• The protein encoded by this gene is a type I membrane receptor for group B coxsackie viruses and subgroup C adenoviruses. (wikipedia.org)
  • The coxsackie and adenovirus receptor, a shared transmembrane receptor, coxsackie B viruses, and some adenoviruses show tropism towards cardiomyocytes. (ontariohomeopath.ca)
  • The most abundant membrane\associated proteins were heat\shock protein family A (Hsp70) member (Hspa5), beta\catenin (Ctnnb1), rho family, small GTP binding protein (Rac1 and Obeticholic Acid Rac3), cadherins (Cdh1 and Cdh3), coxsackie virus and adenovirus receptor (Cxadr) as well as epidermal growth factor receptor (Egfr). (crispr-reagents.com)
  • Coxsackievirus and adenovirus receptor (CAR) is a protein that in humans is encoded by the CXADR gene. (wikipedia.org)
  • The coxsackievirus and adenovirus receptor (CAR) is a cell adhesion molecule used as a docking molecule by some adenoviruses (AdVs) and group B coxsackieviruses. (cnrs.fr)
  • Here, we compare the role of a cell adhesion molecule (CAR), in the internalization of adenoviruses that naturally infect humans and Canidae. (cnrs.fr)
  • Our study highlights the mechanistic differences that a receptor can have for two viruses from the same family. (cnrs.fr)
  • In this review article, we outline key characteristics of major gene therapy viruses-adenovirus, adeno-associated virus (AAV), and lentivirus-and summarize the mechanisms regulating important steps in the virus journey from binding at peripheral nerve terminals to nuclear delivery. (frontiersin.org)
  • This similarity raises the possibility that this of several classes of viruses found as outgrowths from patient was, in fact, infected with a monkey adenovirus. (cdc.gov)
  • 2010). Coxsackievirus and adenovirus receptor (CAR) mediates attachment by all six CVB serotypes, but is definitely inaccessible to viruses within the luminal surface due to its localization within intercellular limited junctions. (biotechpatents.org)
  • 2 recent reports classifi ed monkey adenoviruses into 4 hemagglutination have indicated probable human infection with simian subgroups on the basis of their differential agglutination adenoviruses (SAdVs). (cdc.gov)
  • Human adenovirus (Adv) infection is responsible for most community-acquired pneumonia in infants and children, which results in significant morbidity and mortality in children every year. (hindawi.com)
  • Knowing the miRNA expression profile will help understand the role of miRNAs in modulating the host response to adenovirus infection and possibly improve the diagnosis of adenovirus-infected pneumonia. (hindawi.com)
  • Human adenovirus (Adv) infection is responsible for most community-acquired pneumonia in infants and children [ 1 , 2 ]. (hindawi.com)
  • In rat models, neither coxsackievirus infection nor histological indications of myocarditis occur when CAR is wiped out. (ontariohomeopath.ca)
  • Pleurodynia is an uncommon complication of coxsackievirus B infection. (medscape.com)
  • Coxsackievirus B is an RNA Enterovirus, which usually causes an asymptomatic or brief upper respiratory tract or gastroenteric infection. (medscape.com)
  • In rare cases, other severe sequelae of coxsackievirus B infection develop, including meningitis and carditis. (medscape.com)
  • The incidence of coxsackievirus B infection in neonates is 1 in 2000 live births. (medscape.com)
  • The severity of the coxsackievirus B infection is highest in infants and children. (medscape.com)
  • In infants who develop coxsackievirus B infection, 10% die, usually within the first 4 weeks of life most commonly from cardiac involvement. (medscape.com)
  • The protein may play a role in cell-cell adhesion and is the primary site for the attachment of ADENOVIRUSES during infection. (bvsalud.org)
  • We previously proposed that the preferential transduction of neurons by canine adenovirus type 2 (CAV-2) is due to CAR-mediated internalization. (cnrs.fr)
  • Our proposed pathway of CAV-2 entry is in contrast to that of human AdV type 5 (HAdV-C5) in non-neuronal cells, where internalization is mediated by auxiliary receptors such as integrins. (cnrs.fr)
  • Antibodies to coxsackievirus B serotypes are present in 75% of the population in developed countries. (medscape.com)
  • The coxsackievirus and adenovirus receptor (CAR) has been identified as the cellular receptor for group B coxsackieviruses, including serotype 3 (CVB3). (rcsb.org)
  • Modern developments in PCR technology have made it possible to discover enteroviruses, adenoviruses, parvovirus B19, and human herpesvirus 6 in patients with acute myocarditis, despite the fact that the pathophysiology is poorly understood in humans. (ontariohomeopath.ca)
  • Coxsackievirus B was present in 24% of the 18,000 enteroviruses isolated and reported in the United States from 1970-1979. (medscape.com)
  • We have previously found that adenovirus DNA is cultivated for propagation of poliovirus. (cdc.gov)
  • Adv infects the host cells through binding to different cellular receptors such as coxsackievirus and adenovirus receptor (CAR) [ 12 ]. (hindawi.com)
  • Cryo-electron microscopy (cryo-EM) reconstruction of the CVB3-CAR complex resulted in a 9.0-Å resolution map that was interpreted with the four available crystal structures of CAR, providing a consensus footprint for the receptor binding site. (rcsb.org)
  • Coxsackievirus B3 (CVB3) is a promising novel candidate with particularly valuable features. (ox.ac.uk)
  • Its entry receptor, the coxsackievirus and adenovirus receptor (CAR), and heparan sulfate, which is used for cellular entry by some CVB3 variants, are highly expressed on various cancer types. (ox.ac.uk)
  • Further, HAdV-52 ( 7 ) isolated from Adenoviruses, which can cause infectious diarrhea or a patient with gastroenteritis has been found to be very respiratory infections in humans, were isolated from dissimilar to all previously isolated human adenoviruses monkeys soon after their initial characterization by Rowe but closely related to monkey adenoviruses SAdV-1 and et al. (cdc.gov)
  • These highly upregulated microRNAs may have crucial roles in Adv pathogenesis and are potential biomarkers for adenovirus-infected pneumonia. (hindawi.com)
  • It also exhaustively introduces the concrete mechanism of invading GC cells and the viral genome composition of adenovirus and herpes simplex virus type 1 (HSV-1). (frontiersin.org)
  • The sequence of SAdV-18 was closely related simian adenovirus A (SAdV-A), to which SAdV-3 has to that of human adenovirus F across the whole genome, been assigned. (cdc.gov)
  • Structural analysis of the mechanism of adenovirus binding to its human cellular receptor, CAR. (expasy.org)
  • Here we review evidence showing that apicobasal polarity regulates the inflammatory response: various polarized epithelia asymmetrically secrete chemotactic mediators and polarize adhesion receptors that dictate the route of leukocyte migration within the parenchyma. (hindawi.com)
  • Expression profiles of whole blood microRNAs were altered and distinctly different in adenovirus-infected children. (hindawi.com)
  • The analysis of the cryo-EM structure identifies important virus-receptor interactions that are conserved across picornavirus species. (rcsb.org)
  • These conserved interactions map to variable antigenic sites or structurally conserved regions, suggesting a combination of evolutionary mechanisms for receptor site preservation. (rcsb.org)
  • Lipid rafts are enriched in a number of signaling molecules including receptor tyrosine kinases, the Src family of nonreceptor tyrosine kinases, small G proteins, and adenylyl cyclases (ACs) and CBA-DAF complex can easily contact lipid rafts because of the absence of cytoplasmic website of DAF (Parton and Richards 2003). (biotechpatents.org)
  • Tunicamycin has also been used to study the functional effects of coxsackievirus and adenovirus receptor (CAR) glycosylation in COS-7 cells. (sigmaaldrich.com)
  • These cells can express receptors for cytokines, neuropeptides, and neurotrophins, exerting functions in both the ENS and the immune system, and participating in the modulation of motility and secretion functions of the gastrointestinal tract. (encyclopedia.pub)
  • The classifi cation of monkey adenoviruses was and monkey populations in several locales in Asia, Africa, initially done in a manner analogous to that used for human and Latin America, better characterization of monkey isolates, i.e., on the basis of differences in their ability to adenoviruses is of public health importance. (cdc.gov)
  • As expected, GO\term analysis revealed a significant overrepresentation of proteins related to keywords such as cilium, septin complex, and receptor complex (Fisher's exact test, FDR 0.02). (crispr-reagents.com)
  • Description: Enzyme-linked immunosorbent assay kit for quantification of Human Coxsackievirus and adenovirus receptor in samples from serum, plasma, tissue homogenates and other biological fluids. (mugen-noe.org)
  • The striated muscle is the actual anatomic structure targeted by the coxsackievirus B and is responsible for the attacks of severe chest pain. (medscape.com)
  • Cell surface receptors containing an immunoglobin domain. (embl.de)
  • Adenoviruses readily detected in fecal samples from monkeys who have were also found in rectal swab and fecal samples taken no symptoms of any clinical adenoviral disease ( 9 ). (cdc.gov)
  • In our study, total RNA extracted from whole blood of adenovirus-infected pneumonia children and healthy controls were analyzed by small RNA deep sequencing. (hindawi.com)
  • The top 3 upregulated miRNA (hsa-miR-127-3p, hsa-miR-493-5p, and hsa-miR-409-3p) were identified in adenovirus-infected children and provided a clear distinction between infected and healthy individuals. (hindawi.com)
  • Coxsackievirus B3-Its Potential as an Oncolytic Virus. (ox.ac.uk)
  • In contrast, 30 of the 78 mostly adult patients with coxsackievirus B-associated cardiac disease had pleurodynia. (medscape.com)
  • Cerebral vein sinuses express podoplanin, a natural ligand for CLEC2 receptors on platelets. (bvsalud.org)
  • Both stimulated Rac1 activation, reactive oxygen species (ROS) generation, and enhanced Rac1-dependent NADPH oxidase 1 (NOX1) activity, but independent of the activation of Toll-like receptor 3 (TLR-3). (biotechpatents.org)