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  • neurons
  • By increasing dopamine in the striatum, addictive drugs alter the balance of dopamine and glutamate signals converging onto striatal medium-sized spiny neurons (MSNs) and activate intracellular events involved in long-term behavioral alterations. (isharonline.org)
  • medial
  • corpus genicula´tum see geniculate bodies , lateral, and geniculate bodies , medial. (thefreedictionary.com)
  • Previously it has been proposed that processing one's own reputation requires a reputation representation in the medial prefrontal cortex (mPFC) and a value representation in the striatum. (isharonline.org)
  • After nigrostriatal lesions, m-CPP-induced Fos expression remained unchanged in the subthalamic nucleus but was reduced in the medial quadrants of the striatum and was markedly enhanced in the entopeduncular nucleus. (mendeley.com)
  • Data were analyzed using a region-of-interest approach restricting analysis to the medial and lateral orbitofrontal cortex, the amygdala, the anterior cingulate cortex, and the striatum. (biomedsearch.com)
  • neuronal
  • The striatum, a neuronal nucleus intimately involved in motor behaviour, is one of the brain regions with the highest acetylcholine content. (biomedcentral.com)
  • In affected patients, neuronal degeneration initiates in the striatum and progresses to the cerebral cortex, following a pattern that correlates to clinical progression of HD. (medscape.com)
  • The purpose of this study was to investigate neuroprotective efficiency of N-methyl D-aspartate ( NMDA ) receptor (NMDAR) blockade on the neuronal damage in the less studied and allegedly less affected CA3 hippocampus and striatum in the Mongolian gerbil model of global cerebral ischemia . (curehunter.com)
  • rats
  • In this study, we have investigated the changes of acetylcholine esterase (AChE) enzyme activity, total muscarinic and muscarinic M1 receptor binding and gene expression in the corpus striatum of STZ - diabetic rats and the insulin treated diabetic rats. (biomedcentral.com)
  • Effect of tacrine on in vivo release of dopamine and its metabolites in the striatum of freely moving rats. (biomedsearch.com)
  • The effects of tacrine (THA) on extracellular concentrations of dopamine (DA), 3,4-dihydroxyphenylacetic acid, homovanillic acid and 5-hydroxyindoleacetic acid were investigated in the striatum of freely moving rats, using a microdialysis technique in which tacrine was administered locally via the microdialysis membrane. (biomedsearch.com)
  • muscarinic
  • ACh has complex and clinically important actions in the striatum that are mediated predominantly by muscarinic receptors. (biomedcentral.com)
  • These results suggest the diabetes-induced changes of the cholinergic activity in the corpus striatum and the regulatory role of insulin on binding parameters and gene expression of total and muscarinic M1 receptors. (biomedcentral.com)
  • The study indicates that THA enhances monoamine neurotransmission in the rat striatum, probably via an interaction with both muscarinic and nicotinic heteroreceptors. (biomedsearch.com)
  • control
  • We observed that insulin treatment brought back the decreased maximal velocity (V max ) of acetylcholine esterase in the corpus striatum during diabetes to near control state. (biomedcentral.com)
  • changes
  • Vonsattel et al devised a neural pathologic grading system that scaled the microscopic and gross striatum changes. (medscape.com)
  • follow
  • 4 Damage to the striatum provides an explanation for the Parkinsonian signs that may follow severe poisoning with carbon monoxide. (bmj.com)