BoundProteinsMethylationMethyltransferasesMolecule is covalentlyResiduesAtomsConjugateMolecularCarbonFunctional groupsMoleculesEthylReactiveAntibodyAlbuminInvolvesCarboxylMonomerAminoTerminalElectron groupsBiologicalHydrogenReplicationProcessPolarFormMonomersBondEssentialShapeBaseAdditionSpecificWaterFreeFoundAnalysis
Bound11
- Upon the methylation, a methyl group (-CH 3 ) is covalently bound to a cytosine base. (utwente.nl)
- Monomeric sarcosine oxidase (MSOX) is an inducible bacterial flavoenzyme that catalyzes the oxidative demethylation of sarcosine (N-methylglycine) and contains covalently bound FAD [8alpha-(S-cysteinyl)FAD]. (rcsb.org)
- Phase II metabolic reactions in biological systems (Manahan 1989), methyl mercaptan may be bound as conjugates from which it must be released prior to analysis. (cdc.gov)
- Two such bound fractions of methyl mercaptan have been identified in human serum (Tangerman et al. (cdc.gov)
- 1985). In one fraction, from which the methyl mercaptan is released by acid, the methyl mercaptan is thought to be bound as methyl-beta-D-thioglucuronide. (cdc.gov)
- In another fraction methyl mercaptan is covalently bound to proteins in a disulfide linkage and is released by reaction with dithiothreitol. (cdc.gov)
- Various organic groups may be covalently bound to cobalt atom forming cobalamines. (howmed.net)
- Photosynthetically active FNR (sometimes classified as autotrophic) is a member of the family of soluble monomeric enzymes that contain non-covalently bound FAD (flavin adenine dinucleotide) as the prosthetic group 3 . (nature.com)
- After incorporation of the tethered dNTP, the 3′ end of the primer remains covalently bound to TdT and is inaccessible to other TdT-dNTP molecules. (nature.com)
- The structures of these sensor domains are the first structures of PAS domains containing covalently bound heme. (rcsb.org)
- The FAD molecule is covalently bound in the known structure, however the residue that links to the FAD is not in the alignment. (unl.edu)
Proteins5
- Although, people are not dinousaurs, the concept is the same, our DNA and proteins may often become damaged by losing DNA sequences (methyl groups), without which we cannot function perfectly. (healthy-living.org)
- While BQ, an extreme skin sensitizer, is an electrophile known to covalently modify proteins via Michael Addition (MA) reaction whilst halogen substituted BQD undergo nucleophilic vinylic substitution (SNV) mechanism onto amine and thiol moieties on proteins, the allergenic effects of adding substituents on BQ have not been reported. (cdc.gov)
- Methylation also refers to the addition of methyl group to lysine residues in the histone proteins around which DNA is wrapped. (basicmedicalkey.com)
- Periplasmic sensor domains from two methyl-accepting chemotaxis proteins from Geobacter sulfurreducens (encoded by genes GSU0935 and GSU0582) were expressed in Escherichia coli. (rcsb.org)
- Amino groups are found within amino acids, the building blocks of proteins. (chemicalindustrynews.com)
Methylation5
- DNA methylation is a heritable epigenetic marker that involves DNA methyltransferases covalently transferring a methyl group to the C-5 position of the cytosine ring of DNA (DNMTs). (medgadget.com)
- In April 2019, New England Biolabs has released a new product called 'NEBNext Enzymatic Methyl-seq (EM-seqTM)' as a methylation analysis alternative to bisulfite sequencing. (medgadget.com)
- Methylation is a universal biochemical process which covalently adds methyl groups to a variety of molecular targets that are missing these methyl groups. (healthy-living.org)
- That is, after free radicals (toxins) damage the molecules of our cells, methylation repairs that damage by inserting methyl groups (a carbon atom with three hydrogen atoms) into the molecules, including DNA, where those methyl groups have been damaged and stripped away. (healthy-living.org)
- Methylation refers to the addition of a methyl group to the cytosine residues in DNA. (basicmedicalkey.com)
Methyltransferases2
- Methyl groups (-CH 3 ) may be covalently attached to DNA, without changing the base sequence, by enzymes called DNA methyltransferases . (biotopics.co.uk)
- One such DNA modification is mediated by DNA methyltransferases (DNMT) that covalently add a methyl group to the 5th carbon of a cytosine residue (5-methylcytosine, 5mC) [ 6 ]. (biomedcentral.com)
Molecule is covalently3
- Compositions comprising at least one ethylenically unsaturated monomer to which a photochemically isomerizable or dimerizable molecule is covalently bounded, and at least one ethylenically unsaturated monomer to which a sensitizer is covalently bounded, are outstandingly suitable for producing polymeric alignment layers for liquid crystals. (allindianpatents.com)
- First, the invention provides a composition comprising a) at least one ethylenically unsaturated monomer to which a photochemically isomerizable or dimerizable molecule is covalently bonded, b) at least one ethylenically unsaturated monomer to which a sensitizer is covalently bonded, and c) optionally other ethylenically unsaturated comonomers. (allindianpatents.com)
- The monomers a) are preferably selected from the group of acrylates, methacrylates, acryi-amides and methacrylamides, to which a photochemically isomerizable or dimerizable molecule is covalently bonded directly or via a bridging group in the ester or amide group. (allindianpatents.com)
Residues1
- These AcGXs are homodisperse in length (approximately 100 residues in Arabidopsis ) and, on average, one of every ten xylosyl residues is substituted at O -2 with (4- O -methyl)-α- d -glucuronic acid((Me)Glc p A) [ 13 , 14 ]. (biomedcentral.com)
Atoms3
- Organic compounds typically consist of groups of carbon atoms covalently bonded to hydrogen, usually oxygen, and often other elements as well. (chemicalindustrynews.com)
- Moreover, the atoms to which carbon atoms bond may also be part of a functional group. (chemicalindustrynews.com)
- A functional group is a group of atoms linked by strong covalent bonds and tending to function in chemical reactions as a single unit. (chemicalindustrynews.com)
Conjugate3
- To solve these problems, an amphiphilic polymer-drug conjugate was prepared by attachment of low molecular weight (ie, 2 kDa) methoxy poly(ethylene glycol) methyl ether (mPEG) to gambogic acid (GA-mPEG 2000 ) through an ester linkage and characterized by 1H nuclear magnetic resonance. (dovepress.com)
- The X-ray structure determination of the S-Etodolac conjugate reveals a 'sleeping swan'-like shape, with the covalently bonded Etodolac moiety being folded with the 8-ethyl group inserted inside the hydrophobic cavity of the beta-CD ring. (unict.it)
- In this family, Nanopartz™ has the ability to covalently conjugate to specific antibody locations, thereby for example, leaving necessary primary amines exposed for optimum activity. (nanopartz.com)
Molecular7
- Ruben Kolkman is a PhD student in the Molecular NanoFabrication group and the BIOS lab on a Chip group. (utwente.nl)
- From the physics of boundary friction, it is known that metal soaps bond covalently to a friction surface forming structured protective "molecular pile" layers from polar groups COOMe to promote (due to methyl units CH2) filiform (nematic) flow of boundary layers similar to those that exist in liquid crystals. (smt2.com.au)
- These boundary layers, at the expense of methylene groups (CH3), having incredibly high (commensurable with diamond) molecular hardness, shield the contact surfaces, thereby minimizing wear and friction. (smt2.com.au)
- Determine the molecular shape by counting bonding groups and nonbonding groups separately.Viewed 768 times. (cataleya-vb.de)
- Collection on molecular sieve is also possible (Kangas and Ryosa 1988), although problems are encountered from incomplete desorption of methyl mercaptan from molecular sieve. (cdc.gov)
- To increase the photosensitivity, it is possible to add to the polymers molecular sensitizers which absorb in the wavelength range of the irradiation light and transfer energy to the photoactive, isomerizable or dimerizable groups, the latter groups only being excited to a slight extent, if at all, in the selected wavelength range. (allindianpatents.com)
- Since a fully molecular system facilitates spectroscopic studies of the catalytic process, we are interested in developing such a system that consists of covalently-linked iminium ions. (bgsu.edu)
Carbon2
- Organotin substances are tin compounds having 1, 2, 3 or 4 organic groups attached and are designated as mono-, di-, tri- or tetra-organotin depending on the number of tin-carbon bonds in the molecule. (canada.ca)
- They catalyze the transformation of the N-methyl group of (S)-reticuline into the C-8 berberine bridge carbon of (S)-scoulerine. (unl.edu)
Functional groups3
- Initially, the functional monomer forms a complex and, after polymerization, their functional groups are held by the highly crosslinking polymeric structure. (intechopen.com)
- Furthermore, in an attempt to identify the functional groups responsible for catalytic oxidation from Et-Fl+ ion, a comparative research was conducted with a simple iminium ion derivative N-methyl-9-phenylacridinium perchlorate (Acr+). (bgsu.edu)
- You can think of functional groups as tightly knit "cliques" whose members are unlikely to be parted. (chemicalindustrynews.com)
Molecules2
- Once SMT2 molecules penetrate these surfaces, they bond with loose Fe molecules as they are covalently drawn into the ferrous metal micro-pores. (smt2.com.au)
- Within the layers, the beta-CD macrocycles are held together by a complicated intermolecular hydrogen bond network, in which numerous water molecules and hydroxyl groups are involved. (unict.it)
Ethyl3
- Recent studies showed that azaserinc had reacted covalently with nucleophilic groups (e.G., methyl or ethyl). (moorelifeurgentcare.com)
- The terminal methyl group of the 8-ethyl group enters the centre of cavity from the side of the primary hydroxyl groups and is buried inside the beta-CD macrocycle. (unict.it)
- In addition to van der Waals interactions between the hydrophobic ethyl group and the beta-CD cavity, the folded conformation is further stabilized by one intramolecular H-bond involving the indole N-H group and the primary hydroxyl group of the glucose unit 7. (unict.it)
Reactive2
- The Ntracker™ non reactive methyl terminated nanorods are coated in a proprietary dense layer of hydrophilic polymers that shield the gold surface and give the particles ultra-long circulation times. (nanopartz.com)
- The mechanisms by which isocyanates cause asthma remain unclear, hampering disease prevention, diagnosis, and treatment.7 It is assumed the reactive nature of N=C=O groups underlies isocyanate asthma, with a hapten-based mechanism as the most obvious pathway to pathogenesis.8 However, the critical "self" reaction targets for isocyanate in vivo remain uncertain. (cdc.gov)
Antibody1
- Urine specimen albumin antigen reacts with albumin antibody that is covalently attached to polyacrylamide beads. (cdc.gov)
Albumin1
- The 414K-MDI conjugation appears to covalently cross- link GSH to albumin via GSH's NH2-terminus, a unique conformation possibly resulting from cyclized mono(GSH)-MDI or asymmetric ( S , N -linked) bis(GSH)-MDI conjugates. (cdc.gov)
Involves2
- One embodiment of this method involves covalently bonding to the tissue a monomer capable of further polymerization. (justia.com)
- Optical absorption, electron paramagnetic resonance and NMR spectroscopy have revealed that the heme groups of both sensor domains are high-spin and low-spin in the oxidized and reduced forms, respectively, and that the spin-state interconversion involves a heme axial ligand replacement. (rcsb.org)
Carboxyl3
- The carboxyl group of sarcosine is essential for binding since none is observed with simple amines. (rcsb.org)
- Ntherapy™ nanorods come with similar hydrophilic polymers, but with terminal amine and carboxyl active groups, along with a number of custom popular in vivo targeting ligands. (nanopartz.com)
- Carboxyl groups are found within fatty acids, amino acids, and many other acids. (chemicalindustrynews.com)
Monomer2
- Each monomer contributes: One gives up a hydrogen atom and the other gives up a hydroxyl group. (chemicalindustrynews.com)
- The bonds between their monomers are broken, via the donation of a molecule of water, which contributes a hydrogen atom to one monomer and a hydroxyl group to the other. (chemicalindustrynews.com)
Amino3
- The amino group of sarcosine is not essential, but binding affinity depends on the nature of the substitution (CH(3)XCH(2)CO(2)(-), X = CH(2) (rcsb.org)
- 9~ yl)-1-methyl-ethoxymethyl]-phosphonic acid diisopropoxycarbonyloxymethyl ester (tenofovir disoproxil fumarate, Viread®) and (2R, 5S, cis)-4-amino-5- fluoro-l-(2~ hydroxymethyl-1,3-oxathiolan-5-yl)-(1H)-pyrimidin-2-one (emtricitabine, EmtrivaTM, (-)-cis FTC) and their physiologically functional derivatives. (gc.ca)
- Methyl groups are found within amino acids. (chemicalindustrynews.com)
Terminal1
- The terminal methyl groups is positioned at a distance of 1.06 angstrom from the O(4) plane in the side of the primary hydroxyl groups. (unict.it)
Electron groups1
- Count all electron groups and assign an electron-group arrangement. (cataleya-vb.de)
Biological4
- The purpose of this chapter is to describe the analytical methods that are available for detecting and/or measuring and monitoring methyl mercaptan in'environmental media and in biological samples. (cdc.gov)
- Methods for detection of methyl mercaptan in biological materials are summarized in Table 6-l. (cdc.gov)
- Methyl mercaptan has been determined in a variety of biological materials as shown in Table 6-l. (cdc.gov)
- Normally,'for determination in biological samples, methyl mercaptan is released from the sample matrix and collected on a column of solid sorbent, cryogenically or as headspace gas. (cdc.gov)
Hydrogen2
- Hydrogen sulfide (H2S), dimethyl sulfide ([CH3]2S), and dimethyl disulfide ([CH3]2S2) are other reduced sulfur compounds that may occur along with methyl mercaptan and are commonly determined along with it. (cdc.gov)
- The proposed photohydride, 10-methyl-9-phenyl-9, 10-dihydroacridine (PhAcrH) was oxidized to PhAcr+, with 52% conversion, while only 2.5% of hydrogen is liberated. (bgsu.edu)
Replication2
- The methyl groups are added to the DNA molecule after replication by machinery that is distinct from the machinery that replicates the DNA sequence creating within the hard chemistry of the DNA molecule itself a potential for differential information. (biomedcentral.com)
- Methylate helps accomplish this by donating methyl groups to fill in missing DNA sequence gaps during replication cycles. (healthy-living.org)
Process2
- The process in which a methyl group is covalently attached to a molecule. (ntu.edu.sg)
- Food can be contaminated by PAHs because of the contamination of air, water or soil, and during industrial process, as heating, drying and Polycyclic aromatic hydrocarbons (PAHs) are a group of over 200 smoking process. (bvsalud.org)
Polar1
- Hydroxyl groups are polar. (chemicalindustrynews.com)
Form2
- Transition metals and main group elements form especially robust clusters. (wikipedia.org)
- Complex cobalt containing molecule to which various groups are linked covalently to form cobalamine. (howmed.net)
Monomers1
- It has now been found that, surprisingly, the photosensitivity is considerably increased, the energy density required is considerably reduced and the information of the direction of the polarized irradiation light is retained in the course of energy transfer when copolymers composed of monomers having covalently bonded isomerizable or dimerizable groups and 2 composed of monomers having covalently bonded sensitizers are used to produce alignment layers. (allindianpatents.com)
Bond1
- This makes it possible to have two isomers of 2-butene, one with both methyl groups on the same side of the double bond and one with the methyl groups on opposite sides. (cataleya-vb.de)
Essential1
Shape1
- knoxville weather forecast 7 day Place the steps for determining the shape of a covalently bonded species in the correct order. (cataleya-vb.de)
Base1
- Rev. Conse- this group of the drugs mentioned (nothing but skin and angioedema refers to the base formulation [23]. (moorelifeurgentcare.com)
Addition1
- The NBT binding studies demonstrated that addition of EWG to BQ as exemplified by the chlorine substituted BQDs increased reactivity while addition of EDG as in the methyl substituted BQDs reduced reactivity. (cdc.gov)
Specific1
- Gas chromatography using sensitive and highly specific mass spectrometry (MS) or highly sensitive flame photometric detection (FPD) for detection is the analytical method of choice for the determination of methyl mercaptan in environmental samples. (cdc.gov)
Water2
Free1
- Free radicals constantly damage our DNA , knocking out methyl groups from our DNA. (healthy-living.org)
Found1
- Phosphate groups are found within phospholipids and nucleotides. (chemicalindustrynews.com)
Analysis1
- As a volatile material boiling at only 5.95°C (Windholz 1983), methyl mercaptan, CH3SH, also called methanethiol, is readily determined by gas chromatographic analysis. (cdc.gov)