Cortisol receptors. Medical search. Frequent questions

Cortisol predominantly affects target tissues through the genomic pathway, which involves interacting with cytoplasmic glucocorticoid receptors, and thereby, modulating stress-response gene expressions. (unab.cl)
Subcellular fractionation analysis revealed the presence of cell membrane glucocorticoid receptors. (unab.cl)
During chronic stress, there is hypersecretion of cortisol, creating a down-regulation of the glucocorticoid receptors. (chiroeco.com)
8 The increase in inflammatory by-products further damages the glucocorticoid receptors. (chiroeco.com)
Mothers unable to afford the move to safer neighborhoods had lower levels of glucocorticoid receptors. (umbc.edu)
Having fewer glucocorticoid receptors helped protect their bodies from being overwhelmed by high cortisol levels caused by stress. (umbc.edu)
Researchers also examined indicators of stress and found that both the treatment resistant and drug-free patients have reduced numbers of glucocorticoid receptors which are involved in the body's stress response. (kcl.ac.uk)

We talk about salivary cortisol and the adrenals. (spinalresearch.com.au)
We assessed salivary cortisol exposure and psychological mood state in 56 subjects (35 men and 21 women) screened for moderate stress and supplemented with a standardized/patented MP combination (Relora®, Next Pharmaceuticals) or Placebo for 4 weeks. (ironmagazine.com)
Changes in salivary cortisol and corticosteroid receptor- α mRNA expression following a 3-week multidisciplinary treatment program in patients with fibromyalgia. (bvsalud.org)

Caffeine (CAF) 10 mg/kg raised plasma cortisol and rendered the subjects slightly panicked. (nih.gov)
DZ counteracted YOH effects on plasma cortisol on panic but not on other subjective measures or plasma prolactin. (nih.gov)
Monitor 24-hour urinary free cortisol, serum or plasma cortisol, and patient's signs and symptoms periodically during ISTURISA treatment. (businesswire.com)
Stop ISTURISA and administer exogenous glucocorticoid replacement therapy if serum or plasma cortisol levels are below target range and patients have symptoms of adrenal insufficiency. (businesswire.com)

Most synthetic glucocorticoids (eg, methylprednisolone, dexamethasone) are minimally bound to cortisol-binding globulin and circulate freely, or they are weakly bound to albumin. (medscape.com)
At the cellular level, the actions of glucocorticoids are mediated by a 94-kd protein, the glucocorticoid receptor (GR). The human (h) GR belongs to the steroid/thyroid/retinoic acid superfamily of nuclear receptors and functions as a ligand-dependent transcription factor that regulates the expression of glucocorticoid-responsive genes positively or negatively. (medscape.com)
One way the herb can impact stress is through attenuating the increase of glucocorticoids cortisol and corticosterone. (nutritionaloutlook.com)
Every cell in the human body possesses receptors for glucocorticoids. (lifeextension.com)
Cortisol is the most important of the glucocorticoids. (lifeextension.com)
Still not completely understood is how specificity for glucocorticoids (e.g. cortisol) and mineralocorticoids (e.g. aldosterone) evolved in these receptors. (scivee.tv)
Glucocorticoid Receptor (NR3C1) is a receptor for glucocorticoids that can act as both a transcription factor and as a regulator of other transcription factors. (thermofisher.com)

Somatostatin analogs bind and activate human somatostatin receptors resulting in inhibition of ACTH secretion, which leads to decreased cortisol secretion. (medscape.com)
This action results in the inhibition of ACTH secretion, which in turn leads to decreased cortisol secretion. (medscape.com)
The basal daily rate of cortisol secretion is approximately 6-8 mg/m 2 body surface area, although this can increase as much as 10-fold in response to acute severe stress. (medscape.com)
It's been shown to increase the secretion of several hormones including GH and insulin-like growth factor 1 (IGF-1) and produces sustained increases in the plasma levels of these hormones without affecting cortisol levels. (medium.com)
Aims/hypothesis: Adrenal incidentaloma (AI) are very common, but optimal management of patients with AI and low-grade excess cortisol secretion is not established. (endocrine-abstracts.org)
The adrenal glucocorticoid, cortisol, is an essential stress hormone and its secretion follows a distinct rhythm regulated by the central circadian oscillator in the suprachiasmatic nucleus. (endocrine-abstracts.org)

Mifepristone is an antiprogestational agent, which, at low doses competitively binds to the intracellular progesterone receptor while, at high doses, competitively binds to the glucocorticoid receptor. (medscape.com)
Mifepristone (Korlym) is used to treat hyperglycemia (high blood sugar) in people with a certain type of Cushing's syndrome in which the body makes too much cortisol (a hormone) and who have failed surgery or cannot have surgery to treat this condition. (medlineplus.gov)
Mifepristone is in a class of medications called cortisol receptor blockers. (medlineplus.gov)
Mifepristone has high affinity for the GR-II receptor but little affinity for the GR-I (MR, mineralocorticoid) receptor. (centerwatch.com)
In addition, mifepristone appears to have little or no affinity for estrogen, muscarinic, histaminic or monoamine receptors. (centerwatch.com)

We knew that the GR's specific response to the stress hormone cortisol evolved from an ancestral vertebrate protein that responded to two other hormones - aldosterone and deoxycorticosterone - as well as to cortisol. (nature.com)
We also asked them to provide blood samples to examine the effects of stress at the cellular level, measuring the activity of genes that code for the receptors for the stress hormone cortisol . (umbc.edu)
It can bind the GHRH receptors in the pituitary gland and also stimulate the release and production of the growth hormone greatly. (vanillamist.com)
MK-677, or Ibutamoren, is a potent, long-acting, orally active, selective, and non-peptide agonist of the ghrelin receptor and a growth hormone secretagogue, mimicking the growth hormone (GH)-stimulating action of the endogenous hormone ghrelin . (medium.com)
When a hormone is present in excessive levels, the number of target-cell receptors may decrease. (proprofs.com)
When there is an excess of hormone, the target cells reduce the number of receptors on their surface to decrease their sensitivity to the hormone. (proprofs.com)
Recently, scientists have been documenting cortisol resistance, akin to other hormone resistances such as insulin. (huffpost.com)
Corticosteroids are synthetic substitutes for a hormone the body is supposed to produce on its own (cortisol). (northwestpharmacy.com)
Imbalances in this hormone can cause a multitude of health conditions and adjusting the amount of cortisol in your body can affect how your body responds to illness or chronic condition flare-ups. (northwestpharmacy.com)
Cortisol is a stress hormone that helps you recover from stress. (psychologytoday.com)
People may have the impression that the hormone, cortisol, leads to the experience of stress. (psychologytoday.com)
Most people equate the hormone cortisol with the experience of stress. (psychologytoday.com)
By making a few tweaks in your daily routine you can easily re-shape your receptors for a personal hormone tune-up, resulting in lasting weight control and well-being. (healthwisefoods.com)
Cortisol is an essential stress hormone and replacement with oral hydrocortisone is lifesaving in patients with adrenal insufficiency. (endocrine-abstracts.org)
Cortisol is a steroid hormone released by the adrenals, which sit on top of the kidneys. (chriskresser.com)
cell failure, nash or from the growth hormone receptors in gastrointestinal symptoms. (lorenzopetrantoni.com)
[ 3 ] Brain regions involved in homeostasis as well as reward responses have sex hormone receptors for estrogen and progesterone, making these hormones' active participants in the coordination of eating behavior via affecting gene expression of relevant molecules. (medscape.com)

To evaluate the relationship between white matter integrity and serum cortisol levels during a first depressive episode in drug-naive patients with MDD (MDD group) using a tract-based spatial statistics (TBSS) method. (cambridge.org)
Significant lowering of serum cortisol may result in hypotension, abnormal electrolyte levels, and hypoglycemia. (businesswire.com)
Diagnosis is by history of receiving corticosteroids or by finding elevated and/or relatively autonomous serum cortisol. (msdmanuals.com)

Nevertheless, high cortisol levels from chronic stress are linked to a number of negative mental and physical health outcomes . (umbc.edu)
Chronically high cortisol levels, which are associated with stress, have been shown to kill brain cells, cause premature aging in the brain, and decrease the rate at which new brain cells are made. (chriskresser.com)
My blood tests have shown that I have high cortisol levels at times during the day. (chriskresser.com)

ISTURISA lowers cortisol levels and can lead to hypocortisolism and sometimes life-threatening adrenal insufficiency. (businesswire.com)

How Addison's disease works is that it tells antibodies to attach to the adrenal cortex and destroy the cells that make cortisol and aldosterone. (northwestpharmacy.com)
ISTURISA blocks cortisol synthesis and may increase circulating levels of cortisol and aldosterone precursors and androgens. (businesswire.com)

Pasireotide is a cyclohexapeptide somatostatin analog that binds to human somatostatin receptors (HSSTs) 1, 2, 3, 4 and 5. (medscape.com)
In addition to the glucocorticoid effects that cortisol has because of binding to the glucocorticoid receptor (GR), cortisol can also bind to and activate the mineralocorticoid receptor (MR). When cortisol binds to the kidney, MR is physiologically inhibited by conversion of cortisol to its inactive metabolite cortisone by the enzyme 11beta-hydroxy-steroid dehydrogenase (11beta-OHSD2), which co-localizes with the MR. (medscape.com)
Stress triggers the release of cortisol, which, under normal conditions, binds to the glucocorticoid receptor and is anti-inflammatory. (chiroeco.com)
When cortisol binds to the glucocorticosteroid receptor, it activates a metabolic pathway that suppresses inflammation and immune responses. (thedollpalace.com)

The obtained results strongly suggest that cortisol acts through a non-genomic glucocorticoid receptor-mediated pathway to induce ROS production and contribute to ERK/CREB/PGC1-α signaling pathway activation as stress compensation mechanisms. (unab.cl)
These results suggest that cortisol has a mood-buffering effect. (psychologytoday.com)

At the end of the four weeks, the amount of cortisol in the saliva of the Relora users was 18 percent lower than in the subjects that had been given a placebo. (ironmagazine.com)

The second major physiological stress-response center, the HPA axis, regulates the release of cortisol , which influences many bodily functions such as metabolic, psychological and immunological functions . (wikipedia.org)
This is the system that ultimately leads to the release of cortisol. (psychologytoday.com)

It is a selective antagonist of the progesterone receptor at low doses and blocks the glucocorticoid receptor (GR-II) at higher doses. (centerwatch.com)

Cortisol receptor blockers inhibit the effect of cortisol at the glucocorticoid receptor. (medscape.com)

Pharmacologic therapy for osteoporosis includes most commonly the use of antiresorptive agents to decrease bone resorption, such as bisphosphonates, denosumab, and the selective estrogen-receptor modulator (SERM) raloxifene. (medscape.com)

all of these hormones' regulation is believed controlled, to some extent, by serotonin receptors in the brain. (erowid.org)
Examples of steroid hormones include cortisol, testosterone, and estrogen. (proprofs.com)
There are two hormones that an individual produces during a stressful situation, well known as adrenaline and cortisol . (wikipedia.org)
With reduced numbers of receptors, the body's ability to buffer stress through hormones such as cortisol is diminished, which increases the risk of more severe forms of depression. (kcl.ac.uk)
Adrenaline and cortisol are the two most notable hormones to address here. (lifehack.org)

This may activate mineralocorticoid receptors and cause hypokalemia, edema and hypertension. (businesswire.com)
3MGA and GA can bind to mineralocorticoid receptors with very low affinity, and 3MGA induces apparent mineralocorticoid excess syndrome through dose-dependent inhibition of 11ß-hydroxysteroid dehydrogenase type 2 in renal tissue. (bvsalud.org)

Moreover, myotube preincubation with RU486 and NAC completely suppressed cortisol- and cortisol-BSA-induced ROS production. (unab.cl)

Seven ancient mutations resulted in the GR's cortisol specificity. (nature.com)
The seven key mutations caused the evolution of cortisol specificity, but the five restrictive mutations had little or no effect on the protein's function. (nature.com)
This property allows SARMs the advantage of androgen-receptor specificity, tissue selectivity, and the lack of steroid-related side effects. (medium.com)

Studies have shown that AASs bind to glucocorticoid, progesterone, and estrogen receptors and exert multiple effects. (thedollpalace.com)

Cortisol also produces rapid effects via non-genomic pathways, which do not involve gene transcription. (unab.cl)
Finally, cortisol-BSA induced a significant increase in ERK1/2 and CREB phosphorylation, as well as in CREB-dependent transcriptional activation of the pgc1a gene expression. (unab.cl)
The glucocorticoid receptor (GR) is essential for the correct functioning of the HPA axis, thus alterations in the expression of the GR through altered methylation of the GR gene ( NR3C1 ) (and more specifically exon 1F) might contribute to the development of NSSI in individuals with a history of ACEs, as has been reported for different other mental disorders. (karger.com)
Research studies surveying behavioral associations with SNPs in the Oxytocin Receptor Gene (OXTR) have found links to emotional regulation, behaviors, personality traits, and socially-related diagnoses (1). (salimetrics.com)
2008). Association between the oxytocin receptor (OXTR) gene and autism: relationship to Vineland Adaptive Behavior Scales and cognition. (salimetrics.com)
2014). Common polymorphism in the oxytocin receptor gene (OXTR) is associated with human social recognition skills. (salimetrics.com)
2011). Oxytocin receptor gene (OXTR) is related to psychological resources. (salimetrics.com)
A) Schematic representation of the structure of the human glucocorticoid receptor (hGR) gene. (medscape.com)
Alternative splicing of the hGR gene in exon 9 generates 2 highly homologous receptor isoforms, termed α and β. (medscape.com)
This allows them to bind to intracellular receptors and directly affect gene expression. (proprofs.com)
Mutations in the Glucocorticoid Receptor gene are a cause of glucocorticoid resistance, or cortisol, resistance. (thermofisher.com)
Somatic mutations of the catalytic subunit of cyclic AMP-dependent protein kinase (PRKACA) gene in Japanese patients with several adrenal adenomas secreting cortisol [Rapid Communication]. (cdc.gov)

Instead, they bind to receptors on the cell surface, triggering a cascade of events that ultimately leads to the activation of a second messenger inside the cell. (proprofs.com)

The glucocorticoid receptor is an intracellular protein that, in its ligand-bound form, acts as a nuclear transcription factor to regulate the expression of a diverse array of genes in many areas of the body. (medscape.com)

Cortisol is an essential regulator of neuroendocrine stress responses in teleosts. (unab.cl)
Moreover, no studies have focused on the contribution of non-genomic cortisol pathways in compensatory stress responses in fish. (unab.cl)
Joseph Thornton, an evolutionary biologist at the Howard Hughes Medical Institute and the University of Oregon in Eugene, and his colleagues, used a unique approach to look at the evolution of the glucocorticoid receptor (GR) in vertebrates, a protein involved in the stress response. (nature.com)
2009). Oxytocin receptor genetic variation relates to empathy and stress reactivity in humans. (salimetrics.com)
In particular, Dr. Blackburn's group have documented that excess cortisol response to stress is associated with short telomeres. (huffpost.com)
We need to manage stress skillfully, keep cortisol from getting too high and/or too low, and keep our telomeres long. (huffpost.com)
Today, in part three of my series on the cortisol switch, I've add a few more practices to help you wrangle stress and cortisol, and limit the collateral damage of the cortisol switch. (huffpost.com)
Relora, a combination of extracts from the bark of two Asian trees, Magnolia officinalis and Phellodendron amurense, improves the state of mind of people suffering from mild stress and also lowers their cortisol levels. (ironmagazine.com)
Previous studies have shown the combination of Magnolia/Phellodendron (MP) to reduce both cortisol exposure and the perception of stress/anxiety, while improving weight loss in subjects with stress-related eating. (ironmagazine.com)
These results indicate that daily supplementation with a combination of Magnolia bark extract and Phellodendron bark extract (Relora®) reduces cortisol exposure and perceived daily stress, while improving a variety of mood state parameters, including lower fatigue and higher vigor. (ironmagazine.com)
Cortisol is released in response to stress, but what if I told you that it helps you feel better after stress? (psychologytoday.com)
Taking a dose of cortisol can actually reduce the negative effects of stress. (psychologytoday.com)
These findings counter our expectations but provide important information about how stress and cortisol interact. (psychologytoday.com)
From the beginning of stress to the peak cortisol response can take around 10 minutes. (psychologytoday.com)
What's cortisol doing if it does not even reach its peak until the stress is over? (psychologytoday.com)
In a study examining stress responses in a laboratory, people who showed a greater cortisol response to stress showed less negative mood than those who showed a lesser cortisol response. (psychologytoday.com)
In another study, people who received a dose of cortisol before experiencing stress also showed less negative mood than those who received a placebo . (psychologytoday.com)
In addition to preparing us to respond to stressful situations, our stress physiology (especially cortisol) helps us recover from the effects of stress. (psychologytoday.com)
It is also true in the brain, where cortisol attaches to specific receptors involved in mood, which help us return to our pre-stress emotional states. (psychologytoday.com)
Stress-induced cortisol level elevations are associated with reduced negative affect after stress: indications for a mood-buffering cortisol effect. (psychologytoday.com)
Later in the stress response, cortisol is released, enhancing the brain's use of glucose. (lifehack.org)
[3] In fact, for all people, the natural stress response elevates blood pressure and heart rate as well as cortisol levels, all of which increase blood sugar levels. (lifehack.org)

It does not decrease cortisol production but reduces the effects of excess cortisol, such as high blood sugar levels. (centerwatch.com)
Another problem with excess cortisol production is that it shortens your telomeres. (huffpost.com)
Uncontrolled studies reporting outcomes of adrenalectomy suggest improvements in cardiovascular risk, but all are subject to selection bias, and it is unclear if benefits are due to removal of excess cortisol. (endocrine-abstracts.org)

MK-677, also known as Ibutamoren, is often lumped together with Selective Androgen Receptor Modulators ( SARMs ). (medium.com)
Selective Androgen Receptor Modulators (SARMs) are a class of therapeutic compounds that have similar properties to anabolic agents, but with reduced androgenic properties . (medium.com)

The oxytocin receptor is found in various tissues in the human body, including in a woman's breast and uterus, and in both male and female testicles. (naturaltherapypages.com.au)
This oxytocin receptor provides oxytocin's action within these tissues. (naturaltherapypages.com.au)

A serotonin-containing nerve cell which is stimulated beyond a certain threshold 'fires,' releasing serotonin into the synapse, which then attaches to specialized sites on the 'receiving' nerve cell called 'receptors. (erowid.org)
Serotonin attaches to its receptors, thus modifying the electrical activity of the receiving cell, which in turn either fires itself, or is prevented from firing. (erowid.org)

The AF-1 plays an important role in the interaction of the receptor with molecules necessary for the initiation of transcription, such as coactivators, chromatin modulators, and basal transcription factors, including RNA polymerase II, TATA-binding protein (TBP), and a host of TBP-associated proteins (TAFIIs). (medscape.com)
Resting (basal) cortisol levels are normal everyday quantities that are essential for standard functioning. (wikipedia.org)

Your brain sends a memo through your neurons and then blood to your adrenal glands to pump up the volume on two key players: adrenaline and cortisol. (huffpost.com)
Adrenaline is a neurotransmitter, and it drops after 16 minutes, while cortisol stays high. (huffpost.com)
When adrenaline drops and cortisol stays high, you've got yourself a cortisol switch. (huffpost.com)

Higher daytime cortisol levels because of a hyperactive hypothalamic-pituitary-adrenal axis have been reported in patients with major depressive disorder (MDD). (cambridge.org)
Our findings indicate that the elevated cortisol levels in the MDD group may injure the white matter integrity in the frontal-subcortical and frontal-limbic circuits. (cambridge.org)
Looking at cortisol receptors offers a more cumulative measure of cortisol levels over time. (umbc.edu)
Reactive cortisol levels are increases in cortisol in response to stressors. (wikipedia.org)
Circulating cortisol levels are low at sleep onset, rise between 0200 and 0400 h, peak within an hour of waking and then de. (endocrine-abstracts.org)
My question relates to cortisol levels in general, and in particular, as they relate to fatigue and brain fog. (chriskresser.com)
Decrease or temporarily discontinue ISTURISA if urinary free cortisol levels fall below the target range, there is a rapid decrease in cortisol levels, and/or patients report symptoms of hypocortisolism. (businesswire.com)
Cushing syndrome is a constellation of clinical abnormalities caused by chronic high blood levels of cortisol or related corticosteroids. (msdmanuals.com)
A blood smear was stained with Leish- literature that the numbers of Fc and C3b man stain and was examined to determine receptors on the neutrophil surface increase the differential count and the proportion significantly in the 3rd trimester compared of band forms among the neutrophilic leu- with levels in non-pregnant women of kocytes. (who.int)
Androgen, cortisol, testosterone, and insulin levels were significantly correlated with reward and visual region activation. (medscape.com)

Some of the receptors are cation channels, which can directly depolarize the nociceptor upon activation, while other receptors activate second messenger systems to change neuronal excitability by changing expression of, or modifying the function of, other cation channels. (frontiersin.org)
MCs can secrete nociceptor sensitizing and activating agents, such as serotonin, prostaglandins, histamine, and proteolytic enzymes that can also activate the pain-mediating transient receptor potential vanilloid channels. (frontiersin.org)
The molecular underpinnings common to and connecting these disorders are not known, but may include shared genetic risk factors ( 1 , 8 ), regulation of brain cations ( 9 , 10 ), or common receptor signaling events that activate pain ( 11 ), inflammation ( 12 ), or oxidative ( 13 ) pathways. (frontiersin.org)
Cytokine receptors have a single trans-membrane domain and dimerisation is required to activate intra-cellular signalling pathways. (endocrine-abstracts.org)

Meals that are not properly balanced with blood sugar-stabilizing protein and fat also spike insulin, overwhelming receptor sites and triggering fat storage. (healthwisefoods.com)
When receptors are blocked or already saturated, insulin resistance occurs, giving rise to metabolic syndrome and contributing to high blood sugar and elevated triglycerides. (healthwisefoods.com)
If weight gain, cravings for sugar, intense hunger, feeling frequently hungry, difficulty concentrating, feeling anxious or panicky, lacking focus or motivation, fatigue are your major symptoms, then it is time to clean up your insulin receptor sites. (healthwisefoods.com)
Loss of cortisol rhythmicity is associated with fatigue, depression and insulin resistance. (endocrine-abstracts.org)

Agents in this class that decrease cortisol production and alter the peripheral metabolism of steroids may reduce morbidity. (medscape.com)

A treatment for systemic lupus erythematosus which works by inhibiting a key protein in the immune system called the IFNAR receptor. (lupus.org)
In common with other cytokine receptors the extra-cellular domain of the GHR is proteolitically cleaved and circulates as a binding protein. (endocrine-abstracts.org)

PRKACA mutations in cortisol-producing adenomas and adrenal hyperplasia: a single-center study of 60 cases. (cdc.gov)

However, it rapidly decreases cortisol concentration and may be used as an adjunct to impending surgical procedure. (medscape.com)

It also doesn't release cortisol or prolactin. (vanillamist.com)

Your hippocampus is the place in your brain where you integrate memory, and high cortisol shrinks the hippocampus. (huffpost.com)
Honokiol interacts with the GABA-A receptor in the brain. (ironmagazine.com)
In this podcast, you'll learn how to diagnose high cortisol and how to protect your brain if you're suffering from this problem. (chriskresser.com)

In this study, rainbow trout (Oncorhynchus mykiss) skeletal myotubes were stimulated with physiological concentrations of cortisol and cortisol-BSA, a membrane-impermeable agent, resulting in an early induction of reactive oxygen species (ROS). (unab.cl)

Cortisol is released to prepare us to respond to stressful situations. (psychologytoday.com)
In a quick stressful situation, cortisol may not even be released until the situation is over. (psychologytoday.com)

Cortisol has a diurnal rhythm regulated by the central body clock and this rhythm is a metabolic signal for peripheral tissue clocks. (endocrine-abstracts.org)
Association of glucocorticoid receptor haplotypes with body composition and metabolic parameters in HIV-infected patients from the FRAM study. (cdc.gov)

One remarkable study in people with social phobia examined the impact of a single dose of cortisone (a synthetic version of cortisol) on fear responses to a social stressor. (psychologytoday.com)

It does so by binding it with the GHRP receptors and then activates the GH release. (vanillamist.com)

This is true in the body, where cortisol helps to reduce inflammation. (psychologytoday.com)
Inflammation-from a variety of seemingly unrelated factors-can alter the shape of our receptors, making our hormonal "keys" ineffective. (healthwisefoods.com)

Although cortisol-mediated genomic pathways are well documented in teleosts, non-genomic pathways are not fully understood. (unab.cl)

This makes the pituitary think there is not enough cortisol. (chiroeco.com)
ISTURISA (osilodrostat) is a cortisol synthesis inhibitor indicated for the treatment of adult patients with Cushing's disease for whom pituitary surgery is not an option or has not been curative. (businesswire.com)

Glucocorticoid Receptor can also be found in heteromeric cytoplasmic complexes along with heat shock factors and immunophilins. (thermofisher.com)

7 This increases binding to the mineral corticoid receptors, having a pro-inflammatory effect. (chiroeco.com)

Cushing's syndrome secondary to ectopic cortisol production by an ovarian carcinoma. (medscape.com)
Common genetic variants in the glucocorticoid receptor and the 11ß-hydroxysteroid dehydrogenase type 1 genes influence long-term cognitive impairments in patients with Cushing's syndrome in remission. (cdc.gov)

Anatomy19

Organisms10

Diseases29

Chemicals and Drugs90

Analytical, Diagnostic and Therapeutic Techniques and Equipment38

Psychiatry and Psychology31

Phenomena and Processes33

Disciplines and Occupations1

Anthropology, Education, Sociology and Social Phenomena8

Technology, Industry, Agriculture2

Humanities1

Information Science1

Named Groups3

Health Care16

Glucocorticoid Receptors7

Salivary cortisol3

Plasma cortisol4

Glucocorticoids7

Secretion6

Mifepristone5

Hormone17

Serum3

High cortisol levels3

Lowers cortisol levels1

Aldosterone2

Binds4

Suggest that cortisol2

Amount of cortisol1

Release of cortisol2

Progesterone receptor1

Blockers1

Selective estrogen-1

Hormones5

Mineralocorticoid receptors2

Ru4861

Specificity3

Estrogen Receptors1

Gene12

Bind1

Intracellular1

Stress22

Excess3

Androgen Receptor2

Oxytocin receptor2

Attaches2

Basal2

Adrenaline3

Levels10

Activate4

Insulin4

Decrease1

Protein2

Mutations1

Decreases1

Prolactin1

Brain3

Physiological1

Stressful2

Metabolic2

Cortisone1

Activates1

Inflammation2

Pathways1

Pituitary2

Cytoplasmic1

Increases1

Cushing's2