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  • focal cortical
  • We evaluated the diagnostic capability of a multimodal spectroscopic approach for classifying normal brain tissue and epileptogenic focal cortical dysplasia in children. (unifi.it)
  • We employed fluorescence spectroscopy at two excitation wavelengths (378 nm and 445 nm) and Raman spectroscopy (at 785 nm excitation) for acquiring fluorescence and Raman spectra from 10 normal brains, 16 focal cortical dysplasia specimens and 1 cortical tuber tissue sites using a custom-built multimodal optical point spectroscopic system. (unifi.it)
  • The study resulted in 100% sensitivity and 90% specificity using the information obtained from fluorescence at two distinct wavelengths and Raman spectroscopy for discriminating normal brain tissue and focal cortical dysplasia. (unifi.it)
  • Our results demonstrate that this methodology has the potential to be applied clinically for the detection of focal cortical dysplasia and can help to improve as precise as possible surgical resection of the dysplastic tissue during surgery for epilepsy. (unifi.it)
  • heterotopia
  • The authors suggested that ectopic posterior pituitary lobe with growth hormone deficiency is part of a spectrum associated with septo-optic dysplasia and concluded that the coexistence of periventricular heterotopia dysplasia implies a common underlying genetic mechanism. (ajnr.org)
  • Further, in 1 case, they found the presence of a heterozygous HESX1 mutation, a gene associated with ectopic posterior pituitary lobe and septo-optic dysplasia, and suggested that this gene is important in the development of both ectopic posterior pituitary lobe and periventricular heterotopia. (ajnr.org)
  • fluid-attenuat
  • T2-weighted axial and coronal fluid-attenuated inversion recovery (FLAIR) images showed bifrontal cortical dysplasia and a strip of ectopic gray matter extending from the head of the right caudate nuclei to the orbitofrontal lobe ( Fig 2 A , - B ). T2-weighted axial images also revealed small optic nerves, especially on the right side. (ajnr.org)
  • FLAIR
  • B , Coronal FLAIR image shows a strip of ectopic gray matter extending from the head of the right caudate nuclei to the orbitofrontal cortex ( long arrow ) as well as bifrontal thickening of the cortical gray matter ( short arrow s). (ajnr.org)
  • subsets
  • For example, both Barkovich et al 2 and Miller et al 3 attempted to define and classify septo-optic dysplasia into distinct anatomic subsets. (ajnr.org)
  • frontal
  • In addition, our patient presented with bifrontal cortical dysplasia and an ectopic strip of gray matter in the right frontal lobe. (ajnr.org)
  • A , Axial T2-weighted image reveals thickening of the cortical gray matter at the medial aspect of both frontal lobes, compatible with bifrontal cortical dysplasia ( short arrows ). (ajnr.org)
  • There is focal cortical thickening and a relatively poorly defined transition between gray and white matter, seen in the left frontal lobe on axial and coronal scans, in this 18 month old with intractable seizures. (clinical-mri.com)
  • tissue
  • We evaluated the diagnostic capability of a multimodal spectroscopic approach for classifying normal brain tissue and epileptogenic focal cortical dysplasia in children. (unifi.it)
  • We employed fluorescence spectroscopy at two excitation wavelengths (378 nm and 445 nm) and Raman spectroscopy (at 785 nm excitation) for acquiring fluorescence and Raman spectra from 10 normal brains, 16 focal cortical dysplasia specimens and 1 cortical tuber tissue sites using a custom-built multimodal optical point spectroscopic system. (unifi.it)
  • The study resulted in 100% sensitivity and 90% specificity using the information obtained from fluorescence at two distinct wavelengths and Raman spectroscopy for discriminating normal brain tissue and focal cortical dysplasia. (unifi.it)
  • features
  • This heterogeneity of features has resulted in some disagreement as to how septo-optic dysplasia is to be defined and categorized. (ajnr.org)
  • however, the presence of an ectopic posterior pituitary lobe, optic nerve hypoplasia, optic chiasm hypoplasia, cortical dysplasia, and ectopic gray matter suggests features of septo-optic dysplasia. (ajnr.org)