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  • kinase
  • CFCS is genetically heterogeneous and mutations in the KRAS, BRAF, MAP2K1 (MEK1) and MAP2K2 (MEK2) genes, encoding for components of the RAS-mitogen activated protein kinase (MAPK) signaling pathway, have been identified in up to 90% of cases. (nih.gov)
  • Orange boxes indicate regions coding for the protein kinase domain (residues 68-361 in MEK1 and 72-369 in MEK2 ). (nih.gov)
  • Expression of CRK28 in Nicotiana benthamiana induced cell death, which required intact extracellular Cys residues and a conserved kinase active site. (plantphysiol.org)
  • CRK28-mediated cell death required the common receptor-like protein kinase coreceptor BAK1. (plantphysiol.org)
  • We show the utility and capabilities of COMMA by applying it to three archetypal proteins, namely protein A, the tyrosine kinase KIT and the tumour suppressor p53. (biomedcentral.com)
  • serine
  • SR proteins contain one or two RNA recognition motifs (RRMs) at their N termini as well as a region of repeated serine-arginine dipeptides (RS domain) at their C termini. (rupress.org)
  • Thermophilic (high-temperature) r-proteins contain increased Arginine, Isoleucine, and Tyrosine, and decreased Serine and Threonine compared to mesophilic (lower-temperature), reflecting a known distinction between thermophiles and mesophiles, possibly to account for protein thermostability. (nih.gov)
  • Thermophilic r-proteins (red) contain higher percentages of Arginine (R), Isoleucine (I), and Tyrosine (Y), and lower percentages of Serine (S) and Threonine (T) than mesophilic r-proteins (blue). (nih.gov)
  • isoleucine
  • Using these covariance correlation maps, nearly all assigned isoleucine, leucine, and valine amide resonances of a 52 kDa nonribosomal peptide synthetase cyclization domain were paired with their corresponding methyl groups. (springer.com)
  • Gardner KH, Kay LE (1997) Production and incorporation of 15N, 13C, 2H (1H-1 methyl) isoleucine into proteins for multidimensional NMR studies. (springer.com)
  • spectra
  • Calculating the covariance between sensitive methyl and amide 3D spectra, each providing correlations to C α and C β separately, produces 4D correlation maps directly correlating methyl groups to amide groups. (springer.com)
  • Optimal correlation maps are obtained by extracting residue-specific regions, applying derivative to the dimensions subject to covariance, and multiplying 4D maps stemming from different 3D spectra. (springer.com)
  • allosteric
  • Gouridis G, Karamanou S, Gelis I, Kalodimos CG, Economou A (2009) Signal peptides are allosteric activators of the protein translocase. (springer.com)
  • It is useful to identify residues playing a key role in protein allosteric regulation and to explain the effects of deleterious mutations in a mechanistic way. (biomedcentral.com)
  • patterns
  • No systematic patterns in converted sites were found on mRNAs, and the converted sites rarely encoded residues located at the active sites of proteins. (biomedcentral.com)
  • For fast and reliable identification of functional motifs, the SCE values of a combination of chemical patterns across protein families are further grouped using clustering algorithms. (jbsdonline.com)
  • CSM generates feature vectors that represent distance patterns between protein residues. (biomedcentral.com)
  • nuclear
  • It has a Mr of 35,414, contains 18% basic residues, and contains putative nuclear localization signals. (pnas.org)
  • SR proteins function in nuclear pre-mRNA processing, mRNA export, and translation. (rupress.org)
  • Identification
  • Identification and HLA-Tetramer-Validation of Human CD4+ and CD8+ T Cell Responses against HCMV Proteins IE1 and IE2. (dtu.dk)
  • But this motif is not sufficient for identification of all GTP interacting residues. (biomedcentral.com)
  • The present results were in good agreement with the outcomes of previous, highly manually curated, efforts for the identification of human zinc-binding proteins. (biomedcentral.com)
  • The availability of such methods might allow for the identification of classes of proteins that could be involved in different diseases. (jbsdonline.com)
  • glutathione
  • A glutathione- S -transferase fusion protein containing the COOH-terminal domain of Xklp2 (GST-Xklp2-Tail) was previously found to localize to spindle poles (Boleti, H., E. Karsenti, and I. Vernos. (rupress.org)
  • functional
  • Hence, only the edited form of an mRNA can be translated into a polypeptide with helix-preferring and core-forming residues at the appropriate positions, which is often required for a protein to form a functional three-dimensional (3D) structure. (biomedcentral.com)
  • The global and local conformational similarities between proteins indicate functional similarities and are useful for inferring functions of proteins. (hindawi.com)
  • indicate
  • This structure would indicate that A / a is ancestral but remains agnostic on the pairing of the B / b and C / c proteins. (biomedcentral.com)
  • Our findings indicate that posttranslational modification of SR proteins underlies the regulation of their mRNA export activities and distinguishes pluripotent from differentiated cells. (rupress.org)
  • species
  • Croy, Ronald 2004-10-03 00:00:00 Napin is a 2S storage protein found in the seeds of oilseed rape (Brassica napus L.) and related species. (deepdyve.com)
  • CLAG clusterizes correlation matrices for residues in protein families, gene-expression and miRNA data related to various cancer types, sets of species described by multidimensional vectors of characters, binary matrices. (biomedcentral.com)
  • The methods developed in this paper take sets of paralogs for different proteins found in the same species and make a pairing based on their evolutionary distance relative to a set of other proteins that are unique and so have a known relationship (singletons). (biomedcentral.com)
  • If the pair of proteins is unique to that organism, then pairing-up the proteins on the basis of species name will produce the correct assignment. (biomedcentral.com)
  • However, given the dominant mechanism of gene duplication and diversification in protein evolution, the more typical situation is that there will be a number of choices (paralogs) for each protein with no guidance from the species name to which pairs of proteins interact. (biomedcentral.com)
  • Common PTI responses include Ca 2+ influx, an extracellular reactive oxygen species ( ROS ) burst, activation of mitogen-activated protein kinases (MAPKs), transcriptional reprogramming, and callose deposition ( Boller and Felix, 2009 ). (plantphysiol.org)
  • mRNA
  • Alpha helices on proteins tend to be preferentially coded by translationally fast mRNA regions while the slow segments often code for beta strands and coil regions. (bio.net)
  • extracts
  • Xklp2 is a plus end-directed Xenopus kinesin-like protein localized at spindle poles and required for centrosome separation during spindle assembly in Xenopus egg extracts. (rupress.org)
  • PSSM
  • The position specific score matrix (PSSM) was used in paper [ 7 ] to search the protein databases which provide high sensitivity for detecting remote homologs. (hindawi.com)
  • nearly
  • Application of the LACS algorithm to the current BMRB protein chemical shift database, revealed that nearly 35% of the BMRB entries have δ 15 N values mis-referenced by over 0.7 ppm and over 25% of them have δ 1 H N values mis-referenced by over 0.12 ppm. (springer.com)
  • Nearly all r-proteins carry a net positive charge, but no statistical correlation between the net charge and the binding order was detected. (nih.gov)
  • nitrogen
  • The approach is based on our finding that the secondary 15 N chemical shift of the backbone nitrogen atom of residue i is strongly correlated with the secondary chemical shift difference (experimental minus random coil) between the alpha and beta carbons of residue i − 1. (springer.com)
  • gene
  • However in eukaryotes, gene expression control is complex and co-location does not imply co-expression or interaction of the resulting proteins. (biomedcentral.com)
  • In addition, protein expression of this gene was also assessed to determine possible correlation between promoter hypermethylation and gene silencing. (springer.com)
  • advancement
  • During the past, there was a massive growth of knowledge of unknown proteins with the advancement of high throughput microarray technologies. (hindawi.com)