Cortical neuron. Medical search. Frequent questions

To demonstrate the potential utility of the approach, we examine the major peptide associated with the initiation of Alzheimer's disease, amyloid β-protein (Aβ) at a patho-physiologically relevant concentration in mouse cortical neurons. (bris.ac.uk)

Fading memory relies on recurrent activity patterns in a neuronal network, whereas hidden memory is encoded using synaptic mechanisms, such as facilitation, which persist even when neurons fall silent. (jneurosci.org)
What we have achieved is to bridge these two realms with unprecedented detail, linking electrical activity in neurons with the nanoscale synaptic connections they make with one another. (neurosciencenews.com)
However, the basic function of the perceptron, a linear summation of its inputs and thresholding for output generation, highly oversimplifies the synaptic integration processes taking place in real neurons. (biorxiv.org)
In summary, local neurosteroids influence synaptic transmission during a crucial period of cortical neurodevelopment, findings which may be of importance for establishing normal network connectivity. (dundee.ac.uk)
2010). How the axotomy influences the synaptic structures of the lesioned corticospinal neurons has not been explored. (moam.info)
Basal forebrain cholinergic neurons (BFCNs) modulate synaptic plasticity, cortical processing, brain states and oscillations. (wustl.edu)
Additive impairment of synaptic signaling in cultured cortical neurons by exogenously-applied oligomerized amyloid-beta and airborne nanoparticle s generated during photocopying. (cdc.gov)

Visual-auditory spatial processing in auditory cortical neurons. (ox.ac.uk)

Hidden memories were detected by altered responses of neurons to additional stimulation, and this effect persisted longer than 1 s. (jneurosci.org)
We will measure the effect of soluble a-beta on individual synapses by imaging calcium dynamics in dendritic spines of somatosensory cortical neurons in response to whisker stimulation. (alzheimer-europe.org)
MicrocircuitDB: Biophysically realistic neuron models for simulation of cortical stimulation (Aberra et al. (yale.edu)
Biophysically realistic neuron models for simulation of cortical stimulation (Aberra et al. (yale.edu)
1 . Aberra AS, Peterchev AV, Grill WM (2018) Biophysically realistic neuron models for simulation of cortical stimulation. (yale.edu)
Neurons responsive to visual stimulation have now been described in the auditory cortex of various species, but their functions are largely unknown. (ox.ac.uk)
Spatial sensitivity for visual, auditory and bisensory stimulation was highest in the anterior dorsal field, the auditory area previously shown to be innervated by a region of extrastriate visual cortex thought to be concerned primarily with spatial processing, whereas the posterior pseudosylvian field and posterior suprasylvian field, whose principal visual input arises from cortical areas that appear to be part of the 'what' processing stream, conveyed less information about stimulus location. (ox.ac.uk)
In some neurons, pairing visual and auditory stimuli led to an increase in the spatial information available relative to the most effective unisensory stimulus, whereas, in a smaller subpopulation, combined stimulation decreased the spatial MI. (ox.ac.uk)
Optogenetic stimulation and recording of these GABA neurons in mice revealed that they can discharge in rhythmic bursts at theta frequencies and drive theta activity in limbic cortex. (touro.edu)
We used single neuron recordings and controlled whisker deflections to examine responses of thalamocortical neurons to sensory stimulation in rat survivors of 9 min of asphyxial cardiac arrest incurred on post-natal day 17. (cdc.gov)

This study will measure and differentiate between the effects of soluble a-beta and insoluble plaques on cortical function at several levels: at the level of the single synapse (calcium dynamics in dendritic spines), single neuron (electrophysiology of subthreshold inputs and spike outputs) and cortical network (receptive field organization) in the intact animal. (alzheimer-europe.org)

The cholinergic neurons in the pontomesencephalic tegmentum have been shown to discharge in association with and promote cortical activation during active or attentive waking and paradoxical or rapid eye movement sleep. (touro.edu)
However, GABA neurons lie intermingled with the cholinergic neurons and may contribute to or oppose this activity and role. (touro.edu)
pNon-GABA, which likely included cholinergic, neurons were inhibited during each light pulse to discharge rhythmically in antiphase to the pGABA neurons. (touro.edu)
Such phasic bursting by GABA neurons also occurred in WT mice in association with theta activity during attentive waking and paradoxical sleep.SIGNIFICANCE STATEMENT Neurons in the pontomesencephalic tegmentum, particularly cholinergic neurons, play an important role in cortical activation, which occurs during active or attentive waking and paradoxical or rapid eye movement sleep. (touro.edu)
Yet the cholinergic neurons lie intermingled with GABA neurons, which could play a similar or opposing role. (touro.edu)
Bursting cholinergic neurons (Burst-BFCNs) fired synchronously, phase-locked to cortical theta activity and fired precisely timed bursts after reward and punishment. (wustl.edu)
Regular-firing cholinergic neurons (Reg-BFCNs) were found predominantly in the posterior basal forebrain, displayed strong theta rhythmicity and responded with precise single spikes after behavioral outcomes. (wustl.edu)

Here, we show that the Kv2 family members Kv2.1 and Kv2.2 are expressed in distinct cortical layers and pyramidal cell types associated with specific corticostriatal pathways. (jneurosci.org)
Compartmental simulations of an anatomically characterized cortical pyramidal cell were carried out to study the integrative behavior of a complex dendritic tree. (mit.edu)
We trained deep neural networks (DNNs) to mimic the I/O behavior of a detailed nonlinear model of a layer 5 cortical pyramidal cell, receiving rich spatio-temporal patterns of input synapse activations. (biorxiv.org)
It is characterized by pyramidal cell loss in the frontal and temporal lobes and degeneration of motor neurons in the hypoglossal nucleus and spinal motor neurons. (medscape.com)

These are 3-repeat tau-immunopositive bodies predominantly located in granular neurons in the hippocampal dentate gyrus, hippocampal CA1 pyramidal neurons, and layer II of frontal and temporal cortices. (medscape.com)

Surprisingly, the results demonstrate that Foxp2 function is not required for many function s that it has been proposed to regulate, and therefore plays a more limited role in cortical development than previously thought. (datadryad.org)

SIGNIFICANCE STATEMENT Neurons within the neocortex are arranged in a laminar architecture and contribute to the input, processing, and/or output of sensory and motor signals in a cell- and layer-specific manner. (jneurosci.org)

As a result of local nonlinear dendritic processing, a train of output spikes are generated in the neuron axon, carrying information that is communicated, via synapses, to thousands of other (postsynaptic) neurons. (biorxiv.org)
Automated high content image analysis of dendritic arborization in primary mouse hippocampal and rat cortical neurons in culture. (escholarship.org)
However, analyzing dendritic morphology is challenging, particularly in cultures with high cell density, and manual methods of selecting neurons and tracing dendritic arbors can introduce significant bias, and are labor-intensive. (escholarship.org)
The new functions for assessing dendritic morphology were validated using primary mouse hippocampal and rat cortical neurons transfected with a fluorescently tagged MAP2 cDNA construct. (escholarship.org)
Compared to manual or semi-automated analyses of dendritic arborization, the new functions increase throughput while significantly decreasing researcher bias associated with neuron selection, tracing, and thresholding. (escholarship.org)
However, these changes are superimposed in individuals with reduced brain volume, especially in the hippocampus, and other developmental abnormalities, such as reduced dendritic arborizations, decreased number of spines, spine atrophy, and abnormalities of spine orientation in pyramidal neurons. (medscape.com)
However, because these changes are superimposed on individuals that already have a reduced brain volume, especially in the hippocampus, and other developmental abnormalities, such as reduced dendritic arborizations, decreased number of spines, spine atrophy, and abnormalities of spine orientation in pyramidal neurons, this form of AD is not an exact biologic model or a replica of the AD seen in persons without DS. (medscape.com)
We were also the first to identify and map the dopaminergic projections to the habenula and the spinal cord, and reveal the special dendritic projections from the nigra compacta neurons that allow dopamine to be released from dendrites in the pars reticulata. (lu.se)
4. Björklund, A., Lindvall, O.: Dopamine in dendrites of substantia nigra neurons: suggestions for a role in dendritic terminals. (lu.se)

Finally, we will measure the effects of soluble a-beta and plaques on the receptive field organization of Layer II/III somatosensory cortical neurons to quantify the effects of the neuropathology on an intact neocortical network. (alzheimer-europe.org)

doi:10.1016/j.neuron.2015.04.004. (wikipedia.org)
doi: 10.1016/j.neuron.2013.07.034. (nih.gov)

Experience-dependent adult cortical plasticity requires cognitive association between sensation and reward. (bvsalud.org)
A microtubule-associated protein that is primarily found in neuronal precursor cells and immature NEURONS in embryonic and adult cortical structures. (bvsalud.org)

Teams of annotators on both coasts of the United States simultaneously traced individual neurons through the 3D stacks of images and located connections between individual neurons. (neurosciencenews.com)
To do so, we recorded the spiking activity of on average ∼300 well-isolated individual neurons from organotypic cortical cultures. (biorxiv.org)

We find that Kv2.1 and Kv2.2 exhibit distinct responses to acute phosphorylation-dependent regulation in brain neurons in situ and in heterologous cells in vitro . (jneurosci.org)
Here we use intracellular recordings in somatosensory cortex (SI) neurons of anesthetized rats to show that remote, subthreshold intracortical electrical perturbation can impact such constraints on the responses to a set of spatiotemporal tactile input patterns. (lu.se)
We quantified the spatial tuning of neurons by measuring the responses to stimuli presented across a range of azimuthal positions and calculating the mutual information (MI) between the neural responses and the location of the stimuli that elicited them. (ox.ac.uk)
In an auditory detection task, synchronization of Burst-BFCNs to the auditory cortex predicted the timing of behavioral responses, whereas tone-evoked cortical coupling of Reg-BFCNs predicted correct detections. (wustl.edu)
The limbic system is a grouping of cortical and subcortical structures involved in memory formation and emotional responses. (medscape.com)
Despite the overall increase in firing, by 6 weeks, thalamocortical neurons display degraded receptive fields, with decreased responses to adjacent whiskers. (cdc.gov)

We are now poised to discover cortical connectivity motifs, which may act as building blocks for cerebral network function. (neurosciencenews.com)
Neuroscientists use the term cortical spreading depression to represent at least one of the following cortical processes:[citation needed] The spreading of a self-propagating wave of cellular depolarization in the cerebral cortex. (wikipedia.org)
We found that, although BDNF levels in cultured neurons from the cerebral cortex of low birth weight pups with IUGR were unchanged, TrkB (BDNF receptor) was decreased compared with control-rats. (elsevierpure.com)

Cortical Neuron Maintenance Medium is designed for in vitro culture of iPSC-derived cortical neurons. (ixcellsbiotech.com)
Each lot was tested for the in vitro culture of iPSC-derived cortical neuons. (ixcellsbiotech.com)
Neuronal PKD1 inactivation by pharmacological inhibition or lentiviral silencing in vitro, or by genetic inactivation in neurons in vivo, strongly enhances excitotoxic neuronal death. (nature.com)
These in vitro findings predict that a fleeting excitotoxic insult could act synergistically with complement to destroy cortical neurons and accelerate neurological deterioration. (duke.edu)
Here we investigated in vitro and in vivo the properties, activities, and role of GABA neurons within the laterodorsal tegmental and sublaterodorsal tegmental nuclei (LDT/SubLDT) using male and female transgenic mice expressing channelrhodopsin-(ChR2)-EYFP in vesicular GABA transporter (VGAT)-expressing neurons. (touro.edu)

The aim was to investigate the protective effect of the pre-treatment with lithium on amyloid-beta (Aβ)-induced toxicity and telomere length in neurons. (mdpi.com)

For each neuron, we quantified the amount of computation it performed based on its inputs. (biorxiv.org)
Sensory cortices receive inputs not only from thalamus but also from higher-order cortical regions. (nih.gov)
2013) show that motor cortical inputs can switch barrel cortex into a desynchronized state that enables more faithful representation of subtle sensory stimuli. (nih.gov)

Are Sensory Neurons in the Cortex Committed to Original Trigger Features? (intechopen.com)

The Kv2 family of voltage-gated potassium channel α subunits, comprising Kv2.1 and Kv2.2, mediate the bulk of the neuronal delayed rectifier K + current in many mammalian central neurons. (jneurosci.org)
Cortical lamination is characteristic of the mammalian neocortex. (tmu.edu.tw)

Neurons of different cortical layers express diverse populations of ion channels and possess distinct intrinsic membrane properties. (jneurosci.org)
Here, anatomical and molecular phenotypes of the cortical neuron populations that express FOXP2 were characterized. (datadryad.org)
These functions allow users to select specific populations of neurons as a training set for subsequent automated selection of labeled neurons in high-density cultures. (escholarship.org)
Susceptible neuronal populations also include inhibitory neurons in the thalamic Reticular Nucleus. (cdc.gov)

Electrophysiological activity was recorded from primary cultures of dissociated rat cortical neurons plated on multielectrode arrays. (jneurosci.org)
To do so, we combined network analysis with information theoretic tools to analyze the spiking activity of hundreds of neurons recorded from organotypic cultures of mouse somatosensory cortex. (biorxiv.org)
Proteins extracted from primary cultures of cortical neurons were digested with trypsin followed by fractionation using strong cation exchange chromatography. (usuhs.edu)
Furthermore, in IUGR-rat cultures, anti-apoptotic protein Bcl2 was decreased and BDNF failed to prevent neurons from cell death caused by serum-deprivation. (elsevierpure.com)
In contrast, docosahexaenoic acid treatment (6 μM) increased docosahexaenoic acid content and attenuated glucocorticoid hormone corticosterone (200 μM)-induced cell death (72 hours) in cortical cultures. (pasteur.fr)

AUTHOR SUMMARY Here we answer the question of whether rich club topology in functional cortical circuits supports neural computation as it has been previously shown to do for information propagation. (biorxiv.org)
The weight matrices of the DNN provide new insights into the I/O function of cortical pyramidal neurons, and the approach presented can provide a systematic characterization of the functional complexity of different neuron types. (biorxiv.org)
More interestingly, these deep-layer neurons extend their axons to specific cortical and subcortical sites, which substantially contribute to functional cortical circuitry development and organisation. (tmu.edu.tw)

demonstrate through studies on induced pluripotent stem cell-derived cortical neurons that miR-33a is a potential therapeutic target for the treatment of SPG4-related hereditary spastic paraplegia. (portlandpress.com)

Using in vivo intracellular recordings, we found that epileptic discharges are initiated in layer 5/6 neurons of this cortical region. (moam.info)
Presumed GABA (pGABA) neurons were identified by response to photostimulation and verified by immunohistochemical staining following juxtacellular labeling in vivo pGABA neurons were found to be fast-firing neurons with the capacity to burst when depolarized from a hyperpolarized membrane potential. (touro.edu)
When stimulated in vivo in urethane-anesthetized or unanesthetized mice, the pGABA neurons fired repetitively at relatively fast rates (∼40 Hz) during a continuous light pulse or phasically in bursts (>100 Hz) when driven by rhythmic light pulses at theta (4 or 8 Hz) frequencies. (touro.edu)
Assessment of brain metabolite correlates of adeno-associated virus-mediated over-expression of human alpha-synuclein in cortical neurons by in vivo (1) H-MR spectroscopy at 9.4 T. (lu.se)

We found that activation of D 4 receptors, but not D 2 receptors, induced a rapid translocation of α-CaMKII from cytosol to postsynaptic sites in cultured PFC neurons. (aspetjournals.org)

Our results demonstrate that cortical neurons can be conceptualized as multi-layered "deep" processing units, implying that the cortical networks they form have a non-classical architecture and are potentially more computationally powerful than previously assumed. (biorxiv.org)
By precisely titrating the number of neurons stimulated, we demonstrate that the lower bound for perception of cortical activity is ~14 pyramidal neurons. (ox.ac.uk)
We found that 48-72 hours after cardiac arrest, thalamocortical neurons demonstrate significantly elevated firing rates both during spontaneous activity and in response to whisker deflections. (cdc.gov)

In cultured frontal cortical neurons, however, 3-BTBZ-induced ERK1/2 phosphorylation was significantly more potent than cAMP signaling, with a more prolonged signaling profile than that in HEK293T cells. (monash.edu)
Furthermore, knock down of β-arrestin-2 in frontal cortical neurons abolished 3-BTBZ-induced ERK1/2 phosphorylation, but not cAMP accumulation. (monash.edu)
Patients with motor neuron disease (MND) are generally free of cognitive impairment, but evidence is growing to support an association between MND and frontal lobe or frontotemporal dementia (FTD). (medscape.com)
Signs and symptoms reflect frontal and temporal lobe dysfunction with lower motor neuron-type weakness, muscle atrophy, and fasciculations. (medscape.com)
Marked neuronal loss and cortical atrophy, especially in right ventral and dorsal frontal and anterior temporal regions. (medscape.com)

An initially normal sensory thalamus was repatterned to match the aberrant S1 map by apoptotic deletion of thalamic neurons representing body parts with axons excluded from S1. (nature.com)
Below the cortex are axons, which are long fibers that emanate from and connect neurons. (medscape.com)

We also review current models for the mechanisms of GABA-mediated synchronization of neural activity, focusing on parvalbumin-positive GABA neurons, which are altered in schizophrenia and whose function has been strongly linked to the production of neural synchrony. (hindawi.com)

Worldwide, frontotemporal lobe dementia with motor neuron disease (FTD/MND) is a sporadic condition with an unknown etiology. (medscape.com)
We report two cases of dementia in which cortical degeneration with widespread swollen chromatolytic neurons (SCN) was the dominant pathologic feature. (bvsalud.org)
Dementia with Lewy bodies is chronic cognitive deterioration characterized by cellular inclusions called Lewy bodies in the cytoplasm of cortical neurons. (msdmanuals.com)

Adaptation-induced changes in the temporal-frequency tuning and direction selectivity of cat visual cortical cells were studied. (cambridge.org)
Noticing familiar objects in real world scenes: the role of temporal cortical neurons in natural vision. (bvsalud.org)

Data now suggest that delocalization, accumulation, and ubiquitination of TDP-43 in the cytoplasm of motor neurons are early dysfunctions in the cascade of the events leading to motor neuron degeneration in ALS. (medscape.com)

We found that fleeting activation of ionotropic glutamate receptors sensitizes neurons but not astrocytes to complement attack. (duke.edu)
Astrocytes are abundant cell types in the vertebrate central nervous system and can act as neural stem cells in specialized niches where they constitutively generate new neurons. (frontiersin.org)
Therefore, finding out molecular mechanisms by which reactive astrocytes can be coaxed into neurons will be of utmost importance for regenerative therapies as these astrocytes are the imminent cell types around the lesion site. (frontiersin.org)
Moreover, glucocorticoid hormone corticosterone (200 μM, 72 hours) decreased the percentage composition of neurons while increasing the percentage of astrocytes as assessed by βIII-tubulin and glial fibrillary acidic protein immunostaining, respectively. (pasteur.fr)

It is still not clear whether HN protects the neurons through the attenuation of mitochondrial dysfunction. (scienceopen.com)

The reciprocal rhythmic bursting by the pGABA and pNon-GABA neurons drove rhythmic theta activity in the EEG. (touro.edu)

Robust network of connections between neurons performing similar tasks shows fundamentals of how brain circuits are wired. (neurosciencenews.com)
Even the simplest networks of neurons in the brain are composed of millions of connections, and examining these vast networks is critical to understanding how the brain works. (neurosciencenews.com)
An international team of researchers, led by R. Clay Reid, Wei Chung Allen Lee and Vincent Bonin from the Allen Institute for Brain Science, Harvard Medical School and Neuro-Electronics Research Flanders (NERF), respectively, has published the largest network to date of connections between neurons in the cortex, where high-level processing occurs, and have revealed several crucial elements of how networks in the brain are organized. (neurosciencenews.com)
Neurons are the computational building blocks of the brain. (biorxiv.org)
The earliest born neurons form the deepest layer, of which only a minor proportion of its constituent neurons remain as the brain matures. (tmu.edu.tw)
Many theories of brain function propose that activity in sparse subsets of neurons underlies perception and action. (ox.ac.uk)
The release of neurotransmitters relays signals between neurons and is critical for normal brain function. (medlineplus.gov)
Syntaxin-binding protein 1 is also thought to play a role in the positioning and growth of neurons during brain development. (medlineplus.gov)
Research suggests that a shortage of syntaxin-binding protein 1 also impairs neuron development in the brain, which could underlie encephalopathy and other neurological problems characteristic of this condition. (medlineplus.gov)
The focus of my postdoctoral work was to sort out the anatomical organization of the dopamine and noradrenaline neuron systems in the brain using the new glyoxylic acid histofluorescence method. (lu.se)
2. Lindvall, O., Björklund, A.: The organization of the ascending catecholamine neuron systems in the rat brain as revealed by the glyoxylic acid fluorescence method. (lu.se)

However, factors that determine deep-layer neuron axon projection patterns and targets are largely elusive. (tmu.edu.tw)

Kv2.1 exhibits robust expression across many neuron types and is unique in its conditional role in modulating intrinsic excitability through changes in its phosphorylation state, which affect Kv2.1 expression, localization, and function. (jneurosci.org)
Analyses of endogenous Kv2.2 in cortical neurons in situ and recombinant Kv2.2 expressed in heterologous cells reveal that Kv2.2 is largely refractory to stimuli that trigger robust, phosphorylation-dependent changes in Kv2.1 clustering and function. (jneurosci.org)

We have found some of the first anatomical evidence for modular architecture in a cortical network as well as the structural basis for functionally specific connectivity between neurons," Lee adds. (neurosciencenews.com)

To place a lower bound on the amount of neural activity that can be perceived, we used an all-optical approach to drive behaviour with targeted two-photon optogenetic activation of small ensembles of L2/3 pyramidal neurons in mouse barrel cortex while simultaneously recording local network activity with two-photon calcium imaging. (ox.ac.uk)

Here we investigate the auditory and visual spatial sensitivity of neurons recorded in 5 different primary and non-primary auditory cortical areas of the ferret. (ox.ac.uk)

Lee and Bonin began by identifying neurons in the mouse visual cortex that responded to particular visual stimuli, such as vertical or horizontal bars on a screen. (neurosciencenews.com)

Finally, these findings highlight the context-dependence of GPCR signaling in recombinant cells and neurons, offering new insights into translationally relevant GPR52 signaling mechanisms. (monash.edu)

Transient pioneer neurons in the neocortical marginal zone generate an early corticofugal axonal projection at E12-E16 (Meyer et al. (nih.gov)

With the recent development of sophisticated genetical, optical and electrical techniques it has become clear that many key neuron types (e.g., cortical and hippocampal pyramidal neurons, cerebellar Purkinje cells) are highly complicated I/O information processing devices. (biorxiv.org)
These neurons, which show a distinctive hyperactivity associated with a membrane depolarization, lead the firing of distant cortical cells during the epileptic discharge. (moam.info)
A subset of cortical somatostatin (SST) neurons, the Martinotti cells, gate top down input by inhibiting the apical dendrites of pyramidal cells in laye. (researchgate.net)

Immunocytochemistry and voltage-clamp recordings from outside-out macropatches reveal distinct cellular expression patterns for Kv2.1 and Kv2.2 in intratelencephalic and pyramidal tract neurons of L5, indicating circuit-specific requirements for these Kv2 paralogs. (jneurosci.org)

and the large and prolonged Ca 2 + spike at the apical dendrite of L5 cortical pyramidal neurons ( M E Larkum, Zhu, and Sakmann 1999 ). (biorxiv.org)

DHP), greatly prolonged the mIPSCs of P20 pyramidal neurons, demonstrating these more mature neurons retain the capacity to synthesize GABAaR-active neurosteroids, but now lack the endogenous steroid substrate. (dundee.ac.uk)

Kv2.1 expression is consistently high throughout all cortical layers, especially in layer (L) 5b pyramidal neurons, whereas Kv2.2 expression is primarily limited to neurons in L2 and L5a. (jneurosci.org)
In this study, excitatory toxicity was induced by NMDA, which binds the NMDA receptor in primarily cultured rat cortical neurons. (scienceopen.com)

The activation of GABAA receptors with muscimol, as well as bath application of glutamate, lead to increases in [Ca2+]i in pioneer neurons. (nih.gov)
Consistent with such results, immunocytochemical studies showed a prominent expression of GABAA and NMDA receptors in pioneer neurons. (nih.gov)
The activation of such receptors may be implicated in the remodelling of pioneer neurons during development. (nih.gov)
Scholars@Duke publication: Fleeting activation of ionotropic glutamate receptors sensitizes cortical neurons to complement attack. (duke.edu)

In total, our findings indicate that rich club topology in effective cortical circuits supports not only information propagation but also neural computation. (biorxiv.org)

Discharge and Role of GABA Pontomesencephalic Neurons in Cortical Acti" by Youssouf Cissé, Masaru Ishibashi et al. (touro.edu)

Second, based on this mechanism, the NMDA-rich neuron is shown to be capable of solving a nonlinear pattern discrimination task. (mit.edu)

Much less is known of the highly related Kv2.2 subunit, especially in forebrain neurons. (jneurosci.org)
However, the duration of mIPSCs recorded from L2/3 cortical neurons derived from α1 subunit deleted mice, were similarly under the developmental influence of a neurosteroid tone. (dundee.ac.uk)

Here, through combined use of cortical layer markers and transgenic mouse lines, we show that Kv2.1 and Kv2.2 are localized to functionally distinct cortical cell types. (jneurosci.org)

We propose that differential recruitment of two basal forebrain cholinergic neuron types generates behavior-specific cortical activation. (wustl.edu)

Figure 6: Top-down plasticity repatterns the VPN through exaggerated apoptosis that is selective for VPN neurons representing body parts deleted from S1 in cKO mice. (nature.com)

Insidious attack of cortical neurons by complement has been implicated in Alzheimer's and other neurodegenerative diseases. (duke.edu)

To this aim, through electrophysiology in cats, we explored that visual neurons, throughout the cortical column, have a tendency to alter their inherent properties even when presented a non-visual stimulus. (intechopen.com)

Anatomy82

Organisms15

Diseases6

Chemicals and Drugs73

Analytical, Diagnostic and Therapeutic Techniques and Equipment25

Psychiatry and Psychology11

Phenomena and Processes44

Disciplines and Occupations3

Information Science1

Health Care1

Mouse cortical neurons1

Synaptic7

Auditory cortical neurons1

Stimulation10

Single neuron1

Cholinergic neurons7

Pyramidal cell4

Hippocampal CA1 pyramidal neurons1

Role in cortical1

SIGNIFICANCE STATEMENT Neurons1

Dendritic9

Somatosensory cortical1

10.10162

Adult cortical2

Individual neurons2

Responses6

Cerebral3

Vitro5

Amyloid beta1

Inputs3

Sensory Neurons1

Mammalian2

Populations4

Cultures5

Functional3

Induced pluripotent1

Vivo4

Postsynaptic1

Demonstrate3

Frontal5

Axons2

Synchronization1

Dementia3

Temporal2

Cytoplasm1

Astrocytes4

Dysfunction1

Theta activity1

Brain11

Axon1

Phosphorylation2

Anatomical1

Barrel cortex1

Primary1

Stimuli1

Recombinant1

Neocortical1

Cells3

Patterns1

Spike1

Endogenous1

Primarily2

Receptors4

Neural1

GABA1

NMDA1

Subunit2

Functionally1

Forebrain1

Plasticity1

Alzheimer's1

Electrophysiology1