Cradd signaling adaptor protein. Medical search. Frequent questions

It signals via an N-terminal caspase recruitment domain that interacts with other CARD SIGNALING ADAPTOR PROTEINS such as RIP SERINE-THEONINE KINASES. (nih.gov)
Activation of this enzyme can occur via the interaction of its caspase recruitment domain with CARD SIGNALING ADAPTOR PROTEINS. (umassmed.edu)

Apoptotic adaptor molecule specific for caspase-2 and FASL/TNF receptor-interacting protein RIP. (joplink.net)
In particular, we will discuss the modifications in intrinsic and extrinsic apoptotic pathways caused by proteins encoded by HPV early genes. (mdpi.com)
However, the ability of HPV-infected cells to resist apoptotic signals renders such therapies ineffective. (mdpi.com)

In the presence of RIP and TRADD, CRADD recruits caspase-2 to the TNFR-1 signalling complex. (joplink.net)
CusabioAlternative Name(s): Caspase and RIP adapter with death domain RIP-associated protein with a death domainGene. (joplink.net)
Caspase recruitment domains, or caspase activation and recruitment domains (CARDs), are interaction motifs found in a wide array of proteins, typically those involved in processes relating to inflammation and apoptosis. (wikipedia.org)
Upon activation of Ipaf-1 by the intracellular bacterium S. typhimurium or other stress signals, Ipaf-1 recruits a CARD-containing adapter termed ASC and caspase-1 in unknown stoichiometry via CARD-CARD association. (wikipedia.org)
Mutations in CRADD Result in Reduced Caspase-2-Mediated Neuronal Apoptosis and Cause Megalencephaly with a Rare Lissencephaly Variant. (umassmed.edu)

A signal transducing tumor necrosis factor receptor associated factor that is involved in regulation of NF-KAPPA B signalling and activation of JNK MITOGEN-ACTIVATED PROTEIN KINASES. (uchicago.edu)

Proteins of the death domain (DD) superfamily mediate assembly of oligomeric signaling complexes for the activation of caspases and kinases via unknown mechanisms. (anl.gov)
It plays a role in the host defense response by signaling the activation of CASPASES and the MAP KINASE SIGNALING SYSTEM . (nih.gov)

This processing makes the CARDs available for interaction with the CARD of IPS-1/MAVS/VISA/Cardif, a downstream adapter anchored in the mitochondria. (wikipedia.org)
Physical and functional interaction of filamin (actin-binding protein-280) and tumor necrosis factor receptor-associated factor 2. (uchicago.edu)

Gain-of-function mutations in the intracellular NOD2 protein has been linked to increased risk for Crohn's disease. (wikipedia.org)
Activating mutations in at least two related PYD-containing proteins, cryopyrin/CIAS-1 and pyrin/MEFV, have been linked to Muckle-Wells syndrome and familial Mediterranean fever, respectively. (wikipedia.org)

These domains mediate the formation of larger protein complexes via direct interactions between individual CARDs. (wikipedia.org)

A NOD-signaling adaptor protein that contains a C-terminal leucine-rich domain which recognizes bacterial PEPTIDOGLYCAN . (nih.gov)

The adaptor protein VISA further activates the inhibitor of nuclear factor kappa-B kinase (IKK)-protein-kinase family members. (wikipedia.org)
Fractalkine (CX3CL1) stimulated by nuclear factor kappaB (NF-kappaB)-dependent inflammatory signals induces aortic smooth muscle cell proliferation through an autocrine pathway. (uchicago.edu)

CARDs are a subclass of protein motif known as the death fold, which features an arrangement of six to seven antiparallel alpha helices with a hydrophobic core and an outer face composed of charged residues. (wikipedia.org)

2006). Various studies have also demonstrated the involvement of several other signaling components in virus-induced activation of NF-κB and/or IRF3, including TRAF3, TRAF6, TANK, NEMO (IKKg), TRADD, FADD, and RIP (Kawai et al. (wikipedia.org)
2007). Because of their role as regulators of inflammation, constitutive activation of certain CARD-containing proteins, either conferred by mutation or by constant presence of stress signals, has been suggested to play a causative role in a number of inflammatory syndromes. (wikipedia.org)

A number of CARDs have been shown to play a role in regulating inflammation in response to bacterial and viral pathogens as well as to a variety of endogenous stress signals. (wikipedia.org)
Essential role of sequestosome 1/p62 in regulating accumulation of Lys63-ubiquitinated proteins. (uchicago.edu)

Unlike NLRs, these proteins, termed RIG-I and MDA5, contain twin N-terminal CARDs and C-terminal RNA helicase domains that directly interact with and process the double-stranded viral RNA. (wikipedia.org)