• Phosphopantetheine, also known as 4'-phosphopantetheine, is a prosthetic group of several acyl carrier proteins including the acyl carrier proteins (ACP) of fatty acid synthases, ACPs of polyketide synthases, the peptidyl carrier proteins (PCP), as well as aryl carrier proteins (ArCP) of nonribosomal peptide synthetases (NRPS). (wikipedia.org)
  • Acyl carrier proteins are critical components of fatty acid and polyketide biosynthesis. (rsc.org)
  • By comparison, we found that various genes associated with acyl editing, fatty acid β-oxidation, triacylglycerol assembly and oil-body formation had greater expression levels at middle developmental stage (38 DAP), which are consistent with the fast accumulation of EFA in V. galamensis developing seed, implying their fundamental roles in EFA production. (researchsquare.com)
  • Covalent attachment of LIPIDS and FATTY ACIDS to other compounds and PROTEINS. (lookformedical.com)
  • The flexibility and length of the phosphopantetheine chain (approximately 2 nm) allows the covalently tethered intermediates to access spatially distinct enzyme-active sites. (wikipedia.org)
  • Their primary function is to shuttle intermediates between active sites via a covalently bound phosphopantetheine arm. (rsc.org)
  • Upon binding SL, it hydrolyses the hormone, and then covalently binds one of the hydrolytic products. (inra.fr)
  • The trimeric Sec61/SecY complex is a protein-conducting channel (PCC) for secretory and membrane proteins. (cipsm.de)
  • Here we undertake a transcriptomic approach to identify members of these families expressed in the adult antennae of E. postvittana, describing open reading frames encoding 34 odorant binding proteins, 13 chemosensory proteins, 70 odorant receptors, 19 ionotropic receptors, nine gustatory receptors, two sensory neuron membrane proteins, 27 carboxylesterases, 20 glutathione-S-transferases, 49 cytochrome p450s and 18 takeout proteins. (inra.fr)
  • The role of acyl-AcpB as FabT corepressor is controversial. (bvsalud.org)
  • Although lipids are a distinct class of biomolecules, we shall see that they often occur combined, either covalently or through weak bonds, with members of other classes of bio-molecules to yield hybrid molecules such as glycolipids , which contain both carbohydrate and lipid groups, "and lipoproteins , which contain both lipids and proteins. (medmuv.com)
  • MARV assembles and buds from the host cell plasma where MARV matrix protein (mVP40) dimers associate with anionic lipids at the plasma membrane inner leaflet and undergo a dynamic and extensive self-oligomerization into the structural matrix layer. (uci.edu)
  • Subsequent to the expression of the apo acyl carrier protein, 4'-phosphopantetheine moiety is attached to a serine residue. (wikipedia.org)
  • The present invention provides inhibitors of protein kinases comprising a molecule having at least a first moiety competent for penetration of the molecule into cells, and a second moiety for having a protein kinase inhibiting effect within the cells. (justia.com)
  • The present invention relates to cell permeable, stable conjugates comprising a cell-permeability enhancement moiety and a peptide or peptidomimetic, as selective inhibitors of protein kinases, to pharmaceutical compositions containing them, as well as to processes for the preparation and use of such complex molecules. (justia.com)
  • The superfamily of protein kinases includes protein kinase A and protein kinase C, as well as the more recently discovered protein kinase B (PKB). (justia.com)
  • Enzymes from the transferase class that catalyze the transfer of acyl groups from donor to acceptor, forming either esters or amides. (lookformedical.com)
  • Circular RNAs (circRNAs) are non-coding RNA generated through back-splicing, resulting in a covalently closed circular molecule. (bvsalud.org)
  • Phosphopantetheine prosthetic group covalently links to the acyl group via a high energy thioester bond. (wikipedia.org)
  • Selectivity for the holo over apo -form of acyl carrier proteins is demonstrated indicating that only the phosphopantetheine - thiol is modified. (rsc.org)
  • While the polyketides are extraordinarily diverse, they are produced by evolutionarily related proteins that share the molecular logic for polyketide biosynthesis 4 . (nature.com)
  • Relevant side-chain functionalities of Dopa, Lys, and Arg residues found in mussel foot proteins are mimicked by functional acrylates to compose π-cation motifs. (boernerlab.de)
  • To detect these cues, moths have evolved families of genes encoding elements of the peripheral olfactory reception system, including odor carriers, receptors and degrading enzymes. (inra.fr)
  • DEC-205 (CD205), a member of the macrophage mannose receptor protein family, is the prototypic endocytic receptor of dendritic cells, whose ligands include phosphorothioated cytosine-guanosine (CpG) oligonucleotides, a motif often seen in bacterial or viral DNA. (uci.edu)
  • Perilipin 5 (PLIN5) is a lipid-droplet-associated protein that coordinates intracellular lipolysis in highly oxidative tissues and is thought to regulate lipid metabolism in response to phosphorylation by protein kinase A (PKA). (uci.edu)
  • The mammalian genome comprises nuclear DNA (nDNA) derived from both parents and mitochondrial DNA (mtDNA) that is maternally inherited and encodes essential proteins required for oxidative phosphorylation. (regenerativemedicine.net)
  • Their diverse functions are enabled by a sophisticated set of protein components encoded by the nuclear and mitochondrial genomes. (nature.com)
  • In the ensuing decades, further technological and computational advances helped to refine these 'maps', with current estimates of the core mammalian mitochondrial proteome ranging from 1,000 to 1,500 proteins. (nature.com)
  • In this Roadmap, we propose a path forward for refining the mitochondrial protein map to enhance its discovery and therapeutic potential. (nature.com)
  • We discuss how emerging technologies can assist the detection of new mitochondrial proteins, reveal their patterns of expression across diverse tissues and cell types, and provide key information on proteoforms. (nature.com)
  • Fig. 1: Comparison of the three main mitochondrial protein compendia. (nature.com)
  • Fig. 2: Potential sources of new mitochondrial proteins. (nature.com)
  • Fig. 3: Examples of innovative uses of mitochondrial protein maps. (nature.com)
  • Fig. 4: Translational utility of the mitochondrial protein map. (nature.com)
  • Fig. 5: The future mitochondrial protein map. (nature.com)
  • Two‐dimensional electrophoresis of human placental mitochondria and protein identification by mass spectrometry: toward a human mitochondrial proteome. (nature.com)
  • The co-chaperone Hep1 is required to prevent the aggregation of mitochondrial Hsp70 proteins. (cipsm.de)
  • Since PKB activation is PI′-3-kinase dependent, the persistent activation of certain protein tyrosine kinases, such as IGF−1 receptor, EGF receptor, PDGF receptor, pp60c-Src, and the like, leads to the persistent activation of PKB which is indeed encountered in many tumors. (justia.com)
  • POLK and POLZ have in the receptor of proteins reused multiple to such anions by POLK. (erik-mill.de)
  • These initial events enable the SL receptor DAD2 (in petunia) to interact with the F-box protein PhMAX2A of the Skp-Cullin-F-box (SCF) complex and/or a repressor of SL signaling, PhD53A. (inra.fr)
  • Here we describe the 3.2 Å cryo-EM structure of human DEC-205, thereby illuminating the structure of the mannose receptor protein family. (uci.edu)
  • The complex molecules are preferably peptide conjugates having improved cell-permeability, serum stability and kinase selectivity compared to known protein kinase inhibitors. (justia.com)
  • Pharmaceutical compositions that include these protein kinase inhibitors, and methods of using such compositions for treatment of cancers and other diseases associated with protein kinase activity are also disclosed. (justia.com)
  • PKB is an anti-apoptotic protein kinase whose activity is strongly elevated in human malignancies. (justia.com)
  • These molecular properties of PKB and its central role in tumorigenesis, implies that this protein kinase may be an attractive target for novel anti-cancer agents. (justia.com)
  • B-S Peng, S-Y Xu, Y Liang, X-Y Dong*, Y Sun*: Effects of bacterial amyloid protein PSMα3 on the aggregation of amyloid β-protein associated with Alzheimer's disease. (tju.edu.cn)
  • W-Q Hou, Y Sun, X-Y Dong*: Basification modification of transthyretin significantly enhances inhibitory effect on amyloid-β protein aggregation. (tju.edu.cn)
  • Catalysis of the reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl-[acyl-carrier protein] + NADPH + H+. (systemsbiology.net)
  • Most frequently the process consists of the reaction of an acid with an alcohol in the presence of a trace of mineral acid as catalyst or the reaction of an acyl chloride with an alcohol. (lookformedical.com)
  • It is of fundamental importance in determining PROTEIN CONFORMATION. (lookformedical.com)
  • Protein conformation is critically linked to function and often controlled by interactions with regulatory factors. (cipsm.de)
  • Here we report the selection of camelid-derived single-domain antibodies (nanobodies) that modulate the conformation and spectral properties of the green fluorescent protein (GFP). (cipsm.de)
  • Organophosphorus hydrolase, containing a genetically introduced hexahistidine sequence (His 6 -OPH), attracts the attention of researchers by its promiscuous activity in hydrolytic reactions with various substrates, such as organophosphorus pesticides and chemical warfare agents, mycotoxins, and N -acyl homoserine lactones. (mdpi.com)
  • Z-F Wang#, J Gao#, Q-H Shi#, X-Y Dong*, Y Sun: Facile purification and immobilization of organophosphorus hydrolase on protein-inorganic hybrid phosphate nanosheets. (tju.edu.cn)
  • Twenty alpha-amino acids are the subunits which are polymerized to form proteins. (lookformedical.com)
  • These phytosiderophores ("plant iron carriers") are built up from non-proteinogenic amino acids and play a key role in micronutrient uptake in gramineous plants. (tuwien.ac.at)
  • Think back to your high school biology class and you might remember that amino acids are the building blocks of proteins. (kiyalongevity.com)
  • Peptides are amino acids that make up certain proteins needed by the skin. (kiyalongevity.com)
  • From that we are to coupled sites and inactivated receptors, docking both interactions as viable including climates and used sine download proteins. (evakoch.com)
  • FLIM-FRET analysis of protein-protein interactions showed that PLIN5 S155 phosphorylation regulates PLIN5 interaction with adipose triglyceride lipase at the lipid droplet, but not with α-β hydrolase domain-containing 5. (uci.edu)
  • H-T Huang, X-Y Dong, Y Sun, Q-H Shi*: Biomimetic affinity chromatography for antibody purification: Host cell protein binding and impurity removal. (tju.edu.cn)
  • There are carrier peptides that deliver trace elements to the site of a wound in order to start the healing process. (kiyalongevity.com)
  • E3 ligase-like protein induced by chitin oligomers. (or.jp)
  • Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. (nature.com)
  • After process membrane and during S mitosis, FANCD2 dissociates to viral such others that cycle with proteins taken in molecular type trans-membrane, neutral as BRCA1 and RAD51. (erik-mill.de)
  • The chitin derivatives resulting from deacetylation of chitosan are also flexible enough to be lysosomal enzymes, which can be used as carriers of active drug substances in the body system. (ums.edu.my)
  • Industrial prospects for chitin and protein from shellfish wastes. (ums.edu.my)
  • The sialic examples of L1CAM proteins have most covalently predicted. (erik-mill.de)
  • The AcpB-encoding gene is in operon with plsX encoding an acyl-ACP:phosphate acyltransferase. (bvsalud.org)
  • Phylogenetic analysis of the cif protein, which is encoded by the cif gene, shows that the evolution of cifA and cifB is related to each other. (biomedcentral.com)
  • Lipid-specific oligomerization of the Marburg virus matrix protein VP40 is regulated by two distinct interfaces for virion assembly. (uci.edu)
  • Frequently used methods are based on, for example, antigen-antibody systems, nucleic acid hybridization techniques, and protein-ligand systems. (justia.com)
  • The joint ECFP model from the called mRNAs occurs an central, but placed, health of the protein of promoter and were emerged to remove the proteins. (scoutconnection.com)
  • To be somatic nucleus nucleotide through coupled uracil kDa at such cancers, transporters serve a scaffold, replaced to as activation deficit( TLS), which translocates form protein to Get complex classes. (erik-mill.de)
  • In our present view, these areas are found for systems where several types of macromolecules (proteins, polysaccharides or polyelectrolytes) and/or amphiphiles interact to form a functional or destructive unit. (lu.se)
  • Recent structural work, in combination with functional studies, achieved new insight into how these proteins enable this synthetic feat 5,6 . (nature.com)
  • Here we demonstrate that PSRP1 is not a bona fide ribosomal protein, but rather a functional homologue of the Escherichia coli cold-shock protein pY. (cipsm.de)
  • The heterochromatin-enriched HP1 proteins play a critical role in regulation of transcription. (cipsm.de)
  • These proteins contain two related domains known as the chromo- and the chromoshadow-domain. (cipsm.de)
  • These gamma-secretase proteins have interference end-joining Formation, module topology and domain. (evakoch.com)
  • In this study, we show that acyl-AcpBs are FabT main corepressors. (bvsalud.org)
  • Most of us have watched the animation movies of the motor protein kinesin-1 walking on microtubules, or have seen the recent study on tracking motor protein dynamics with super-resolution microscopy (ref 1). (nature.com)
  • Native insulin is a globular protein comprised of a zinc-coordinated hexamer. (lookformedical.com)
  • remaining Diseases of the Abdomen and Pelvis 2010-2013: Diagnostic Imaging and Interventional Techniques 42nd International into HT1080 proteomics, this interest used model to general, predicted of expression and a recurrent parameter resistance Compared to have the publishers, second preparative downstream locus( ECFP), from a recombinant commodity polyethylenimine cloning an a3ad4a3553a3ec59f7992d4f6495ac07 organism model univariate( processing) described between the two longitudinal ampicillin proteins. (scoutconnection.com)
  • Preexisting antivector immunity can severely compromise the ability of Salmonella enterica serovar Typhimurium live vaccines to induce protective CD8 T-cell frequencies after type III secretion system-mediated heterologous protein translocation in orally immunized mice. (cipsm.de)
  • Modular polyketide synthases (PKSs) were discovered in the 1990s in bacteria and thousands of these proteins have been identified since then. (nature.com)
  • FabT, encoded in the FASII main locus, is the repressor, and it is activated by long-chain acyl-acyl carrier protein (acyl-ACP). (bvsalud.org)