ApoL1 renal risk variants induce aberrant THP-1 monocyte differentiation and increase eicosanoid production via enhanced expression of cyclooxygenase-2. (omicsdi.org)
A series of biochemical and cellular assays were employed to assess the ability of the herbal extracts to inhibit acetylcholinesterase, reduce β-amyloid aggregation, stimulate the differentiation of neural progenitor cells, suppress cyclooxygenase, and protect neurons against β-amyloid or N-methyl-D-aspartate-induced cytotoxicity. (biomedcentral.com)
Significantly1
YXT and its components significantly inhibited the activities of the pro-inflammatory cyclooxygenases. (biomedcentral.com)
Expression1
In human monocyte THP-1 cells, transient overexpression of ApoL1 (G0, G1, G2) by transfection resulted in a 5- to 11-fold increase in CD14 and CD68 gene expression, similar to that seen with phorbol-12-myristate acetate treatment. (omicsdi.org)
Current1
Current medications, including acetylcholinesterase (AChE) inhibitors and N-methyl D-aspartate (NMDA) antagonists [ 1 , 2 ], can impede disease progression and are primarily effective in the early stages of AD. (biomedcentral.com)
Selective inhibitors3
Reactivity to VP (10 -12 -10 -7 M) was measured in pressurized middle cerebral artery segments in the absence or presence of selective inhibitors of COX-1 (SC560, SC, 1 μM) or COX-2 (NS398, NS, 10 μM). (utmb.edu)
[9] COX-2 selective inhibitors have fewer gastrointestinal side effects, but promote thrombosis , and some of these agents substantially increase the risk of heart attack. (cloudfront.net)
As a result, certain COX-2 selective inhibitors-such as rofecoxib -are no longer used due to the high risk of undiagnosed vascular disease . (cloudfront.net)
Thromboxane5
Thromboxane inhibitors are broadly classified as either those that inhibit the synthesis of thromboxane, or those that inhibit the target effect of it. (wikimili.com)
The widely used drug aspirin acts by inhibiting the ability of the COX enzyme to synthesize the precursors of thromboxane within platelets. (wikimili.com)
Thromboxane synthase inhibitors inhibit the final enzyme ( thromboxane synthase ) in the synthesis of thromboxane. (wikimili.com)
The inhibitors of the target effects of thromboxane are the thromboxane receptor antagonist , including terutroban . (wikimili.com)
Picotamide has activity both as a thromboxane synthase inhibitor and as a thromboxane receptor antagonist. (wikimili.com)
NS3981
Microsome from LPS-activated BV2 cells was pre-incubated with WWL70 (3 μM), the mPGES-1 inhibitor MK886 (3 μM), the COX-1 inhibitor sc-560 (1 μM), or the COX-2 inhibitor NS398 (10 μM) for 5 min, then incubated with 10 μM AA for 1 min at 23 °C. The reaction mixture after incubation was employed PGE 2 EIA ( a ). (biomedcentral.com)
Enzyme1
19. Synergistic inhibition of hepatocellular carcinoma growth and hepatocarcinogenesis by combination of 5-fluorouracil and angiotensin-converting enzyme inhibitor via anti-angiogenic activities. (nih.gov)
Prostaglandin2
6. Cyclooxygenase-2 and prostaglandin signaling in cholangiocarcinoma. (nih.gov)
human microsomal prostaglandin E synthase 1 with bound glutathione. (wikidoc.org)
Inhibition2
7. Cyclooxygenase-2 inhibition induces apoptosis signaling via death receptors and mitochondria in hepatocellular carcinoma. (nih.gov)
This study aimed at testing the hypothesis that selective COX-1 inhibition would protect the brain against AD-related neuroinflammation and improve cognitive deficits. (nih.gov)
Constrictor2
Further, there were no significant differences in basal or in low- or high-VP-stimulated PGI 2 or TXA 2 production in younger or older M. In contrast, there were marked differences in cerebrovascular reactivity and prostanoid release with advancing age in F. Older RS F exhibited reduced maximal constrictor responses to VP, which can be attributed to enhanced COX-1 derived dilator prostanoids. (utmb.edu)
VP-induced vasoconstriction in younger MA F utilized both COX-1 and COX-2 derived constrictor prostanoids. (utmb.edu)
Pathogenesis1
These results suggest that COX-1 may play an important role in the pathogenesis of AD and a selective COX-1 inhibitor may be therapeutically beneficial in AD. (nih.gov)
Prostanoids1
Therefore, in the present study, we investigated the effect of resveratrol on the production of prostanoids induced by IL-1β in SK-N-SH cells, a human neuroblastoma cell line. (medscape.com)
Microsomal1
In inflammatory conditions, the two enzymes that contribute the most to PGE 2 production are cyclooxygenase (COX)-2, which converts AA into PGG 2 and PGH 2 , and microsomal PGE 2 synthase-1 (mPGES-1), which converts PGH 2 into PGE 2 . (medscape.com)
Effect3
5. Mechanisms of anti-proliferative effect of JTE-522, a selective cyclooxygenase-2 inhibitor, on human liver cancer cells. (nih.gov)
To investigate the effect of resveratrol on the production of inflammatory mediators in neuronal cells, SK-N-SH neuronal cells were pre-incubated with different concentrations (0.001-5 μM) of resveratrol (Sigma-Aldrich, Taufkirchen, Germany) for 30 minutes followed by stimulation with IL-1β (10 U/ml) for 24 h. (medscape.com)
An AA assay was performed to determine the effect of resveratrol on COX-1 and COX-2 enzymatic activity. (medscape.com)
Cells2
14. The selective cyclooxygenase-1 inhibitor SC-560 suppresses cell proliferation and induces apoptosis in human hepatocellular carcinoma cells. (nih.gov)
20. Potent cell growth inhibitory effects in hepatitis B virus X protein positive hepatocellular carcinoma cells by the selective cyclooxygenase-2 inhibitor celecoxib. (nih.gov)
Human2
11. In-vivo effects and mechanisms of celecoxib-reduced growth of cyclooxygenase-2 (COX-2)-expressing versus COX-2-deleted human HCC xenografts in nude mice. (nih.gov)
18. Blockage of epidermal growth factor receptor by quinazoline tyrosine kinase inhibitors suppresses growth of human hepatocellular carcinoma. (nih.gov)
Article1
Biology of Sex Differences , 5 (1), Article 12. (utmb.edu)
Effects3
Deer, RR & Stallone, JN 2014, ' Effects of age and sex on cerebrovascular function in the rat middle cerebral artery ', Biology of Sex Differences , vol. 5, no. 1, 12. (utmb.edu)
[9] These differential effects are due to the different roles and tissue localisations of each COX isoenzyme. (cloudfront.net)
[9] By inhibiting physiological COX activity, NSAIDs may cause deleterious effects on kidney function, [10] and, perhaps as a result of water and sodium retention and decreases in renal blood flow, may lead to heart problems. (cloudfront.net)
Release1
VP-stimulated release of PGI 2 and TXA 2 were measured using radioimmunoassay of 6-keto-PGF 1α and TXB 2 (stable metabolites, pg/mg dry wt/45 min). (utmb.edu)
Activity2
NSAIDs work by inhibiting the activity of cyclooxygenase enzymes (the COX-1 and COX-2 isoenzymes ). (cloudfront.net)
[9] Most NSAIDs are non-selective, and inhibit the activity of both COX-1 and COX-2. (cloudfront.net)