Protein StabilityEnzyme StabilityDrug StabilityProtein DenaturationThermodynamicsProtein FoldingModels, MolecularMolecular Sequence DataAmino Acid SequenceProtein ConformationMutationRNA StabilityProteinsProtein BindingProtein Structure, TertiaryTemperatureCircular DichroismUbiquitinationProtein Structure, SecondaryProteasome Endopeptidase ComplexProteolysisKineticsUbiquitinGuanidineProtein EngineeringMutagenesis, Site-DirectedAmino Acid SubstitutionCell LineBinding SitesEscherichia coliProtein UnfoldingBase SequenceUbiquitin-Protein LigasesProtein Processing, Post-TranslationalCalorimetry, Differential ScanningHot TemperatureHalf-LifeRecombinant ProteinsHydrogen-Ion ConcentrationStructure-Activity RelationshipModels, ChemicalUreaMuramidaseHEK293 CellsSpectrometry, FluorescenceHydrogen BondingRNA, MessengerSolventsPhosphorylationBacterial ProteinsCrystallography, X-RayStatic ElectricityCell Line, TumorMutant ProteinsCysteineMutation, MissenseTransition TemperaturePlasmidsDNA-Binding ProteinsRecombinant Fusion ProteinsAmino Acid MotifsTranscription, GeneticDNA, CircularAmino AcidsLysineHydrophobic and Hydrophilic InteractionsNuclear ProteinsDNASequence Homology, Amino AcidHeLa CellsModels, BiologicalElectrophoresis, Polyacrylamide GelDisulfidesTranscription FactorsSignal TransductionLeupeptinsSequence AlignmentDimerizationGene Expression RegulationTransfectionSolubilitySUMO-1 ProteinComputer SimulationCOS CellsPeptidesMolecular StructureProtein Structure, QuaternaryTumor Suppressor Protein p53Carrier ProteinsSerineUbiquitinsProtein MultimerizationRibonucleasesPoint MutationProto-Oncogene Proteins c-mdm2SumoylationTime FactorsSaccharomyces cerevisiaeSaltsMembrane Proteins