• The entry of coxsackievirus into cells, especially endothelial cells, is mediated by coxsackievirus and adenovirus receptor. (wikipedia.org)
  • The coxsackievirus and adenovirus receptor (CAR) has been identified as the cellular receptor for group B coxsackieviruses, including serotype 3 (CVB3). (rcsb.org)
  • The coxsackievirus and adenovirus receptor (CAR) is a cell adhesion molecule used as a docking molecule by some adenoviruses (AdVs) and group B coxsackieviruses. (cnrs.fr)
  • Its entry receptor, the coxsackievirus and adenovirus receptor (CAR), and heparan sulfate, which is used for cellular entry by some CVB3 variants, are highly expressed on various cancer types. (ox.ac.uk)
  • With control of poliovirus infections in much of the world, more attention has been focused on understanding the nonpolio enteroviruses such as coxsackievirus. (wikipedia.org)
  • The coxsackieviruses subsequently were found to cause a variety of infections, including epidemic pleurodynia (Bornholm disease), and were subdivided into groups A and B based on their pathology in newborn mice. (wikipedia.org)
  • The CDC found that coxsackievirus infections accounted for approximately 25% of all neonatal enterovirus infections (26,737) from 1983 to 2003. (medscape.com)
  • Recent studies have highlighted a role for the type III IFNs (also called IFNλs) in reducing permissiveness to infections with enteric viruses including coxsackievirus. (scilifelab.se)
  • Infections by Enteroviruses such as Coxsackievirus B (CVB) are candidate triggers of type 1 diabetes (T1D). (institutcochin.fr)
  • The coxsackievirus causes most HFM infections. (kidshealth.org)
  • Human infections with enteroviruses such as coxsackievirus A (CVA) are generally mild, but severe complications were more often reported for infections caused by enterovirus 71 (EV71) ( 1 , 2 ). (blogspot.com)
  • In humans, viruses are commonly suspected as causative agents, including coxsackievirus B3 (CVB3), a member of the Enterovirus genus of the Picornaviridae family. (unl.edu)
  • Das Mausmodell der Coxsackievirus B3 (CVB3)-Myokarditis eignet sich zur Untersuchung von Suszeptibilitätsfaktoren, die für eine chronische Erkrankung prädestinieren. (fu-berlin.de)
  • Coxsackievirus B3 (CVB3) is a promising novel candidate with particularly valuable features. (ox.ac.uk)
  • Methods: In order to study sex differences in the innate immune response, five male and female BALB/c mice were infected intraperitoneally with coxsackievirus B3 (CVB3) or phosphate buffered saline and their spleens were harvested 12 h later for microarray analysis. (elsevierpure.com)
  • The development of insulin-dependent diabetes has recently been associated with recent enteroviral infection, particularly coxsackievirus B pancreatitis. (wikipedia.org)
  • [ 4 ] Coxsackieviruses have been identified in the respiratory tract up to 3 weeks after initial infection and in feces up to 8 weeks after initial infection. (medscape.com)
  • PRV-101 is an investigational polyvalent vaccine being developed for the prevention of acute coxsackievirus B (CVB) infection and the potential delay or prevention of type 1 diabetes (T1D) and celiac disease. (pipelinereview.com)
  • Coxsackievirus infection was found to upregulate TLR4 on mast cells and macrophages immediately following infection. (elsevierpure.com)
  • Coxsackievirus infection in the pathogenesis of type 1 diabetes: Linking environmental triggers and autoimmune mechanisms. (institutcochin.fr)
  • We report infection of 4 children with recombinant coxsackievirus A2 in Hong Kong. (blogspot.com)
  • Taking a quick look at the symptoms of acute Yersinia enterocolitica, they look very similar to the symptoms of acute coxsackievirus B infection, especially the right lower quadrant pain (though I think coxsackievirus B can cause pain in both lower quadrants). (phoenixrising.me)
  • I suggest considering an alternative diagnosis: that you had an acute coxsackievirus B gastrointestinal infection, a virus strongly linked to ME/CFS, and it was this which kicked off your ME/CFS. (phoenixrising.me)
  • Among them, 422 were infected with coxsackievirus A16 (CVA16), 334 were infected with enterovirus 71 (EV71), 38 were co-infected with EV71 and CVA16, and 35 were infected with other enteroviruses. (flutrackers.com)
  • Most recent HFMD outbreaks have been caused by enterovirus A71 (EV-A71), coxsackievirus A16 (CVA16), CVA10, and CVA6. (ox.ac.uk)
  • Coxsackievirus A16 (CVA16) is an etiologic agent of hand, foot, and mouth disease (HFMD) that affects young children, and although typically self-limited, severe complications, and fatal cases have been reported. (tmu.edu.tw)
  • In general, group A coxsackieviruses tend to infect the skin and mucous membranes, causing herpangina , acute hemorrhagic conjunctivitis (AHC), and hand-foot-and-mouth (HFM) disease. (medscape.com)
  • Based on its pathogenicity, Coxsackievirus is divided into two groups: A and B. Coxsackievirus group A affects the skin and mucous membranes, causing hand-foot-mouth disease in children, and coxsackievirus group B, affects internal organs, resulting in more severe conditions such as gastroenteritis , pericarditis , myocarditis , and encephalitis . (osmosis.org)
  • In Thailand, hand, foot, and mouth disease (HFMD) is usually caused by enterovirus 71 or coxsackievirus A16. (cdc.gov)
  • Coxsackievirus B3 is a possible etiologic agent in some forms of myocarditis and idiopathic dilated cardiomyopathy. (nih.gov)
  • Although coxsackievirus A16 has historically been the primary etiologic agent of HFMD in the United States, CVA6 has emerged as the cause in many recently reported outbreaks ( 1 - 5 ). (cdc.gov)
  • Coxsackieviruses primarily are transmitted via the fecal-oral route and respiratory aerosols, although transmission via fomites also is possible. (medscape.com)
  • From 2002-2004, an estimated 16.4-24.3% of these illnesses were attributed to coxsackievirus serotypes. (medscape.com)
  • The group B coxsackieviruses (CVBs) exist in six serotypes (CVB1 to CVB6). (unl.edu)
  • With years of experience and professional scientists, Creative Biolabs provides high-quality antibody development services targeting different proteins against different serotypes of coxsackieviruses for our global clients. (creative-biolabs.com)
  • Coxsackievirus counters the host innate immune response by blocking type III interferon expression. (scilifelab.se)
  • Many similarities are described in the pathogenesis of Coxsackievirus and the adjuvant-induced model of myocarditis including upregulation of particular TLRs and cytokines soon after inoculation. (elsevierpure.com)
  • Rose, Noel R. / Viruses as adjuvants for autoimmunity : Evidence from Coxsackievirus-induced myocarditis . (elsevierpure.com)
  • Dr Chia talks about these acute coxsackievirus B symptoms in the Invest in ME conference videos. (phoenixrising.me)
  • Infectious coxsackievirus may be recovered from the heart during this phase. (rupress.org)
  • At the peak of the infectious phase, myocardial replication of coxsackievirus was increased 530 times in nurslings which had been forced to swim. (rupress.org)
  • Deng C, Li X, Liu S, Xu L, Ye H, Qin CF, Zhang B (2015) Development and characterization of a clinical strain of Coxsackievirus A16 and an eGFP infectious clone. (virosin.org)
  • Coxsackievirus A10 (CVA10) is one of the major etiological agents of hand, foot, and mouth disease. (virosin.org)
  • Vaccines against Group B Coxsackieviruses and Their Importance" by Kiruthiga Mone, Ninaad Lasrado et al. (unl.edu)
  • Coxsackieviruses are divided into group A and group B viruses based on early observations of their pathogenicity in neonatal mice. (wikipedia.org)
  • Coxsackievirus B-3 myocardiopathy was induced in weanling mice by intraperitoneal and intracerebral inoculations of the Nancy strain. (rupress.org)
  • Bioinformatic analysis of the sequences identified coxsackievirus A6 (CVA6) in all four nasopharyngeal specimens. (cdc.gov)
  • Coxsackieviruses are among the leading causes of aseptic meningitis (the other usual suspects being echovirus and mumps virus). (wikipedia.org)
  • Bian L, Wang Y, Yao X, Mao Q, Xu M, Liang Z (2015) Coxsackievirus A6: a new emerging pathogen causing hand, foot and mouth disease outbreaks worldwide. (virosin.org)
  • Coxsackievirus A6 was the causative agent. (cdc.gov)
  • Group A coxsackieviruses were noted to cause a flaccid paralysis that was caused by generalized myositis, whereas group B coxsackieviruses were noted to cause a spastic paralysis due to focal muscle injury and degeneration of neuronal, pancreatic, and myocardial tissue. (medscape.com)
  • Coxsackieviruses are a few related enteroviruses that belong to the Picornaviridae family of nonenveloped, linear, positive-sense single-stranded RNA viruses, as well as its genus Enterovirus, which also includes poliovirus and echovirus. (wikipedia.org)
  • Coxsackieviruses belong to the family Picornaviridae and the genus Enterovirus , which also includes poliovirus and echovirus. (medscape.com)
  • Coxsackie ( virus ) is a cytolytic virus of the picornaviridae family, an enterovirus (a group containing the polioviruses , coxsackieviruses, and echoviruses ). (wikidoc.org)
  • A committee sponsored by the National Foundation for Infantile Paralysis categorized EVs and other enteroviruses (ie, coxsackievirus group A and group B, polioviruses) together in 1957. (medscape.com)
  • The CDC reports coxsackievirus A16 as the virus most frequently isolated in hand, foot, and mouth disease (HFMD). (medscape.com)
  • Suspected HFMD cases were defined as painful blisters in the oropharynx and blisters on Coxsackievirus the palms, soles, knees, elbows, and/or buttocks. (cdc.gov)
  • Coxsackievirus A10 (CV-A10) is a leading cause of hand, foot, and mouth disease (HFMD). (bvsalud.org)
  • Cavatak, a wild-type Coxsackievirus A21, is being used in human clinical trials as an oncolytic virus. (wikipedia.org)
  • Coxsackievirus B3-Its Potential as an Oncolytic Virus. (ox.ac.uk)
  • Materials and Methods: Through our first screening assay, we found that coxsackievirus A11 (CVA11) displayed potent oncolytic activities. (elsevierpure.com)
  • We tested whether coxsackievirus A11 (CVA11) has oncolytic activity in human CRC cells in vitro and in vivo. (elsevierpure.com)
  • Anti-coxsackievirus antibodies have been extensively used as important elements in diagnostic assays for disease screening and researches. (creative-biolabs.com)
  • The discovery of the coxsackieviruses yielded further evidence that viruses can sometimes interfere with each other's growth and replication within a host animal. (wikipedia.org)
  • Based on structural data of the RNA-dependent RNA polymerase, rational targeting of key residues, and screens for Coxsackievirus B3 fidelity variants, we isolated nine polymerase variants with mutator phenotypes, which allowed us to probe the effects of lowering fidelity on virus replication, mutability, and in vivo fitness. (hal.science)
  • Coxsackievirus is a single-stranded RNA virus belonging to the enterovirus genus and the picornaviridae family. (osmosis.org)
  • Coxsackieviruses, the leading causes of aseptic meningitis, are a few related enteroviruses that belong to the Picornaviridae family of non-enveloped, linear, positive-sense single-stranded RNA viruses. (creative-biolabs.com)
  • Human coxsackieviruses belong to the family Picornaviridae and genus Enterovirus . (blogspot.com)
  • Systemic neonatal disease often is associated with group B coxsackieviruses. (medscape.com)
  • In 2007, an outbreak of coxsackievirus occurred in eastern China. (wikipedia.org)
  • Both group A and group B coxsackieviruses can cause nonspecific febrile illnesses, rashes, upper respiratory tract disease, and aseptic meningitis. (wikipedia.org)
  • A method for the detection of coxsackievirus B3 RNA was developed using the polymerase chain reaction based on the amplification of a cDNA copy of the positive-strand viral RNA. (nih.gov)
  • A natural recombinant of coxsackievirus A2 was found in 4 children with respiratory symptoms in Hong Kong, China, during the summer of 2012. (blogspot.com)
  • It is commonly caused by coxsackievirus A16 (an enterovirus), and less often by other types of viruses. (maryland.gov)
  • The sensitivity of the technique was established at approximately 1 to 100 plaque-forming units of virus per gram of tissue, and the specificity was established as limited to the coxsackievirus B3 serotype among nine viruses tested. (nih.gov)
  • PRVB ), a biopharmaceutical company dedicated to intercepting and preventing immune-mediated disease, today announced the initiation of PROVENT ( PRO tocol for coxsackievirus V accin E in healthy volu NT eers), a first-in-human study of its polyvalent inactivated coxsackievirus B (CVB) vaccine candidate, PRV-101. (pipelinereview.com)
  • Numerous group A coxsackieviruses are responsible for causing CNS disease similar to poliomyelitis. (medscape.com)
  • and Eghtesady, Pirooz, "Virome analysis and association of positive coxsackievirus B serology during pregnancy with congenital heart disease. (wustl.edu)
  • Bian L et al (2019) Hand, foot, and mouth disease associated with coxsackievirus A10: more serious than it seems. (virosin.org)