Correlates with rapid progression of disease. Medical search. Frequent questions

The severity of the inflammatory process has been correlated with the rapidity of disease progression (11) . (ajnr.org)
Conclusion: CD8 + T cells become activated (dual expression of DR and CD38) and lose CD28, some acquiring CD57, in relation to rapidity of disease progression in pediatric HIV infection. (houstonmethodist.org)

Patients with HLA types associated with rapid disease progression recognize a significantly smaller fraction of their known repertoire of viral epitopes than do patients with HLA types associated with slow progression. (unige.ch)
These data provide an immunological mechanism to explain HLA-related risk of progression to AIDS and emphasize the central role of viral evolution in the pathogenesis of HIV. (unige.ch)
This rapid viral replication prevents the normal replacement of the epithelial cells that line the small intestine, which results in diarrhea, vomiting, dehydration, and secondary bacterial infection. (catwatchnewsletter.com)
Such an analysis has the potential to help inform the immunological basis for rapid viral control and disease progression. (nature.com)
We found that LTNPs have substantial lower expression of miR-382-5p that positively correlates with viral loads. (rnabiology.org)
Objective: The purpose of this investigation was to determine the distribution of CD8 + T-cell subsets in HIV + children and correlate the findings with degree of immunosuppression and HIV viral burden. (houstonmethodist.org)
CD38 + CD8 + T-cell percentages did not correlate with viral burden as it has been seen to do in HIV + adults. (houstonmethodist.org)
HA410 trade name] is indicated for the treatment of chronic hepatitis B in adults with: · compensated liver disease and evidence of immune active disease, i.e. active viral replication, persistently elevated serum alanine aminotransferase (ALT) levels and histological evidence of active inflammation and/or fibrosis. (who.int)
Mylan Laboratories Ltd.), HA410 · compensated liver disease and evidence of immune active disease, i.e. active viral replication, persistently elevated serum ALT levels and histological evidence of active inflammation and/or fibrosis. (who.int)
Previous studies by us and others have suggested that differences in disease progression rate may be associated with both viral parameters, such as diversity or infecting subtype and host immune responses. (lu.se)
The main goal of this project is to dissect the relationship between HIV-1 viral diversity, evolutionary dynamics, innate immune responses, and acute retroviral syndrome during acute HIV-1 infection, and how they contribute to disease pathogenesis during the acute and chronic stages of infection. (lu.se)

To determine the association between incubation period and severity of disease, we first estimated the difference in mean incubation period between patients who died and those who survived. (cdc.gov)
The type and number of dividing cells that are destroyed correlates directly with the severity of the resulting clinical disease. (catwatchnewsletter.com)
Classification of AMD is based on disease severity and includes mild, intermediate, and advanced stages. (eyesoneyecare.com)
1 COPD is preventable and treatable and causes significant extrapulmonary effects that contribute to disease severity in a subset of patients. (basicmedicalkey.com)
Most importantly this defense response was more prompt in the resistant than the susceptible host indicating that a resistant host makes different choices from a susceptible host during infection which ultimately influences the severity of the disease. (nature.com)
Increasing body mass index, neck circumference, Epworth Sleepiness Scale score, hypertension, congestive heart failure, and type 2 diabetes correlated with increasing OSA severity. (cdc.gov)
Only 59% of treated patients reported good adherence to treatment with positive airway pressure, and response to treatment correlated with OSA severity. (cdc.gov)

Small studies have suggested that HPV ctDNA levels correlate with total disease burden and levels mirror fluctuations in disease status in patients with R/M HPV OPSCC. (eurekalert.org)

Arthritis News : What is the Relationship of RA Disease Activity to Radiographic Progression of Joint Damage? (hopkinsarthritis.org)
Prevention of radiographic progression of joint damage has thus become a goal of treatment, and an outcome for many clinical trials. (hopkinsarthritis.org)
These questions are not readily answered by conventional statistical analysis methods which use time-averaged estimates of radiographic progression and disease activity over a study interval. (hopkinsarthritis.org)
Time-averaged estimates do not take into account the variability of disease within an individual patient, and also assume a linear rate of radiographic progression. (hopkinsarthritis.org)
Regression models using GEE were constructed to evaluate trends in radiographic progression. (hopkinsarthritis.org)
Then baseline variables thought to be predictive of radiographic progression (age at baseline, sex, rheumatoid factor, baseline Sharp score, baseline DAS score) were entered into the model. (hopkinsarthritis.org)
The time averaged radiographic progression in this cohort was 9.5 Sharp points per year. (hopkinsarthritis.org)
Using GEE, the rate of radiographic progression was found to slow slightly with increasing disease duration. (hopkinsarthritis.org)
Of the baseline variables considered, only RF positivity and Sharp score at baseline were positive correlated with radiographic progression. (hopkinsarthritis.org)
However, the mean interval DAS, and SD of the mean interval DAS, were also positively correlated with radiographic progression even after adjusting for RF positivity and baseline Sharp scores. (hopkinsarthritis.org)
Thus, periods of higher disease activity (mean interval DAS) or fluctuating disease activity (SD of mean interval DAS) were associated with more radiographic progression. (hopkinsarthritis.org)
The time averaged radiographic progression in this cohort was 7.7 Sharp points per year, but the rate of radiographic progression tended to slightly slow with increasing disease duration. (hopkinsarthritis.org)

Some markers (eg, MYCN oncogene amplification, DNA index, segmental chromosomal aberrations, histopathology) correlate with progression and prognosis. (msdmanuals.com)
The rapid growth and high rate of recurrence of GBM make surgical resection non-curative and leads to poor prognosis of this disease ( 4 ). (spandidos-publications.com)
Although the therapies of HCC have undergone rapid progress during the past decades, ranging from surgical and local treatment to molecular-targeted therapy and immunotherapy, the prognosis is undesirable [ 2 , 3 ]. (hindawi.com)
Methyltransferase-like 3 (METTL3) correlates with the poor prognosis of HCC and promotes the progression of HCC [ 11 ]. (hindawi.com)
Wilms tumor 1-associated protein (WTAP) was investigated to be a poor prognosis factor and contributed to the progression of HCC via the HuR-ETS1-p21/p27 axis [ 14 ]. (hindawi.com)
Biomarkers are required to identify individuals in the preclinical phase, explain phenotypic diversity, measure progression and estimate prognosis. (lu.se)

The incubation period of an infectious disease is the time from the moment of exposure to an infectious agent until signs and symptoms of the disease appear ( 1 ). (cdc.gov)
To be effective in disease modification, therapies will require testing and application in patients with only mild symptoms. (neurodegenerationresearch.eu)
We will evaluate whether this approach results in differing types of symptoms or of symptom progression in individual patients, depending on their imaging results. (neurodegenerationresearch.eu)
Middle-aged and older adults with frequent depressive symptoms were more likely to experience rapid decline in kidney function and progression to chronic kidney disease, study investigators reported. (renalandurologynews.com)
Frequent depressive symptoms correlate with rapid decline in kidney function in healthy adults, a new Chinese study finds. (renalandurologynews.com)
Particular depressive symptoms including bother, difficulty concentrating, thinking everything is an effort, and feeling lonely significantly associated with rapid kidney function decline. (renalandurologynews.com)
Depressive symptoms linked to rapid kidney function decline [news release]. (renalandurologynews.com)
Symptoms and signs of neuroblastoma depend on the site of the primary cancer and pattern of disease spread. (msdmanuals.com)
Iranzo A, Valldeoriola F, Santamaria J, Tolosa E, Rumia J. Sleep symptoms and polysomnographic architecture in advanced Parkinson's disease after chronic bilateral subthalamic stimulation. (medigraphic.com)
Atypical additional symptoms that do not occur in the classic Parkinson's disease, for example, include problems with speech or early falls. (bz-bx.net)
These diseases, especially in the initial stage, can present symptoms phenotypically for Parkinson's disease. (bz-bx.net)
The differential diagnosis should question the diagnosis of idiopathic Parkinson's disease, if poor response to L-dopa, rapid progression and additionally warning symptoms occur. (bz-bx.net)
Definition: Multiple system atrophy (MSA) is a progressive, neurodegenerative disease, which may present clinically in the form of autonomous dysfunction, Parkinsonian syndrome, cerebellar symptoms or pyramidal tract signs. (bz-bx.net)
Addition of idelalisib to bendamustine/rituximab, apart from improving PFS and OS, had a neutral to beneficial impact on HRQL in patients with R/R CLL, particularly by reducing leukemia-specific disease symptoms. (biomedcentral.com)
Accumulated data indicate that hematopoietic stem cell transplantation may be effective under optimal conditions in preventing the progression of central nervous system symptoms in neuronopathic forms of lysosomal storage diseases (such as Krabbe disease), including some of the mucopolysaccharidoses, oligosaccharidoses, sphingolipidoses, and lipidoses as well as peroxisome disorders such as X-linked adrenoleukodystrophy. (medscape.com)
Symptoms of Crohn disease include intermittent attacks of diarrhea, constipation, abdominal pain, and fever. (medscape.com)
We'll be discussing evidence that people who have coronavirus disease without symptoms can still spread the disease. (cdc.gov)

Centers for Disease Control and Prevention. (cdc.gov)
Announcer] This program is presented by the Centers for Disease Control and Prevention. (cdc.gov)

Silicosis is a potentially fatal and typically chronic fibrotic lung disease caused by occupational exposure to respirable crystalline silica dust (1). (cdc.gov)
Chronic lymphocytic leukemia (CLL) is a clinically heterogeneous disease characterized by the accumulation of CD5CD23 B-cell lymphocytes. (haematologica.org)
In the China Health and Retirement Longitudinal Study (CHARLS), 260 (5.5%) of 4763 adults aged 45 years and older who were initially free of chronic kidney disease (CKD) later experienced an annual decline in estimated glomerular filtration rate (eGFR) of 5 mL/min/1.73 m 2 or more. (renalandurologynews.com)
Investigators calculated eGFR using the Chronic Kidney Disease Epidemiology Collaboration equation including both serum creatinine and cystatin C. (renalandurologynews.com)
Given its availability and ease of use, several studies have focused on the assessment of the diaphragm thanks to CT, particularly in patients undergoing chronic respiratory diseases. (frontiersin.org)
A diagnosis of left ventricular systolic dysfunction, chronic kidney disease and increasing age predicted ReSPECT form completion. (bvsalud.org)
In a phase 3 randomized, double-blind, placebo-controlled trial, treatment with idelalisib, a phosphoinositol-3 kinase δ inhibitor, + bendamustine/rituximab improved progression-free survival (PFS) and overall survival (OS) in adult patients with relapsed/refractory chronic lymphocytic leukemia (R/R CLL). (biomedcentral.com)
Unlike obstructive lung diseases, such as asthma and chronic obstructive pulmonary disease (COPD), which show a normal or increased total lung capacity (TLC), restrictive disease are associated with a decreased TLC. (medscape.com)
Chronic obstructive pulmonary disease (COPD) is a treatable and preventable disease characterized by progressive airflow limitation that is not fully reversible and is associated with an abnormal inflammatory response of the lungs to noxious particles or gases. (basicmedicalkey.com)
Because most patients exhibit some features of each disease, the appropriate emphasis of COPD pathophysiology is on small airway disease and parenchymal damage that contributes to chronic airflow limitation. (basicmedicalkey.com)
Chronic obstructive pulmonary disease (COPD) is a common lung disease characterized by airflow limitation that is not fully reversible and is both chronic and progressive. (basicmedicalkey.com)
In order to standardize the care of patients with COPD and present evidence-based recommendations, the National Heart, Lung, and Blood Institute (NHLBI) and the World Health Organization (WHO) launched the Global Initiative for Chronic Obstructive Lung Disease (GOLD) in 2001. (basicmedicalkey.com)
Fissures or fistulas may occur in persons with chronic disease. (medscape.com)
Acute and chronic inflammation, with lymphocytic and giant cell perivascular infiltrates, and lymphoid follicles are the most common histologic findings in oral and GI Crohn disease. (medscape.com)

The test performance study used 125 residual laboratory CSF specimens from 47 patients with a CNS malignant neoplasm and 56 patients with other neurological diseases. (stanford.edu)
The same favourable effect in clinical practice comes from the accumulated knowledge of the complex clinical picture of various causes of RPD, associated specific neurological features (pyramidal signs, ataxia, myoclonus) and systematic features (weight loss, hyponatraemia, hepatic disorders) and their mode of progression. (touchneurology.com)
Eight dogs presented with acute onset and rapid progression of multifocal neurological signs were selected to the study. (biomedcentral.com)

Inherent in this technically accurate paradox is that while the former supports the well-established link between microbial pathogens and infectious diseases, the latter infers that disease susceptibility can be modified by extramicrobial factors [ 1 - 3 ]. (hindawi.com)
A plausible extension of this concept relates to the involvement of vitamin D in immunomodulation and the role the vitamin appears to have in a number of infectious diseases. (hindawi.com)
Advances in Infectious Diseases , 12 , 50-56. (scirp.org)
The major diagnostic decision is between infectious and non-infectious diseases. (biomedcentral.com)

Scl-70 antibodies are associated with more severe scleroderma disease. (wikipedia.org)
However, the continuing occurrence of silicosis deaths in young adults reflects relatively recent overexposures, some of sufficient magnitude to cause severe disease and death after relatively short periods of exposure. (cdc.gov)
Dr. Scott describes the progression of the disease as follows: "The clinical signs usually start about three or four days following infection and include fever, severe depression and lethargy, vomiting, diarrhea and dehydration. (catwatchnewsletter.com)
Rapid and severe dehydration is the biggest problem. (catwatchnewsletter.com)
Young A, Home M, Churchward T, Freezer N, Holmes P, Ho M. Comparison of sleep disturbance in mild versus severe Parkinson's disease. (medigraphic.com)
RPD represents an unusual but severe condition that causes distress not only for patients and their relatives but also for the clinicians involved, as multiple investigations and decisions about management must be made urgently to avoid misdiagnosing a treatable condition and to preserve as much of the neural tissue as possible from definite damage. (touchneurology.com)
We aim to delineate the similarities between IgA-mediated neutrophil-directed blistering skin diseases and the severe pulmonary COVID-19 infection by reviewing the relevant medical literatures, in order to compare the pathological mechanisms of these two different clinical situations. (scirp.org)
Since dapsone is effective in treating IgA-mediated skin diseases by blocking the binding of neutrophils to the tissue site, it could also be an effective treatment for severe cases of COVID-19 lung injury, which has a similar pathological mechanism. (scirp.org)
Of the patients reporting good adherence, a greater proportion of those with severe OSA (27%) than with mild or moderate disease (0%-12%) reported an excellent response to treatment. (cdc.gov)
MS is universally a severe disease, and brain atrophy is accelerated in all patients. (medscape.com)
Improved participation could allow more precise characterisation of the burden and characteristics of pneumoconiosis in US coal miners and provide an important early detection tool to prevent cases of severe disease. (cdc.gov)
To our knowledge, since 2000, two studies have reported on disease progression in US coal workers with severe pneumoconiosis. (cdc.gov)

Soluble guanylate cyclase (sGC) is recurrently upregulated in post-chemotherapy progression CDX models, which correlates with acquired chemoresistance. (diagenode.com)
Expression and activation of sGC is regulated by Notch and nitric oxide (NO) signalling with downstream activation of protein kinase G. Genetic targeting of sGC or pharmacological inhibition of NO synthase re-sensitizes a chemoresistant CDX progression model in vivo, revealing this pathway as a mediator of chemoresistance and potential vulnerability of relapsed SCLC. (diagenode.com)
Previously, it has been identified that miRNAs are involved in the progression and chemoresistance of numerous types of cancer, including GBM ( 10 , 11 ). (spandidos-publications.com)

We will test the hypothesis that the progression of cognitive decline will be more rapid in the synucleinopathy with both A? (neurodegenerationresearch.eu)
The odds of rapid kidney function decline significantly increased by 15% for every 5-point increase in CES-D score, Xianhui Qin, MD, of Nanfang Hospital, Southern Medical University, in Guangzhou, China and colleagues reported in the Clinical Journal of the American Society of Nephrology . (renalandurologynews.com)
The odds of rapid decline increased 1.24-fold for a moderate CES-D score of 10 or higher but less than 21 and 2.18-fold for a high score of 21 or more, compared with a reference score of less than 10. (renalandurologynews.com)
In most cases, the cognitive decline observed in RPD can be attributed to a single underlying disorder. (touchneurology.com)
Introduction: Synaptic dysfunction and degeneration is one of the earliest events in Alzheimer's disease (AD) and the best correlate of cognitive decline. (lu.se)

Second, does clinically assessed disease activity correlate with radiographic damage? (hopkinsarthritis.org)
therefore, there is a period during which degeneration is ongoing, but disease is not yet clinically evident. (bmj.com)
These patients are classified clinically as either Parkinson disease with dementia (PDD) or as dementia with Lewy bodies (DLB). (neurodegenerationresearch.eu)
If caused by parenchymal lung disease, restrictive lung disorders are accompanied by reduced gas transfer, which may be marked clinically by desaturation after exercise. (medscape.com)
Recently, the term meningoencephalitis of unknown origin (MUO) has been introduced to all clinically diagnosed cases based on advanced imaging and cerebrospinal fluid (CSF) analysis of non-infectious inflammatory CNS disease [ 1 - 3 ]. (biomedcentral.com)

MUO includes all the specific subtypes of non-infectious inflammatory disease that can be identified through histopathology, including granulomatous meningoencephalomyelitis (GME) and necrotizing encephalitis (NE), but does not include the diseases without evidence of explicit CNS involvement, such as steroid-responsive meningitis-arteritis (SRMA) [ 1 ]. (biomedcentral.com)

amyloid and tau endophenotype, and that the progression of cognitive impairment in subjects with this endophenotype will correlate with the progression of NFT pathology as determined in follow-up [18F]AV1451-PET. (neurodegenerationresearch.eu)
Although no precise definition for rapidly progressive dementia (RPD) exists, this term is generally used to refer to cases with significant and progressive cognitive impairment that occurs over weeks or months. (touchneurology.com)

1 The genetic and molecular mechanisms involved in the development of the disease are not well known, but recent observations suggest that the modulation of survival signals interfering with apoptosis may be a pivotal tool in the pathogenesis of CLL. (haematologica.org)
After comparing the pathological mechanisms between skin disease and COVID-19-related lung injury, we will then discuss the proposed treatment. (scirp.org)
TCMSP also provides drug targets and diseases of each active compound, which can automatically establish the compound-target and target-disease networks that let users view and analyze the drug action mechanisms. (scienceopen.com)
The detailed underlying mechanisms that determine differences in disease progression and clinical presentation of acute HIV infection (AHI) are largely unknown. (lu.se)

In addition, beta-hCG serves as an ideal tumor marker for monitoring gestational trophoblastic disease and has set the standard with which other assays must be compared. (medscape.com)
The crossing point (Cp) values from SARS-CoV-2 RT-PCR assays has also been correlated with culture positivity to suggest that Cp values above 33-34 may no longer be associated with replication-competent virus 7 . (nature.com)
Nevertheless, plasma assays have been found to be unreliable markers for disease progression, irrespective of subtype. (ajnr.org)

Background: CD8 + T-cell subsets have not been adequately described in HIV-infected (HIV + ) children classified with respect to disease progression as rapid-progressors (RPs) and non-rapid progressors (non-RPs). (houstonmethodist.org)
The CD8 + T-cell subsets were correlated with mean CD4 + T-cell percentages and HIV RNA levels. (houstonmethodist.org)

Tandberg E, Larsen JP, Karlsen K.A community-based study of sleep disorders in patients with Parkinson's disease. (medigraphic.com)
Health related quality of life in Parkinson's disease: a prospective longitudinal study. (medigraphic.com)
Insomnia in Parkinson's disease: frequency and progression over time. (medigraphic.com)
Wetter TC, Collado-Seidel V, Pollmacher T, Yassouridis A, Trenkwalder C. Sleep and periodic leg movement patterns in drug-free patients with Parkinson's disease and multiple system atrophy. (medigraphic.com)
Polysomnographic sleep measures in Parkinson's disease patients with treatment-induced hallucinations. (medigraphic.com)
Parkinson's disease and sleepiness: an integral part of PD. (medigraphic.com)
Sleep issues in Parkinson's disease. (medigraphic.com)
Agid Y. Parkinson's disease: pathophysiology. (medigraphic.com)
In contrast to classic Parkinson's disease, Atypical Parkinsonism is characterized by a more aggressive disease progression leading to loss of motor function and significantly reduced life expectancy. (bz-bx.net)
While such collaborations have existed in Parkinson's disease for many years, the required globalization of research activities in the field of Atypical Parkinsonism has only just begun. (bz-bx.net)

This information provides a potential use of TR as an accurate diagnostic tool for the rapid postmortem diagnosis of AD neuropathology. (springer.com)
Jellinger KA, Bancher C (1997) Proposals for re-evaluation of current autopsy criteria for the diagnosis of Alzheimer's disease. (springer.com)
Processing of such data can be used to identify, extract, correlate, evaluate and disseminate various linguistic or multimodal phenotypes and measurements, which then can be applied to aid diagnosis, monitor the progression or predict individuals at risk . (gu.se)
Oral manifestations can prove crucial in diagnosis and usually parallel the intestinal disease course. (medscape.com)

In recent years, we have used a variety of tau immunological markers combined with the dye thiazin red (TR), an accurate marker to differentiate the fibrillar from the nonfibrillar state of both amyloid-β and tau in Alzheimer's disease (AD). (springer.com)
It has been suggested that different virological and immunological events during the very early stages of HIV infection may determine the rate of the future disease course of the individual patient. (lu.se)

Systemic juvenile idiopathic arthritis (sJIA), adult-onset Still's disease (AOSD), gout, and pseudogout: rheumatologist. (aetna.com)
They include idiopathic fibrotic diseases, connective-tissue diseases, drug-induced lung disease, environmental exposures (inorganic and organic dusts), and primary diseases of the lungs (including sarcoidosis). (medscape.com)
Non-infectious inflammatory diseases of the canine central nervous system (CNS) are common idiopathic disorders grouped under the term meningoencephalomyelitis of unknown origin (MUO). (biomedcentral.com)
Particularly, NME is an idiopathic inflammatory disease of the CNS that is characterized by prominent necrosis and infiltration of inflammatory cells, including lymphocytes, plasma cells, and monocytes or histiocytes into the cerebral cortex and/or white matter, hippocampus, thalamus, and leptomeninges. (biomedcentral.com)
Crohn disease is an idiopathic disorder that can involve the entire GI tract with transmural inflammation, noncaseating granulomas, and fissures. (medscape.com)

1-4 The subacute nature of RPD excludes other conditions with fulminant progression such as infectious or metabolic acute encephalopathies, which progress within hours or days and typically commence as an acute confusional state. (touchneurology.com)
Acute exacerbations of COPD have a significant impact on disease progression and mortality. (basicmedicalkey.com)

Braak Alafuzoff I, Arzberger T et al (2006) Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry. (springer.com)
synucleinopathy will likely require targeting of the pathologic pathways involved, and this in turn, necessitates ability to determine the type(s) of pathology present in individual patients and assessment of which pathologies most strongly drive progression of cognitive impairments. (neurodegenerationresearch.eu)
Restrictive lung diseases are characterized by a reduction in FRC and other lung volumes because of pathology in the lungs, pleura, or structures of the thoracic cage. (medscape.com)

In multivariate analysis of progression-free survival and overall survival, bax/bcl-2 was an independent prognostic factor ( P =0.0002 and P =0.002). (haematologica.org)
Data obtained from patients with androgen- independent prostatic carcinoma have revealed that prostate-specific antigen (PSA) correlates with survival in patients with normal bombesin levels. (cancernetwork.com)
Although TMZ has been identified to improve the survival rates of patients with GBM, a majority experience disease progression within one year ( 3 ). (spandidos-publications.com)

This study used a machine learning approach (Restricted Boltzmann Machine) to perform an unsupervised analysis of 991 medication profiles of patients managed in the intensive care unit (ICU) to explore pharmacophenotypes that correlated with ICU complications (e.g., mechanical ventilation) and patient-centered outcomes (e.g., length of stay, mortality). (ahrq.gov)
We investigated bax/bcl-2 ratio by flow cytometry in 502 patients and identified a cut off of 1.50 to correlate bax/bcl-2 ratio with well-established clinical and biological prognosticators. (haematologica.org)
Here, Welsing et al ( Arthritis Rheum 50(7):2082, 2004 ) use GEE to investigate the longitudinal relationship of RA disease activity to radiographic damage in two different cohorts of RA patients. (hopkinsarthritis.org)
Patients are treated according to the discretion of their treating rheumatologist, but have regular assessments of disease activity (reported as DAS (disease activity scores) collected at baseline and every 3 months) and radiographs of hands and feet obtained at baseline and every three years. (hopkinsarthritis.org)
The baseline characteristics of patients enrolled in each of the cohorts was remarkably similar except that the COBRA group had higher disease activity at baseline (as required by the study protocol) and was followed for a longer period of time. (hopkinsarthritis.org)
The use of more reliable prognostic tools or staging systems may overcome this difficulty and a nonhistological prostate cancer staging system has already shown that patients with visceral involvement but minimal bone disease have the highest chance of responding to a combination of doxorubicin, mitomycin-C, and 5-fluorouracil. (cancernetwork.com)
This model of disease progression may be an important prognostic tool and have implications for the treatment of patients with stage D malignancy. (cancernetwork.com)
With advancing age, the chances of getting GA increase, with approximately 1 in 29 patients over age 75 having GA and 1 in 4 patients over age 90 having the disease. (eyesoneyecare.com)
Early assignment of disease progression among patients with X-linked adrenoleukodystrophy (ALD) is critical for the appropriate selection of effective therapy. (ajnr.org)
18 (86%) of the 21 patients had disease progression revealed by the follow-up evaluations based on MR imaging (Loes) and neurologic scores. (ajnr.org)
for 18 (82%) of the 22 patients, no evidence of disease progression was revealed by the follow-up evaluations. (ajnr.org)
In this study, we evaluated the association between contrast enhancement on the T1-weighted spin-echo MR images of patients with X-linked ALD and disease progression based on clinical evaluation and MR imaging scores. (ajnr.org)
LRP6 and VEGF levels in the vitreous body from patients with PDR were increased and correlated mutually. (molvis.org)
Atypical Parkinsonism affects about five to ten percent of patients with Parkinsonism and includes the diseases Corticobasal Degeneration, Progressive Supranuclear Palsy, Lewy Body Dementia and Multiple System Atrophy. (bz-bx.net)
Despite this improvement, CLL remains incurable, and the majority of patients experience disease relapse [ 2 ]. (biomedcentral.com)
The second study evaluated patients who were enrolled in an ongoing prospective study between April 1, 2014, and July 31, 2019, with presentations that were suggestive of neuroinflammatory disease but who were ultimately diagnosed with a CNS malignant neoplasm. (stanford.edu)
However, the natural course of the disease is quite variable among patients. (basicmedicalkey.com)
Wilcoxon test was performed to assess the difference between percent change in HPV16 ctDNA after one cycle of treatment in patients with progressive disease (PD) and those deriving benefit (non-PD). (eurekalert.org)
The Kruskal-Wallis analysis test were performed to evaluate for differences in percent change of HPV ctDNA after one cycle of treatment between patients with progressive disease (PD), stable disease (SD), partial response (PR), and complete response (CR) on restaging imaging. (eurekalert.org)
Limited prior data demonstrate that a rapid clearance profile of HPV ctDNA is associated with decreased risk of locoregional recurrence in patients receiving chemoradiation for locally advanced HPV OPSCC, and that levels may increase at the time of recurrence. (eurekalert.org)
The assay would predict progressive disease prior to radiographic imaging in patients undergoing treatment for R/M HPV OPSCC. (eurekalert.org)
The Swiecicki Research Team concluded in their Oncotarget Research Output that this data suggests that changes in HPV16 ctDNA may be predictive of progressive disease in patients with R/M HNSCC receiving systemic therapy. (eurekalert.org)
Age of onset and clinical manifestations may vary widely among patients with a given lysosomal storage disease, and significant phenotypic heterogeneity between family members carrying identical mutations has been reported. (medscape.com)
Enzyme replacement therapy (ERT) appears safe and effective for peripheral manifestations in patients with Gaucher disease types I and III, Fabry disease, mucopolysaccharidosis I (Hurler, Hurler-Scheie, and Scheie syndromes), mucopolysaccharidosis II (Hunter syndrome), mucopolysaccharidosis VI (Maroteaux-Lamy syndrome), Pompe disease, and recently Batten disease (neuronal ceroid lipofuscinoses, CLN2). (medscape.com)
In general, transplantation yields the best results when performed early in the course of the disease (ie, in an asymptomatic affected sibling of a child with a lysosomal storage disorder), in centers with experience in performing transplantations to treat inherited metabolic disorders, and in patients healthy enough to tolerate the conditioning and transplantation regimen. (medscape.com)
Importantly, this implies that up to 78% of the variation in HIV disease progression rate between patients remains to be explained. (lu.se)
Intraoral involvement in Crohn disease occurs in 8-29% of patients and may precede intestinal involvement. (medscape.com)
Whether patients with orofacial granulomatoses will subsequently develop intestinal manifestations of Crohn disease is uncertain, but histologic similarities between the oral lesions and the intestinal lesions are obvious. (medscape.com)
NEW ORLEANS - With numerous agents for multiple sclerosis (MS) seemingly more effective in halting disease activity than the older "platform" drugs, can a case be made for starting almost all patients with newly diagnosed MS on them? (medscape.com)
He explained that approximately one third of patients will have a fairly indolent disease course and that aggressive treatment can be started if their condition worsens. (medscape.com)
In a 20-year population-based study he coauthored, 34% of patients still had an EDSS score less than 3 some 10 years from disease onset, 21% had a score less than 4, and 15% had a score of 0 to 2. (medscape.com)
MRI - especially for showing the emergence of T1 gadolinium-enhancing lesions - is a good way to monitor patients with mild disease started on platform drugs. (medscape.com)

Bhatt MH, Podder N, Chokroverty S. Sleep and neurodegenerative diseases. (medigraphic.com)
Atypical Parkinsonian syndromes (APS) feature a heterogeneous group of progressive neurodegenerative diseases, to which multiple system atrophy (MSA), dementia with Lewy bodies (DLB), progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) are counted. (bz-bx.net)

Normalization of tumor marker values may indicate cure despite radiographic evidence of persistent disease. (medscape.com)
Oncotarget published " Human papilloma virus circulating tumor DNA assay predicts treatment response in recurrent/metastatic head and neck squamous cell carcinoma " which reported that despite the rising incidence of human papillomavirus related oropharyngeal squamous cell carcinoma, treatment of metastatic disease remains palliative. (eurekalert.org)
Even with new treatments such as immunotherapy, response rates are low and can be delayed, while even mild tumor progression in the face of an ineffective therapy can lead to rapid death. (eurekalert.org)
Rapid blood and lymphatic spread and breast tumor emboli are the main features ofIBC 4 . (bvsalud.org)

My research interests include predictive modeling, data management / coordination and medical monitoring, lung diseases and disorders, biomarker discovery and longitudinal data analysis. (cincinnatichildrens.org)

Univariate Cox and least absolute shrinkage and selection operator (LASSO) analyses were used to identify the set of estrogen-related differentially expressed genes (ERDEGs) associated with progression-free intervals (PFI) and to establish a prediction model. (biomedcentral.com)

However, even in the more common and usually slowly progressive dementias such as Alzheimer's disease, frontotemporal lobar degeneration, dementia with Lewy bodies and other degenerative dementias, as well as vascular dementia, establishment and progression of the disease is occasionally surprisingly accelerated, leading to a clinical presentation of RPD. (touchneurology.com)

In this case, ART should be continued (AI) with regimens that are designed to maintain CD4 counts, preserve treatment options, delay clinical progression, and minimize toxicity. (hiv.gov)

In summary, we demonstrated the vital role of m 6 A RNA methylation regulators in the initial presentation and progression of HCC and constructed a nomogram which would predict the clinical outcome and provide a basis for individualized therapy. (hindawi.com)
Clinical characteristics that predict risk of development and progression of OSA include a large neck circumference and male sex. (cdc.gov)

The changes in foveal thickness were correlated with those of VA during the 2-year follow-up period with a mean of 3.8±1.5 injections (including the first injection). (bmj.com)

MYCN amplification occurs in about 20% of neuroblastoma cases and is associated with advanced disease and unfavorable biology. (msdmanuals.com)
MiRNAs 29a-3p and 34b-3p also resulted downregulated in vivo in a murine neuroblastoma progression model. (oncotarget.com)

Disease resulting from infection with this virus is called panleukopenia - from the Greek words for all types (pan) of white blood cells (leuko) that are greatly reduced in number (penia). (catwatchnewsletter.com)
Nevertheless, a rapid course might also represent the aggravation of an undiagnosed disease attributable to a secondary cause, usually an infection or a metabolic dysregulation. (touchneurology.com)
Interestingly, the disease progression rate can vary considerably between individuals (with time to AIDS ranging between months to decades), and the immune specificity against HIV infection has been suggested to only explain about 22% of the most reliable predictor of when AIDS will develop? (lu.se)

Some of the most notable discoveries made at my lab include identifying pediatric phenotypes of rapid lung disease progression using the U.S. Cystic Fibrosis Registry and the geo- and bio-marker-informed prediction modeling of rapid lung disease progression. (cincinnatichildrens.org)

Various conditions involving the central nervous system (CNS) can emerge as RPD, including Creutzfeld-Jakob disease (CJD) and other spongiform encephalopathies, vascular disorders, autoimmune and paraneoplastic encephalopathies, subacute infections, metabolic and toxic disorders and systemic diseases (see Table 1 ). (touchneurology.com)

The Oncotarget authors found that longitudinal changes of HPV16 ctDNA correlate with treatment response and that ctDNA responses are observed earlier than conventional imaging. (eurekalert.org)

Anemia also occasionally occurs when bleeding into these highly vascular tumors causes a rapid drop in hemoglobin. (msdmanuals.com)

The influence of lung disease on the diaphragm has been poorly studied. (frontiersin.org)
Lung transplantation (LTx), by replacing a diseased lung with a healthy one, is an interesting model to evaluate the evolution of the diaphragmatic morphology before and after transplantation in the context of lung disease. (frontiersin.org)
Restrictive lung diseases are characterized by reduced lung volumes, either because of an alteration in lung parenchyma or because of a disease of the pleura, chest wall, or neuromuscular apparatus. (medscape.com)
The first is intrinsic lung diseases or diseases of the lung parenchyma. (medscape.com)
The diseases cause inflammation or scarring of the lung tissue (interstitial lung disease) or result in filling of the air spaces with exudate and debris (pneumonitis). (medscape.com)
Diseases of these structures result in lung restriction, impaired ventilatory function, and respiratory failure (eg, nonmuscular diseases of the chest wall, neuromuscular disorders). (medscape.com)
The mnemonic "PAINT" has been used to divide the causes of restrictive lung disease into pleural, alveolar, interstitial, neuromuscular, and thoracic cage abnormalities. (medscape.com)
In cases of intrinsic lung disease, the physiological effects of diffuse parenchymal disorders reduce all lung volumes by the excessive elastic recoil of the lungs, relative to the outward recoil forces of the chest wall. (medscape.com)

Standardization of the neuropathologic assessment of Alzheimer's disease. (springer.com)
The neuropathologic findings do not, however, correlate substantially with subject clinical classification as PDD versus DLB. (neurodegenerationresearch.eu)

In this study we have compared expression of a panel of 13 reported anti-HIV miRNAs in human PBMCs from long term non progressors (LTNPs), regular progressors and rapid progressors. (rnabiology.org)

The odds of the secondary outcome, rapid progression to CKD stage 3 or higher, significantly increased by 26% per 5-point increment in CES-D, the investigators also reported. (renalandurologynews.com)
The expression level of PAX6 reportedly is inversely correlated with the tumorigenicity and invasion of GBM cell lines and is significantly reduced in GBMs ( 7 , 8 ). (spandidos-publications.com)

Oral findings as described above warrant a full systemic evaluation for intestinal Crohn disease, including referral for colonoscopy and biopsy with histopathologic correlation. (medscape.com)
Participation in CWHSP is voluntary, and these findings are influenced by participation patterns, so for many miners it remains unclear how rapidly their disease progressed. (cdc.gov)

The canine non-infectious inflammatory diseases of the central nervous system (CNS) are common diseases that can affect the brain, spinal cord, and/or the meninges. (biomedcentral.com)
Clinical signs of non-infectious CNS inflammatory disorders are frequently very similar to those of infectious CNS diseases and even those of neoplasia [ 1 ]. (biomedcentral.com)

McLean CA, Harney MC, Gonzales MF (1994) Cytological demonstration of features of Alzheimer's disease using brain smear technique. (springer.com)
A study of 15 cases with graded intellectual status in ageing and Alzheimer's disease. (springer.com)
Luna-Munoz J, Garcia-Sierra F, Falcon V, Menendez I, Chavez-Macias L, Mena R (2005) Regional conformational change involving phosphorylation of tau protein at the Thr231, precedes the structural change detected by Alz-50 antibody in Alzheimer's disease. (springer.com)
However, it is important to point out that even neurodegenerative disorders such as Alzheimer's disease (AD), dementia with Lewy bodies and frontotemporal dementia present in rare cases as a subacute dementia instead of a slowly progressive deterioration of higher functions. (touchneurology.com)

Failure of memory and other higher mental functions (dementia) is increasingly recognized as a major source of disability in Parkinson disease and related conditions. (neurodegenerationresearch.eu)
The term rapidly progressive dementia (RPD) is used to describe cases with a progression course which usually ranges between weeks and months. (touchneurology.com)
Alzheimer's disease (AD) is the most common cause of dementia. (lu.se)

Veterans may be at an elevated risk for OSA because of increased prevalence of factors associated with the development and progression of OSA. (cdc.gov)

Similarly, serum bombesin levels appear to be a useful prognostic tool in cases of neuroendocrine differentiated disease. (cancernetwork.com)

Lysosomal storage diseases describe a heterogeneous group of dozens of rare inherited disorders characterized by the accumulation of undigested or partially digested macromolecules, which ultimately results in cellular dysfunction and clinical abnormalities. (medscape.com)

In addition, global disease burden, as shown by the double-echo spin-echo images, was assessed using a visual scoring method (Loes score). (ajnr.org)
2 By 2020, it is estimated that COPD will rank fifth in burden of disease and third as a cause of death throughout the world. (basicmedicalkey.com)

Combinatorial regulation is highly probable in dictating differential disease progression as average expression of miR-382-5p and miR-155-5p can substantially distinguish LTNP individuals from regular progressors. (rnabiology.org)

And so, in the setting of a really rapidly evolving outbreak, a rapid review is probably more preferable because we're always getting this new information constantly trickling out, and at some point you've got to take that information and rapidly synthesize it in order to inform a public health intervention. (cdc.gov)

PC-ALCL is one of the primary cutaneous CD30 + T-cell lymphoproliferative disorders, a wide spectrum of disease, with lymphomatoid papulosis (LyP) at the benign end of the spectrum and PC-ALCL at the malignant end. (medscape.com)
The second is extrinsic disorders or extrapulmonary diseases. (medscape.com)
Lysosomal storage diseases are generally classified by the accumulated substrate and include the sphingolipidoses, oligosaccharidoses, mucolipidoses, mucopolysaccharidoses (MPSs), lipoprotein storage disorders, lysosomal transport defects, neuronal ceroid lipofuscinoses and others. (medscape.com)

Smoking cessation, and avoidance of other known toxins causing COPD, are the only management strategies proven to slow the progression. (basicmedicalkey.com)
1 The goals of the GOLD organization are to increase awareness of COPD and reduce morbidity and mortality associated with the disease. (basicmedicalkey.com)

Population frequency of HLA types (or supertypes) and their capacity to elicit cytotoxic T lymphocyte responses are also negatively correlated. (unige.ch)

Dr Weinshenker emphasized that aggressive disease definitely should be treated aggressively from the start. (medscape.com)

Furthermore, clinical markers (neurologic and cognitive scores) are relatively insensitive to early nervous system involvement and minor disease progression (9) . (ajnr.org)

The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)

Anatomy16

Organisms6

Diseases53

Chemicals and Drugs58

Analytical, Diagnostic and Therapeutic Techniques and Equipment62

Psychiatry and Psychology1

Phenomena and Processes52

Disciplines and Occupations2

Technology, Industry, Agriculture1

Information Science7

Named Groups1

Health Care30

Geographicals1

Rapidity of disease progression2

Viral11

Severity7

Levels correlate1

Radiographic progression12

Prognosis6

Symptoms17

Centers for Diseas2

Chronic14

Neurological3

Infectious diseases4

Severe12

Chemoresistance3

Decline5

Clinically5

Histopathology1

Cognitive impairment2

Mechanisms4

Assays3

Subsets2

Parkinson's10

Diagnosis4

Immunological2

Idiopathic5

Acute2

Pathology3

Survival3

Patients32

Neurodegenerative diseases2

Tumor4

Predictive1

Expressed genes1

Clinical presentation1

Toxicity1

Predict2

Thickness1

Neuroblastoma2

Infection3

Pediatric1

Systemic diseases1

Longitudinal1

Vascular1

Lung8

Neuropathologic2

MiRNAs1

Significantly2

Findings2

Inflammatory2

Alzheimer's Disease4

Dementia3

Prevalence1

Serum1

Heterogeneous group1

Burden2

Expression1

Rapidly1

Disorders3

COPD2

Responses1

Aggressive disease1

Involvement1

Oncotarget1