The differential diagnosis of a renal tumor in a young patient with hypertension includes Juxtaglomerular cell tumor, Wilms' tumor, and renal cell carcinoma, all of which may produce renin. (wikipedia.org)
Wilms tumor (WT) represents over 90% of all pediatric kidney tumors. (bvsalud.org)
More than 80% of renal tumors of childhood are Wilms tumor (nephroblastoma) ( 1 , 2 ). (abdominalkey.com)
Most Wilms tumor occurs in children between the ages of 2 and 4 years ( 3 ). (abdominalkey.com)
Wilms tumor may be associated with hemihypertrophy and aniridia and with genital anomalies, such as cryptorchidism and hypospadias ( 5 ). (abdominalkey.com)
Patients with Beckwith-Wiedemann syndrome and Denys-Drash syndrome have an increased risk of developing Wilms tumor ( 5 , 6 ). (abdominalkey.com)
Wilms tumor is believed to arise from embryonic tissues called nephrogenic rests that fail to undergo normal involution ( 7 ). (abdominalkey.com)
The development of Wilms tumor has been linked to mutations of the WT1 and WT2 genes located on chromosome 11 at 11p13 and 11p15.5, respectively ( 8 , 9 ). (abdominalkey.com)
Wilms tumor often is greater than 5 cm in diameter, with an average size of 10 cm ( 3 ). (abdominalkey.com)
Adrenal5
citation needed] Renal segmental hypoplasia (Ask-Upmark kidney)[citation needed] Neurogenic hypertension - excessive secretion of norepinephrine and epinephrine which promotes vasoconstriction resulting from chronic high activity of the sympathoadrenal system, the sympathetic nervous system and the adrenal gland. (wikipedia.org)
Pheochromocytoma - a tumor which results in an excessive secretion of norepinephrine and epinephrine which promotes vasoconstriction Hyperaldosteronism (Conn's syndrome) - idiopathic hyperaldosteronism, liddle's syndrome (also called pseudoaldosteronism), glucocorticoid remediable aldosteronism Cushing's syndrome - an excessive secretion of glucocorticoids causes the hypertension Hyperparathyroidism Acromegaly Hyperthyroidism Hypothyroidism A variety of adrenal cortical abnormalities can cause hypertension, In primary aldosteronism there is a clear relationship between the aldosterone-induced sodium retention and the hypertension. (wikipedia.org)
Wiedemann-Beckwith syndrome is related to abnormalities on chromosome 11p15 and characterized by multiple craniofacial anomalies, abdominal wall defects, and tumors of the genitourinary tract, liver, adrenal gland, and central nervous system among other abnormalities. (abdominalkey.com)
Adachi J , Hirai Y , Terui K , Nakano T , Fukuda Y , Suda T , Sasano H . A report of 7 cases of adrenal tumors secreting both cortisol and aldosterone. (comprehensivephysiology.com)
Kidney13
It has many different causes including endocrine diseases, kidney diseases, and tumors. (wikipedia.org)
Hypertension can also be produced by diseases of the renal arteries supplying the kidney. (wikipedia.org)
Chronic kidney disease[citation needed] Kidney disease / renal artery stenosis - the normal physiological response to low blood pressure in the renal arteries is to increase cardiac output (CO) to maintain the pressure needed for glomerular filtration. (wikipedia.org)
The classification of epithelial tumors of the kidney has in particular undergone substantial progress in the last two decades with major contributions from genetic typing of renal cell carcinomas (RCCs). (abdominalkey.com)
the adjective renal meaning related to the kidney is from Latin rēnēs , meaning kidneys. (wikidoc.org)
On this medial aspect of each kidney is an opening, called the hilum , which admits the renal artery , the renal vein , nerves , and the ureter . (wikidoc.org)
The outer portion of the kidney is called the renal cortex , which sits directly beneath the kidney's loose connective tissue/fibrous capsule . (wikidoc.org)
Each kidney receives its blood supply from the renal artery , two of which branch from the abdominal aorta . (wikidoc.org)
Upon entering the hilum of the kidney, the renal artery divides into smaller interlobar arteries situated between the renal papillae. (wikidoc.org)
Blood from these capillaries collects in renal venules and leaves the kidney via the renal vein . (wikidoc.org)
The kidney is innervated by the renal and ureteric nerve , which arises from the renal plexus . (wikidoc.org)
Beta 2-microglobulin is present in small amounts in serum, csf, and urine of normal people, and to a much greater degree in the urine and plasma of patients with tubular proteinemia, renal failure, or kidney transplants. (lookformedical.com)
Benign5
There are several different kinds of benign renal tumors, which may originate from a wide range of cell types. (pediagenosis.com)
Although certain benign tumors have characteristic radiologic findings, most cannot be distinguished from malignant tumors using imaging alone. (pediagenosis.com)
Some of the more common and well-documented benign renal tumors are presented here. (pediagenosis.com)
adenomatoid t. a small benign t. of the male epididymis and female genital tract , consisting of fibrous tissue or smooth muscle enclosing anastomosing glandlike spaces containing acid mucopolysaccharide lined by flattened cells that have ultra-structural characteristics of mesothelial cells. (en-academic.com)
Chromophobe1
Biopsies, however, are also unreliable because oncocytoma-like areas can be found in chromophobe renal cell carcinomas. (pediagenosis.com)
it is thought that decreased perfusion of renal tissue due to stenosis of a main or branch renal artery activates the renin-angiotensin system. (wikipedia.org)
Here, however, increased CO cannot solve the structural problems causing renal artery hypotension, with the result that CO remains chronically elevated. (wikipedia.org)
TFE3 RCC in an older adult and review the literature with an emphasis on practical diagnostic approaches for predominantly cystic, low-grade, clear cell renal tumors. (bvsalud.org)
Glomerular capillaries2
Glomerular filtration rate (GFR) is the volume of fluid filtered from the renal glomerular capillaries into the Bowman's capsule per unit time. (passmed.uk)
Branching off these cortical arteries are the afferent arterioles supplying the glomerular capillaries, which drain into efferent arterioles. (wikidoc.org)
Oncocytoma1
Thus even a suspected oncocytoma is generally treated like a renal cell carcinoma, with the definitive diagnosis established only after surgical resection of the entire mass. (pediagenosis.com)
Collecting duct1
They are believed to originate from the intercalated cells of the collecting duct. (pediagenosis.com)
Tubular1
However, excess myoglobin can occlude the renal filtration system leading to acute tubular necrosis and acute renal dysfunction. (passmed.uk)
Kidneys2
Small cortical lesions are seen in 7% to 23% of kidneys at the time of autopsy. (pediagenosis.com)
Congenital absence of one or both kidneys, known as unilateral or bilateral renal agenesis , can occur. (wikidoc.org)
Pediatric1
The first section will cover those tumors that characteristically are associated with the pediatric population. (abdominalkey.com)
Arteries1
At the outer medulla, the interlobar arteries branch into arcuate arteries, which course along the border between the renal medulla and cortex, giving off still smaller branches, the cortical radial arteries (sometimes called interlobular arteries ). (wikidoc.org)
Pelvis1
The tip of each pyramid (called a papilla ) empties into a calyx , and the calices empty into the renal pelvis . (wikidoc.org)
Perirenal1
The tumor is usually circumscribed by a pseudocapsule formed of compressed renal and perirenal tissues. (abdominalkey.com)
Tubules2
Characteristic histopathologic findings include round to polygonal cells that have strongly eosinophilic cytoplasm and round nuclei, and which are arranged in nests, acini, tubules, and microcysts. (pediagenosis.com)
Creatinine is an endogenous molecule, synthesised in the body, that is freely filtered by the glomerulus (but also secreted by the renal tubules in very small amounts). (passmed.uk)
Reninoma - rare juxtaglomerular tumor associated with hypertension We present a case study of two female patients, aged 20-30 years, who were diagnosed with reninoma, a rare juxtaglomerular tumor associated with hypertension, high plasma renin and hypokalemia. (bvsalud.org)
Abdominal1
Less commonly, the tumors may cause flank pain, hematuria, and a palpable abdominal mass. (pediagenosis.com)
Diabetic1
Question 3 - A 78-year-old diabetic man undergoes renal function tests. (passmed.uk)
Undergoes1
characterized histologically by columnar cells organized in a ductlike configuration interspersed with spindle-shaped cells and amyloidlike deposition that gradually undergoes dystrophic calcification . (en-academic.com)
Urine1
Which condition presents with a positive urine dipstick test for blood, but no blood cells on urine microscopy? (passmed.uk)
Adults1
Oncocytomas account for approxmately 5% of renal tumors in adults. (pediagenosis.com)
Structural1
A heterogeneous family of water-soluble structural proteins found in cells of the vertebrate lens. (lookformedical.com)
Tissue2
brown t. a mass of fibrous tissue containing hemosiderin-pigmented macrophages and multinucleated giant cells, replacing and expanding part of a bone in primary hyperparathyroidism . (en-academic.com)
neoplastic cells are frequently palisaded at the periphery of the small groups, and the latter have a tendency to infiltrate surrounding tissue . (en-academic.com)
Rare1
The presence of fat, however, is not pathognomonic for AML, since certain primary renal sarcomas (such as liposarcoma) and rare renal cell carcinomas may also contain fat. (pediagenosis.com)
Clear cell1
BACKGROUND: In clear cell renal cell carcinoma (ccRCC), only some patients can benefit from immunotherapy therapy, and it is urgent to find immune-related molecular markers and targets. (bvsalud.org)
Outer1
An 11-kDa protein associated with the outer membrane of many cells including lymphocytes. (lookformedical.com)
Cases1
Grossly, the tumors appear well-circumscribed and mahogany brown, with a central stellate scar seen in about one third of cases. (pediagenosis.com)
Types1
The purpose of this chapter is to familiarize the reader with the tumor types encountered in the human rather than to provide a comprehensive diagnostic reference, which is better handled in more comprehensive textbooks and monographs. (abdominalkey.com)
Patients2
CONCLUSIONS: Patient survival is poor and immune cell infiltration is abnormal when TYMP is highly expressed in ccRCC, suggesting that ccRCC patients could benefit from using TYMP as a molecular diagnostic and therapeutic target. (bvsalud.org)
70% to 80% of patients with tuberous sclerosis develop renal AMLs, typically in their fourth decade. (pediagenosis.com)
Develop1
This is a somewhat arbitrary designation, as most tumors can develop over a wide age range. (abdominalkey.com)