• The cranial nerve nuclei are a series of bilateral grey matter motor and sensory nuclei located in the midbrain , pons and medulla that are the collections of afferent and efferent cell bodies for many of the cranial nerves . (radiopaedia.org)
  • The solitary nucleus (also called nucleus of the solitary tract , nucleus solitarius, or nucleus tractus solitarii (SN or NTS) ) [1] [2] is a series of sensory nuclei (clusters of nerve cell bodies) forming a vertical column of grey matter in the medulla oblongata of the brainstem. (wikipedia.org)
  • The nucleus solitarius is a series of purely sensory nuclei forming a vertical column of grey matter embedded within the medulla oblongata . (wikipedia.org)
  • Cranial nerves 9, 10, and 11 originate from the Medulla. (proprofs.com)
  • In most pontine and cranial nerve nuclei and in the medulla, only subunit alpha1-, beta2- and gamma2-immunoreactivities were strong, whereas the inferior olive was significantly labeled only for subunits beta1, gamma1 and gamma2. (nih.gov)
  • The olives are swellings in the medulla containing underlying inferior olivary nuclei (containing various nuclei and afferent fibers). (wikidoc.org)
  • The sensory nuclei are arranged in a column which spans from the midbrain through the pons and medulla and into the upper cervical cord. (pacs.de)
  • Abducens nerve emerges from the brain stem in the posterior cranial fossa from a groove at the junction of the pons and medulla oblongata medial to the facial nerve exit. (brainmadesimple.com)
  • The nerve arises from the hypoglossal nucleus in the medulla as a number of small rootlets, passes through the hypoglossal canal and down through the neck, and eventually passes up again over the tongue muscles it supplies into the tongue. (iiab.me)
  • The hypoglossal nerve arises as a number of small rootlets from the front of the medulla , the bottom part of the brainstem , [1] [2] in the anterolateral sulcus which separates the olive and the pyramid . (iiab.me)
  • The hypoglossal nerve emerges as several rootlets (labelled here as number 12) from the olives of the medulla (labelled 13), part of the brainstem . (iiab.me)
  • Just lateral to this are the autonomic (or visceral) efferent nuclei. (wikipedia.org)
  • There is a separation, called the sulcus limitans, and lateral to this are the sensory nuclei. (wikipedia.org)
  • More lateral, but also less posterior, are the general somatic afferent nuclei. (wikipedia.org)
  • Alternatively, the term Edinger-Westphal nucleus is often used to refer to the adjacent population of non-preganglionic neurons that do not project to the ciliary ganglion, but rather project to the spinal cord, dorsal raphe nucleus, lateral septal nuclei, lateral hypothalamic area and the central nucleus of the amygdala, among other regions. (wikipedia.org)
  • Both of the superior colliculi are linked to a respective lateral geniculate nucleus. (databasefootball.com)
  • In most cases, the abducens nucleus and nerve are absent or hypoplastic, and the lateral rectus muscle is innervated by a branch of the oculomotor nerve. (bionity.com)
  • In both cases the sixth cranial nerve nucleus was absent, as was the sixth nerve, and the lateral rectus muscle was innervated by the inferior division of the third or oculomotor cranial nerve. (bionity.com)
  • Amyotrophic lateral sclerosis and other motor neuron diseases are characterized by steady, relentless, progressive degeneration of corticospinal tracts, anterior horn cells, bulbar motor nuclei, or a combination. (msdmanuals.com)
  • Lateral (and dorsal) to the olives are the rootlets for cranial nerves IX and X ( glossopharyngeal and vagus , respectively). (wikidoc.org)
  • Between the basal pons, cranial nerve 6, 7 and 8 emerge (medial to lateral). (wikidoc.org)
  • Courses anteriorly in the lateral wall of the cavernous sinus inferior to the trochlear nerve and is crossed medially by the oculomotor nerve . (pacs.de)
  • Motor nuclei for CNs innervating branchial muscle are more lateral (CN 5 [motor for muscles of mastication], CN 7, CN 9, CN 10). (mhmedical.com)
  • Somatic sensory and special sensory cranial nerve nuclei are most lateral (CNs 5 and 8). (mhmedical.com)
  • All the extraocular muscles are innervated by the oculomotor nerve (CN III) except the superior oblique and lateral rectus muscles, which are innervated by the trochlear nerve (CN IV) and abducent nerve (CN VI), respectively. (brainmadesimple.com)
  • [4] The hypoglossal nerve moves forward lateral to the hyoglossus and medial to the stylohyoid muscles and lingual nerve . (iiab.me)
  • All the nuclei except that of the trochlear nerve (CN IV) supply nerves of the same side of the body. (wikipedia.org)
  • Cranial nerves IV (trochlear nerve) and III (oculomotor nerve) originate from the midbrain. (proprofs.com)
  • The trochlear nerve controls the superior oblique muscle, which helps with eye movement, while the oculomotor nerve controls several eye muscles responsible for eye movement, pupil constriction, and focusing. (proprofs.com)
  • Near the superior colliculi are the inferior colliculi, which are responsible for the processing of auditory information and are found just above the trochlear nerve. (databasefootball.com)
  • Similarly, the tectum is also near the point of emergence for the trochlear nerve. (databasefootball.com)
  • Laterally, the trochlear nerve has emerged after emerging out of the dorsal rostral pons and wrapping around to the anterior. (wikidoc.org)
  • The trochlear nerve is a pure motor nerve having no sensory component. (brainmadesimple.com)
  • This fasciculus connects the abducent nerve nucleus with the nuclei of the oculomotor nerve (CN III), trochlear nerve (CN IV), and vestibulocochlear nerve (CN VIII). (brainmadesimple.com)
  • Extensive interconnections exist between many of these nuclei, as well as with other brainstem nuclei and white matter tracts, such as the medial lemniscus and medial longitudinal fasciculus . (radiopaedia.org)
  • Pyriform neurons project to the nucleus of the medial longitudinal fasciculus (nMLF) and cranial nerve nuclei III and IV, while commissural neurons project to the contralateral nBOR. (umass.edu)
  • Cranial nerve V, also known as the trigeminal nerve, originates from the pons, which is a part of the brainstem. (proprofs.com)
  • The basilar pons and the pontine tegmentum contain nuclei and tracts. (dipg.org)
  • The basilar pons contains a complex combination of tracts (bundles of axons) and nuclei (collections of cell bodies of neurons). (dipg.org)
  • At the rostral pons, the occulomotor nerve emerges at the midline. (wikidoc.org)
  • The motor nucleus is located in the upper pons and gives off the smaller motor root which bypasses the trigeminal ganglion and innervates the muscles of mastication as well as mylohyoid , the anterior belly of digastric , tensor tympani and tensor palatini . (pacs.de)
  • The trigeminal nerve exits at the mid pons anteriorly, courses through the prepontine cistern (cisternal portion), and crosses the porus trigeminus to enter a prolongation of dura at the apex of the petrous temporal bone known as the Meckel cave (cavernous portion) where its fibers form the trigeminal ganglion, which is also known as the Gasserian or semilunar ganglion. (pacs.de)
  • A somatic motor nerve originating in the abducens nucleus in the pons. (unboundmedicine.com)
  • There is only one nucleus for each of the abducent nerves that is present in the upper pons (seen in the cut section of upper pons) at the level of facial colliculi. (brainmadesimple.com)
  • Axons carrying information to and from the cranial nerves form a synapse first at these nuclei. (wikipedia.org)
  • The afferent arm of the response consists of the retina, optic nerve axons, and the optic tract and radiations. (vin.com)
  • Lower MNDs affect the anterior horn cells or cranial nerve motor nuclei or their efferent axons to the skeletal muscles. (msdmanuals.com)
  • Instead, they have facial nerve axons traversing superficial to underlying abducens (CN VI) nuclei. (wikidoc.org)
  • The cranial nerve nuclei are the collections of cell bodies whose axons give rise to the cranial nerves . (mhmedical.com)
  • The neuronal cell bodies of a nerve's axons are in the brain, the spinal cord, or ganglia, but the nerves run only in the peripheral nervous system. (unboundmedicine.com)
  • Nerves with axons that conduct electrochemical impulses toward the central nervous system (CNS) are afferent, nerves with axons that conduct impulses away from the CNS are efferent, and nerves with both afferent and efferent axons are mixed. (unboundmedicine.com)
  • The components of the eighth cranial nerve (CN VIII) carrying axons that convey information regarding sound and balance between the spiral ganglion in the inner ear and the cochlear nuclei in the brainstem. (unboundmedicine.com)
  • The nuclei of the cranial nerves are the collection of cell bodies of axons forming that cranial nerve. (brainmadesimple.com)
  • Just before exiting the skull it runs along the floor of the middle cranial fossa and gives off the middle meningeal nerve which ascends to supply the anterior dura of the middle cranial fossa. (pacs.de)
  • 24. Base of the skull - middle cranial fossa. (edu.pl)
  • It moves forward in the middle cranial fossa and enters into the cavernous sinus along with the internal carotid artery. (brainmadesimple.com)
  • The Edinger-Westphal nucleus supplies preganglionic parasympathetic fibers to the eye, constricting the pupil, accommodating the lens, and convergence of the eyes. (wikipedia.org)
  • The cochlea consists of nerve fibers and specialized cells designed to detect a plethora of sound frequencies and noise levels. (home-remedies-for-you.com)
  • They also help control certain eye movements and interact with fibers of the optic nerve. (databasefootball.com)
  • The cerebral hemispheres are joined by a thick band of nerve fibers known as the corpus callosum. (suffernomore.com)
  • For example, intramuscular injections of BTX produce local relaxation of treated muscles by inhibiting the release of acetylcholine, a neurotransmitter that is present at the junctions of nerve and muscle cells and that regulates the delivery of messages from neurons to muscle fibers. (suffernomore.com)
  • additionally it receives afferent fibers from the glossopharyngeal nerve and vagus nerve . (pacs.de)
  • Before the cranial nerves exit the brainstem, their fibers are referred to as fascicles . (mhmedical.com)
  • Facial colliculi are actually rounded, bulged structures that are formed by the winding of fibers of the facial nerve around the nuclei of abducent nerves. (brainmadesimple.com)
  • The paired nuclei are posterior to the main motor nucleus (oculomotor nucleus) and anterolateral to the cerebral aqueduct in the rostral midbrain at the level of the superior colliculus. (wikipedia.org)
  • Which Cranial nerve(s) come from the midbrain? (proprofs.com)
  • it was darkest in midbrain and pontine nuclei. (nih.gov)
  • Gustatory (taste) sensation from the facial nerve (CN VII) via the chorda tympani (from anterior 2/3 of the tongue), glossopharyngeal nerve (CN IX) (from posterior 1/3) and vagus nerve (CN X) (from small area on the epiglottis). (wikipedia.org)
  • Chemoreceptors and mechanoreceptors of the general visceral afferent pathway (GVA) from the carotid body and carotid sinus via (the carotid sinus nerve of) the glossopharyngeal nerve (CN IX), and from aortic bodies and sinoatrial node via the vagus nerve (CN X). (wikipedia.org)
  • The auricular branch of the vagus nerve is a sensory nerve emerging from the superior ganglion of the vagus nerve, joined by branches from the glossopharyngeal (CN IX) and facial nerves, and innervating the lower part of the tympanic membrane and the floor of the external auditory canal. (unboundmedicine.com)
  • The Vagus nerve is one exception that provides innervation to structures in the head and neck region as well as in the abdomen and chest cavity. (brainmadesimple.com)
  • The hypoglossal nerve is the twelfth cranial nerve , and innervates all the extrinsic and intrinsic muscles of the tongue , except for the palatoglossus which is innervated by the vagus nerve . (iiab.me)
  • It then travels close to the vagus nerve and spinal division of the accessory nerve , [2] spirals downwards behind the vagus nerve and passes between the internal carotid artery and internal jugular vein lying on the carotid sheath . (iiab.me)
  • After leaving the skull, the hypoglossal nerve spirals around the vagus nerve and then passes behind the deep belly of the digastric muscle . (iiab.me)
  • A cranial nerve nucleus is a collection of neurons (gray matter) in the brain stem that is associated with one or more of the cranial nerves. (wikipedia.org)
  • In general, motor nuclei are closer to the front (ventral), and sensory nuclei and neurons are closer to the back (dorsal). (wikipedia.org)
  • The term "Edinger-Westphal nucleus" also referred to what is now known as the centrally-projecting Edinger-Westphal nucleus, intermingled population of non-preganglionic neurons that do not project to the ciliary ganglion but to various regions throughout the central nervous system. (wikipedia.org)
  • Unlike the classical preganglionic neurons that contain choline acetyltransferase, neurons of the Centrally-projecting Edinger-Westphal nucleus contain various neuropeptide such as urocortin and cocaine- and amphetamine-regulated transcript. (wikipedia.org)
  • Preganglionic oculomotor neurons within the Edinger-Westphal nucleus are to be referred to as the EWpg, and the neuropeptide-containing neurons shall be known as the centrally-projecting Edinger Westphal nucleus, or EWcp. (wikipedia.org)
  • [6] [7] Some neuronal subpopulations in the SN, such as the noradrenergic cell group A2 and the aldosterone -sensitive HSD2 neurons project as far ventral as the bed nucleus of the stria terminalis . (wikipedia.org)
  • The cochlea is connected to the cranial nerve, brain stem nuclei and the neurons of the cortex. (home-remedies-for-you.com)
  • Furthermore, the vast majority of 5-HT 1D -IR neurons are unmyelinated peptidergic afferents that distribute peripherally, including the dura, cornea, and the sciatic nerve. (jneurosci.org)
  • We observed scattered 5-HT 1D -IR neurons in the nodose ganglia, and there was sparse terminal immunoreactivity in the solitary nucleus. (jneurosci.org)
  • Collections of neurons that serve a particular function are called nuclei. (dipg.org)
  • We also review the cranial nerves, their origin in the brain stem, as well as the ensembles of local circuit neurons that organize the simple behaviors of the face and head. (mhmedical.com)
  • Several motor and sensory nuclei form longitudinal columns in the brainstem, leading to some authors describing them as single discontinuous longitudinal nuclear columns rather than the more numerous individual separate nuclei. (radiopaedia.org)
  • Bilirubin staining can be noted on autopsy of fresh specimens in the regions of the basal ganglia, hippocampus, substantia nigra, and brainstem nuclei. (medscape.com)
  • It is both large and complicated and has multiple brainstem nuclei (sensory and motor) as well as many interconnections with other cranial nerves. (pacs.de)
  • The solitary nucleus projects to a large number of other regions of the brain including the paraventricular nucleus of the hypothalamus , the central nucleus of the amygdala , as well as other nuclei in the brainstem (such as the parabrachial area , locus coeruleus , dorsal raphe nucleus , and other visceral motor or respiratory networks). (wikipedia.org)
  • nerve cells that discharge signals that result in alternating fluctuations of electrical impulses along certain tracts of the central nervous system. (suffernomore.com)
  • The pontine tegmentum is made up of cranial nerves which serve the head and neck, associated nuclei, the reticular formation (neural network involved in functions including cardiovascular control, pain modulation, sleep and awakening), and tracts (both ascending and descending). (dipg.org)
  • This area is a bit below the autonomic motor nuclei, and includes the nucleus ambiguus, facial nerve nucleus, as well as the motor part of the trigeminal nerve nucleus. (wikipedia.org)
  • It contributes the autonomic, parasympathetic component to the oculomotor nerve (CN III), ultimately providing innervation to the iris sphincter muscle and ciliary muscle to mediate the pupillary light reflex and accommodation, respectively. (wikipedia.org)
  • It controls the sleep-wake cycle and vital functions via the ascending reticular activating system and the autonomic nuclei, respectively. (fiocruz.br)
  • Each facial colliculus , contrary to their names, do not contain the facial nerve nuclei. (wikidoc.org)
  • In patients with brainstem involvement, T2/FLAIR hyperintensity was noted in the cerebellar peduncles, facial nerve nuclei and/or other cranial nerve nuclei. (bvsalud.org)
  • Subunit alpha6-immunoreactivity was only present in granule cells of the cerebellum and the cochlear nucleus, and subunit gamma1-immunoreactivity was preferentially located in the central and medial amygdaloid nuclei, in pallidal areas, the substantia nigra pars reticulata and the inferior olive. (nih.gov)
  • The efferent component of the response includes the primary motor cortex, cerebellum, and the nucleus and nerve of cranial nerve VII (facial nerve). (vin.com)
  • Posterior view of the brainstem with cerebellum removed revealing the locations of the cranial nerve nuclei. (mhmedical.com)
  • It is the most rostral of the parasympathetic nuclei in the brain stem. (wikipedia.org)
  • The centrally projecting Edinger-Westphal nucleus-I: Efferents in the rat brain" (PDF). (wikipedia.org)
  • Cranial nerve V comes from what part of the brain stem? (proprofs.com)
  • Cranial nerves are a set of nerves that emerge directly from the brain and are responsible for controlling various functions of the head and neck. (proprofs.com)
  • In bulbar palsies, only the cranial nerve motor nuclei in the brain stem (bulbar nuclei) are affected. (msdmanuals.com)
  • But the portions of the brain stem that control the cranial nerves are much more complex than the corresponding parts of the spinal cord that control the spinal nerves because cranial nerves mediate more complex behaviors. (mhmedical.com)
  • A nerve that conducts impulses toward the brain or spinal cord. (unboundmedicine.com)
  • Cranial nerves are so named because they originate directly from the brain. (brainmadesimple.com)
  • Most of the cranial nerves originate from the brain stem. (brainmadesimple.com)
  • The hypoglossal nerve arises as a series of rootlets, from the caudal brain stem, here seen from below. (iiab.me)
  • The rootlets of the hypoglossal nerve arise from the hypoglossal nucleus near the bottom of the brain stem . (iiab.me)
  • You may find the Brain and Nerve articles more useful, or one of our many articles on Diseases & Conditions , Medical Syndromes , Health & Wellness or Home Remedies . (medicalnotes.info)
  • The brainstem conveys sensory and motor inputs between the spinal cord and the brain, and contains nuclei of the cranial nerves. (fiocruz.br)
  • Nuclear disorders are caused by disease of the oculomotor, trochlear, or abducens nuclei in the BRAIN STEM. (bvsalud.org)
  • 25. Base of the skull - posterior cranial fossa. (edu.pl)
  • Increasing evidence implicates herpes simplex type I and herpes zoster virus reactivation from cranial-nerve ganglia. (medscape.com)
  • VZV has the capacity to persist as a latent infection in dorsal root or extra medullary cranial ganglia. (cdc.gov)
  • Near the sulcus limitans are the visceral afferent nuclei, namely the solitary tract nucleus. (wikipedia.org)
  • Organ specific regions of neuronal architecture are preserved in the solitary nucleus. (wikipedia.org)
  • Another area, not on the dorsum of the brainstem, is where the special visceral efferents nuclei reside. (wikipedia.org)
  • Chemoreceptors and mechanoreceptors of the general visceral afferent pathway (GVA) with endings located in the heart, lungs, airways, gastrointestinal system, pharynx, and liver via the glossopharyngeal and vagus nerves. (wikipedia.org)
  • These cranial nerves are the abducens nerve , facial nerve and the vestibulocochlear nerve , respectively. (wikidoc.org)
  • It also interacts with the third and fourth cranial nerves, oculomotor and trochlear, respectively, as well as with the eighth cranial nerve (vestibulocochlear nerve) to perform conjugate eye movements (discussed later). (brainmadesimple.com)
  • [6] Signals from muscle spindles on the tongue travel through the hypoglossal nerve, moving onto the lingual nerve which synapses on the trigeminal mesencephalic nucleus . (iiab.me)
  • Subunit alpha3-immunoreactivity was observed in the glomerular and external plexiform layers of the olfactory bulb, in the inner layers of the cerebral cortex, the reticular thalamic nucleus, the zonal and superficial layers of the superior colliculus, the amygdala and cranial nerve nuclei. (nih.gov)
  • For the internal strabismus, the defect sometimes is due to any damage to the abducent nerve, the sixth cranial nerve. (brainmadesimple.com)
  • In the following text, we shall have a look at the origin, course, classification, and functional component(s) of the abducent nerve. (brainmadesimple.com)
  • Last but not least, we shall have a look at the diseases caused by damage to the abducent nerve. (brainmadesimple.com)
  • The abducent or abducent nerve is the sixth cranial nerve (CN VI). (brainmadesimple.com)
  • Much like the superior colliculi, the inferior colliculi are connected to the corresponding medial geniculate nucleus, and they send information to them. (databasefootball.com)
  • In contrast, the trochlear nuclei are found at the level of the inferior colliculus and they help refine vision, focusing the eyes on proximal objects. (databasefootball.com)
  • the inferior alveolar nerves innervate the lower teeth and gingivae. (unboundmedicine.com)
  • The inferior alveolar nerve (from CN V3) runs in the mandibular canal, giving off branches to the lower teeth and gingivae as it passes. (unboundmedicine.com)
  • The oculomotor nerve runs the ventral width of the tegmentum, emerging out of the nucleus. (databasefootball.com)
  • It gives branches to the pterygopalatine ganglion but also receives parasympathetic nerves from the ganglion via the greater petrosal nerve . (pacs.de)
  • Close to the midline are the motor efferent nuclei, such as the oculomotor nucleus, which control skeletal muscle. (wikipedia.org)
  • Some nuclei are small and contribute to a single cranial nerve, such as some of the motor nuclei. (radiopaedia.org)
  • Rodier PM, Ingram JL, Tisdale B, Nelson S, Romano J . Embryological origin for autism: developmental anomalies of the cranial nerve motor nuclei. (nature.com)
  • Bell palsy is an acute, unilateral, peripheral, lower-motor-neuron facial nerve paralysis that gradually resolves over time in 80-90% of cases. (medscape.com)
  • In front of the contact, the motor axon loses its myelin sheath and forms nerve terminal branches. (intechopen.com)
  • The neuroanatomical connections between the visual and motor nuclei of the anuran mesencephalon were investigated using horseradish peroxidase and the Golgi technique. (umass.edu)
  • The caudate nuclei are specifically thought to process and transmit cognitive information that influences the initiation of complex motor activities. (suffernomore.com)
  • The CNS, which receives sensory impulses from and sends motor impulses to the peripheral nervous system (i.e., nerves outside the CNS), plays an essential role in the coordination and control of the entire body. (suffernomore.com)
  • Underlying each of these are motor nuclei for the respective cranial nerves. (wikidoc.org)
  • The trigeminal nerve is the fifth cranial nerve and its primary role is relaying sensory information from the face and head, although it does provide motor control to the muscles of mastication . (pacs.de)
  • Motor nuclei for CNs innervating skeletal muscle are medial (CNs 3, 4, 6, and 12). (mhmedical.com)
  • Symptoms of nerve injury include paresthesias, loss of sensation and position sense, impaired motor function, cranial nerve malfunction, changes in reflexes, and impairments in glandular secretion. (unboundmedicine.com)
  • The posterior auricular nerve is a motor branch of the facial nerve (CN VII) that innervates the posterior and intrinsic auricular muscles. (unboundmedicine.com)
  • The sensory and motor innervation to the structures in the head and neck region of the body is exclusively provided by the cranial nerves. (brainmadesimple.com)
  • It is a long, slender, motor nerve and supplies only one of the extraocular muscles of the eye and functions in the movement of the eyeball within the orbit. (brainmadesimple.com)
  • As we know, the abducens nerve is a motor nerve. (brainmadesimple.com)
  • [lower-alpha 1] It is a nerve with a solely motor function . (iiab.me)
  • Damage to the nerve or the neural pathways which control it can affect the ability of the tongue to move and its appearance, with the most common sources of damage being injury from trauma or surgery, and motor neuron disease . (iiab.me)
  • Brainstem dysfunction may lead to sensory and motor deficits, cranial nerve palsies, impairment of consciousness, dysautonomia, and respiratory failure. (fiocruz.br)
  • The primordial piriform cortex at the surface is close to the primordial olfactory bulb where the olfactory nerves enter. (ehd.org)
  • Rather, it is a cortical response that requires the entire peripheral and central visual pathways, as well as the visual cortex and the facial nucleus and cranial nerve, to be intact. (vin.com)
  • Specialized clusters of nerve cells or nuclei within the caudate receive input from certain regions of the cerebral cortex. (suffernomore.com)
  • The cerebral aqueduct contains the nuclei of two pairs of cranial nerves , the oculomotor nuclei and the trochlear nuclei. (databasefootball.com)
  • Los trastornos nucleares son originados por enfermedades de los nĂșcleos oculomotores, trocleares o abducens en el TRONCO CEREBRAL. (bvsalud.org)
  • With the exception of the reticular thalamic nucleus, which was prominently stained for subunits alpha3, beta1, beta3 and gamma2, most thalamic nuclei were rich in alpha1-, alpha4-, beta2- and delta-immunoreactivities. (nih.gov)
  • And these molecules can be released from both nerve terminal (anterograde signal), and from muscle fiber (retrograde signal). (intechopen.com)