the octameric, sarcomeric muscle-type mitochondrial CK (s-mtCK) in 1996. (wikipedia.org)
  • Two protein subunits form into 3 different isozymes: CK-MM, CK-MB, and CK-BB. (medscape.com)
  • Reviewed are the phosphorylation events reporting activation of protein kinases and the key substrates critical for the DNA damage signaling (DDS). (shengsci.com)
  • Lactiplantibacillus plantarum ELF051 also regulated the Toll-like receptor/myeloid differentiation primary response 88/nuclear factor kappa light chain enhancer of activated B cells (TLR4/MyD88/NF-κB) and the phosphatidylinositol 3-kinase/protein kinase B/ NF-κB (PI3K/AKT/ NF-κB) inflammatory signaling pathways. (bvsalud.org)
  • PD also involves multiple neurotransmitters (not just dopamine), and highly progressive forms of PD are linked with chronic inflammation, cell damage, protein glycation, high blood sugar, lack of activity, poor dietary choices, and more. (iherb.com)
Phosphocreatine5
Serum2
Cytosolic4
  • The atomic structure of the banana-shaped, dimeric cytosolic brain-type BB-CK was solved in 1999 at a resolution of 1,4 Å. (wikipedia.org)
  • Cytosolic BB-CK, as well as muscle-type MM-CK both form banana-shaped symmetric dimers, with one catalytic active site in each subunit. (wikipedia.org)
  • The bound cytosolic CK accepts the PCr shuttled through the cell and uses ADP to regenerate ATP, which can then be used as an energy source by the ATPases (CK is associated intimately with the ATPases, forming a functionally coupled microcompartment). (wikipedia.org)
  • Expression of nucleoside diphosphate kinase, mitochondria-associated adenylate kinase, and several mitochondria-associated creatine kinase isozymes was highest in the outer retina, whereas expression of cytosolic adenylate kinase and brain creatine kinase was higher in the cones, horizontal cells, and amacrine cells indicating the diversity of ATP-buffering strategies among retinal neurons. (molvis.org)
Isozymes1
  • The 2 subunits can form 3 isozymes: CK-MM, CK-MB, and CK-BB. (medscape.com)
Liver2
Muscle11
  • CK-BB is predominantly expressed in brain and smooth muscle, including vascular and uterine tissue. (wikipedia.org)
  • Whereas MM-CK is expressed in sarcomeric muscle, that is, skeletal and cardiac muscle, MB-CK is expressed in cardiac muscle, and BB-CK is expressed in smooth muscle and in most non-muscle tissues. (wikipedia.org)
  • In skeletal muscle, by contrast, it normally accounts for ≤1%, CK-MM being the dominant form, though the percentage can be as high as 10% in conditions reflecting skeletal muscle injury and regeneration (eg, severe exercise, muscular dystrophy, polymyositis). (evexiadiagnostics.com)
  • Meat consumption, exercise, amount of muscle and testosterone affect creatine store. (healthandmedicine.net)
  • Forming fat-free muscle mass, reducing fatigue, improving mood and increasing bone density are among the benefits of creatine. (healthandmedicine.net)
  • Skeletal muscle can keep a certain amount of creatine, taking more than the capacity does not increase the level. (healthandmedicine.net)
  • Sportsmen like athletes, weightlifters and bodybuilders who need speed or muscle burst in a short period can use creatine supplements. (healthandmedicine.net)
  • Muscle-related complaints and high creatine kinase (CK) blood levels have been reported in 16-51 % of patients with acne treated with isotretinoin. (medicaljournals.se)
  • On the other hand, if the test reveals that the level of creatine kinase circulating in the blood is higher than it should be in normal conditions, then chances are that the human body in question has suffered damage either to the muscle or the brain. (creatinejournal.com)
  • If most of this sounds like gibberish to you, just remember that a heart attack, a muscle disease or a stroke may result in abnormally raised creatine kinase levels in the blood. (creatinejournal.com)
  • Creatine (and Glutamine) helped me to gain and maintain muscle like never before (about 4 years ago). (creatinejournal.com)
Isoforms2
  • Both mt-CK isoforms form octameric structures (built of 4 banana-like dimers) with a four-fold symmetry and a central channel. (wikipedia.org)
  • Creatine kinase (CK) exists in three isoforms: CK1 (CK-BB), CK2 (CK-MB), and CK3 (CK-MM). (ashp.org)
Supplements2
  • Creatine (from Greek kreas , flesh) holds a special place among sport supplements, as it is one of the most studied ergogenic aids on the market with a long tradition of use (discovered in 1927). (cregaatine.com)
  • Creatine in nutrients is digested more slowly than supplements. (healthandmedicine.net)
Supplementation3
Monohydrate2
Levels1
Tissue2
  • Finding which specific form of CPK is elevated helps determine which tissue has been damaged. (mfine.co)
  • It relates targeted that the venous information of L-arginine can Determine living in controls discharged by exercise-related improvement, that was blood of Larginine as a Source for advances can form in EC tissue somatic to environment of albumin failure( SOA) and anti-fibrotic 31-AUG-2006 organ interventions and that obesity with sensory L-arginine can be EC reticulum. (siriuspixels.com)
Refers1
  • indirect bilirubin refers to the unconjugated form (water insoluble form). (ashp.org)
Phosphate1
  • In this reaction, Pcr is degraded to creatine and phosphate group which is then bound to adenosine diphosphate, thus creating ATP. (cregaatine.com)
Bleeding disorders1
  • Further, the ADP-scavenging action of creatine kinase has been implicated in bleeding disorders: persons with highly elevated plasma CK could be prone to major bleeding. (wikipedia.org)
Molecular1
  • The molecular formulae of GAA and creatine in their synthetic pathway are shown in Picture 3. (cregaatine.com)
Reaction1
  • In this chemical reaction, two amino acids bind together, forming GAA and a by-product ornithine. (cregaatine.com)
Test measures1
Diseases2
  • It also protects against neurological diseases and is used to treat disorders occurred when the body cannot metabolize the creatine. (healthandmedicine.net)
  • Awareness, diagnosis, and control of tickborne rickettsial diseases are most effectively addressed by considering the intersecting components of human, animal, and environmental health that collectively form the foundation of One Health ( 1 ), an approach that integrates expertise from multiple disciplines and facilitates understanding of these complex zoonoses. (cdc.gov)
Include3
  • Two important forms of vitamin D include vitamin D3 (cholecalciferol) and vitamin D2 (ergocalcitol). (xhfhj.com)
  • Other names for a creatine kinase test include: CK total. (fbscan.com)
  • The most severe forms of osteogenesis imperfecta, particularly type II, can include an abnormally small, fragile rib cage and underdeveloped lungs. (nih.gov)
Type3
  • n\nThere are at least 19 recognized forms of osteogenesis imperfecta, designated type I through type XIX. (nih.gov)
  • Type I (also known as classic non-deforming osteogenesis imperfecta with blue sclerae) is the mildest form of osteogenesis imperfecta. (nih.gov)
  • n\nThe milder forms of osteogenesis imperfecta, including type I, are characterized by bone fractures during childhood and adolescence that often result from minor trauma, such as falling while learning to walk. (nih.gov)
Adulthood1
  • People with mild forms of the condition typically have a blue or grey tint to the part of the eye that is usually white (the sclera), and about half develop hearing loss in adulthood. (nih.gov)
Lungs1
  • CPK-BB is present in the lungs and brain. (mfine.co)
Found1
Reference Range1
  • Some analytes exist in several forms and each has a different reference range. (ashp.org)
Important3
  • The two most important forms o f vitamin D are vitamin D3 (cholecalciferol) and vitamin D2 (ergot calciferol). (xhfhj.com)
  • This is a very important function, and even though it doesn't sound like much, creatine kinase definitely has its work cut out. (creatinejournal.com)
  • Overall, the Regulation BB is an important tool for ensuring that financial institutions are meeting the credit needs of their entire communities, including low- and moderate-income neighborhoods. (intactone.com)
Level2
Total2
  • Results for the total and each form are reported. (ashp.org)
  • This graph shows the total number of publications written about "Creatine Kinase" by people in this website by year, and whether "Creatine Kinase" was a major or minor topic of these publications. (ucdenver.edu)
People1
  • Below are the most recent publications written about "Creatine Kinase" by people in Profiles. (ucdenver.edu)
Body2
  • Creatine is a substance that is naturally produced in our body from three amino acids - arginine, glycine, and methionine. (cregaatine.com)
  • Creatine is an organic acid that helps provide energy to the cells in the body, especially in muscles. (healthandmedicine.net)