• In this study, differentially expressed genes (DEGs) under drought and flooding conditions were investigated using Illumina RNA-Seq transcriptome profiling. (frontiersin.org)
  • Differentially expressed genes (DEGs) may be responsible for phenotypic differences between various biological conditions. (mdpi.com)
  • We have investigated potential mechanisms of regulation of rotavirus gene expression by functional evaluation of two differentially expressed viral mRNAs. (microbiologyresearch.org)
  • In total, 873 lncRNAs and 2480 mRNAs were determined to be differentially expressed genes in RGCs from normal control and FDM guinea pigs. (bvsalud.org)
  • Skin wrinkles as it ages because the collagen proteins in skin become glycated and linked together, making them less flexible and supple. (mskcc.org)
  • Glycated proteins begin to build up. (mskcc.org)
  • For decades, scientists have known that, despite its name, "junk DNA" in fact plays a critical role: While the coding genes provide blueprints for building proteins, which direct most of the body's functions, some of the noncoding sections of the genome, including regions previously dismissed as "junk," seem to turn up or down the expression of those genes. (stanford.edu)
  • But it's been unclear how certain noncoding regions influence gene-expression levels - that is, the number of times a gene is copied into RNA and used to make proteins. (stanford.edu)
  • Connecting all disrupted pairs of proteins, we construct an "ASD disrupted network. (springer.com)
  • Genes encoding disrupted complementary interactors tend to be risk genes, and an interaction network built from these proteins is enriched for ASD proteins. (springer.com)
  • The fact that the Gimap genes are located together in a tight cluster on RNO4 (and in conserved synteny with many other species), combined with their sequence similarities, suggests the possibility that the proteins carry out similar function. (hindawi.com)
  • How do genes direct the production of proteins? (medlineplus.gov)
  • Most genes contain the information needed to make functional molecules called proteins. (medlineplus.gov)
  • A few genes produce regulatory molecules that help the cell assemble proteins. (medlineplus.gov)
  • Amino acids are the building blocks of proteins. (medlineplus.gov)
  • Through the processes of transcription and translation, information from genes is used to make proteins. (medlineplus.gov)
  • Mutant proteins in familial benign pemphigus create a loss of sensitivity to Ca 2+ and Mn 2+ ion binding and transport. (medscape.com)
  • This process is mediated by a complex molecular machinery known as the spliceosome, which enables the production of multiple and functionally distinct proteins from single genes. (lu.se)
  • Remarkably, the researchers said, MBSR also altered the genes and protein markers of inflammation, including the inflammatory marker C-reactive protein (CRP) and a group of genes regulated by the transcription factor NF-kB. (scitechdaily.com)
  • Transcription factors attach to noncoding DNA, regulating the expression of protein-coding genes. (stanford.edu)
  • These random, or stochastic, bursts of protein expression are described in detail in a separate paper Xie and colleagues presented in Nature. (harvard.edu)
  • We measured the levels of gene 5 and gene 6 mRNA and showed that they were not significantly different, and protein analysis indicated no difference in stability of NSP1 compared with VP6. (microbiologyresearch.org)
  • Nucleotide sequence and expression in Escherichia coli of the gene encoding the nonstructural protein NCVP2 of bovine rotavirus. (microbiologyresearch.org)
  • Cloning and nucleotide sequence of the simian rotavirus gene 6 that codes for the major inner capsid protein. (microbiologyresearch.org)
  • We investigate the functional relevance of de novo missense variants, specifically whether they are likely to disrupt protein interactions, and nominate novel genes in risk for ASD through integrated genomic, transcriptomic, and proteomic analyses. (springer.com)
  • Finally, we integrate protein interactions and cell-type-specific co-expression networks together with published association data to implicate novel genes in ASD risk in a cell-type-specific manner. (springer.com)
  • Consistent with other studies, genes identified by disrupted protein interactions are expressed early in development and in excitatory and inhibitory neuronal lineages. (springer.com)
  • Disrupted protein interactions identify gene sets involved in risk for ASD. (springer.com)
  • Using the newly released and larger ASC dataset, we confirm these observations and take them in several new directions: (1) By defining a set of genes encoding these disrupted protein interactors in ASD subjects and another for their siblings, we evaluate their expression patterns in developing brain from fetal to early postnatal development and within general cell types of brain tissue. (springer.com)
  • Positional cloning of lymphopenia ( lyp ) in the BB rat revealed a frameshift mutation in Gimap5 , a member of at least seven related GTPase Immune Associated Protein genes located on rat chromosome 4q24. (hindawi.com)
  • Gimap5 is a member of at least seven related GTPase Immune Associated Protein ( Gimap ) genes located within 150 Kilobases (Kb) on rat chromosome (RNO) 4 [ 2 , 3 ]. (hindawi.com)
  • Gimap5 was identified as the lyp gene in the BBDP rat through a frameshift mutation and premature truncation of the Gimap5 protein [ 2 , 6 ] and can be rescued in a P1-derived artificial chromosome (PAC) transgenic rat [ 7 ]. (hindawi.com)
  • This gene encodes one of the three members of the human AKT serine-threonine protein kinase family which are often referred to as protein kinase B alpha, beta, and gamma. (senescence.info)
  • Subsequent phosphorylation of both threonine residue 308 and serine residue 473 is required for full activation of the AKT1 protein encoded by this gene. (senescence.info)
  • To explore the effect of DNA methyltransferase, demethylase and methyl-CpG binding protein MeCP2 on the expressions and methylation of hMSH2 and proto-oncogene in human gastric cancer. (wjgnet.com)
  • A highly reliable set of protein-protein interactions is predicted through this integrative approach making use of existing protein-protein interaction data from yeast, human, C. elegans and D. melanogaster. (ugent.be)
  • Localization, biological process, and co-expression data are used as powerful indicators for protein-protein interactions. (ugent.be)
  • De Bodt S, Proost S, Vandepoele K, Rouzé P, Van de Peer Y. Predicting protein-protein interactions in Arabidopsis thaliana through integration of orthology, gene ontology and co-expression. (ugent.be)
  • The journey from gene to protein is complex and tightly controlled within each cell. (medlineplus.gov)
  • The type of RNA that contains the information for making a protein is called messenger RNA (mRNA) because it carries the information, or message, from the DNA out of the nucleus into the cytoplasm. (medlineplus.gov)
  • Translation, the second step in getting from a gene to a protein, takes place in the cytoplasm. (medlineplus.gov)
  • The diagnosis of PTLD is made by histopathologic evidence of lymphoproliferation, commonly with the presence of EBV DNA, RNA, or protein detected in tissue. (medscape.com)
  • The researchers created their "atlas" by taking advantage of a form of a recently invented technique known as single-cell mRNA sequencing, which allowed them to capture and sequence mRNA from more than 250,000 single cells. (medicalxpress.com)
  • 촉진자) 서열을 사용해 유전자 군집(즉, 구조유전자(structural gene) 군집)을 단일 mRNA 분자로 전사(transcription)하기 시작합니다. (jove.com)
  • Polyribosome analysis showed that the majority of gene 6 mRNA was present on large polysomes. (microbiologyresearch.org)
  • In contrast, sedimentation of more than half of the gene 5 mRNA was subpolysomal. (microbiologyresearch.org)
  • The change in distribution of gene 5 mRNA in polyribosome gradients in response to treatment with low concentrations of cycloheximide suggested that gene 5 is a poor translation initiation template compared with gene 6 mRNA. (microbiologyresearch.org)
  • The average mRNA level of Dnmt1 gene from cancerous tissue was higher and that of mbd2 gene from cancerous tissue was lower than that from non-cancerous tissue, respectively. (wjgnet.com)
  • METHODS: RNA sequencing was performed to analyze lncRNA and mRNA expression profiles in RGCs between guinea pigs with form-deprived myopia (FDM) and normal control guinea pigs, and related ceRNA networks were constructed. (bvsalud.org)
  • Gene ontology (GO) term enrichment analysis was used to highlight the most relevant GO terms associated with a given gene list following toxin exposure. (plos.org)
  • Then, potentially important genes in ceRNA networks were verified by qRTâ PCR, and Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were performed to explore biological functions in the RGCs of FDM guinea pigs. (bvsalud.org)
  • Scientists armed with whole genome sequence data can now ask questions about genome structure and organization that impact gene expression. (genengnews.com)
  • The account expands to include a brief discussion of other regulatory mechanisms that govern the expression of lambda's genome. (the-scientist.com)
  • To create and use a custom reference package, Space Ranger requires a reference genome sequence (FASTA file) and gene annotations (GTF file). (10xgenomics.com)
  • Path(s) to genes GTF file(s) containing annotated genes for your genome reference. (10xgenomics.com)
  • done Writing genes index file into reference folder (may take over 10 minutes for a 3Gb genome). (10xgenomics.com)
  • and rapidly determine all the DNA sequences in the genome that regulate the expression of a specific gene. (finchannel.com)
  • Read were aligned transcriptome by RSEM to RefSeq gene annotation (April 23, 2013), and unmapped reads were aligned to genome by Bowtie. (nih.gov)
  • My research involves identifying gene regulatory elements across the genome to help us understand how chromatin structure dictates cell function and fate. (duke.edu)
  • STRs make up about 5% of the human genome. (stanford.edu)
  • To discover how the arachnid developed this ability, González, Gainett and their fellow researchers sequenced the daddy longlegs' genome - and eventually, they succeeded in creating a daddy shortlegs, by manipulating its genes. (npr.org)
  • Critical to sub-classify SRBCTs, Khan et al .6 used to measure genome-wide gene expres- .com decisions in cancer therapeutics are to microarrays to monitor the expression sion for a variety of biological samples. (lu.se)
  • Improved access to bioinformatics tools enables scientists to process, manage, and store raw data, annotate sequences to define genes, and quantitate RNA sequence data to get insight into gene expression patterns. (genengnews.com)
  • They created a computer program to search through the thousands of possible drug-disease combinations to find drugs and diseases whose gene expression patterns essentially cancelled each other out. (sciencedaily.com)
  • Genes can maintain spatiotemporal expression patterns by long-range interactions between cis-acting elements. (duke.edu)
  • An alternative approach is gene coexpression analysis, which detects groups of genes with similar expression patterns across unrelated sets of transcriptomic data from the same organism. (mdpi.com)
  • For genes encoding the disrupted interactions, we evaluate their expression patterns across developing brains and within specific cell types, using both bulk and inferred cell-type-specific brain transcriptomes. (springer.com)
  • 0 pression patterns of 96 transcripts and prognosis based on a limited representing 80 known genes and 20 13 numbers of markers1-5. (lu.se)
  • Gene-expression patterns used to differentiate four type cause heart damage, and markable finding that genes cur- types of SRBCT. (lu.se)
  • The progress being made by a number of companies and academic researchers enabling resolution of questions from genomic analysis was shared at the recent "Plant and Animal Conference" in San Diego. (genengnews.com)
  • The scientists drew their data from the NIH National Center for Biotechnology Information Gene Expression Omnibus, a publicly available database that contains the results of thousands of genomic studies on a wide range of topics, submitted by researchers across the globe. (sciencedaily.com)
  • New York University researchers have created a "developmental atlas" of gene expression in neurons, using gene sequencing and machine learning to categorize more than 250,000 neurons in the brains of fruit flies. (medicalxpress.com)
  • Researchers previously identified the roughly 60,000 cells and 200 neuronal types that make up fruit flies' optic lobes , the areas of the brain that process visual information , including color vision and detection of objects and motion. (medicalxpress.com)
  • In their new study in Nature , researchers in Desplan's lab sought to thoroughly characterize the diversity of neurons in the optic lobe and build a "developmental atlas" of gene expression , comparing cells in the brains of adult flies and exploring differences during development. (medicalxpress.com)
  • While building their "developmental atlas," the researchers made several discoveries. (medicalxpress.com)
  • Research areas Through programs spanning genetics, biology, and therapeutic development, Broad researchers are making discoveries that drive biomedical science forward. (broadinstitute.org)
  • Technology areas Our researchers use their expertise in creating, adapting, and applying a variety of technologies to enable science here and beyond. (broadinstitute.org)
  • Further, knowing that loneliness is associated with an increase in the activity of inflammation-related genes that can promote a variety of diseases, the researchers examined gene expression and found that this same form of meditation significantly reduced expression of inflammatory genes. (scitechdaily.com)
  • A study led by researchers at Stanford Medicine have unraveled some of the mystery of how non-coding DNA changes the level of gene expression. (stanford.edu)
  • Starting in the 1980s, researchers noticed that changes to these repetitive sequences can affect gene expression," said the study's lead author, Connor Horton, who was a technician in Fordyce's lab. (stanford.edu)
  • To better understand the role of short tandem repeats in gene expression, the researchers stripped the mechanisms down to their basics: transcription factors and naked DNA. (stanford.edu)
  • Using this gene therapy technique with specialised nanoparticles, researchers from Penn Engineering and the Massachusetts Institute of Technology ("MIT") developed a way to turn off specific genes in cells of bone marrow. (davidicke.com)
  • The researchers found that the daddy longlegs, also known as harvestmen, evolved their special legs not through a genetic secret ingredient but by reusing parts of the same genetic recipe found in other arthropods, such as genes that affect tarsomeres - subsegments of the leg. (npr.org)
  • Rather than trying to turn a gene off entirely, the researchers wanted to turn it down to a very low setting. (npr.org)
  • When the researchers turned down the expression of two specific genes, the daddy longlegs developed much shorter legs than usual. (npr.org)
  • Using a small seed list of known cartilage-selective genes, UGET extended the list of known genes by identifying 32 new highly cartilage-selective genes. (discovermagazine.com)
  • For example, if a disease increased the activity of certain genes, the program tried to match it with one or more drugs that decreased the activity of those genes. (sciencedaily.com)
  • RNA nanoparticles are currently FDA-approved as a liver-targeted therapy but hold promise for many diseases, ranging from covid-19 vaccines to drugs that can permanently repair disease genes," said Daniel Anderson, one of the authors of the study. (davidicke.com)
  • The most common approach in transcriptomics (RNA-seq and microarrays) is differential gene expression analysis (DGEA). (mdpi.com)
  • This Special Issue includes 12 research articles and one review on the topic of differential gene expression and coexpression. (mdpi.com)
  • It is shown that reactive oxygen species metabolism and oxidative stress responsive genes are deregulated. (nature.com)
  • A Genetic Switch: Gene Control and Phage A. Mark Ptashne. (the-scientist.com)
  • Despite sharing the same genetic information , neurons achieve this diversity by turning on different sets of genes in each neuron type and at each point in their development. (medicalxpress.com)
  • Molecular genetic analysis of the switch-like regulation of daf-7 expression in the ASJ neuron pair reveals a hierarchy of regulation among multiple inputs-sex, age, nutritional status, and microbial environment-which function in the modulation of behavior. (elifesciences.org)
  • He is the inventor of the so-called AntagoNAT oligonucleotide technology, which allows for upregulation of genes in genetic and other disorders. (wikipedia.org)
  • Building genetic regulatory network (GRN) can help to understand the regulatory mechanism between genes and the function of organisms. (scirp.org)
  • Ji, R. , Liu, D. and Zhang, W. (2010) The application of hidden markov model in building genetic regulatory network. (scirp.org)
  • Our aim was to clone and sequence the cDNA of the BB diabetes prone (DP) and diabetes resistant (DR) alleles of all seven Gimap genes in the congenic DR. lyp rat line with 2 Mb of BB DP DNA introgressed onto the DR genetic background. (hindawi.com)
  • A curated database of genes associated with dietary restriction in model organisms either from genetic manipulation experiments or gene expression profiling. (senescence.info)
  • [ 6 ] This gene defect is similar to the genetic defect in Darier disease , which also is a calcium pump defect, ATP2A2 . (medscape.com)
  • Bone marrow makes more than 220 billion new blood cells every day. (davidicke.com)
  • Amy Radunz, a nutritionist from the department of animal sciences at the University of Wisconsin in River Falls, has partnered with molecular biologist Hasan Khatib, an associate professor at University of Wisconsin-Madison, to ask how differences in maternal diet during pregnancy induce gene expression and DNA methylation changes in fetal tissues in sheep. (genengnews.com)
  • Promoter methylation of p16 INK4A , c-myc and hMSH2 genes was assayed by methylation-specific PCR (MSP) and sequencing (mapping). (wjgnet.com)
  • They're based on the analysis of DNA methylation, a biological process by which CH3 methyl groups are added to the DNA molecule and that determines gene expression. (medscape.com)
  • A complex intronic enhancer regulates expression of the CFTR gene by direct interaction with the promoter. (duke.edu)
  • Using a lentiviral vector containing either H-Ras oncogene and a hairpin targeting p53 or both tumor suppressor genes, NF-1 and p53, Dr. Friedmann-Morvinski can induce the formation of a glioma tumor in mice injected in the brain. (genengnews.com)
  • The authors used artificial neural croarrays is to study changes in gene ex- .nature organ the tumor arose from, how big it networks (ANNs) to identify gene-ex- pression that accompany changes in is, and what it looks like after it has pression signatures associated with spe- cell physiology, such as during develop- been imbedded in wax and colored cific subtypes of tumors. (lu.se)
  • Red not have the tumor-specific ex- with these dangerous drugs, rhab- represents relatively high expression level, whereas green pression pattern. (lu.se)
  • Our results suggest that regulation of gene expression in sensory neurons can function in the integration of a wide array of sensory information and facilitate decision-making behaviors in C. elegans . (elifesciences.org)
  • [ 4 ] . Study of familial and sporadic cases of familial benign pemphigus in the Chinese population has revealed a number of mutations scattered throughout the ATP2C1 gene. (medscape.com)
  • Cross-Sectional Study for the Detection of Mutations in the Beta-Globin Gene Among Patients with Hemoglobinopathies in the Bengali Population. (cdc.gov)
  • Small and Large Ribosomal Subunit Deficiencies Lead to Distinct Gene Expression Signatures that Reflect Cellular Growth Rate. (broadinstitute.org)
  • In addition, gene set enrichment analysis (GSEA) was performed to identify possible molecular signatures that associate with Chl1 expression silencing. (lu.se)
  • Transfection of promoter-reporter constructs demonstrated that the element displays classical tissue-specific enhancer properties and can independently recruit factors necessary for transcription initiation. (duke.edu)
  • The study also looked at the impact of paternally expressed genes: IGF2, PEG1, PEG3, DLK1, and DIO3 for transcriptomic and epigenomic alterations of the imprinted genes in fetal tissues. (genengnews.com)
  • The resource catalogs changes in gene activity under various conditions, such as in diseased tissues or in response to medications. (sciencedaily.com)
  • The transcriptional levels of p16 INK4A and MeCP2 genes did not display any difference between gastric cancerous and matched non-cancerous tissues. (wjgnet.com)
  • RNA sequencing data revealed a high expression of CHL1 in pancreatic islets and adipose tissues compared to liver and muscles tissues. (lu.se)
  • Reads aligning non-uniquely to multiple genes cause the pipeline to detect fewer molecules. (10xgenomics.com)
  • The expression of key molecules of β-cell function including Insulin, Pdx1, Gck, Glut2, and Insrβ was down-regulated in Chl1 -silenced cells at transcriptional and translational levels. (lu.se)
  • Gene expression may be affected in benign familial pemphigus, as may phosphorylation of adhesion molecules. (medscape.com)
  • In addition, we retrospectively tested UGET and other gene expression based prioritization tools to identify disease-causing genes within known linkage intervals. (discovermagazine.com)
  • The linkage between SDOH and epigenetic changes makes epigenetics a potentially important tool for health equity science . (cdc.gov)
  • Here, we show that C. elegans males exhibit an altered, male-specific expression pattern of daf-7 in the ASJ sensory neuron pair with the onset of reproductive maturity, which functions to promote male-specific mate-searching behavior. (elifesciences.org)
  • Diversity of the different cell types that make up our brains can only be fully understood in light of their developmental history," said NYU Biology Professor Claude Desplan, the study's senior author. (medicalxpress.com)
  • The 'atlas' constitutes an enormous resource for the research community: we can now simply look up whether a particular gene is active or not in any cell type of our choice and at any point during its development. (medicalxpress.com)
  • In addition, in order to phenotypically anchor the gene expression data, changes in the heterogeneity of cell subtype populations and cell cycle phase were monitored using flow cytometry. (plos.org)
  • However, cell wall synthesis related genes were up-regulated under drought stress and down-regulated under flooding stress. (frontiersin.org)
  • The changes in expression of genes involved in regulating the flux of cell wall precursors and starch/sugar content can serve as an adaptive mechanism for soybean survival under stress conditions. (frontiersin.org)
  • RNA interference is a gene therapy that could potentially be used to "treat a variety of diseases" by delivering short strands of RNA that block specific genes from being turned on in a cell. (davidicke.com)
  • Using inferred gene co-expression for three neuronal cell types-excitatory, inhibitory, and neural progenitor-we implicate several hundred genes in risk (FDR \(\le \hspace{0.17em}\) 0.05), ~ 60% novel, with characteristics of genuine ASD genes. (springer.com)
  • Across cell types, these genes affect neuronal morphogenesis and neuronal communication, while neural progenitor cells show strong enrichment for development of the limbic system. (springer.com)
  • Their gene expression during brain development and within cell types highlights how they relate to ASD. (springer.com)
  • At this time, there is a paucity of information as to the expression of the Gimap genes in specific cell types. (hindawi.com)
  • Whereas α2 laminins promoted islet cell clustering, they did not affect gene expression. (nature.com)
  • In contrast, culturing on Laminin-421 induced the expression of β-cell genes, including Ins1 , MafA , and Glut2 , and significantly improved glucose-stimulated insulin secretion. (nature.com)
  • holds gene ids, cell ids and gene expression values. (lu.se)
  • In a study published in the Molecular Cell journal, they explain what makes hematopoietic stem cells acquire malignant traits in cancer. (lu.se)
  • Of these, 7 of 10 tested were validated by qPCR including the novel cartilage-specific genes SDK2 and FLJ41170. (discovermagazine.com)
  • The up-regulation of proto-oncogene may be the consequence of epigenetic control of gene expression by demethylase, and mbd2 is involved in the regulation of hMSH2 expression in human gastric cancer. (wjgnet.com)
  • Your reference should have only a small number of overlapping gene annotations. (10xgenomics.com)
  • To be considered for transcriptome alignment, genes must have annotations with feature type 'exon' (column 3) in the GTF file. (10xgenomics.com)
  • Scientists have found that within the flock, the genes expressed, or "turned on," in the brains of the fearless birds are markedly different from those in the birds that exhibit fear. (neurosciencenews.com)
  • For example, when wildlife are presented with something new in their environment, the genes in their brains respond, helping them process the information, compare it to past experience and decide whether they should approach or avoid the novel object," Lattin said. (neurosciencenews.com)
  • However, the transcription level of the above genes was not associated with biological behaviours of gastric cancers. (wjgnet.com)
  • Liquid biopsies based on genomic biomarkers could make MCED a reality, especially for cancers for which there is no standard screening process. (medscape.com)
  • According to the authors, "in cases in which the MCED test detects a cancer signal in this context, the probability of a diagnosis of cancer being made is considerably higher and may identify cancers at sites other than those suspected during the initial referral phase, thus reducing delays in diagnosis. (medscape.com)
  • RNA splicing is a major nexus of gene expression regulation, shaping cellular identity during development, frequently altered in human cancers. (lu.se)
  • Epigenetics assesses how environmental and other factors alter the expressions of genes. (cdc.gov)
  • The expression of photosynthesis and chlorophyll synthesis related genes were significantly reduced under both types of stresses, which limit the metabolic processes and thus help prolong survival under extreme conditions. (frontiersin.org)
  • Authors of the study, published Sept. 22 in Science , believe it's the first to offer a roadmap to understanding how STR changes can impact gene expression. (stanford.edu)
  • The important genes and related signaling pathways were further verified by qRTâ PCR, immunohistochemistry, immunofluorescence and Western blot in myopia in FDM guinea pigs, FDM mice, and highly myopic adults. (bvsalud.org)
  • Ruderfer DM, Roberts DC, Schreiber SL, Perlstein EO, Kruglyak L. Using expression and genotype to predict drug response in yeast. (broadinstitute.org)
  • When Gm SubPep is supplied to soybean cultures, it was found to induce the expression of defense genes. (isaaa.org)
  • The gene ATP2C1 encodes the human secretory pathway Ca ++ -ATPase hSPCA1, which is dysfunctional and causes abnormal calcium release from the Golgi apparatus and endoplasmic reticulum. (medscape.com)
  • Zhang, Z.-F. (2004) Constructing and predicting gene regulatory network using micro-array data. (scirp.org)
  • These data provide the first insight into the three- dimensional (3D) structure of the CFTR locus and confirm the contribution of intronic cis-acting elements to the regulation of CFTR gene expression. (duke.edu)
  • We discovered that this is needed to make up a unique id for all entries that we want to track in array design features and raw data. (lu.se)
  • These data define a regulatory mechanism for the difference in amounts of VP6 and NSP1 and provide evidence for post-transcriptional control of rotavirus gene expression mediated by the translational efficiency of individual viral mRNAs. (microbiologyresearch.org)
  • Our data substantiates the Gimap5 frameshift mutation as the primary defect with only limited contributions to lymphopenia from the remaining Gimap genes. (hindawi.com)
  • RNA sequencing data revealed a high expression of CHL1 in pancreatic islets. (lu.se)
  • It then goes on to extrapolate from these mechanisms to possible developmental decisions made in eukaryotic cells. (the-scientist.com)
  • Cancer cells are especially dependent on this form of sanitation, which may make them vulnerable to treatments that remove it. (mskcc.org)
  • The glycation damage builds up over time and can change the cells' function and fate. (mskcc.org)
  • Cells can chemically modify their histones to control which genes are turned on or off. (mskcc.org)
  • The cystic fibrosis transmembrane conductance regulator gene (CFTR) is expressed primarily in epithelial cells. (duke.edu)
  • For example, cerebellar granule cells express six subunit genes abundantly (α 1 , α 6 , β 2 , β 3 , γ 2 , and δ), and so they probably have several distinct GABA A receptor subtypes of unknown subunit stoichiometry. (jneurosci.org)
  • The anti-SARS-CoV-2 BNT162b2 vaccine suppresses mithramycin-induced erythroid differentiation and expression of embryo-foetal globin genes in human erythroleukemia K562 cells, bioRvix. (davidicke.com)
  • What makes blood stem cells transform? (lu.se)
  • To make a better understanding of stochastic dynamics, I will show how large deviation theory can be used to compute optimal escape paths from the neighbourhood of the steady state, and will discuss clinical implications of results. (surrey.ac.uk)
  • Finally, we observed a significantly higher gene correlation shared between genes in disease networks associated with similar complex or Mendelian disorders. (discovermagazine.com)
  • Celsius, the largest co-normalized microarray dataset of Affymetrix based gene expression, was used to calculate the correlation between all possible gene pairs on all platforms, and generate stored indexes in a web searchable format. (discovermagazine.com)
  • In order to effectively adapt to an environment, organisms need to be able to analyze both their internal state and external surroundings to make behavioral decisions that will maximize their chances of survival. (elifesciences.org)
  • Coexpressed genes tend to be involved in similar biological processes. (mdpi.com)
  • Our study provides interesting and important evidence that some of the behavior differences could be led by gene expression," said LSU Department of Biological Sciences Assistant Professor Christine Lattin, who is the lead author on the paper published by PLOS ONE today. (neurosciencenews.com)
  • chrischen1/GNET2 documentation built on June 29, 2022, 8:53 a.m. (rdrr.io)
  • The neurobiological gene receptors we've identified could help other scientists develop drugs to target neophobia or anxiety even in our own species," Lattin said. (neurosciencenews.com)
  • Clarification was requested on the implications of the regulatory requirements for the licensing of new medicines in the United States of America, which make an exception for diseases such as smallpox, where clinical trials of such drugs in human volunteers are not possible, and allow approval on the basis of the results of animal studies only. (who.int)
  • Positional cloning of the lyp gene revealed a frame shift mutation in Gimap5 (previously known as Ian5 or Ian4L1 ). (hindawi.com)
  • Nucleus-specific expression in the multinuclear mushroom-forming fungus reveals different nuclear regulatory programs. (broadinstitute.org)
  • The specific expression and distribution of the different BM components in the islets were yet to be fully characterized. (nature.com)
  • Among the tests currently under development making use of this specific characteristic is the Galleri test, which is the most advanced of them all. (medscape.com)