Create embryonic cells. Medical search. Frequent questions

For the first time researchers can now compare iPSC differentiation to the same process an egg goes through after the transfer of a somatic cell genome. (the-scientist.com)
This could help researchers identify abnormalities in iPSC differentiation, correct them, and develop pluripotent stem cells that don't harbor tumorigenic qualities and do not require the use of human embryos. (the-scientist.com)
Is the Subject Area "Cell differentiation" applicable to this article? (plos.org)
The ability to perform lineage tracing at the single-cell level is critical to reconstructing dynamic transitions during cell differentiation. (biorxiv.org)
Mammalian SWI/SNF [also called Brg/Brahma-associated factors (BAFs)] are evolutionarily conserved chromatin-remodeling complexes regulating gene transcription programs during development and stem cell differentiation. (ox.ac.uk)
Furthermore, differentiation of trophoblast stem cells in the presence of PFI-3 was markedly enhanced. (ox.ac.uk)
The data present a key function of BAF bromodomains in stem cell maintenance and differentiation, introducing a novel versatile chemical probe for studies on acetylation-dependent cellular processes controlled by BAF remodeling complexes. (ox.ac.uk)
The exact process of differentiation is not yet understood and although embryonic stem cells can, in principle, provide for all human tissue, scientists are some way from controlling the process. (spiked-online.com)
During preimplantation stages, differentiation occurs between precursors of embryonic and extraembryonic structures. (medscape.com)
In addition to regulating each other through feedback loops, these genes also regulate downstream target genes involved in the maintenance and differentiation of embryonic stem cells. (lu.se)
I've also worked with differentiation from embryonic stem cells into interneurons. (lu.se)
To use this knowledge to improve beta cell differentiation protocols. (lu.se)
First, we utilized single cell sequencing to dissect the differentiation of stem cells to midbrain dopaminergic neurons. (lu.se)
At these sites, which are a compound of stromal cells, extracellular matrix and soluble factors, complex molecular interactions that maintain the essential properties of stem cells occur, such as self-renewal and differentiation into multiple lineages, according to the organism's needs. (bvsalud.org)

Currently, embryos left over from infertility treatments are the only source of human embryonic stem cells. (sciencedaily.com)
But it also plays a much more mundane role in regular cell development, and the formation of blood cells and the cells that form the spinal cord in later-stage embryos. (sciencedaily.com)
In contrast, currently existing hESC lines were derived from leftover embryos created for. (the-scientist.com)
A couple of studies show some success in generating early microscopic embryos, but this [study] is the first successful pluripotent stem cell line," said Daley. (the-scientist.com)
Scientists announced this week that they have successfully produced embryonic stem cells by transferring the DNA of human skin cells into unfertilized human eggs to produce embryos, a technique the Church considers to be an abuse of human life. (womenofgrace.com)
But the embryonic fantasy will continue to be fermented of exclusive miracles just around the corner, for as long as biotech companies need to ensure access to human embryos for more practical research. (catholicleader.com.au)
Human embryos reach the blastocyst stage 4-5 days post fertilization, at which time they consist of 50-150 cells. (wikipedia.org)
Isolating the inner cell mass (embryoblast) using immunosurgery results in destruction of the blastocyst, a process which raises ethical issues, including whether or not embryos at the pre-implantation stage have the same moral considerations as embryos in the post-implantation stage of development. (wikipedia.org)
Embryonic stem cells (ESCs), derived from the blastocyst stage of early mammalian embryos, are distinguished by their ability to differentiate into any embryonic cell type and by their ability to self-renew. (wikipedia.org)
According to Kime, "perhaps our most important finding was that natural molecules found in the early mouse embryo can reprogram cultured cells to become surprisingly similar in function to early embryos. (sciencedaily.com)
When they examined small clusters of cells a few days before they matured into the blastocyst-like structures, they found that the cells contained gene expression for totipotency that are found in two-cell embryos. (sciencedaily.com)
Cells within the precursors resembled embryos at an earlier stage before compaction, which was good evidence that the precursor clusters might include totipotent cells. (sciencedaily.com)
The implanted structures often grew and produced many types of cells that resembled those naturally found in early developing embryos. (sciencedaily.com)
That survey, conducted by the Council on American-Islamic Relations (CAIR) shows that 37 percent said they opposed the use of stem cells from human embryos in medical research while 35 percent supported its use and 29 percent had no opinion. (lifesitenews.com)
By not using actual embryos, scientists at two Oregon-based institutions sidestepped one of the largest issues surrounding stem cell technology. (bigthink.com)
Stem cell therapies have long been seen as a holy grail treatment for many common diseases including multiple sclerosis and Parkinson's disease, yet many have questioned the ethics of using developing human embryos for this purpose. (bigthink.com)
The issue of research involving stem cells derived from human embryos is increasingly the subject of a national debate and dinner table discussions," said President George W. Bush in a 2001 speech announcing his policy on embryonic stem cell research. (erlc.com)
Where do the embryos for embryonic stem cells come from? (erlc.com)
Oftentimes during the process, more embryos are created than are implanted into a woman's womb. (erlc.com)
Currently, all human embryonic stem cell lines in use today were created from embryos generated by IVF. (erlc.com)
T6080The Stable Bcl-x Knockout Mouse Embryonic Fibroblast Cell Line was generated from embryos of a pregnant mouse heterozygous for. (topsan.org)
Interest in using stem cells from cloned human embryos has revived after success by scientists in the United States and Korea. (bioedge.org)
Nature adds that rogue scientists might implant cloned embryos into wombs to create cloned children, a possibility which is widely condemned. (bioedge.org)
Single-cell RNA sequencing revealed that the different types of cells found within the structures had similar gene expression patterns to cells found in natural blastocysts or post-implantation embryos. (eurekalert.org)
A gene for a green fluorescent protein was inserted into the genomes of stem cells, which were then injected into macaque embryos grown for around four days in vitro. (planer.com)
Scientists from the Milner Centre for Evolution have uncovered a new quality control system that removes damaged cells from early developing embryos. (bath.ac.uk)
The team of scientists analysed previously published data on gene activity of each individual cell from 5-day old embryos and discovered around a quarter of the cells didn't fit the profile of any of the known cell types (pre-embryo, pre-placenta etc). (bath.ac.uk)
Staining of embryos by project collaborators in Spain confirmed the existence of the cells with proteins derived from the jumping genes. (bath.ac.uk)
What we are seeing within embryos also looks like survival of the fittest but this time between almost identical cells. (bath.ac.uk)
Embryonic stem cells are derived from early embryos and have the ability to differentiate into any cell type. (spiked-online.com)
Michigan would join 47 other states in permitting research on human embryos and the creation of new embryonic stem cell lines in Michigan if Proposal 2008-02 is adopted by the voters on November 4. (crcmich.org)
It prohibits non-therapeutic research that jeopardizes the life or health of a human embryo, fetus, or neonate, thereby precluding research on embryos to derive human embryonic stem cell lines. (crcmich.org)

MLL1 plays a key role in the uncontrolled explosion of white blood cells that's the hallmark of leukemia, which is why U-M researchers originally developed MM-401 to interfere with it. (sciencedaily.com)
Researchers have developed a new technique for creating human embryonic stem cells by fusing adult somatic cells with embryonic stem cells. (news-medical.net)
In theory, researchers can induce embryonic stem cells to mature into a variety of specialized cells. (news-medical.net)
For that reason, many researchers believe stem cells offer promise for creating populations of specialized cells that can be used to rejuvenate organs, such as the pancreas or heart, that are damaged by disease or trauma. (news-medical.net)
Stem cells also provide a model system in which researchers can study the causes of genetic disease and the basis of embryonic development. (news-medical.net)
Eggan, Melton and their colleagues decided to pursue their alternative route after other researchers had shown that genetic reprogramming can occur when mouse somatic cells are fused to mouse embryonic stem cells. (news-medical.net)
In the studies published in Science, the researchers combined human fibroblast cells with human embryonic stem cells in the presence of a detergent-like substance that caused the two cell types to fuse. (news-medical.net)
The researchers demonstrated that they had achieved fusion of the two cell types by searching the fused cells for two distinctive genetic markers present in the somatic fibroblast and stem cells. (news-medical.net)
The researchers were also able to further confirmed that fusion occurred by studying the chromosomal makeup of the fused cells. (news-medical.net)
The researchers also performed fusion experiments using pelvic bone cells as the somatic cells and a different human embryonic cell line, to demonstrate that their technique was not restricted to one adult cell type or embryonic cell line. (news-medical.net)
Before the technique will ever make it to the clinic, however, researchers must find a way to remove genomic material from the egg cell. (the-scientist.com)
The researchers, based at Tsinghua University, Beijing, China, and Drexel University, Philadelphia, USA, used extrusion-based 3-D printing to produce a grid-like 3-D structure to grow embryoid body that demonstrated cell viability and rapid self-renewal for 7 days while maintaining high pluripotentcy. (phys.org)
The researchers hope that this technique can be developed to produce embryoid body at a high-throughput, providing the basic building blocks for other researchers to perform experiments on tissue regeneration and/or for drug screening studies. (phys.org)
Researchers are currently focusing heavily on the therapeutic potential of embryonic stem cells, with clinical use being the goal for many laboratories. (wikipedia.org)
Researchers have generated 3D blastocyst-like structures from stem cells. (sciencedaily.com)
An international collaboration of researchers from the RIKEN Center for Biosystems Dynamics Research (BDR) in Japan and Gladstone Institutes in the USA have generated 3D blastocyst-like structures from stem cells. (sciencedaily.com)
The Wisconsin Alumni Research Foundation , eager to make human embryonic stem cell lines available "to as many researchers as possible," last month changed and clarified policies that govern how it licenses the cells. (consumerwatchdog.org)
I think that there has been a lot of misunderstanding from the beginning about our efforts to distribute the cells and to make them available to researchers," Andy Cohn, director of government and public relations for the foundation, told BTW this week. (consumerwatchdog.org)
This is an effort by a non-profit foundation to get the cells out to as many researchers as possible," he added. (consumerwatchdog.org)
Second, WARF has enacted policies that will enable "easier and simpler, cost-free cell transfers among researchers," according to the statement. (consumerwatchdog.org)
However, the process is still ethically controversial, as researchers first create a human embryo and then destroy it to create stem cells. (bioedge.org)
A six-person review committee consisting of stem cell researchers, an editor from the journal Nature, and members of the Science editorial boad determined that the editors of Science followed the correct review procedures at the time the papers were published. (lifenews.com)
Researchers used stem cells obtained from the embryonic tissue of cynomolgus monkeys, a type of macaque commonly used in genetics research because of their similarity to humans. (planer.com)
This process, the researchers suggest, looks like a form of quality control: selection between cells in favour of the good ones. (bath.ac.uk)
Researchers hope to use these cells to grow healthy tissue to replace injured or diseased tissues in the human body. (medlineplus.gov)
18 Sep, 2007 12:13 pm Rice University researchers have engineered musculoskeletal cartilages with human embryonic stem cells, with the hope of eventually using the neotissue. (scitizen.com)
6 Jun, 2007 07:00 pm Researchers have reprogrammed skin cells into embryonic stem cells. (scitizen.com)
The move was celebrated by researchers hoping to use such cells for research, but it is likely that the decision will be appealed. (biopharminternational.com)
Some suggest that it is Congress' role to tell researchers what kinds of cells to use. (ontheissues.org)
For the first time, US researchers have cloned embryonic stem cells from adult cells, a breakthrough on the path towards helping doctors treat a host of diseases. (medicalxpress.com)
In experiments reported Wednesday in the journal Nature, researchers used two cutting-edge laboratory techniques-cloning and cell reprogramming-to make fresh tissue that was a perfect genetic match for patients suffering from the disorder. (foxnews.com)
Researchers may, however, conduct research on embryonic stem cell lines created outside of Michigan and may study adult stem cells. (crcmich.org)
Researchers from Lund University in Sweden have published an article in Cell Stem Cell describing the generation of functional dopaminergic neurons from human embryonic stem cells. (medgadget.com)

And, since these cell types are derived from three different parts of the embryo, this really demonstrated the ability of these cells to give rise to a variety of different cell types. (news-medical.net)
The fusion ultimately gives rise to a microscopic embryo, from which embryonic stem cells can theoretically be derived. (the-scientist.com)
In the best case, an early embryo consisting of a few cells may form, but these are not capable of giving rise to human life, nor hESCs for therapeutic purposes. (the-scientist.com)
The resulting clone developed into a microscopic embryo, which survived long enough for pluripotent stem cell lines to be derived. (the-scientist.com)
Scientifically, for serious technical reasons - that of tumour formation and immune rejection - embryo stem cells are highly unlikely ever to be trialled in humans, while adult stem cells are already making dramatic advances in human trials even here in Australia - spinal injury (at Brisbane's Princess Alexandra Hospital), heart disease (Newcastle's John Hunter Institute), and in the months ahead, Parkinson's (Melbourne's Peter McCallum Institute). (catholicleader.com.au)
Embryonic stem cells (ESCs) are pluripotent stem cells derived from the inner cell mass of a blastocyst, an early-stage pre-implantation embryo. (wikipedia.org)
Rapid cell division allows the cells to quickly grow in number, but not size, which is important for early embryo development. (wikipedia.org)
After many more cell divisions, the embryo turns into a blastocyst that is implanted in the womb where it differentiates and grows into a fetus. (sciencedaily.com)
As stem cells within a developing human embryo differentiate within the cell, their capacity to diversify generally becomes more limited and their ability to generate many differentiated cell types also becomes more restricted. (erlc.com)
Embryonic stem cells (ESCs) are stem cells that have been taken from the inner cell mass of a blastocyst, an embryo of about 150 cells that has not yet implanted into a woman's uterus. (erlc.com)
The process of obtaining stem cells leads to the destruction of the embryo from which the cells are taken. (erlc.com)
It creates an embryo only for the purpose of harvesting its cells. (bioedge.org)
The other paper claimed Hwang's team successfully cloned a human embryo to be killed for her stem cells. (lifenews.com)
In a paper published April 6 in the journal Cell Stem Cell , a team of investigators from China report for the first time the creation of embryo-like structures from monkey embryonic stem cells. (eurekalert.org)
This research has created an embryo-like system that can be induced and cultured indefinitely," says co-corresponding author Qiang Sun, also of CAS. (eurekalert.org)
These factors induced the stem cells to form embryo-like structures for the first time using non-human primate cells. (eurekalert.org)
In future work, the investigators plan to focus on further developing the system of culturing embryo-like structures from monkey cells. (eurekalert.org)
Scientists studying gene activity data of the early human embryo have discovered an overlooked type of cell which self-destructs within days of forming, as part of a quality control process to protect the developing foetus. (bath.ac.uk)
Co-lead author Professor Laurence Hurst, from the Milner Centre for Evolution at the University of Bath, said: "If a cell is damaged by the jumping genes - or any other sort of error such as having too few or too many chromosomes - then the embryo is better off removing these cells and not allowing them to become part of the developing baby. (bath.ac.uk)
Conversely, the single-cell data showed that the key cells that will become the embryo (the inner cell mass or ICM) don't contain jumping genes but instead express a virus-like gene called human endogenous virus H. This helps suppress the young jumping genes in the inner cell mass, fitting with an emerging pattern that we use our old genetic enemies to fight our new ones. (bath.ac.uk)
Embryonic stem cells are pluripotent cells derived from embryonic tissue in a process that usually results in the destruction of the embryo. (biopharminternational.com)
Nor is the embryo just a "fertilized egg", or just a "clump of cells", or appear only when the zygote is formed, or appear later after the zygote is formed, or appear after implantation - or even a week after that at 14-days. (lifeissues.net)
2. Nuclear transfer is a technique used to duplicate genetic material by creating an embryo through the transfer and fusion of a diploid cell in an enucleated female oocyte.2 Cloning has a broader meaning than nuclear transfer as it also involves gene replication and natural or induced embryo splitting (see Annex 1). (who.int)
I have been asked to comment on the latest news that scientists are now able to harvest embryonic stem cells without killing the embryo. (christianliferesources.com)
Specifically, two new procedures are being reported in an effort to avoid the ethical offense of killing the embryo when extracting stem cells. (christianliferesources.com)
It involves extracting a cell from an embryo and then stimulating that cell to produce stem cells. (christianliferesources.com)
Ms. Charo was even more pointed in her observation, "Instead, they created a terminally ill embryo. (christianliferesources.com)
As an example, aliquots of trichloroethylene (79016) (TCE) were added directly to embryonic cultures and, after 24 hours, each embryo was graded for ultrastructural abnormalities. (cdc.gov)

In a surprising new finding, scientists have shown that mouse stem cells treated with the drug reverted to an 'embryonic' state. (sciencedaily.com)
It's the first time that scientists have shown they can get stem cells to revert to their original state by erasing specific labels called epigenetic markers. (sciencedaily.com)
SCNT involves transferring the nuclei of adult cells, called somatic cells, into oocytes in which scientists have removed the nuclei. (news-medical.net)
The scientists knew that if their studies were successful, it would provide the research community with a new option for producing reprogrammed cells using embryonic stem cells, which are more plentiful and easier to obtain than unfertilized human eggs. (news-medical.net)
Scientists at Stanford University in California have been able to coax embryonic stem cells into becoming eggs and sperm, which could one day lead to the creation of children through entirely artificial means. (womenofgrace.com)
British scientists are hailing the recent creation of human sperm cells that they believe could revolutionize fertility treatment. (womenofgrace.com)
A recent open letter to all Australian parliaments from nine senior medical scientists tries to counter these fantasies, warning that 'undue expectations have been created in the community, particularly in those with various medical afflictions, as to the imminence and likely scope of embryonic stem cell therapy. (catholicleader.com.au)
For several years, scientists have been able to convert somatic cells--like skin cells--into pluripotent cells. (sciencedaily.com)
Scientists from the Oregon Health & Science University and the Oregon National Primate Research Center figured out that the fragility of human egg cells - into which a nucleus from another human cell, in this case skin, is transferred and begins to produce stem cells - required a different approach. (bigthink.com)
By learning how stem cells differentiate and become specialized, scientists hope to gain a better understanding of how cells in general work and what can go wrong. (erlc.com)
Scientists are unlikely to rush into creating human embryonic stem cell lines. (bioedge.org)
STANDING OUT Scientists used to think that ribosomes, molecular machines that build proteins, are identical and interchangeable. (sciencenews.org)
Scientists have found a way to possibly avoid using embryonic stem. (scitizen.com)
The case began when a lawsuit was brought against the National Institutes of Health (NIH) by Dr. James Sherley and Dr. Theresa Deisher, scientists opposed to embryonic stem cell research. (biopharminternational.com)
The scientists also claimed that funding embryonic stem cell research hurt their ability to receive federal funding for their own research using adult stem cells. (biopharminternational.com)
This is a momentous day-not only for science, but for the hopes of thousands of patients and their families who are relying on NIH-funded scientists to pursue life-saving discoveries and therapies that could come from stem cell research. (biopharminternational.com)
Scientists anticipate that in the future stem cell lines will provide a virtually unending supply of pancreatic cells for diabetic patients, neuronal cells for patients with neural disorders such as Parkinson's or Alzheimer's disease, and a host of heart cells that may treat a variety of cardiac problems. (spiked-online.com)
It might be expected that the richest nation on Earth would encourage its top scientists to pursue this work with vigor rather than limiting funding opportunities, creating legal barriers and fencing off any newly developed cell lines. (spiked-online.com)
Scientists have made significant advances in the quest to treat mitochondrial disease, an incurable genetic malady that afflicts thousands of U.S. children each year. (foxnews.com)
The scientists noticed that one or two of those embryonic-like cell lines had spontaneously lost their mutations. (foxnews.com)
Scientists have now come up with a new technology that involves cancer diagnosis through a simple urine test using a strip of paper, making diagnosis simple and affordable for people. (medicaldaily.com)
Scientists were initially interested in somatic-cell nuclear transfer as a means of determining whether genes remain functional even after most of them have been switched off as the cells in a developing organism assume their specialized functions as blood cells, muscle cells, and so forth. (who.int)

When provided with the appropriate signals, ESCs initially form precursor cells that in subsequently differentiate into the desired cell types. (wikipedia.org)
ESCs divide very frequently due to a shortened G1 phase in their cell cycle. (wikipedia.org)
Retinoblastoma proteins that inhibit the transcription factor E2F until the cell is ready to enter S phase are hyperphosphorylated and inactivated in ESCs, leading to continual expression of proliferation genes. (wikipedia.org)
Despite this difference in the cell cycle when compared to ESCs grown in media containing serum these cells have similar pluripotent characteristics. (wikipedia.org)
and 7,029,913 - are all entitled "Primate embryonic stem cells," and pertain to specific purified preparations of primate ESCs, as well as methods for isolating the cells. (consumerwatchdog.org)
PCGF6-PRC1 bound loci are highly enriched for promoters of germ cell-related genes in mouse embryonic stem cells (ESCs). (ox.ac.uk)
Conditional ablation of Pcgf6 in ESCs leads to robust de-repression of such germ cell-related genes, in turn affecting cell growth and viability. (ox.ac.uk)
These cells have been described as embryonic stem cells (ESCs) and. (scitizen.com)
These progenitors which are derived from either embryonic stem cells (ESCs) or healthy induced pluripotent stem cells (iPSCs) express wild-type levels of a-syn, thus making them equally susceptible to developing Lewy bodies over time. (lu.se)

Our assays showed that the hybrid cells, unlike adult cells, showed the development potential of embryonic stem cells," said Eggan. (news-medical.net)

Adult stem cells are sometimes referred to as somatic stem cells to differentiate them from human germ cells, sperm cells and egg cells. (erlc.com)

The cells are being studied to be used as clinical therapies, models of genetic disorders, and cellular/DNA repair. (wikipedia.org)
Due to their plasticity and potentially unlimited capacity for self-renewal, embryonic stem cell therapies have been proposed for regenerative medicine and tissue replacement after injury or disease. (wikipedia.org)
For example, 3M's Zeta Plus™ products, used to make life-saving plasma therapies, are manufactured in several locations throughout the globe, strategically located where demand for them is highest. (genengnews.com)
Considerable time and effort has been spent in developing targeted therapies to fight SLE, yet only one therapy, belimumab (Benlysta), a monoclonal antibody targeting B cell-activating factor, or BAFF, has been approved for the treatment of SLE in the last half-century 16 . (nature.com)
The data presented in this thesis may serve as valuable resources to help optimize future cell replacement therapies for patients suffering from PD. (lu.se)
Likewise, the knowledge of stem cell biology is crucial to the development of stem cell therapies, based on tissue engineering applied to dentistry, seeking the regeneration of dental tissues damaged or lost by caries, trauma or genetic diseases. (bvsalud.org)
Therapies based on the application of stem cells have great potential in the prevention and treatment of several diseases, such as cancer, diabetes, cardiovascular disease, spinal cord injuries, neurological diseases such as Parkinson's and Alzheimer's, and in the regeneration of various tissues and organs. (bvsalud.org)
However, further studies are required to gain complete understanding of stem cell biology, which is fundamental for the development of successful cell-based therapies 1-3 . (bvsalud.org)

These cells - capable of generating all cell types in the body - could be used as the 'lego bricks' to build tissue constructs, larger structures of tissues, and potentially even micro-organs. (phys.org)
And because of the significant possibility that ESC-derived cells can run amuck, growing out of control or forming improper tissues throughout the body, Geron has already said they will have to monitor the patients for 15 years to assess the danger. (lifenews.com)
Second, stem cells may prove to be an indispensable source of transplantable cells and tissues for repair and regeneration. (erlc.com)
In this study, we have provided strong evidence that naïve monkey pluripotent stem cells possess the capability of differentiating in vivo into all the various tissues composing a monkey body,' co-author Professor Miguel Esteban from the University of Chinese Academy of Sciences, Guangzhou, China told Nature. (planer.com)
This male macaque exhibited organs with a mixture of both sets of cells, including green eyes and fingertips, demonstrating tissues featuring a high proportion of cells derived from the injected stem cells. (planer.com)
Publishing their results in Cell, the authors analysed 26 different tissues, showing that donor cells accounted for 21 to 92 percent of the constituent cells, with an average incidence of 67 percent. (planer.com)
We have a very high level of contribution, with the donor cells forming a big part of the tissues (and) complex structures all over the monkey body. (planer.com)
We modeled the development of embryonic tissues from hPSCs and delineated the ontogeny of hematopoietic cells by mitochondrial variant lineage tracing. (biorxiv.org)
27 Jun, 2007 06:08 pm Stem cells have the potential to become all the cells and tissues in the human body. (scitizen.com)
Blastocytes obtained through nuclear transfers would be used to generate the embryonic stem cells that could be differentiated to specific tissues or organs for transfer to the nuclear donor. (spiked-online.com)
Tissues in which cells select for the defective PORCN gene show anomalies. (medscape.com)
Understanding how stem cells behave in the niche is extremely important in order to extract these cells from their natural habitat, expand them in vitro and transplant the stem cells back to the patient, to repair and/or regenerate tissues and organs, with no risks to the individual's integrity. (bvsalud.org)

We've demonstrated that we don't have to manipulate the pluripotent genes to get to the ground state, but rather that we can block all other options of where the cell 'wants' to go. (sciencedaily.com)
Furthermore, Eggan noted that genetic analyses of the fused cells revealed that the somatic cell genes characteristic of adult cells had all been switched off, while those characteristic of embryonic cells had been switched on. (news-medical.net)
With the exception of a few genes one way or the other -- which is perhaps because these cells are now tetraploid -- the hybrid cells are indistinguishable from human embryonic stem cells," he said. (news-medical.net)
A breakthrough in somatic cell nuclear transfer opens the possibility of producing human embryonic stem cells with a patient's own genes. (the-scientist.com)
While iPSCs avoid the ethical issues surrounding embryonic stem cells, the methods used to derive them sometimes induce mutations in cancer causing genes, making them unsuitable for therapeutic purposes. (the-scientist.com)
They found that many genes related to the outer/inner cell fates of blastocysts were present in the induced structures, but at lower than natural levels, indicating that the new technique does not perfectly reproduce blastocysts. (sciencedaily.com)
A chimeric monkey has been created using embryonic stem cells with two different sets of genes, a new study has demonstrated. (planer.com)
While we try and suppress these jumping genes by any means possible, very early in development they are active in some cells, probably because we cannot get our genetic defences in place fast enough. (bath.ac.uk)
PCGF6 thus links sequence specific target recognition by the MAX/MGA complex to PRC1-dependent transcriptional silencing of germ cell-specific genes in pluripotent stem cells. (ox.ac.uk)
Alternatively, transgenesis and gene targeting techniques can be used to introduce the patient's genes into the stem cell line. (spiked-online.com)
One, using cell reprogramming, was aimed at patients who have only some-say, 30% to 40%-of their mitochondrial genes mutated. (foxnews.com)
A patient's diseased skin cells were first treated with a cocktail of genes, a technique known as cell reprogramming. (foxnews.com)
The fact that the DNA of a fully differentiated (adult) cell could be stimulated to revert to a condition comparable to that of a newly fertilized egg and to repeat the process of embryonic development demonstrates that all the genes in differentiated cells retain their functional capacity, although only a few are active. (who.int)
With a kinetic modeling approach we ascribe function to the observed OCT4-SOX2-NANOG network by making plausible assumptions about the interactions between the transcription factors at the gene promoter binding sites and RNA polymerase (RNAP), at each of the three genes as well as the target genes. (lu.se)

A further test comparing the blastocyst-like structures with their precursors showed that cells in the matured structures were bound close together--a hallmark of blastocyst formation and polarization that is the result of a process called compaction. (sciencedaily.com)
We generated GABAergic interneuron precursors from human embryonic stem cells (hESCs) and grafted them in the hippocampi of rats developing chronic SRSs after kainic acid‐induced status epilepticus. (lu.se)

Genenta Science, which is engaged in the development of hematopoietic stem progenitor cell immuno-gene therapy for cancer, signed a development and manufacturing service agreement with AGC Biologics to manufacture cell therapy lentivirus-based product for Genenta's ongoing clinical programs. (genengnews.com)
Recent studies have isolated distinct cell populations from infantile hemangiomas that display properties equivalent to aberrant progenitor cells, suggesting that, in addition to malignant tumors, benign tumors may also contain a stem cell-like component. (medscape.com)
Although biochemical functions of the human PORCN gene are not well characterized, Wnt signaling may be involved in the phenotypic expression of focal dermal hypoplasia where defective/deficient Wnt signaling could affect cell fate or result in failure of a progenitor cell line to expand. (medscape.com)
The first part of the thesis (Paper I, II, III) shows the development and improvement of a hESC-based system of for virus-mediated direct reprogramming of human glial progenitor cells into both induced dopaminergic neurons (iDANs) and GABAergic interneurons. (lu.se)
Likewise, these cells give rise to progenitor cells committed to a particular cell lineage, and play a crucial role in tissue repair and homeostasis. (bvsalud.org)

In addition to their potential in regenerative medicine, embryonic stem cells provide a possible alternative source of tissue/organs which serves as a possible solution to the donor shortage dilemma. (wikipedia.org)
According to a 2002 article in PNAS, "Human embryonic stem cells have the potential to differentiate into various cell types, and, thus, may be useful as a source of cells for transplantation or tissue engineering. (wikipedia.org)
In tissue engineering, the use of stem cells are known to be of importance. (wikipedia.org)
Cloning describes the processes used to create an exact genetic replica of another cell, tissue or organism. (medlineplus.gov)
8 Jun, 2007 04:13 pm Stem cells provide the starting material for the development and repair of every organ and tissue in the body and they are present in all stages of life. (scitizen.com)
The ban on funding did not apply to stem cells derived from adult tissue. (biopharminternational.com)
Adult tissue-derived mesenchymal stromal cells (MSCs) are showing promise in clinical trials for systemic lupus erythematosus (SLE). (nature.com)
A renewable, tissue culture source of human cells capable of differentiating into a wide variety of cell types would have broad applications in basic research and therapeutic techniques. (spiked-online.com)
Current screening of potential new drugs is done using cell lines derived from animals or 'abnormal' human tissue such as tumor cells. (spiked-online.com)
The resulting tissue will be an almost exact genetic match to the patient and will therefore not face rejection and transplantation can be made much safer without the need for immune suppression. (spiked-online.com)
The neural crest cells give rise to the connective tissue components, including cartilage, bone, and ligaments in the facial and oral regions. (medscape.com)
Transplantations of fetal tissue in the 1980s and 1990s provided proof-of-concept for the potential of cell replacement therapy for PD and some patients benefitted greatly from their transplants. (lu.se)
However, post-mortem analysis of transplanted tissue revealed accumulation of pathological Lewy bodies in a small subset of transplanted cells over time, revealing a host-to-graft disease propagation. (lu.se)
Niches are special microenvironments in tissue where stem cells are located. (bvsalud.org)

All specialized cells arise originally from stem cells, and ultimately form a small number of embryonic cells that appear during the first few days of development. (erlc.com)
The Milan site has been manufacturing lentiviral vectors and drug product for Genenta's ongoing programs since 2016, starting with the initial process development steps. (genengnews.com)
Because monkeys are closely related to humans evolutionarily, we hope the study of these models will deepen our understanding of human embryonic development, including shedding light on some of the causes of early miscarriages. (eurekalert.org)
Further application of monkey blastoids can help to dissect the molecular mechanisms of primate embryonic development. (eurekalert.org)
This work was supported the National Key Research and Development Program of China, Shanghai Municipal Science and Technology Major Project, the Strategic Priority Research Program of the Chinese Academy of Sciences, the Basic Frontier Scientific Research Program of CAS, the Haihe Laboratory of Cell Ecosystem Innovation Fund, Tsinghua-Peking Center for Life Sciences, the Startup Fund, and the Dushi Special Fund at School of Life Sciences, Tsinghua University. (eurekalert.org)
We further applied mitochondrial variant lineage tracing to spatial transcriptomics and identified the clonal development of both erythro-myeloid progenitors and their niche cells. (biorxiv.org)
Our study highlights the power of mitochondrial variants as an endogenous marker for clonal tracking in modeling human development from stem cells. (biorxiv.org)
We also find a role for PCGF6 in pre- and peri-implantation mouse embryonic development. (ox.ac.uk)
This study represents an important step in the development of a commercially scalable and efficacious cell therapy for SLE/LN. (nature.com)
This procedure remains problematic because human life at this stage of the development is exceptionally fragile, and therefore this cell-extraction procedure is extremely dangerous. (christianliferesources.com)
Remarkable progress in science and technology has led to the development of powerful tools for genome sequencing and editing increasing ability to study gene expression and function at multiple levels from cells to populations. (cdc.gov)
The ectoderm is well around the stomodeum by the fourth week of embryonic development and contributes to the formation of the face and the nasal and oral cavities. (medscape.com)
At the early stages of embryonic development, the vertebrate face has a common plan. (medscape.com)
Wnt signaling is critical for normal embryonic development of the skin, bones, and other structures. (medscape.com)
Since Wnt signaling proteins cannot be released without the PORCN protein, and Wnt signaling is important for normal embryonic development, the defects found in this disorder are related to lack of Wnt signaling. (medscape.com)
Wnt proteins are key regulators of embryonic development. (medscape.com)
Here, we detail three protocols modeling different aspects of human paraxial mesoderm development in vitro: a 2D cell monolayer system recapitulating dynamics of the human segmentation clock, a 3D organoid system called "somitoid" supporting the simultaneous formation of somite-like structures, and another organoid system called "segmentoid" reconstituting in vivo-like hallmarks of somitogenesis. (bvsalud.org)
This insight has revolutionised research in ecology and evolution, ranging topics from embryonic development to thermal adaptation and fitness in the wild. (lu.se)
The successful generation of beta cells in vitro and regeneration of pancreatic beta cells in vivo will require a thorough understanding of the pathways that direct the normal development and function of these cells. (lu.se)
Understanding the mechanisms underlying embryonic beta cell development will be a prerequisite for the development of a universally available cell replacement therapy in diabetes. (lu.se)

A new controversy is brewing over government backing of Ebola vaccines that are using aborted fetal cell lines even though vaccines developed from moral alternatives are just as effective. (womenofgrace.com)
Unlike fetal stem cells, which have been previously used to create dopaminergic neurons, embryonic stem cells (from existing stem cell lines) offer an abundant, readily accessible supply of cells. (medgadget.com)

Led by Prof. Malin Parmar, the team differentiated dopaminergic neurons from human embryonic stem cells in culture, then transplanted them into the brains of rats that were modeled to exhibit the symptoms of Parkinson's. (medgadget.com)
Prof. Parmar and colleagues showed that following transplantation, the embryonic stem cell-derived dopaminergic neurons exhibited the functional characteristics of native dopaminergic neurons, including dopamine production as well as long distance extension and connection with target regions in the brain. (medgadget.com)
Using whole‐cell patch‐clamp recordings, we characterised the maturation of the grafted cells into functional GABAergic inter-neurons in the host brain, and we confirmed the presence of functional inhibitory synaptic connections from grafted cells onto the host neurons. (lu.se)
I had this plan of making an orchard of neurons, where they grow as trees in the end, and I wanted something that also symbolize the flow of time as well. (lu.se)
Because of this local degeneration of a relatively small population of dopaminergic neurons in the midbrain, PD has been considered an especially interesting candidate for cell-replacement therapy. (lu.se)
Direct neuronal reprogramming of a somatic cell into therapeutic neurons, without a transient pluripotent state, provides new promise for the large number of individuals afflicted by neurodegenerative diseases or brain injury. (lu.se)
This approach could be potentially applied directly in the brain by targeting resident cells as a source of new neurons. (lu.se)

The fusion causes the adult cells to undergo genetic reprogramming, which results in cells that have the developmental characteristics of human embryonic stem cells. (news-medical.net)
The findings validate this controversial method, and may one day allow therapeutic stem cells to be created from a patient's own genetic material. (the-scientist.com)
The technique provides the first opportunity to make hESCs that carry the same genetic material as the patients. (the-scientist.com)
Noggle said the findings may also pave the way for better induced pluripotent stem cells (iPSCs), which form when somatic cells are regressed to a pluripotent state through the use of genetic factors. (the-scientist.com)
We explored the use of naturally occurring somatic mutations in mitochondrial transcripts detected in single-cell RNA-seq as genetic lineage barcodes in HPSC. (biorxiv.org)
In this study, we used an enrichment of scRNA-seq mitochondrial reads and a robust computational method to identify clonally relevant mitochondrial variants as endogenous genetic barcodes for clonal tracking of early embryonic hematopoiesis from hPSC. (biorxiv.org)
Banking of multiple cell lines with varying genetic spectrum that can be matched to patients is one possibility. (spiked-online.com)
Here, the stem cell line is created using the genetic properties of the prospective recipient via somatic cell nuclear transfer. (spiked-online.com)
if it implants and the pregnancy goes to term, the resulting individual will carry the same nuclear genetic material as the donor of the adult somatic cell. (who.int)
However, an animal created through this technique would not be a precise genetic copy of the source of its nuclear DNA because each clone derives a small amount of its DNA from the mitochondria of the egg (which lie outside the nucleus) rather than from the donor of cell nucleus. (who.int)

Pera is professor of cell and neurobiology at the Keck School of Medicine and Director of the Eli & Edythe Broad CIRM Center for Regenerative Medicine and Stem Cell Research at the University of Southern California. (ca.gov)
If stem cells can be used to produce new and differentiated cells that are damaged because of disease (such as Parkinson's disease) or injury (e.g., spinal cord damage), it would transform regenerative medicine. (erlc.com)

On August 9, 2001, President Bush announced that only embryonic stem cell lines created before that date could be used in federally funded research. (ca.gov)
Martin Pera has a CIRM grant to develop techniques for creating high quality new human embryonic stem cell lines. (ca.gov)
Do Ebola Vaccines Need to Use Embryonic Stem Cell Lines? (womenofgrace.com)
One group from CHA University in Seoul reported in Cell Stem Cell in April that it had managed to use cell nuclei from two men, aged 35 and 75, to create embryonic stem cell lines. (bioedge.org)
There have been many false dawns in the field of embryonic stem cell research, but these results seem to confirm that it is possible to use adult cells to create genetically matched stem cell lines. (bioedge.org)
This new technique could be used to develop stem cell lines without use of controversial. (scitizen.com)
The issue is whether that law's restrictions apply to research conducted on stem cell lines that had been developed without federal funding. (biopharminternational.com)
NIH has interpreted the law narrowly, and argued that creating embryonic stem cells is not the same as using lines created without federal funding for research purposes. (biopharminternational.com)
Voted YES on expanding research to more embryonic stem cell lines. (ontheissues.org)
Exploring the potential of human-derived cell lines and glial cell line-derived neurotrophic factor for network inhibition. (lu.se)
In the skin, these abnormalities follow the embryonic lines of Blaschko. (medscape.com)

Other techniques can reprogram "adult" cells in the human body taken from skin, for example -- but the cells still carry baggage from their previous state. (sciencedaily.com)
It is more likely that the new technique will see immediate use in helping to accelerate understanding of how embryonic cells "reprogram" somatic cells to an embryonic state. (news-medical.net)

The drug specifically targets markers on histones, the protein "spools" that DNA coils around to create structures called chromatin. (sciencedaily.com)
Published in the journal Stem Cell Reports , the study shows that the blastocyst-like structures very closely resemble actual blastocysts, and even induce proper changes in the uterus after being implanted in pseudo-pregnant mice. (sciencedaily.com)
In his original report, Thompson demonstrated that human embryonic stem cells could be coaxed into developing gut-like structures, bone, cartilage and muscle (1). (spiked-online.com)
Mitochondria are tiny structures inside cells that act as batteries, converting carbohydrates and fats into energy. (foxnews.com)

The first pluripotent human embryonic stem cells (hESCs) have been generated from somatic cell nuclear transfer, according to a study published today (October 5) in Nature . (the-scientist.com)
First, WARF created a policy allowing companies without a license to the cells to sponsor research on hESCs at academic or non-profit institutions. (consumerwatchdog.org)

Their analyses showed that the hybrid cells were "tetraploid" - meaning they contained the combined chromosomes of both the somatic cells and the embryonic stem cells. (news-medical.net)

The long term goal for this experiment was to do cell fusion in a way that would allow the elimination of the embryonic stem cell nucleus to create an embryonic stem cell from the somatic cell," said Melton. (news-medical.net)
Somatic cell nuclear transfer typically involves the transfer of genomic information from a somatic cell into an unfertilized egg cell whose nucleus has been removed. (the-scientist.com)
Instead of removing the egg genome prior to nuclear transfer, he and his colleagues added the somatic cell nucleus directly to the intact egg. (the-scientist.com)
The nucleus of an adult somatic cell (such as a skin cell) is removed and transferred to an enucleated egg, which is then stimulated with electric current or chemicals to activate cell division. (who.int)

Mouse embryonic stem cells are known to be tumorigenic - that is, they can grow uncontrollably and become cancerous. (spiked-online.com)

This investment in manufacturing represents a significant step forward based on our expectation that our treatment has the potential to impact the tumor micro-environment and break immune tolerance in solid tumors. (genengnews.com)
The "stem cell theory of cancer" states that a subpopulation of cells with stem cell-like properties plays a central role in the formation, sustainment, spread, and drug resistant characteristics of malignant tumors. (medscape.com)
These findings provide supporting evidence that enrichment for proteins involved in pluripotency is not restricted solely to malignant tumors as is suggested by the "stem cell theory of cancer", but additionally extends to common benign vascular tumors such as hemangiomas. (medscape.com)

The investigators started with macaque embryonic stem cells, which they exposed to a number of growth factors in cell culture. (eurekalert.org)

HEF, human embryonic fibroblasts. (cdc.gov)
One way we did this was by converting adult fibroblasts, or skin cells, into interneurons. (lu.se)

This could allow us to create cells that are useful for transplantation for a variety of diseases without the problem of immunological rejection," said Noggle in a press briefing. (the-scientist.com)
Transplantation of cells releasing γ‐aminobutyric acid (GABA) could be used to counteract the imbalance between ex-citation and inhibition within epileptic neuronal networks. (lu.se)
Therefore, a central goal of diabetes research is to regenerate pancreatic beta cells or produce large numbers of functional beta cells for transplantation into diabetic patients. (lu.se)

Stem cells have two unique characteristics: (1) an almost unlimited capacity for self-renewal (they can theoretically divide without limit to replenish other cells for as long as the person is alive) and (2) they retain the potential to produce differentiated and specialized cell types. (erlc.com)

These ribosomes may not build all kinds of proteins, instead opting to craft only specialty products. (sciencenews.org)
In this fashion, mice or other laboratory animals that exhibit particular traits can be created for specialized studies, or herds of farm animals (such as goats, sheep or cows) can be created that produce pharmaceutically useful proteins in their milk. (who.int)
This gene provides instructions for making a protein that is responsible for modifying other proteins, including Wnt proteins. (medscape.com)
Using multimodal live-cell imaging, here we first show that multiple endogenous and synthetic lipid-anchored proteins, despite maintaining stable tight association with the inner leaflet of the plasma membrane, were unexpectedly depleted from the membrane domains where the signaling network was spontaneously activated such as in the new protrusions as well as within the propagating ventral waves. (bvsalud.org)

The U.S. Food and Drug Administration (FDA) has approved the world's first human clinical trial of a therapy involving embryonic stem cells, a move that has been condemned by the Vatican as "unacceptable. (womenofgrace.com)
That's the mantra of Dr. Larry Goldstein, director of the Sanford Stem Cell Clinical Center at University of California, San Diego, who always cautions that selling hope with false promises is big business among stem cell clinics. (nationalrighttolifenews.org)
Based on results from Phase I of the ongoing Phase I/II clinical trial, we are scaling up the manufacturing process to be ready for Phase II of the trial," said Pierluigi Paracchi, CEO of Genenta. (genengnews.com)
However, the inability to manufacture large quantities of functional cells from a single donor as well as donor-dependent variability in quality limits their clinical utility. (nature.com)
There are major obstacles to overcome before a stem cell line is liable to reach clinical trials. (spiked-online.com)
Help us make reference on Medscape the best clinical resource possible. (medscape.com)
Today, clinical trials using stem cell-derived dopaminergic progenitors have commenced. (lu.se)
Next, in order to study the potential of autologous cell replacement therapy we transplanted progenitors derived from a PD patient into a pre-clinical rat model. (lu.se)

The Food and Drug Administration (FDA) is delaying a bid by biotech company Geron Corp. to become the first to conduct human trials with embryonic stem cells, pending review of new studies. (womenofgrace.com)
As of this writing, there were 2,002 adult stem cell trials in patients listed. (lifenews.com)

Novavax to Use Vivalis' Duck Embryonic Stem Cell Line for Vaccine. (genengnews.com)

He's bullish on the therapeutic potential of stem cells, but consistently urges skepticism. (nationalrighttolifenews.org)

Pluripotency factors Oct4 and Nanog play a role in transcriptionally regulating the embryonic stem cell cycle. (wikipedia.org)
Recent ChIP experiments of human and mouse embryonic stem cells have elucidated the architecture of the transcriptional regulatory circuitry responsible for cell determination, which involves the transcription factors OCT4, SOX2 and NANOG. (lu.se)

Self-renewal conditions must prevent the cells from clumping and maintain an environment that supports an unspecialized state. (wikipedia.org)

Funding for stem cell research in two of the most liberal states in the nation - California and Maryland - appears to be shifting away from embryonic to adult stem cells. (womenofgrace.com)
WASHINGTON, Aug 24, 2001 (LSN.ca) - A survey of American Muslim opinion released yesterday shows a slight majority of Muslims are against embryonic stem cell research and a vast majority against human cloning. (lifesitenews.com)
The danger has made even some proponents of embryonic stem cell research concerned about the risky nature of Geron s human experiment , instead of making a political point . (lifenews.com)
Receive a free daily email report from LifeNews.com with the latest pro-life news stories on abortion, euthanasia and stem cell research. (lifenews.com)
Although the method discovered by the Oregon team can be considered a type of cloning, team leader Shoukhrat Mitalipov says, " Our research is directed toward generating stem cells for use in future treatments to combat disease…[We do not] believe our findings might be used by others to advance the possibility of human reproductive cloning. (bigthink.com)
The changes, which include new guidelines for company-sponsored academic research and lab-to-lab transfer of cells, have thus far been welcomed by the hESC research community. (consumerwatchdog.org)
The latter clarification coincided with an announcement by CIRM , a non-profit research institute established in early 2005, that it had approved 72 stem cell-related research grants totaling $45 million over two years to 20 academic and non-profit research centers in California. (consumerwatchdog.org)
In fact, the FTCR, along with New York-based watchdog group Public Patent Foundation and Burnham Institute for Medical Research stem cell scientist Jeanne Loring , believe that the patents shouldn't even exist, and have publicly stated that WARF should abandon its claims to them. (consumerwatchdog.org)
Though not intended to be an exhaustive explanation of this important topic, we believe this will help to clarify and explain the questions most frequently asked about embryonic stem cell research. (erlc.com)
Why are stem cells so important to research? (erlc.com)
There are two main reasons stem cells are of interest to both scientific and medical research. (erlc.com)
And this week, the New York Stem Cell Foundation Research Institute announced in Nature that it had created a line of cells from a woman with Type 1 diabetes. (bioedge.org)
The papers made fantastic claims about embryonic stem cell research studies that turned out to be false. (lifenews.com)
In handling fraudulent stem-cell research articles, journal editors went above and beyond existing procedures to try and verify the findings, but in today's competitive publishing environment, more stringent, less trusting safeguards are now essential,' the committe said, according to a Science statement LifeNews.com obtained. (lifenews.com)
Cell Stem Cell ( @CellStemCell ), published by Cell Press, is a monthly journal that publishes research reports describing novel results of unusual significance in all areas of stem cell research. (eurekalert.org)
Each issue also contains a wide variety of review and analysis articles covering topics relevant to stem cell research ranging from basic biological advances to ethical, policy, and funding issues. (eurekalert.org)
PHILADELPHIA - Protein-manufacturing factories within cells are picky about which widgets they construct, new research suggests. (sciencenews.org)
8 Feb, 2008 06:09 pm Six years ago, biomedical engineer Michael King was exploring the strange rolling motion of white blood cells when his research took a radical turn. (scitizen.com)
27 Nov, 2007 10:41 am Tony Maciulis talks with Dr. Jon LaPook about a breakthrough in stem cell research. (scitizen.com)
21 Nov, 2007 10:54 am A huge advancement in stem cell research--and a stake in the heart of human cloning--was announced yesterday. (scitizen.com)
6 Sep, 2007 12:57 pm British authorities decided yesterday to permit research that uses animal eggs to create human stem cells because of the limited supply of human eggs. (scitizen.com)
25 Jun, 2007 04:43 pm On June 7, the House of Representatives voted 247-176 to pass a bill (S 5) that would allow federal funding for research using stem cells derived from. (scitizen.com)
29, 2011, a federal appeals court has lifted a ban on federal funding for embryonic stem cell (ESC) research. (biopharminternational.com)
In August 2010, a district court agreed with the plaintiffs that embryonic stem cell research violated federal law and blocked funding, but a three-judge appeals court temporarily lifted the ban in September. (biopharminternational.com)
Instead, we should foster all of these methods, and we should adequately fund and have ethical oversight over all ethical stem cell research. (ontheissues.org)
Amniotic fluid stem cells are now available to open a broad new area of research. (ontheissues.org)
5. In 2001, France and Germany requested the United Nations General Assembly to develop international conventions on human reproductive cloning, therapeutic cloning and research on stem cells. (who.int)
Alternatively, research using eggs may point the way to methods which mimic their properties using other human cells and chemical agents. (spiked-online.com)
I would also add that it is important we do not lose sight of the fact that while in theory embryonic stem cell research holds promise for some hope in treating maladies, nothing has been proven. (christianliferesources.com)
To make genomics benefit the health of populations, equitable representation is needed in genomic research. (cdc.gov)
Your charitable donation allows us to continue providing the high-quality public policy research you turn to when making decisions. (crcmich.org)
Take the issues of cloning and embryonic stem cell research. (breakpoint.org)
Somatic-cell nuclear transfer, the technique by which Dolly was created, was first used 40 years ago in research with tadpoles and frogs. (who.int)
Andreas' research focuses on generating brain cells, specifically interneurons, in the lab, which has significant implications for the study of neurodegenerative and neuropsychiatric disorders. (lu.se)
Combining cell biology and electrophysiology, his work has the potential to create personalized disease models for future research. (lu.se)

In its usual style, Geron has put out a press release that it has injected the first patient for its trial of embryonic stem cells for spinal cord injury. (lifenews.com)
Contrary to what most of the news stories report, Geron is not injecting growing embryonic stem cells into a patient. (lifenews.com)
It will be difficult to determine whether Geron s injected cells had any real effect. (lifenews.com)
Of note is that now, a year and a half after approval, Geron has finally listed their experiment, the only approved embryonic stem cell trial, at ClinicalTrials.gov. (lifenews.com)
Dr Thomas Okarma, who heads up the Geron Corporation, claims to have heart cells that 'beat' in laboratory dishes developed from stem cells (2). (spiked-online.com)

theoretically the cells will grow, migrate and specialize around the spinal cord, creating a sheath around nerves and also perhaps secreting nerve growth factors to enhance nerve survival. (lifenews.com)

One of the key findings from the study was that the fusion cells have the characteristics of human embryonic stem cells. (news-medical.net)

Her rapporterer vi en rekombinationsmedieret kassette udveksling (RMCE) -baseret struktur-funktion tilgang i KO embryonale stamceller, som giver mulighed for den molekylære dissektion af forskellige funktionelle domæner eller varianter af et protein. (jove.com)
We report a potent and cell active protein interaction inhibitor, PFI-3, that selectively binds to essential BAF bromodomains. (ox.ac.uk)

Now, they're working to see if the MM-401 eraser technique works with human stem cells that bear some resemblance to mouse epiblast stem cells. (sciencedaily.com)
This approach could become an alternative to somatic cell nuclear transfer (SCNT), a method that is currently used to produce human stem cells. (news-medical.net)
It is likely that human stem cells will have similar properties. (spiked-online.com)

So, while this does not obviate the need for human oocytes, it demonstrates that this general approach of cell fusion is an interesting one that should be further explored. (news-medical.net)
The recent findings of the pluripotent epithelial cells demonstrates how quickly the world has changed. (ontheissues.org)

We show that exposure of embryonic stem cells to PFI-3 led to deprivation of stemness and deregulated lineage specification. (ox.ac.uk)
The myogenic cells of the muscles constitute a separate cell lineage. (medscape.com)

It Was Good: Making Art to the Glory of God (Square Halo Books, 2000) by Ed Bustard (editor) and others, and Imagine: A Vision for Christians in the Arts (InterVarsity, 2001) by Steve Turner. (breakpoint.org)

The result is functional mosaicism of cells. (medscape.com)
Unlike mammals, birds have nucleated red blood cells that retain almost all functional organelles in the mature state. (lu.se)

Pluripotent stem cells have shown promise in treating a number of varying conditions, including but not limited to: spinal cord injuries, age related macular degeneration, diabetes, neurodegenerative disorders (such as Parkinson's disease), AIDS, etc. (wikipedia.org)
Adult Stem Cells have already shown published scientific evidence documenting effective treatment for spinal cord injury. (lifenews.com)
Laura Dominguez is one of the spinal cord injury patients who has benefited from adult stem cells. (lifenews.com)
This video illustrates Geron's, a California based cell therapy company, embryonic stem cell therapy for spinal cord injury in rats. (technologyreview.com)

To understand the molecular and cellular mechanisms that control beta cell maturation and function in the embryonic and adult pancreas. (lu.se)

Sperm donation creates a web of exceedingly complex relationships. (bioedge.org)

Anatomy50

Organisms29

Diseases6

Chemicals and Drugs61

Analytical, Diagnostic and Therapeutic Techniques and Equipment35

Phenomena and Processes78

Disciplines and Occupations2

Technology, Industry, Agriculture1

Information Science4

Health Care1

Differentiation14

Embryos32

Researchers33

Embryo28

Scientists22

ESCs9

Potential of embryonic stem1

Germ cells1

Therapies8

Tissues12

Genes14

Precursors2

Progenitor5

Tissue14

Development20

Fetal2

Neurons7

Genetic10

Regenerative2

Lines11

Reprogram2

Structures4

HESCs2

Somatic cells1

Nucleus4

Stem cells are known1

Tumors3

Macaque1

Fibroblasts2

Transplantation3

Capacity for self-renewal1

Proteins4

Clinical8

Trials2

Vaccine1

Therapeutic potential1

Oct42

Self-renewal1

Research35

Geron5

Theoretically1

Characteristics1

Protein2

Human stem cells3

Demonstrates2

Lineage2

20011

Functional2

Spinal4

Maturation1

Sperm1